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% Ratio of Prescribing of Antidepressant, Hypnotic and Antipsychotic Drugs in General Practice in England 0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100% Jun-03 Sep-03 Dec-03 Mar-04 Jun-04 Sep-04 Dec-04 Mar-05 Jun-05 Sep-05 Dec-05 Mar-06 Jun-06 Sep-06 Dec-06 Mar-07 Jun-07 Sep-07 Dec-07 Mar-08 Jun-08 Q uarterto % of Item s A ntidepressants Hypnotics Antipsychotics © CopyrightNHSBSA 2008

% Ratio of Prescribing of Antidepressant, Hypnotic and Antipsychotic Drugs in General Practice in England

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Page 1: % Ratio of Prescribing of Antidepressant, Hypnotic and Antipsychotic Drugs in General Practice in England

% Ratio of Prescribing of Antidepressant, Hypnotic and Antipsychotic Drugs in General Practice in England

0%

10%

20%

30%

40%

50%

60%

70%

80%

90%

100%

Jun-03

Sep-03

Dec-03

Mar-04

Jun-04

Sep-04

Dec-04

Mar-05

Jun-05

Sep-05

Dec-05

Mar-06

Jun-06

Sep-06

Dec-06

Mar-07

Jun-07

Sep-07

Dec-07

Mar-08

Jun-08

Quarter to

% o

f Ite

ms

Antidepressants Hypnotics Antipsychotics

© Copyright NHSBSA 2008

Page 2: % Ratio of Prescribing of Antidepressant, Hypnotic and Antipsychotic Drugs in General Practice in England

% Ratio of Spending on Antidepressant, Hypnoticand Antipsychotic Drugs in General Practice in England

0%

10%

20%

30%

40%

50%

60%

70%

80%

90%

100%

Jun-03

Sep-03

Dec-03

Mar-04

Jun-04

Sep-04

Dec-04

Mar-05

Jun-05

Sep-05

Dec-05

Mar-06

Jun-06

Sep-06

Dec-06

Mar-07

Jun-07

Sep-07

Dec-07

Mar-08

Jun-08

Quarter to

% o

f NIC

(£)

Antidepressants Hypnotics Antipsychotics

© Copyright NHSBSA 2008

Page 3: % Ratio of Prescribing of Antidepressant, Hypnotic and Antipsychotic Drugs in General Practice in England

Trends in Prescribing of Hypnotics in General Practice in England

0

500,000

1,000,000

1,500,000

2,000,000

2,500,000

3,000,000

Jun-03

Sep-03

Dec-03

Mar-04

Jun-04

Sep-04

Dec-04

Mar-05

Jun-05

Sep-05

Dec-05

Mar-06

Jun-06

Sep-06

Dec-06

Mar-07

Jun-07

Sep-07

Dec-07

Mar-08

Jun-08

Quarter to

Item

s

Temazepam Zopiclone Nitrazepam Zolpidem Lormetazepam Others

© Copyright NHSBSA 2008

Page 4: % Ratio of Prescribing of Antidepressant, Hypnotic and Antipsychotic Drugs in General Practice in England

Trends in Spending on Hypnotics in General Practice in England

0

1,000,000

2,000,000

3,000,000

4,000,000

5,000,000

6,000,000

7,000,000

8,000,000

9,000,000

Jun-03

Sep-03

Dec-03

Mar-04

Jun-04

Sep-04

Dec-04

Mar-05

Jun-05

Sep-05

Dec-05

Mar-06

Jun-06

Sep-06

Dec-06

Mar-07

Jun-07

Sep-07

Dec-07

Mar-08

Jun-08

Quarter to

NIC

(£)

Temazepam Zopiclone Nitrazepam Zolpidem Lormetazepam Others

© Copyright NHSBSA 2008

Page 5: % Ratio of Prescribing of Antidepressant, Hypnotic and Antipsychotic Drugs in General Practice in England

Quantities of "Z" drugs (Zaleplon, Zolpidem & Zopiclone) Prescribedin General Practice in England (Quarter to June 2008)

0

100,000

200,000

300,000

400,000

500,000

600,000

700,000

1 to 7

8 to 14

15 to 21

22 to 28

29 to 35

36 to 42

43 to 49

50 to 56

57 to 63

64 to 70

71 to 77

78 to 84

> 84

Quantities on Prescriptions

Item

s

© Copyright NHSBSA 2008

Page 6: % Ratio of Prescribing of Antidepressant, Hypnotic and Antipsychotic Drugs in General Practice in England

Quantities of Selected Hypnotics (Tabs/Caps)Prescribed in General Practice in England

(Quarter to June 2008)

0

100,000

200,000

300,000

400,000

500,000

600,000

700,000

1 to 7

8 to 14

15 to 21

22 to 28

29 to 35

36 to 42

43 to 49

50 to 56

57 to 63

64 to 70

71 to 77

78 to 84

> 84

Quantities on Prescriptions

Item

s

"Z" drugs Temazepam Nitrazepam

© Copyright NHSBSA 2008

Page 7: % Ratio of Prescribing of Antidepressant, Hypnotic and Antipsychotic Drugs in General Practice in England

% of Prescriptions for Selected Hypnotics (Tabs/Caps) in General Practice in England for Defined Quantities

(Quarter to June 2008)

0%

10%

20%

30%

40%

50%

60%

1 to 7

8 to 14

15 to 21

22 to 28

29 to 35

36 to 42

43 to 49

50 to 56

57 to 63

64 to 70

71 to 77

78 to 84

> 84

Quantities on Prescriptions

% It

ems

"Z" drugs Temazepam Nitrazepam

© Copyright NHSBSA 2008

Page 8: % Ratio of Prescribing of Antidepressant, Hypnotic and Antipsychotic Drugs in General Practice in England

Trends in Prescribing of Anxiolytics in General Practice in England

0

200,000

400,000

600,000

800,000

1,000,000

1,200,000

1,400,000

1,600,000

1,800,000

Jun-03

Sep-03

Dec-03

Mar-04

Jun-04

Sep-04

Dec-04

Mar-05

Jun-05

Sep-05

Dec-05

Mar-06

Jun-06

Sep-06

Dec-06

Mar-07

Jun-07

Sep-07

Dec-07

Mar-08

Jun-08

Quarter to

Item

s

Diazepam Lorazepam Chlordiazepoxide Oxazepam Buspirone Others

© Copyright NHSBSA 2008

Page 9: % Ratio of Prescribing of Antidepressant, Hypnotic and Antipsychotic Drugs in General Practice in England

Trends in Spending on Anxiolytics in General Practice in England

0

1,000,000

2,000,000

3,000,000

4,000,000

5,000,000

6,000,000

7,000,000

8,000,000

9,000,000

Jun-03

Sep-03

Dec-03

Mar-04

Jun-04

Sep-04

Dec-04

Mar-05

Jun-05

Sep-05

Dec-05

Mar-06

Jun-06

Sep-06

Dec-06

Mar-07

Jun-07

Sep-07

Dec-07

Mar-08

Jun-08

Quarter to

NIC

(£)

Diazepam Lorazepam Chlordiazepoxide Oxazepam Buspirone Others

© Copyright NHSBSA 2008

Page 10: % Ratio of Prescribing of Antidepressant, Hypnotic and Antipsychotic Drugs in General Practice in England

Trends in Prescribing of Antipsychotic Drugs (BNF 4.2.1) in General Practice in England

0

200,000

400,000

600,000

800,000

1,000,000

1,200,000

1,400,000

1,600,000

1,800,000

Jun-03

Sep-03

Dec-03

Mar-04

Jun-04

Sep-04

Dec-04

Mar-05

Jun-05

Sep-05

Dec-05

Mar-06

Jun-06

Sep-06

Dec-06

Mar-07

Jun-07

Sep-07

Dec-07

Mar-08

Jun-08

Quarter to

Item

s

"Atypical" antipsychotic drugs "Typical" antipsychotic drugs

© Copyright NHSBSA 2008

Page 11: % Ratio of Prescribing of Antidepressant, Hypnotic and Antipsychotic Drugs in General Practice in England

Trends in Spending on Antipsychotic Drugs (BNF 4.2.1) in General Practice in England

0

10,000,000

20,000,000

30,000,000

40,000,000

50,000,000

60,000,000

70,000,000

Jun-03

Sep-03

Dec-03

Mar-04

Jun-04

Sep-04

Dec-04

Mar-05

Jun-05

Sep-05

Dec-05

Mar-06

Jun-06

Sep-06

Dec-06

Mar-07

Jun-07

Sep-07

Dec-07

Mar-08

Jun-08

Quarter to

NIC

(£)

"Atypical" antipsychotic drugs "Typical" antipsychotic drugs

© Copyright NHSBSA 2008

Page 12: % Ratio of Prescribing of Antidepressant, Hypnotic and Antipsychotic Drugs in General Practice in England

Trends in Prescribing of "Typical" Antipsychotics in General Practice in England

0

100,000

200,000

300,000

400,000

500,000

600,000

Jun-03

Sep-03

Dec-03

Mar-04

Jun-04

Sep-04

Dec-04

Mar-05

Jun-05

Sep-05

Dec-05

Mar-06

Jun-06

Sep-06

Dec-06

Mar-07

Jun-07

Sep-07

Dec-07

Mar-08

Jun-08

Quarter to

Item

s

Chlorpromazine Haloperidol Trifluoperazine Sulpiride Thioridazine Promazine Other Typicals

© Copyright NHSBSA 2008

Page 13: % Ratio of Prescribing of Antidepressant, Hypnotic and Antipsychotic Drugs in General Practice in England

Trends in Spending on "Typical" Antipsychotics in General Practice in England

0

500,000

1,000,000

1,500,000

2,000,000

2,500,000

3,000,000

3,500,000

4,000,000

Jun-03

Sep-03

Dec-03

Mar-04

Jun-04

Sep-04

Dec-04

Mar-05

Jun-05

Sep-05

Dec-05

Mar-06

Jun-06

Sep-06

Dec-06

Mar-07

Jun-07

Sep-07

Dec-07

Mar-08

Jun-08

Quarter to

NIC

(£)

Chlorpromazine Haloperidol Trifluoperazine Sulpiride Thioridazine Promazine Other Typicals

© Copyright NHSBSA 2008

Page 14: % Ratio of Prescribing of Antidepressant, Hypnotic and Antipsychotic Drugs in General Practice in England

Trends in Prescribing of "Atypical" Antipsychotics in General Practice in England

0

50,000

100,000

150,000

200,000

250,000

300,000

350,000

400,000

450,000

Jun-03

Sep-03

Dec-03

Mar-04

Jun-04

Sep-04

Dec-04

Mar-05

Jun-05

Sep-05

Dec-05

Mar-06

Jun-06

Sep-06

Dec-06

Mar-07

Jun-07

Sep-07

Dec-07

Mar-08

Jun-08

Quarter to

Item

s

Quetiapine Amisulpride Risperidone Olanzapine Other Atypicals

© Copyright NHSBSA 2008

Page 15: % Ratio of Prescribing of Antidepressant, Hypnotic and Antipsychotic Drugs in General Practice in England

Trends in Spending on "Atypical" Antipsychotics in General Practice in England

0

5,000,000

10,000,000

15,000,000

20,000,000

25,000,000

30,000,000

Jun-03

Sep-03

Dec-03

Mar-04

Jun-04

Sep-04

Dec-04

Mar-05

Jun-05

Sep-05

Dec-05

Mar-06

Jun-06

Sep-06

Dec-06

Mar-07

Jun-07

Sep-07

Dec-07

Mar-08

Jun-08

Quarter to

NIC

(£)

Quetiapine Amisulpride Risperidone Olanzapine Other Atypicals

© Copyright NHSBSA 2008

Page 16: % Ratio of Prescribing of Antidepressant, Hypnotic and Antipsychotic Drugs in General Practice in England

Trends in Prescribing of Olanzapine Tablets by Strength in General Practice in England

0

20,000

40,000

60,000

80,000

100,000

120,000

140,000

160,000

180,000

Jun-03

Sep-03

Dec-03

Mar-04

Jun-04

Sep-04

Dec-04

Mar-05

Jun-05

Sep-05

Dec-05

Mar-06

Jun-06

Sep-06

Dec-06

Mar-07

Jun-07

Sep-07

Dec-07

Mar-08

Jun-08

Quarter to

Item

s

2.5mg 5mg 7.5mg 10mg 15mg 20mg

© Copyright NHSBSA 2008

Page 17: % Ratio of Prescribing of Antidepressant, Hypnotic and Antipsychotic Drugs in General Practice in England

Trends in Prescribing of Quetiapine by Strength in General Practice in England

0

20,000

40,000

60,000

80,000

100,000

120,000

140,000

160,000

180,000

200,000

Jun-03

Sep-03

Dec-03

Mar-04

Jun-04

Sep-04

Dec-04

Mar-05

Jun-05

Sep-05

Dec-05

Mar-06

Jun-06

Sep-06

Dec-06

Mar-07

Jun-07

Sep-07

Dec-07

Mar-08

Jun-08Quarter to

Item

s

25mg 100mg 150mg 200mg 300mg

© Copyright NHSBSA 2008

Page 18: % Ratio of Prescribing of Antidepressant, Hypnotic and Antipsychotic Drugs in General Practice in England

Trends in Prescribing of Risperidone Tablets by Strength in General Practice in England

0

20,000

40,000

60,000

80,000

100,000

120,000

140,000

160,000

Jun-03

Sep-03

Dec-03

Mar-04

Jun-04

Sep-04

Dec-04

Mar-05

Jun-05

Sep-05

Dec-05

Mar-06

Jun-06

Sep-06

Dec-06

Mar-07

Jun-07

Sep-07

Dec-07

Mar-08

Jun-08

Quarter to

Item

s

0.5mg 1mg 2mg

3mg 4mg 6mg

© Copyright NHSBSA 2008

Page 19: % Ratio of Prescribing of Antidepressant, Hypnotic and Antipsychotic Drugs in General Practice in England

Trends in Prescribing of and Spending on Valproic Acid (Depakote®) in General Practice in England

0

10,000

20,000

30,000

40,000

50,000

60,000

70,000

80,000

90,000

Jun-03

Sep-03

Dec-03

Mar-04

Jun-04

Sep-04

Dec-04

Mar-05

Jun-05

Sep-05

Dec-05

Mar-06

Jun-06

Sep-06

Dec-06

Mar-07

Jun-07

Sep-07

Dec-07

Mar-08

Jun-08

Quarter to

Item

s

£0

£200,000

£400,000

£600,000

£800,000

£1,000,000

£1,200,000

£1,400,000

£1,600,000

£1,800,000

£2,000,000

NIC

(£)

Items NIC

© Copyright NHSBSA 2008

Page 20: % Ratio of Prescribing of Antidepressant, Hypnotic and Antipsychotic Drugs in General Practice in England

Trends in Prescribing of and Spending on Lithium in General Practice in England

0

20,000

40,000

60,000

80,000

100,000

120,000

140,000

160,000

180,000

200,000

220,000

Jun-03

Sep-03

Dec-03

Mar-04

Jun-04

Sep-04

Dec-04

Mar-05

Jun-05

Sep-05

Dec-05

Mar-06

Jun-06

Sep-06

Dec-06

Mar-07

Jun-07

Sep-07

Dec-07

Mar-08

Jun-08

Quarter to

Item

s

£0

£100,000

£200,000

£300,000

£400,000

£500,000

£600,000

NIC

(£)

Items NIC (£)

© Copyright NHSBSA 2008

Page 21: % Ratio of Prescribing of Antidepressant, Hypnotic and Antipsychotic Drugs in General Practice in England

Trends in Prescribing of Antidepressants in General Practice in England

0

500,000

1,000,000

1,500,000

2,000,000

2,500,000

3,000,000

3,500,000

4,000,000

4,500,000

5,000,000

Jun-03

Sep-03

Dec-03

Mar-04

Jun-04

Sep-04

Dec-04

Mar-05

Jun-05

Sep-05

Dec-05

Mar-06

Jun-06

Sep-06

Dec-06

Mar-07

Jun-07

Sep-07

Dec-07

Mar-08

Jun-08

Quarter to

Item

s

TCA and related MAOIs SSRIs Other antidepressant drugs

© Copyright NHSBSA 2008

Page 22: % Ratio of Prescribing of Antidepressant, Hypnotic and Antipsychotic Drugs in General Practice in England

Trends in Spending on Antidepressants in General Practice in England

0

10,000,000

20,000,000

30,000,000

40,000,000

50,000,000

60,000,000

70,000,000

Jun-03

Sep-03

Dec-03

Mar-04

Jun-04

Sep-04

Dec-04

Mar-05

Jun-05

Sep-05

Dec-05

Mar-06

Jun-06

Sep-06

Dec-06

Mar-07

Jun-07

Sep-07

Dec-07

Mar-08

Jun-08

Quarter to

NIC

(£)

TCA and related MAOIs SSRIs Other antidepressant drugs

© Copyright NHSBSA 2008

Page 23: % Ratio of Prescribing of Antidepressant, Hypnotic and Antipsychotic Drugs in General Practice in England

Trends in Prescribing of Tricyclic and related antidepressants in General Practice in England

0

500,000

1,000,000

1,500,000

2,000,000

2,500,000

3,000,000

Jun-03

Sep-03

Dec-03

Mar-04

Jun-04

Sep-04

Dec-04

Mar-05

Jun-05

Sep-05

Dec-05

Mar-06

Jun-06

Sep-06

Dec-06

Mar-07

Jun-07

Sep-07

Dec-07

Mar-08

Jun-08

Quarter to

Item

s

Amitriptyline Dosulepin Trazodone Lofepramine Clomipramine Trimipramine Imipramine Others

© Copyright NHSBSA 2008

Page 24: % Ratio of Prescribing of Antidepressant, Hypnotic and Antipsychotic Drugs in General Practice in England

Trends in Spending on Tricyclic and related antidepressantsin General Practice in England

0

2,000,000

4,000,000

6,000,000

8,000,000

10,000,000

12,000,000

14,000,000

16,000,000

18,000,000

20,000,000

Jun-03

Sep-03

Dec-03

Mar-04

Jun-04

Sep-04

Dec-04

Mar-05

Jun-05

Sep-05

Dec-05

Mar-06

Jun-06

Sep-06

Dec-06

Mar-07

Jun-07

Sep-07

Dec-07

Mar-08

Jun-08

Quarter to

NIC

(£)

Amitriptyline Dosulepin Trazodone Lofepramine Clomipramine Trimipramine Imipramine Others

© Copyright NHSBSA 2008

Page 25: % Ratio of Prescribing of Antidepressant, Hypnotic and Antipsychotic Drugs in General Practice in England

Trends in Prescribing of SSRIs in General Practice in England

0

500,000

1,000,000

1,500,000

2,000,000

2,500,000

3,000,000

3,500,000

4,000,000

4,500,000

5,000,000

Jun-03

Sep-03

Dec-03

Mar-04

Jun-04

Sep-04

Dec-04

Mar-05

Jun-05

Sep-05

Dec-05

Mar-06

Jun-06

Sep-06

Dec-06

Mar-07

Jun-07

Sep-07

Dec-07

Mar-08

Jun-08

Quarter to

Item

s

Citalopram Fluoxetine Paroxetine Sertraline Escitalopram Fluvoxamine

© Copyright NHSBSA 2008

Page 26: % Ratio of Prescribing of Antidepressant, Hypnotic and Antipsychotic Drugs in General Practice in England

Trends in Spending on SSRIs in General Practice in England

0

10,000,000

20,000,000

30,000,000

40,000,000

50,000,000

60,000,000

70,000,000

Jun-03

Sep-03

Dec-03

Mar-04

Jun-04

Sep-04

Dec-04

Mar-05

Jun-05

Sep-05

Dec-05

Mar-06

Jun-06

Sep-06

Dec-06

Mar-07

Jun-07

Sep-07

Dec-07

Mar-08

Jun-08

Quarter to

NIC

(£)

Citalopram Fluoxetine Paroxetine Sertraline Escitalopram Fluvoxamine

© Copyright NHSBSA 2008

Page 27: % Ratio of Prescribing of Antidepressant, Hypnotic and Antipsychotic Drugs in General Practice in England

Trends in Prescribing of Other Antidepressant drugs (BNF 4.3.4) in General Practice in England

0

200,000

400,000

600,000

800,000

1,000,000

1,200,000

1,400,000

Jun-03

Sep-03

Dec-03

Mar-04

Jun-04

Sep-04

Dec-04

Mar-05

Jun-05

Sep-05

Dec-05

Mar-06

Jun-06

Sep-06

Dec-06

Mar-07

Jun-07

Sep-07

Dec-07

Mar-08

Jun-08

Quarter to

Item

s

Venlafaxine Mirtazapine Duloxetine Flupentixol Others

© Copyright NHSBSA 2008

Page 28: % Ratio of Prescribing of Antidepressant, Hypnotic and Antipsychotic Drugs in General Practice in England

Trends in Spending on Other Antidepressant drugs (BNF 4.3.4) in General Practice in England

0

5,000,000

10,000,000

15,000,000

20,000,000

25,000,000

30,000,000

35,000,000

40,000,000

Jun-03

Sep-03

Dec-03

Mar-04

Jun-04

Sep-04

Dec-04

Mar-05

Jun-05

Sep-05

Dec-05

Mar-06

Jun-06

Sep-06

Dec-06

Mar-07

Jun-07

Sep-07

Dec-07

Mar-08

Jun-08

Quarter to

NIC

(£)

Venlafaxine Mirtazapine Duloxetine Flupentixol Others

© Copyright NHSBSA 2008

Page 29: % Ratio of Prescribing of Antidepressant, Hypnotic and Antipsychotic Drugs in General Practice in England

Trends in Prescribing of and Spending on Atomoxetinein General Practice in England

0

2000

4000

6000

8000

10000

12000

14000

Jun-03

Sep-03

Dec-03

Mar-04

Jun-04

Sep-04

Dec-04

Mar-05

Jun-05

Sep-05

Dec-05

Mar-06

Jun-06

Sep-06

Dec-06

Mar-07

Jun-07

Sep-07

Dec-07

Mar-08

Jun-08

Quarter to

Item

s

£0

£200,000

£400,000

£600,000

£800,000

£1,000,000

£1,200,000

NIC

(£)

Items NIC

© Copyright NHSBSA 2008

Page 30: % Ratio of Prescribing of Antidepressant, Hypnotic and Antipsychotic Drugs in General Practice in England

Trends in Prescribing of and Spending on Methylphenidate in General Practice in England

0

20,000

40,000

60,000

80,000

100,000

120,000

140,000

Jun-03

Sep-03

Dec-03

Mar-04

Jun-04

Sep-04

Dec-04

Mar-05

Jun-05

Sep-05

Dec-05

Mar-06

Jun-06

Sep-06

Dec-06

Mar-07

Jun-07

Sep-07

Dec-07

Mar-08

Jun-08

Quarter to

Item

s

£0

£500,000

£1,000,000

£1,500,000

£2,000,000

£2,500,000

£3,000,000

£3,500,000

£4,000,000

£4,500,000

NIC

(£)

Items NIC (£)

© Copyright NHSBSA 2008

Page 31: % Ratio of Prescribing of Antidepressant, Hypnotic and Antipsychotic Drugs in General Practice in England

Trends in Prescribing of Methylphenidate Preparations in General Practice in England

0

20,000

40,000

60,000

80,000

100,000

120,000

140,000

Jun-03

Sep-03

Dec-03

Mar-04

Jun-04

Sep-04

Dec-04

Mar-05

Jun-05

Sep-05

Dec-05

Mar-06

Jun-06

Sep-06

Dec-06

Mar-07

Jun-07

Sep-07

Dec-07

Mar-08

Jun-08

Quarter to

Item

s

Modified Release Standard

© Copyright NHSBSA 2008

Page 32: % Ratio of Prescribing of Antidepressant, Hypnotic and Antipsychotic Drugs in General Practice in England

Trends in Spending on Methylphenidate Preparations in General Practice in England

0

500,000

1,000,000

1,500,000

2,000,000

2,500,000

3,000,000

3,500,000

4,000,000

4,500,000

Jun-03

Sep-03

Dec-03

Mar-04

Jun-04

Sep-04

Dec-04

Mar-05

Jun-05

Sep-05

Dec-05

Mar-06

Jun-06

Sep-06

Dec-06

Mar-07

Jun-07

Sep-07

Dec-07

Mar-08

Jun-08

Quarter to

NIC

(£)

Modified Release Standard

© Copyright NHSBSA 2008

Page 33: % Ratio of Prescribing of Antidepressant, Hypnotic and Antipsychotic Drugs in General Practice in England

Trends in Prescribing of Methadone in General Practice in England

0

100,000

200,000

300,000

400,000

500,000

600,000

Jun-03

Sep-03

Dec-03

Mar-04

Jun-04

Sep-04

Dec-04

Mar-05

Jun-05

Sep-05

Dec-05

Mar-06

Jun-06

Sep-06

Dec-06

Mar-07

Jun-07

Sep-07

Dec-07

Mar-08

Jun-08

Quarter to

Item

s

Liquid Tablets/Capsules Injection Others

© Copyright NHSBSA 2008

Page 34: % Ratio of Prescribing of Antidepressant, Hypnotic and Antipsychotic Drugs in General Practice in England

Trends in Spending on Methadone in General Practice in England

0

1,000,000

2,000,000

3,000,000

4,000,000

5,000,000

6,000,000

7,000,000

8,000,000

Jun-03

Sep-03

Dec-03

Mar-04

Jun-04

Sep-04

Dec-04

Mar-05

Jun-05

Sep-05

Dec-05

Mar-06

Jun-06

Sep-06

Dec-06

Mar-07

Jun-07

Sep-07

Dec-07

Mar-08

Jun-08

Quarter to

NIC

(£)

Liquid Tablets/Capsules Injection Others

© Copyright NHSBSA 2008

Page 35: % Ratio of Prescribing of Antidepressant, Hypnotic and Antipsychotic Drugs in General Practice in England

Trends in Prescribing of Methadone (Excluding Liquid Formulations) in General Practice in England

0

2,000

4,000

6,000

8,000

10,000

12,000

Jun-03

Sep-03

Dec-03

Mar-04

Jun-04

Sep-04

Dec-04

Mar-05

Jun-05

Sep-05

Dec-05

Mar-06

Jun-06

Sep-06

Dec-06

Mar-07

Jun-07

Sep-07

Dec-07

Mar-08

Jun-08

Quarter to

Item

s

Tablets/Capsules Injection Others

© Copyright NHSBSA 2008

Page 36: % Ratio of Prescribing of Antidepressant, Hypnotic and Antipsychotic Drugs in General Practice in England

Trends in Prescribing of Older Antiepileptic Drugs in General Practice in England

0

200,000

400,000

600,000

800,000

1,000,000

1,200,000

1,400,000

1,600,000

1,800,000

Jun-03

Sep-03

Dec-03

Mar-04

Jun-04

Sep-04

Dec-04

Mar-05

Jun-05

Sep-05

Dec-05

Mar-06

Jun-06

Sep-06

Dec-06

Mar-07

Jun-07

Sep-07

Dec-07

Mar-08

Jun-08

Quarter to

Item

s

Carbamazepine Sodium Valproate & Valproic acid Phenytoin & Phenytoin SodiumClonazepam Phenobarbital & Phenobarbital Sodium ClobazamOthers

© Copyright NHSBSA 2008

Page 37: % Ratio of Prescribing of Antidepressant, Hypnotic and Antipsychotic Drugs in General Practice in England

Trends in Spending on Older Antiepileptic Drugs in General Practice in England

0

5,000,000

10,000,000

15,000,000

20,000,000

25,000,000

30,000,000

35,000,000

Jun-03

Sep-03

Dec-03

Mar-04

Jun-04

Sep-04

Dec-04

Mar-05

Jun-05

Sep-05

Dec-05

Mar-06

Jun-06

Sep-06

Dec-06

Mar-07

Jun-07

Sep-07

Dec-07

Mar-08

Jun-08

Quarter to

NIC

(£)

Carbamazepine Sodium Valproate & Valproic acid Phenytoin & Phenytoin SodiumClonazepam Phenobarbital & Phenobarbital Sodium ClobazamOthers

© Copyright NHSBSA 2008

Page 38: % Ratio of Prescribing of Antidepressant, Hypnotic and Antipsychotic Drugs in General Practice in England

Trends in Prescribing of Newer Antiepileptic Drugs in General Practice in England

0

200,000

400,000

600,000

800,000

1,000,000

1,200,000

1,400,000

Jun-03

Sep-03

Dec-03

Mar-04

Jun-04

Sep-04

Dec-04

Mar-05

Jun-05

Sep-05

Dec-05

Mar-06

Jun-06

Sep-06

Dec-06

Mar-07

Jun-07

Sep-07

Dec-07

Mar-08

Jun-08

Quarter to

Item

s

Gabapentin Lamotrigine Pregabalin

Levetiracetam Topiramate Others

© Copyright NHSBSA 2008

Page 39: % Ratio of Prescribing of Antidepressant, Hypnotic and Antipsychotic Drugs in General Practice in England

Trends in Spending on Newer Antiepileptic Drugs in General Practice in England

0

10,000,000

20,000,000

30,000,000

40,000,000

50,000,000

60,000,000

Jun-03

Sep-03

Dec-03

Mar-04

Jun-04

Sep-04

Dec-04

Mar-05

Jun-05

Sep-05

Dec-05

Mar-06

Jun-06

Sep-06

Dec-06

Mar-07

Jun-07

Sep-07

Dec-07

Mar-08

Jun-08

Quarter to

NIC

(£)

Gabapentin Lamotrigine Pregabalin

Levetiracetam Topiramate Others

© Copyright NHSBSA 2008

Page 40: % Ratio of Prescribing of Antidepressant, Hypnotic and Antipsychotic Drugs in General Practice in England

Trends in Prescribing of Co-beneldopa and Co-careldopa in General Practice in England

0

50,000

100,000

150,000

200,000

250,000

300,000

350,000

400,000

Jun-03

Sep-03

Dec-03

Mar-04

Jun-04

Sep-04

Dec-04

Mar-05

Jun-05

Sep-05

Dec-05

Mar-06

Jun-06

Sep-06

Dec-06

Mar-07

Jun-07

Sep-07

Dec-07

Mar-08

Jun-08

Quarter to

Item

s

Co-beneldopa Co-careldopa

© Copyright NHSBSA 2008

Page 41: % Ratio of Prescribing of Antidepressant, Hypnotic and Antipsychotic Drugs in General Practice in England

Trends in Spending on Co-beneldopa and Co-careldopa in General Practice in England

0

500,000

1,000,000

1,500,000

2,000,000

2,500,000

3,000,000

3,500,000

4,000,000

4,500,000

5,000,000

Jun-03

Sep-03

Dec-03

Mar-04

Jun-04

Sep-04

Dec-04

Mar-05

Jun-05

Sep-05

Dec-05

Mar-06

Jun-06

Sep-06

Dec-06

Mar-07

Jun-07

Sep-07

Dec-07

Mar-08

Jun-08

Quarter to

NIC

(£)

Co-beneldopa Co-careldopa

© Copyright NHSBSA 2008

Page 42: % Ratio of Prescribing of Antidepressant, Hypnotic and Antipsychotic Drugs in General Practice in England

Trends in Prescribing of Other Dopaminergic Drugs used in Parkinsonism in General Practice in England

0

50,000

100,000

150,000

200,000

250,000

300,000

Jun-03

Sep-03

Dec-03

Mar-04

Jun-04

Sep-04

Dec-04

Mar-05

Jun-05

Sep-05

Dec-05

Mar-06

Jun-06

Sep-06

Dec-06

Mar-07

Jun-07

Sep-07

Dec-07

Mar-08

Jun-08

Quarter to

Item

s

Ropinirole Pramipexole Cabergoline

Apomorphine Entacapone Levodopa/Carbidopa/Entacapone

Amantadine Selegiline Others

© Copyright NHSBSA 2008

Page 43: % Ratio of Prescribing of Antidepressant, Hypnotic and Antipsychotic Drugs in General Practice in England

Trends in Spending on Other Dopaminergic Drugs used in Parkinsonism in General Practice in England

0

5,000,000

10,000,000

15,000,000

20,000,000

25,000,000

Jun-03

Sep-03

Dec-03

Mar-04

Jun-04

Sep-04

Dec-04

Mar-05

Jun-05

Sep-05

Dec-05

Mar-06

Jun-06

Sep-06

Dec-06

Mar-07

Jun-07

Sep-07

Dec-07

Mar-08

Jun-08

Quarter to

NIC

(£)

Ropinirole Pramipexole CabergolineApomorphine Entacapone Levodopa/Carbidopa/EntacaponeAmantadine Selegiline Others

© Copyright NHSBSA 2008

Page 44: % Ratio of Prescribing of Antidepressant, Hypnotic and Antipsychotic Drugs in General Practice in England

Trends in Prescribing of Antimuscarinic Drugs in General Practice in England

0

50,000

100,000

150,000

200,000

250,000

300,000

Jun-03

Sep-03

Dec-03

Mar-04

Jun-04

Sep-04

Dec-04

Mar-05

Jun-05

Sep-05

Dec-05

Mar-06

Jun-06

Sep-06

Dec-06

Mar-07

Jun-07

Sep-07

Dec-07

Mar-08

Jun-08

Quarter to

Item

s

Procyclidine Trihexyphenidyl Orphenadrine Others

© Copyright NHSBSA 2008

Page 45: % Ratio of Prescribing of Antidepressant, Hypnotic and Antipsychotic Drugs in General Practice in England

Trends in Spending on Antimuscarinic Drugs in General Practice in England

0

200,000

400,000

600,000

800,000

1,000,000

1,200,000

1,400,000

1,600,000

1,800,000

2,000,000

Jun-03

Sep-03

Dec-03

Mar-04

Jun-04

Sep-04

Dec-04

Mar-05

Jun-05

Sep-05

Dec-05

Mar-06

Jun-06

Sep-06

Dec-06

Mar-07

Jun-07

Sep-07

Dec-07

Mar-08

Jun-08

Quarter to

NIC

(£)

Procyclidine Trihexyphenidyl Orphenadrine Others

© Copyright NHSBSA 2008

Page 46: % Ratio of Prescribing of Antidepressant, Hypnotic and Antipsychotic Drugs in General Practice in England

Trends in Prescribing of and Spending on Buprenorphine and Buprenorphine / Naloxone

(BNF 4.10 Opioid Dependence) in General Practice in England

0

20,000

40,000

60,000

80,000

100,000

120,000

140,000

Jun-03

Sep-03

Dec-03

Mar-04

Jun-04

Sep-04

Dec-04

Mar-05

Jun-05

Sep-05

Dec-05

Mar-06

Jun-06

Sep-06

Dec-06

Mar-07

Jun-07

Sep-07

Dec-07

Mar-08

Jun-08

Quarter to

Item

s

£0

£500,000

£1,000,000

£1,500,000

£2,000,000

£2,500,000

£3,000,000

£3,500,000

£4,000,000

£4,500,000

NIC

(£)

Items NIC(£)

© Copyright NHSBSA 2008

Page 47: % Ratio of Prescribing of Antidepressant, Hypnotic and Antipsychotic Drugs in General Practice in England

Trends in Prescribing of and Spending on Lofexidinein General Practice in England

0

200

400

600

800

1,000

1,200

1,400

1,600

Jun-03

Sep-03

Dec-03

Mar-04

Jun-04

Sep-04

Dec-04

Mar-05

Jun-05

Sep-05

Dec-05

Mar-06

Jun-06

Sep-06

Dec-06

Mar-07

Jun-07

Sep-07

Dec-07

Mar-08

Jun-08

Quarter to

Item

s

£0

£10,000

£20,000

£30,000

£40,000

£50,000

£60,000

£70,000

NIC

(£)

Items NIC (£)

© Copyright NHSBSA 2008

Page 48: % Ratio of Prescribing of Antidepressant, Hypnotic and Antipsychotic Drugs in General Practice in England

Trends in Prescribing of and Spending on Naltrexonein General Practice in England

0

500

1,000

1,500

2,000

2,500

3,000

3,500

4,000

Jun-03

Sep-03

Dec-03

Mar-04

Jun-04

Sep-04

Dec-04

Mar-05

Jun-05

Sep-05

Dec-05

Mar-06

Jun-06

Sep-06

Dec-06

Mar-07

Jun-07

Sep-07

Dec-07

Mar-08

Jun-08

Quarter to

Item

s

£0

£20,000

£40,000

£60,000

£80,000

£100,000

£120,000

£140,000

NIC

(£)

Items NIC (£)

© Copyright NHSBSA 2008

Page 49: % Ratio of Prescribing of Antidepressant, Hypnotic and Antipsychotic Drugs in General Practice in England

Trends in Prescribing of Drugs for Dementiain General Practice in England

0

50,000

100,000

150,000

200,000

250,000

Jun-03

Sep-03

Dec-03

Mar-04

Jun-04

Sep-04

Dec-04

Mar-05

Jun-05

Sep-05

Dec-05

Mar-06

Jun-06

Sep-06

Dec-06

Mar-07

Jun-07

Sep-07

Dec-07

Mar-08

Jun-08Quarter to

Item

s

Donepezil Galantamine Rivastigmine Memantine

© Copyright NHSBSA 2008

Page 50: % Ratio of Prescribing of Antidepressant, Hypnotic and Antipsychotic Drugs in General Practice in England

Trends in Spending on Drugs for Dementiain General Practice in England

0

2,000,000

4,000,000

6,000,000

8,000,000

10,000,000

12,000,000

14,000,000

16,000,000

18,000,000

Jun-03

Sep-03

Dec-03

Mar-04

Jun-04

Sep-04

Dec-04

Mar-05

Jun-05

Sep-05

Dec-05

Mar-06

Jun-06

Sep-06

Dec-06

Mar-07

Jun-07

Sep-07

Dec-07

Mar-08

Jun-08

Quarter to

NIC

(£)

Donepezil Galantamine Rivastigmine Memantine

© Copyright NHSBSA 2008

Page 51: % Ratio of Prescribing of Antidepressant, Hypnotic and Antipsychotic Drugs in General Practice in England

Trends in Prescribing of Melatonin in General Practice in England

0

2,000

4,000

6,000

8,000

10,000

12,000

14,000

16,000

18,000

Jun-03

Sep-03

Dec-03

Mar-04

Jun-04

Sep-04

Dec-04

Mar-05

Jun-05

Sep-05

Dec-05

Mar-06

Jun-06

Sep-06

Dec-06

Mar-07

Jun-07

Sep-07

Dec-07

Mar-08

Jun-08

Quarter to

Item

s

These figures may exclude some proprietary preparations containing Melatonin

© Copyright NHSBSA 2008

Page 52: % Ratio of Prescribing of Antidepressant, Hypnotic and Antipsychotic Drugs in General Practice in England

Trends in Spending on Melatonin in General Practice in England

0

200,000

400,000

600,000

800,000

1,000,000

1,200,000

Jun-03

Sep-03

Dec-03

Mar-04

Jun-04

Sep-04

Dec-04

Mar-05

Jun-05

Sep-05

Dec-05

Mar-06

Jun-06

Sep-06

Dec-06

Mar-07

Jun-07

Sep-07

Dec-07

Mar-08

Jun-08

Quarter to

NIC

(£)

These figures may exclude some proprietary preparations containing Melatonin

© Copyright NHSBSA 2008

Page 53: % Ratio of Prescribing of Antidepressant, Hypnotic and Antipsychotic Drugs in General Practice in England

Trends in Instalment Dispensing Forms in General Practice in England

0

100,000

200,000

300,000

400,000

500,000

600,000

700,000

Jun-03

Sep-03

Dec-03

Mar-04

Jun-04

Sep-04

Dec-04

Mar-05

Jun-05

Sep-05

Dec-05

Mar-06

Jun-06

Sep-06

Dec-06

Mar-07

Jun-07

Sep-07

Dec-07

Mar-08

Jun-08

Quarter to

Item

s

Instalment dispensing form - (Hosp / Clinic)

Instalment dispensing form - (GP / Nurse / Pharmacist)

© Copyright NHSBSA 2008