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8/3/2019 1 Introduction Lesson - Reading 3-15
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Immunology
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My name is ________ and Im a 48-
yr-old man with chronic renal failure.
About 8 days ago, I underwent
cadaveric renal transplant. Today I
was told I developed pathologically
elevated creatinine levels.
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My name is ______ . Thing is, twenty-four
hours after placement of a catheter, I
developed fever and chills. Within 1 hour my
systolic blood pressure fell 30 points and I
developed swelling in my extremities and
severe edema in my lungs, as demonstrated
by chest x-ray. Despite valiant efforts by the
hospital staff, I died a few hours later.
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My name is _______ and Im a 32-year-old
woman. I came to the emergency
department because ofsudden blindness.
They asked about my history, and I told
them about my right leg giving out from
time to time, causing me to have episodes
ofweakness and falling.
In this mornings MRI they pointed out
that I had periventricular plaques.
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My name is _________ and Im 23 years
old. I came to my physician with a
bacterial infection. He asked me about
my history and I told him I have a history
of recurrent bacterial, fungal and viral
infections. My last blood test showed low
levels of all my immune cells.
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My name is ________ and Im a 12-year-old
girl. I was brought to my pediatrician 3 monthsago by my mother because I had a fever. The
physician noticed I had features of albinism
and my mother stated that Ive always looked
this way. The physician diagnosed
staphylococcalinfection and gave meantibiotics.
Now, Im back with streptococcalinfection.
Apparently my medical records indicate that I
have had repeated bouts ofstaphylococcaland
streptococcalinfections for my entire life.
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My name is _______ and Im 8 years old. I
have cystic fibrosis. Although I do everything
Im told to do by the grown-ups, my lungs
keep getting infected with bacteria. Im not
so much bothered by that, but more that theeffects of the infections are much stronger in
my case than other children.
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My name is ________ and Im a clinical
researcher studying how to make vaccines
more effective. I just combined an
experimental vaccine, with Freunds
complete adjuvant. By this I obtained
enhanced vaccine potency.
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My name is ________ and Im a 32-year-old man with Hodgkin's lymphoma. A
month ago I underwent bone marrow
transplantation, my brother was the donor.
After transplantation I was put on a
course ofimmunosuppressants and was
monitored for immune cell blood content,
with no apparent abnormal findings since.
This week, they found out that I have
developed an immune attack against my
own intestine.
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My name is _______ and I dont know
how I ended up in Immunology class!
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My name is ________ and Im a 12-
year old boy from Haifa. I live on anti-
allergy pills and if I ever forget to takethem, I really really really suffer.
In fact, it doesnt even help me if Itake the pills after an attack had begun.
We just moved to Arad and my life
improved greatly!
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My name is _________ and Im Dr. Lewis post-doc
fellow. Despite Dr. Lewis plead, my family went on
vacation last year, we went to Thailand. My daughters
and son ran barefoot on the beach. They all came home
with this:
I will never go on
vacation again! Instead
I will work in Lewis lab
all day long!
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My name is _________ and Im a bottle of powder
from smallpox lesions.
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My name is _______ and I was just
evacuated from my home to a safe-house
because my husband hit me. I can still
describe the last slap in the face, it hurt
so bad! Turned red, swollen, immobile
and warm. But after a while it returned to
normal.
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My name is ______ and Im a Neutrophil. Im
also nicknamed PMN (for polymorphonuclear).
When the kid with cystic fibrosis spoke I
remembered how each infection he had, Irushed out from the blood stream as I was
attractedto the inflamed area within minutes,
crossing many barriers on the way.
When I reached the damaged region, I spilled
my content and also swallowed the bacteria!
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My name is _______ and Im a Macrophage. I dontroam the blood, I actually sit inside tissues as a resident
cell.
When I sense damage, I immediately turn very active
and start to spread the word to other cells around me,
causing damage, swallowing local elements and creating
a lot of injury.
I think my reputation should be rectified, ask me
why!
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My name is _______ and Im a T cell.
My school is the thymus, thats where I learn to
become what I am and also have to promise not to
attack the body that I live in.
While I myself can identify a single antigen, my
friends and me altogether can target almost the
entire universe of molecules!
I hate immunosuppression!
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My name is ______ and Im a B cell.
I also have very specific taste in
antigens like the T cell, in fact, I
generate antibodies when called
upon. But, I also uptake molecules
from my surroundings and present
them to T cells. When excited I turn
huge and change my name to a
plasma cell.
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My name is ______ and Im a
dendritic cell. I sit literally in every area
and tissue of the body, scouting for
molecules to uptake, carry with me and
deliver them to T cells.
If I do it when my surroundings are
inflamed, the T cells will respond
aggressively. Otherwise, things look quite
differently! Ask me about Crohns
disease!
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My name is ______ and Im a Lymph node.
I collect vessels from distal locations, which
contain lymphatic fluid and also dendritic cells.
Inside, I allow these to engage with T cells
and B cells.
The fluid leaves by a single duct and
eventually reaches the blood circulation.
Me? I sit behind your knee, draining your
foot to see what molecules your DCs collected.
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My name is ______ and Im a protein in the Complement
system. Not cells, not tissues, were just a group of
circulating proteins that can start a cascade of cleavageevents from various triggers. Once activated, we can kill a
cell, and we can attract cells to a damaged area.
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My name is ______ and Im an
Antibody. Also a protein. Im very
specific about my target, which
makes me a wonderful tool for
researchers.
The fun thing is, that my
chromosomal DNA that makes-up
my amino-acid sequence is not like
the rest of the body! Weird ha!
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My name is ______ and
Im your bone marrow!
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Skin? Immunology?
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Who do we attack?
Infectious? Non-infectious?
Both?
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Is it a T cell disease?
Is it a B cell disease?
Is it both?
Is it neither?
Is it an inflammatory disease?
Is it viral?
Is it a toxin-related disease?
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