2 Energy and Thermodynamics

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    Topics

    1. Introduction

    2.Energy and thermodynamics

    3.Feeding and ingestion

    4. Ionic gradient, electrical potential

    5.Electrical signals and neurons

    6.Locomotion, muscle and skeleton

    7.Heat production and body temperature

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    Reading assignment

    Energy and life

    http://hyperphysics.phy-astr.gsu.edu/hbase/biology/enercyc.html

    Thermodynamics

    http://www.estrellamountain.edu/faculty/farabee/biobk/BioBookEner1.html

    Biological system and thermodynamics

    http://www.bio.net/bionet/mm/neur-sci/1995-July/019223.html

    Obesity

    http://www.nlm.nih.gov/medlineplus/obesity.html

    Food label and calorie information

    http://www.nutritiondata.com/

    Which exercise burns more calorie?

    http://www.healthcentral.com/diet-exercise/quizzes-251185.html

    http://hyperphysics.phy-astr.gsu.edu/hbase/biology/enercyc.htmlhttp://www.estrellamountain.edu/faculty/farabee/biobk/BioBookEner1.htmlhttp://www.bio.net/bionet/mm/neur-sci/1995-July/019223.htmlhttp://www.nlm.nih.gov/medlineplus/obesity.htmlhttp://www.nutritiondata.com/http://www.healthcentral.com/diet-exercise/quizzes-251185.htmlhttp://www.healthcentral.com/diet-exercise/quizzes-251185.htmlhttp://www.healthcentral.com/diet-exercise/quizzes-251185.htmlhttp://www.healthcentral.com/diet-exercise/quizzes-251185.htmlhttp://www.healthcentral.com/diet-exercise/quizzes-251185.htmlhttp://www.healthcentral.com/diet-exercise/quizzes-251185.htmlhttp://www.nutritiondata.com/http://www.nlm.nih.gov/medlineplus/obesity.htmlhttp://www.bio.net/bionet/mm/neur-sci/1995-July/019223.htmlhttp://www.bio.net/bionet/mm/neur-sci/1995-July/019223.htmlhttp://www.bio.net/bionet/mm/neur-sci/1995-July/019223.htmlhttp://www.bio.net/bionet/mm/neur-sci/1995-July/019223.htmlhttp://www.bio.net/bionet/mm/neur-sci/1995-July/019223.htmlhttp://www.estrellamountain.edu/faculty/farabee/biobk/BioBookEner1.htmlhttp://hyperphysics.phy-astr.gsu.edu/hbase/biology/enercyc.htmlhttp://hyperphysics.phy-astr.gsu.edu/hbase/biology/enercyc.htmlhttp://hyperphysics.phy-astr.gsu.edu/hbase/biology/enercyc.html
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    What is physiology?

    Physiology deals with the (1) processes,

    (2) activities and (3) phenomenaincidental

    to and characteristics oflife.

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    What is live?

    What is death?

    Why do you need a supply

    of energy to be alive?

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    What are living organisms made of?atoms

    molecules

    macromolecular complex

    elementary cellular structures

    organelles

    cellstissues

    organ systems

    animal

    (Chemistry)

    (Biochemistry)macromolecules

    (Cell Biology)

    (Genetics)(Histology)

    (Physiology)

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    Energyis necessary to maintain

    structure, but structure is in turn

    necessary to utilize the energy.

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    Laws of Thermodynamics

    1. The amount ofenergy present in this

    Universe is constant.

    2. There is alwaysa certain amount ofenergy which changes into a lower quality

    form such as heat and becomes less

    available to do work.

    (Concept of entropy)

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    Different forms of energyGravitational energy

    Energy of rotationEnergy of orbital motion

    Energy of nuclear fission

    Energy of nuclear fusionSolar energy

    Sound energy

    Electrical energy

    Energy of chemical reaction

    Chemical potential energy

    Heat

    Cosmic radiation

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    Laws of Thermodynamics

    1. The amount ofenergy present in this

    Universe is constant.

    2. There is alwaysa certain amount ofenergy which changes into a lower quality

    form such as heat and becomes less

    available to do work.

    (Concept of entropy)

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    Both 1st and 2nd Laws ofThermodynamics refer to observations

    made on the Universe and not only the

    system that we are interested in.

    Universe= System +Surrounding

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    SURROUNDING

    SYSTEM

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    Living systems would appear defy theSecond Law of Thermodynamics because oftheir high degree of maintained order.

    How do you reconcile the low entropy of anorganism with this fundamental physical law?

    Can the 2nd law of thermodynamics beapplied here?

    egg

    Highly-ordered

    organism

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    Ingestion of food by animal increases the entropy of

    the food molecules by breaking them down intosmaller molecules of lower free energy content.

    The free energy liberated is utilized by animal cells

    to drive energy-requiring reactions.

    H2OCO2

    Nitrogenous

    waste

    H2O

    H2O

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    Initial State

    Final State

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    In relationship to chemical reactions, Gibbs Free

    Energy(G)defines if the reaction would go

    spontaneously from the initial state to the final state.

    where H = change in enthalpy (heat content)

    G = H - T S

    G = H +(- T S)

    S = change in entropy (energy that is highly

    dispersed and not available to do work)

    Reactions would go spontaneously in the direction of

    achieving a final state of lower internal energy in the

    system.

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    Initial State

    Final State

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    Whats the meaning ofG?

    -G= the maximum amount of energytheoretically available for the system to dobiological useful work on its surrounding

    when the system goes from initial state tothe final state if the process is reversible.

    = Exergonic

    G = Gfinal - Ginitial

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    + G= the amount of energytheoreticallythesurrounding has to supply to the system so

    that it can go from the initial state to the final

    state

    = Endergonic

    G = Gfinal - Ginitial

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    G = 0 = equilibrium

    A + B C + D

    Keq = [C] [D]

    [A] [B]

    IfKeqis very big, e.g. 106, we basically still assumethere is some A and some B left.

    Thermodynamics deals with collections of matter.

    It does not apply to several molecules. As such itsanalyses depend a lot on statistical probability.

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    Under what condition will an

    endergonic reaction proceed?

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    ADP

    C6H12O6 + 6O2COUPLE

    ATP

    6CO2 + 6H2O

    G = +7000 cal / mole

    G = -420,000cal / mole

    G = -686,000cal / mole

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    Biological TranducersTransformation Transducers

    Chemical electrical

    mechanicalChemical

    Chemical osmotic

    Light

    Sound

    electrical

    electrical

    Light chemical

    Brain, nerve

    Nose, tongue

    Muscle

    Kidney

    Eye

    Ear

    Plant

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    What is unique to living organisms?

    The essential feature of living organisms is

    their ability to capture, transformand

    storevarious forms of energy accordingto the specific instructions of their

    individual genetic materials.

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    Photosynthesis

    (leaf)CO2 + H2O O2 + C6H12O6

    PLANTS

    Solar

    energy

    Respiration (mitochonddria)

    ATP

    Mechanical Transport Assembly

    contractionof solute of biomolecules

    ADP ADP ADP

    Protein

    FatsCarbohydrate

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    Solar energy/light

    Chemical potential energy e.g. Na+ or K+ gradient

    Chemical energy, ATP

    Chemical energy, e.g. carbohydrate

    Electrical energy, e.g. membrane potential

    Heat

    Heat

    Heat

    Heat

    Chemical energy, ATP

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    End

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    Teaching is transmission of knowledge

    to students

    Instruction Paradigm

    Versus

    Teaching is facilitation of students

    learning

    Learning Paradigm

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    Be an Active Listener

    People speak at 100 to 175 words per minute,but they can listen intelligently at up to 300 words

    per minute.

    Mind-driftthinking about other things whilelistening to someone.

    Listen with a purpose (gain info, obtain

    directions, understand others, solve problems,

    share interests, show support)

    Try repeating words mentally as they say it

    control mind drift.

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    Topics

    1. Introduction

    2.Energy and thermodynamics

    3.Feeding and ingestion4. Ionic gradient, electrical potential

    5.Electrical signals and neurons

    6.Locomotion, muscle and skeleton

    7.Heat production and body temperature

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