Upload
others
View
1
Download
0
Embed Size (px)
Citation preview
�������� � 20 � � 28 � 20160701 �
Chinese Journal of Tissue Engineering Research July 1, 2016 Vol.20, No.28
P.O. Box 10002, Shenyang 110180 www.CRTER.org
4234
����
www.CRTER.org
������1990���
��������
���������
���������
!"#��$�%&'(
)*+,-./012
3456789:
;?@AB�C#�
%��$�DE�C#�
F$��������
����������
�����G
570208
�����:R394.2
���:B
����:2095-4344
(2016)28-04234-09
�����2016-04-06
�
��
�
���������������
�
��
�
�������(����������������������� 570208)
������������. ���������������[J].������� �2016�20(28):4234-4242.
DOI: 10.3969/j.issn.2095-4344.2016.28.019 ORCID: 0000-0002-1918-8803(���)
�����
����
������������������������������ !"#$��%&'
()*+(,-Karp./01'234�5*+"#�6789:;:?$�@A
"#�BC-01BCDEFG�HIJ8K�LMNOIP QR�NORSTNORU�VRW
XYOI�Z[�YO-
���������������\]A"#^����%_`ab�cdef�abegh
i4LMNOjkRlbmn(opabRqrstRuvtw/^uvxyRz{R�NO^M|
l�)R�[N}~R�}~R3D�.�`ab]cdY3"#`ab
w�`ab-
��
���01��"#}F����I����-*\�����fm
01@A"#�}Fm�-`ab3%�01 ¡¢-
���]%����01�`ab%_£¤-
���¥¦stem cell, mesenchymal stem cells, preconditioning, homing, migration§3¨©ª«cd
"¬5 PubMed®¯¨© 2000° 1±@ 2015° 9±�)`ab%����01�²
³�´µ+¶�·¸¹º 72»²³%_£¤-
���� �������\]A"#^����%_`ab�¼½%P01@ !"#
¾&¿À"#}Fmn-"#`abÁ��BÂÃx�Ä�ÅÆÇÈLMNOÅ.m�¾
&%����01-����`ab�ÉÊ[N}~R�NOËÌ.�¥���
�LMNO Q3mnÍ��BÇÈPÅÎ%A�01-̀ ab/3�ÏÐn
)ÑÒÓÎÔÕÖ×-
!"#�
���!"#!���!����!����!������!"#!��!��$%!&'(
)*+,-.
$�#�
�����!"#!����
%&'(�
&'()*+,-.(811151)
����������������
�������
��
�����������
������������
���� !
"#�3D$%�&'�!
�����()*+,-��
./01234
567839:
����;�
���������
��?@!
"#�A;BC
DE!
FG�����
��7H6I�,JK
�����. ���������������
ISSN 2095-4344 CN 21-1581/R CODEN: ZLKHAH
4235
www.CRTER.org
Wang Guo-ren, Studying
for master’s degree,
Physician, Department of
Urology, Affiliated Haikou
Hospital, Xiangya School
of Medicine, Central South
University, Haikou 570208,
Hainan Province, China
Corresponding author:
Bai Zhi-ming, M.D., Chief
physician, Professor,
Doctoral supervisor,
Department of Urology,
Affiliated Haikou Hospital,
Xiangya School of
Medicine, Central South
University, Haikou 570208,
Hainan Province, China
Preconditioning strategies for promoting mesenchymal stem cell homing
Wang Guo-ren, Bai Zhi-ming (Department of Urology, Affiliated Haikou Hospital, Xiangya School of
Medicine, Central South University, Haikou 570208, Hainan Province, China)
Abstract
BACKGROUND: Homing is the initial and key procedure of stem cells-based tissue restoration. Current
studies have shown that the inability to recruit bone marrow mesenchymal stem cells to target tissue with
high efficiency remains a significant barrier to tissue restoration. Preconditioning strategy provides a new
insight to promote stem cell homing.
OBJECTIVE: To review preconditioning strategies for promoting the homing of stem cells.
METHODS: In PubMed database, different combinations of terms from “stem cell, mesenchymal stem
cells, preconditioning, homing, migration” served as search terms to retrieve articles referring
preconditioning strategies for promoting mesenchymal stem cell homing published from January 2000 to
September 2015. According to the inclusion criteria, 72 articles were selected for final review.
RESULTS AND CONCLUSION: Pretreating target tissue or mesenchymal stem cells ahead of cell
transplantation, known as tissue preconditioning or cell preconditioning, prominently promotes the homing
of mesenchymal stem cells, therefore enhancing tissue restoration effect. Tissue preconditioning is
designed to up-regulate expression of chemokines by varying the local microenvironment, thereby
increasing homing ability of mesechymal stem cells. Mesenchymal stem cell preconditioning strategies, for
example, gene modification and cytokine induction, are mainly to up-regulate expression of chemokine
receptors on the surface of mesenchymal stem cells as effectors, and thus promote targeted cell homing.
Overall, preconditioning strategy will bring great hope to apply stem cell therapy into the clinic.
Subject headings: Mesenchymal Stem Cells; Transplantation; Tissue Engineering
Funding: the Natural Science Foundation of Hainan Province, China, No. 811151
Cite this article: Wang GR, Bai ZM. Preconditioning strategies for promoting mesenchymal stem cell
homing. Zhongguo Zuzhi Gongcheng Yanjiu. 2016;20(28):4234-4242.
0 �� Introduction
������������������
���������
[1-3]
����� !"#
[4-6]
�$%
&��'(�)/�)*+,- !"#
[7-9]
./0�
������123*��� !"#�456,-
*7�89:;
[10]
.?@ABCD�����
���� E�FG56�HI��������B
JKL
[11-12]
MNOPQ
[13]
MNO���LR
[14]
MNO
STUVWX
[15-17]
.
YZ[�\]^_`4abcCD'BCD��
�������defgh
[18]
���4"#\]
^M������\]^i�_`.jklab��
�������\]^_`bmno.
1���������Data and methods
1.1 ��������
1.1.1 pqLrs PubMedLrs(http://www.ncbi.
nlm.nih.gov/pubmed/).
1.1.2 pqLrs�tu^v PubMedLrs�w
Bxyz�{|}~jLrs�jLr�.
1.1.3 pqMpq'pq� 4
Mpqno�j�jk
%nfpq�tuMpq�tu
�pq���f~�pq_
`.
���stem cell�mesenchymal stem cells�
preconditioning�homing�migration.
�������� stem cell�preconditioning�
homing¡¢ stem cell�preconditioning�migration¡¢
mesenchymal stem cells � preconditioning �
homing¡¢ mesenchymal stem cells�preconditioning�
migration¡�£¤"bmpq.
�����2000Z1¥�2015Z9¥.
1.2 ���������
1.2.1 j¦t§ ¨�
��
�1�©ªbm.
1.2.2 j�¦t« ¬jkoc®¯'��
�M��U\]^_`l������°.±²³M
²r�´�jk.µ¤�¶·�jtuY¸¹@U
yzº»�j.
1.2.3 ¼½�j ¾¿À«1UÁÂDMÃ-
Dj.
1.2.4 �ÄÅÆ ÇÈQpqÉÊ162Ëj�ÌÍ
�����. ���������������
P.O. Box 10002, Shenyang 110180 www.CRTER.org
4236
www.CRTER.org
������������������
���������������� �!"#
$%&'()*+,-./012���34567
728��9�:;?�@ABC ��DE��
>?�@AF&���G&BCH6IJ�C�:
KL���G&BCMNOPQ�RQSTRUQ
VWXYQZ[(S[)Q\]^3_���`a�
��bcJ��3
2������Results �
2.1 ���������� d%efgh�ij
kfghO&��lmnokpqmnrstd
%efghuv5wxyz{|u�}~�
3Karp^
[10]
ij~fgh�z{�
�}|uz{�3
Lfgh�ij��5�ÚÛd%efgh�|u�:;�è�
�ÈÉ(green fluorescent proteinGFP)�³Â��
�y/ö÷CCL21®ö÷PBS��
z>?W+CCL21ö÷z|uyÜ/�GFP
+
g
��PubMed���
�������162��
����� 109
�������
����
������72
����stem cell, mesenchymal stem cells,
preconditioning, homing, migration
� 1 ������
� 2 �������������
[28]
�����. ���������������
ISSN 2095-4344 CN 21-1581/R CODEN: ZLKHAH
4237
www.CRTER.org
h+� !r��³eghÌÆÂÃ1�é+w,-�d%
efghijn:~õ�O&3Zhang^
[38]
o&(
)é+~w,-õ�Ld%efghwdef
gÓKLhijNj����NR�wijV
�é+,-5NRz{§ghª«
�����. ���������������
P.O. Box 10002, Shenyang 110180 www.CRTER.org
4238
www.CRTER.org
5ghW¬CXCR4¯ÄijxÅW¶®¯
kLd%efghij¢Ò.���¸¹Ô
:3d%efgh./0ïðí˳Â"°Qgh
ÂñL^¤�®d%efghW¬ÀÁÂÃxÅ
¢£:rîÚÄW¶'õ�wij3
2.3.1 ³Â"° o&j²³j²�_´µô³
Â?@ÚÛd%efghW¬xÅ?mA
CXCR4W¶îÚ�d%efgh�ijW+�b
·�}õ�Ä�Nuv���NR6¸¢£3Chen
^
[46]
om+î¹>º3»��r³Â"°îÚ
CXCR1
[47]
QCCR1W¶
[48]
V}¶µJõ�d%e
fghij��3
¼ÀÁÂÃxÅd%efgh�gh½W¬
nW¶Ä:-gh|uÕp�
�����. ���������������
ISSN 2095-4344 CN 21-1581/R CODEN: ZLKHAH
4239
www.CRTER.org
hõö÷ij�3
Toma^
[64]
o&c¢£ÊøòÃùÅ�ú
eé+ûd%efghW¬®()GLfgh
é+�Qüª«§ýîô}�xy
2HÁ3Kokhuis^
[65]
o&)[\÷WGLfg
hé+w§ý !ÝÞ§ý�d%e
fghõ�Ä�yz{|�"#O&ABãV
�Âé+û�d%efghé+û[�5
�³þ�fgh�()*Â�£3
���.ïW3()$��¯���B
ã�mA�õ�t����Ä�¸¹Ô:kr
!d%efghwQ/�
[66]
3Wei^
[66]
o&.
ïW3()./0d%efgh5>Ögh
CXCR4¯SDF-1 mRNA?@îÚÅ|uABV�
d%efgh�|uWb·�SDF-1-CXCR4
F�ZAMD3100Þ./0ïðbc?G�
�@3
V!pAø./0ïðO&¸¹��:;�
�!È��P�ÄD3Ô/�0(õ./0
ïð��0�@3
���������������������
������������������
� �!����� !"#��$%&'()*��
"�#$�+�,%&-./0)*�12��
%&'(���345678 CNKI 9:;�
?@AB 3CDE�
%&)*���7�1F!BG�HIJKG��L
MNOPQRS��
���+�TU��VWXYZ[�\�]3^�_
`Babc���\�]d��efgh�ijklmn
oijpqrs�tN6uv�&wxyz�{|Y}~�
#D��
�����. ���������������
P.O. Box 10002, Shenyang 110180 www.CRTER.org
4240
www.CRTER.org
%&,-���345�6,��
4%&��
4 �� References
[1] Fuchs E, Segre JA. Stem cells: a new lease on life.
Cell. 2000;100(1):143-155.
[2] Horwitz EM, Le Blanc K, Dominici M, et al. Clarification
of the nomenclature for MSC: The International
Society for Cellular Therapy position statement.
Cytotherapy. 2005;7(5):393-395.
[3] Dominici M, Le Blanc K, Mueller I, et al. Minimal criteria
for defining multipotent mesenchymal stromal cells.
The International Society for Cellular Therapy position
statement. Cytotherapy. 2006;8(4):315-317.
[4] Chamberlain G, Fox J, Ashton B, et al. Concise review:
mesenchymal stem cells: their phenotype, differentiation
capacity, immunological features, and potential for
homing. Stem Cells. 2007;25(11):2739-2749.
[5] Deak E, Seifried E, Henschler R. Homing pathways of
mesenchymal stromal cells (MSCs) and their role in
clinical applications. Int Rev Immunol. 2010;29(5):514-
529.
[6] Fong EL, Chan CK, Goodman SB. Stem cell homing in
musculoskeletal injury. Biomaterials. 2011;32(2):
395-409.
[7] Zhu XY, Lerman A, Lerman LO. Concise review:
mesenchymal stem cell treatment for ischemic kidney
disease. Stem Cells. 2013;31(9):1731-1736.
[8] Cashman TJ, Gouon-Evans V, Costa KD.
Mesenchymal stem cells for cardiac therapy: practical
challenges and potential mechanisms. Stem Cell Rev.
2013;9(3):254-265.
[9] Chou SH, Lin SZ, Kuo WW, et al. Mesenchymal stem
cell insights: prospects in cardiovascular therapy. Cell
Transplant. 2014;23(4-5):513-529.
[10] Karp JM, Leng Teo GS. Mesenchymal stem cell
homing: the devil is in the details. Cell Stem Cell. 2009;
4(3):206-216.
[11] Rombouts WJ, Ploemacher RE. Primary murine MSC
show highly efficient homing to the bone marrow but
lose homing ability following culture. Leukemia. 2003;
17(1):160-170.
[12] Phinney DG, Prockop DJ. Concise review: mesenchymal
stem/multipotent stromal cells: the state of
transdifferentiation and modes of tissue repair-current
views. Stem Cells. 2007;25(11):2896- 2902.
[13] Chen J, Li Y, Wang L, et al. Therapeutic benefit of
intravenous administration of bone marrow stromal
cells after cerebral ischemia in rats. Stroke. 2001;
32(4):1005-1011.
[14] Wu J, Sun Z, Sun HS, et al. Intravenously administered
bone marrow cells migrate to damaged brain tissue
and improve neural function in ischemic rats. Cell
Transplant. 2008;16(10):993-1005.
[15] Freyman T, Polin G, Osman H, et al. A quantitative,
randomized study evaluating three methods of
mesenchymal stem cell delivery following myocardial
infarction. Eur Heart J. 2006;27(9):1114-1122.
[16] Omori Y, Honmou O, Harada K, et al. Optimization of a
therapeutic protocol for intravenous injection of human
mesenchymal stem cells after cerebral ischemia in
adult rats. Brain Res. 2008;1236:30-38.
[17] Bai ZM, Deng XD, Li JD, et al. Arterially transplanted
mesenchymal stem cells in a mouse reversible
unilateral ureteral obstruction model: in vivo
bioluminescence imaging and effects on renal fibrosis.
Chin Med J (Engl). 2013;126(10):1890-1894.
[18] Yu SP, Wei Z, Wei L. Preconditioning strategy in stem
cell transplantation therapy. Transl Stroke Res. 2013;
4(1):76-88.
[19] Liu ZJ, Zhuge Y, Velazquez OC. Trafficking and
differentiation of mesenchymal stem cells. J Cell
Biochem. 2009;106(6):984-991.
[20] Chen FM, Wu LA, Zhang M, et al. Homing of
endogenous stem/progenitor cells for in situ tissue
regeneration: Promises, strategies, and translational
perspectives. Biomaterials. 2011;32(12):3189-3209.
[21] Vanden Berg-Foels WS. In situ tissue regeneration:
chemoattractants for endogenous stem cell
recruitment. Tissue Eng Part B Rev. 2014;20(1):28-39.
[22] Wynn RF, Hart CA, Corradi-Perini C, et al. A small
proportion of mesenchymal stem cells strongly
expresses functionally active CXCR4 receptor capable
of promoting migration to bone marrow. Blood. 2004;
104(9):2643-2645.
[23] Sharma M, Afrin F, Satija N, et al. Stromal-derived
factor-1/CXCR4 signaling: indispensable role in
homing and engraftment of hematopoietic stem cells in
bone marrow. Stem Cells Dev. 2011;20(6):933-946.
[24] Zhu H, Mitsuhashi N, Klein A, et al. The role of the
hyaluronan receptor CD44 in mesenchymal stem cell
migration in the extracellular matrix. Stem Cells. 2006;
24(4):928-935.
[25] Sackstein R, Merzaban JS, Cain DW, et al. Ex vivo
glycan engineering of CD44 programs human
multipotent mesenchymal stromal cell trafficking to
bone. Nat Med. 2008;14(2):181-187.
[26] Zhang A, Wang Y, Ye Z, et al. Mechanism of
TNF-α-induced migration and hepatocyte growth factor
production in human mesenchymal stem cells. J Cell
Biochem. 2010;111(2):469-475.
�����. ���������������
ISSN 2095-4344 CN 21-1581/R CODEN: ZLKHAH
4241
www.CRTER.org
[27] Ryu CH, Park SA, Kim SM, et al. Migration of human
umbilical cord blood mesenchymal stem cells
mediated by stromal cell-derived factor-1/CXCR4 axis
via Akt, ERK, and p38 signal transduction pathways.
Biochem Biophys Res Commun. 2010;398(1):105-110.
[28] Marquez-Curtis LA, Janowska-Wieczorek A.
Enhancing the migration ability of mesenchymal
stromal cells by targeting the SDF-1/CXCR4 axis.
Biomed Res Int. 2013;2013:561098.
[29] Gao H, Priebe W, Glod J, et al. Activation of signal
transducers and activators of transcription 3 and focal
adhesion kinase by stromal cell-derived factor 1 is
required for migration of human mesenchymal stem
cells in response to tumor cell-conditioned medium.
Stem Cells. 2009;27(4):857-865.
[30] Lee MJ, Jeon ES, Lee JS, et al. Lysophosphatidic acid
in malignant ascites stimulates migration of human
mesenchymal stem cells. J Cell Biochem. 2008;104(2):
499-510.
[31] Shang YC, Wang SH, Xiong F, et al. Wnt3a signaling
promotes proliferation, myogenic differentiation, and
migration of rat bone marrow mesenchymal stem cells.
Acta Pharmacol Sin. 2007;28(11):1761-1774.
[32] Ponte AL, Marais E, Gallay N, et al. The in vitro
migration capacity of human bone marrow
mesenchymal stem cells: comparison of chemokine
and growth factor chemotactic activities. Stem Cells.
2007;25(7):1737-1745.
[33] Ji JF, He BP, Dheen ST, et al. Interactions of
chemokines and chemokine receptors mediate the
migration of mesenchymal stem cells to the impaired
site in the brain after hypoglossal nerve injury. Stem
Cells. 2004;22(3):415-427.
[34] Sasaki M, Abe R, Fujita Y, et al. Mesenchymal stem
cells are recruited into wounded skin and contribute to
wound repair by transdifferentiation into multiple skin
cell type. J Immunol. 2008;180(4):2581-2587.
[35] Zhou SB, Wang J, Chiang CA, et al. Mechanical
stretch upregulates SDF-1α in skin tissue and induces
migration of circulating bone marrow-derived stem
cells into the expanded skin. Stem Cells. 2013;31
(12):2703-2713.
[36] Burks SR, Nguyen BA, Tebebi PA, et al. Pulsed
focused ultrasound pretreatment improves
mesenchymal stromal cell efficacy in preventing and
rescuing established acute kidney injury in mice. Stem
Cells. 2015;33(4):1241-1253.
[37] Wu S, Li L, Wang G, et al. Ultrasound-targeted stromal
cell-derived factor-1-loaded microbubble destruction
promotes mesenchymal stem cell homing to kidneys in
diabetic nephropathy rats. Int J Nanomedicine. 2014;9:
5639-5651.
[38] Zhang Y, Ye C, Wang G, et al. Kidney-targeted
transplantation of mesenchymal stem cells by
ultrasound-targeted microbubble destruction promotes
kidney repair in diabetic nephropathy rats. Biomed Res
Int. 2013;2013:526367.
[39] Oron U, Tuby H, Maltz L, et al. Autologous bone-marrow
stem cells stimulation reverses post-ischemic-
reperfusion kidney injury in rats. Am J Nephrol. 2014;
40(5):425-433.
[40] Tuby H, Maltz L, Oron U. Induction of autologous
mesenchymal stem cells in the bone marrow by
low-level laser therapy has profound beneficial effects
on the infarcted rat heart. Lasers Surg Med. 2011;
43(5):401-409.
[41] Aicher A, Heeschen C, Sasaki K, et al. Low-energy
shock wave for enhancing recruitment of endothelial
progenitor cells: a new modality to increase efficacy of
cell therapy in chronic hind limb ischemia. Circulation.
2006;114(25):2823-2830.
[42] Qiu X, Lin G, Xin Z, et al. Effects of low-energy
shockwave therapy on the erectile function and tissue of
a diabetic rat model. J Sex Med. 2013;10(3):738-746.
[43] Huang Z, Ma T, Ren PG, et al. Effects of orthopedic
polymer particles on chemotaxis of macrophages and
mesenchymal stem cells. J Biomed Mater Res A. 2010;
94(4):1264-1269.
[44] Gibon E, Yao Z, Rao AJ, et al. Effect of a CCR1
receptor antagonist on systemic trafficking of MSCs
and polyethylene particle-associated bone loss.
Biomaterials. 2012;33(14):3632-3638.
[45] Cao Z, Zhang G, Wang F, et al. Protective effects of
mesenchymal stem cells with CXCR4 up-regulation in
a rat renal transplantation model. PLoS One. 2013;
8(12):e82949.
[46] Chen W, Li M, Cheng H, et al. Overexpression of the
mesenchymal stem cell Cxcr4 gene in irradiated mice
increases the homing capacity of these cells. Cell
Biochem Biophys. 2013;67(3):1181-1191.
[47] Kim SM, Kim DS, Jeong CH, et al. CXC chemokine
receptor 1 enhances the ability of human umbilical
cord blood-derived mesenchymal stem cells to migrate
toward gliomas. Biochem Biophys Res Commun. 2011;
407(4):741-746.
[48] Huang J, Zhang Z, Guo J, et al. Genetic modification of
mesenchymal stem cells overexpressing CCR1
increases cell viability, migration, engraftment, and
capillary density in the injured myocardium. Circ Res.
2010;106(11):1753-1762.
[49] Meng F, Rui Y, Xu L, et al. Aqp1 enhances migration of
bone marrow mesenchymal stem cells through
regulation of FAK and β-catenin. Stem Cells Dev. 2014;
23(1):66-75.
�����. ���������������
P.O. Box 10002, Shenyang 110180 www.CRTER.org
4242
www.CRTER.org
[50] Li P, Gao Y, Liu Z, et al. DNA transfection of bone
marrow stromal cells using microbubble-mediated
ultrasound and polyethylenimine: an in vitro study. Cell
Biochem Biophys. 2013;66(3):775-786.
[51] Shi M, Li J, Liao L, et al. Regulation of CXCR4
expression in human mesenchymal stem cells by
cytokine treatment: role in homing efficiency in
NOD/SCID mice. Haematologica. 2007;92(7):897-904.
[52] Fan H, Zhao G, Liu L, et al. Pre-treatment with IL-1β
enhances the efficacy of MSC transplantation in
DSS-induced colitis. Cell Mol Immunol. 2012;9(6):
473-481.
[53] Noiseux N, Borie M, Desnoyers A, et al.
Preconditioning of stem cells by oxytocin to improve
their therapeutic potential. Endocrinology. 2012;
153(11):5361-5372.
[54] Xinaris C, Morigi M, Benedetti V, et al. A novel strategy
to enhance mesenchymal stem cell migration capacity
and promote tissue repair in an injury specific fashion.
Cell Transplant. 2013;22(3):423-436.
[55] Zhu M, Feng Y, Dangelmajer S, et al. Human
cerebrospinal fluid regulates proliferation and
migration of stem cells through insulin-like growth
factor-1. Stem Cells Dev. 2015;24(2):160-171.
[56] Tsai LK, Leng Y, Wang Z, et al. The mood stabilizers
valproic acid and lithium enhance mesenchymal stem
cell migration via distinct mechanisms.
Neuropsychopharmacology. 2010;35(11):2225-2237.
[57] Kim YS, Noh MY, Kim JY, et al. Direct GSK-3β
inhibition enhances mesenchymal stromal cell
migration by increasing expression of β-PIX and
CXCR4. Mol Neurobiol. 2013;47(2):811-820.
[58] Najafi R, Sharifi AM. Deferoxamine preconditioning
potentiates mesenchymal stem cell homing in vitro and
in streptozotocin-diabetic rats. Expert Opin Biol Ther.
2013;13(7):959-972.
[59] Li S, Deng Y, Feng J, et al. Oxidative preconditioning
promotes bone marrow mesenchymal stem cells
migration and prevents apoptosis. Cell Biol Int. 2009;
33(3):411-418.
[60] Das R, Jahr H, van Osch GJ, et al. The role of hypoxia
in bone marrow-derived mesenchymal stem cells:
considerations for regenerative medicine approaches.
Tissue Eng Part B Rev. 2010;16(2):159-168.
[61] Liu H, Liu S, Li Y, et al. The role of
SDF-1-CXCR4/CXCR7 axis in the therapeutic effects
of hypoxia-preconditioned mesenchymal stem cells for
renal ischemia/reperfusion injury. PLoS One. 2012;
7(4):e34608.
[62] Hu X, Wei L, Taylor TM, et al. Hypoxic preconditioning
enhances bone marrow mesenchymal stem cell
migration via Kv2.1 channel and FAK activation. Am J
Physiol Cell Physiol. 2011;301(2):C362-372.
[63] Wei JF, Wei L, Zhou X, et al. Formation of Kv2.1-FAK
complex as a mechanism of FAK activation, cell
polarization and enhanced motility. J Cell Physiol. 2008;
217(2):544-557.
[64] Toma C, Fisher A, Wang J, et al. Vascular endoluminal
delivery of mesenchymal stem cells using acoustic
radiation force. Tissue Eng Part A. 2011;17(9-10):
1457-1464.
[65] Kokhuis TJ, Skachkov I, Naaijkens BA, et al. Intravital
microscopy of localized stem cell delivery using
microbubbles and acoustic radiation force. Biotechnol
Bioeng. 2015;112(1):220-227.
[66] Wei FY, Leung KS, Li G, et al. Low intensity pulsed
ultrasound enhanced mesenchymal stem cell
recruitment through stromal derived factor-1 signaling
in fracture healing. PLoS One. 2014;9(9):e106722.
[67] Huang CH, Chen MH, Young TH, et al. Interactive
effects of mechanical stretching and extracellular
matrix proteins on initiating osteogenic differentiation
of human mesenchymal stem cells. J Cell Biochem.
2009;108(6):1263-1273.
[68] Suhr F, Delhasse Y, Bungartz G, et al. Cell biological
effects of mechanical stimulations generated by
focused extracorporeal shock wave applications on
cultured human bone marrow stromal cells. Stem Cell
Res. 2013;11(2):951-964.
[69] Sheu JJ, Lee FY, Yuen CM, et al. Combined therapy
with shock wave and autologous bone marrow-derived
mesenchymal stem cells alleviates left ventricular
dysfunction and remodeling through inhibiting
inflammatory stimuli, oxidative stress & enhancing
angiogenesis in a swine myocardial infarction model.
Int J Cardiol. 2015;193:69-83.
[70] Huang X, Zhang F, Wang Y, et al. Design
considerations of iron-based nanoclusters for
noninvasive tracking of mesenchymal stem cell
homing. ACS Nano. 2014;8(5):4403-4414.
[71] Zhang Q, Nguyen AL, Shi S, et al. Three-dimensional
spheroid culture of human gingiva-derived
mesenchymal stem cells enhances mitigation of
chemotherapy-induced oral mucositis. Stem Cells Dev.
2012;21(6):937-947.
[72] Won YW, Patel AN, Bull DA. Cell surface engineering
to enhance mesenchymal stem cell migration toward
an SDF-1 gradient. Biomaterials. 2014;35(21):
5627-5635.