2017 Hopkins C.A.R.E.S. Summer Symposium

July 27, 2017 Armstrong Medical Education Building

10:00 a.m. - 4:30 p.m.

Career

Academic and

Research Experiences for

Students

2

TABLE OF CONTENTS

HOPKINS C.A.R.E.S. SUMMER SYMPOSIUM AND NETWORK .................................................................. 3

2017 HOPKINS C.A.R.E.S. SUMMER PROGRAMS .......................................................................................... 4

PRESENTATION SCHEDULE ......................................................................................................................... 5

BACKGROUND STORIES .............................................................................................................................. 6-7

KEYNOTE SPEAKER ......................................................................................................................................... 8

POSTER PRESENTATIONS- SESSION 1 .................................................................................................... 9-14

ORAL PRESENTATIONS ................................................................................................................................. 15

POSTER PRESENTATIONS- SESSION 2 .................................................................................................. 16-21

HIGH SCHOOL STUDENT AWARDS ............................................................................................................ 22

PROGRAM DESCRIPTIONS .......................................................................................................................23-27

2017 HOPKINS C.A.R.E.S. ORGANIZING COMMITTEE ............................................................................ 28

HOPKINS C.A.R.E.S. SPONSORS ................................................................................................................... 29

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The Hopkins C.A.R.E.S. SUMMER SYMPOSIUM and NETWORK:

1. Showcase Summer Programs that provide paid internships in Hopkins laboratories, clinics, and offices across the medical campus for nearly 300 students with more than half from Baltimore City high schools.

2. Provide opportunities for 200 selected students to deliver a professional

presentation to an audience of 350 attendees, including Hopkins faculty, faculty and recruits from local colleges and universities, and each other.

3. Bolster high school students’ academic and social confidence by enabling

them to compete and compare the quality of their academic presentations to high achieving undergraduates from all over the United States.

4. Inspire a generation of future leaders by providing a stage for students and

keynote speakers of international prominence to share their journey, struggles, and lessons learned in achieving their dreams.

5. Invest in untapped local talent to generate a homegrown workforce with a

college degree and improve the odds of success among aspiring leaders to pursue a career in science, public health, or medicine.

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2017 HOPKINS C.A.R.E.S. SUMMER PROGRAMS

Basic Science Institute (BSI)

o Institute for Computational Medicine (ICM)

Biophysics Research for Baltimore Teens (BRBT)

Center for Talented Youth Student Summer Research Program (CTY)

Centro SOL Programa de Verano para Jóvenes

Diversity and Academic Advancement Summer Institute (DAASI)

The Foundation for Advanced Research in the Medical Services (FARMS)

Health Career Opportunities Program (HCOP)

Institute for NanoBiotechnology Research Experience for Undergraduates (INBT)

Johns Hopkins Biomedical Engineering

The Johns Hopkins Internship in Brain Science Program (JHIBS)

Kennedy Krieger Institute

o Hopkins Center for Health Disparities Solutions

o Maternal and Child Health-Leadership Education, Advocacy, and Research

Network (MCH-LEARN)

o Maternal Child Health Careers/Research Initiatives for Student

Enhancement-Undergraduate Program (MCHC/RISE-UP)

o Public Health Leadership & Learning Undergraduate Student Success

(PLLUSS) Program

Medical Education Resources Initiative for Teens (MERIT)

Pulmonary and Critical Care Medicine Summer Internship Program (PCCM)

Summer Academic Research Experience (SARE)

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PRESENTATION SCHEDULE

TIME SESSION SPEAKER(S) LOCATION

9:00 am - 10:00 am REGISTRATION AMEB, 1st Floor Lobby

10:00 am – 10:05 am WELCOME Roy Ziegelstein, M.D., Vice Dean for Education

AMEB, 1st Floor Auditorium

10:05 am – 10:35 am KEYNOTE SPEAKER

Felicia Hill-Briggs, Ph.D., ABPP

AMEB, 1st Floor Auditorium

10:35 am – 11:15 am FEATURED STUDENT STORIES

Micheal Munson, PCCM

Bryan Itzep, HCOP

Katherine Quintin, BSI

Francis Mejia, Centro SOL

Sarah Tayel, MCH-LEARN

AMEB, 1st Floor Auditorium

11:30 am – 12:30 pm POSTER SESSION 1

2017 C.A.R.E.S. Summer Programs

AMEB, 1st and 2nd Floor Lobbies

12:30 pm – 1:00 pm LUNCH AMEB, 1st and 2nd Floor Lobbies

1:00 pm – 2:00 pm ORAL

PRESENTATIONS 2017 C.A.R.E.S. Summer

Programs AMEB, 1st Floor

Auditoriums (East and West)

2:00 pm – 3:00 pm POSTER SESSION

2 2017 C.A.R.E.S. Summer

Programs AMEB, 1st and 2nd

Floor Lobbies 3:00 pm - 3:30 pm Scholarship Awards AMEB, 1st Floor

Auditorium 3:30 pm RECEPTION Felicia Hill-Briggs, Ph.D.,

ABPP

AMEB, 1st Floor Lobby

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BACKGROUND STORIES

Micheal Munson “Paralysis is strong, but you're stronger”

Program: Pulmonary and Critical Care Medicine Summer Program

Current School: Baylor University Future Goals: Physician-Scientist (M.D./Ph.D.)

Bryan Itzep

“After a while, you learn to understand the turmoils of life and turn the cycle of pain into something worthwhile – into wisdom”

Program: Health Career Opportunities Program (HCOP) Current School: Belmont University

Future Goals: Physician-Scientist

Francis Mejia “As an undocumented student, you may feel like there aren’t many

opportunities for you but there are many opportunities. You just need to go out and look for them”

Program: Centro SOL

Current School: Baltimore Polytechnic Institute Future Goals: Nursing

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Katherine Quintin “The key to realizing a dream is to focus not on success or failure

but on significance - and then even the small steps and little victories

along your path will take on greater meaning”. - Oprah Winfrey

Program: Basic Science Institute, Summer Internship Program Current School: University of West Florida

Future Goals: To become a Physician

Sarah Tayel “Don't let society's flawed definitions or generalizations of who or

what group of people are like become your own. Let us all embrace one another, and stand in solidarity. Our world needs love and peace now more than ever.”

Program: Maternal Child Health-Leadership Education, Advocacy,

Research Network (MCH-LEARN) at Kennedy Krieger Current School: University of Maryland College Park

Future Goals: Couple, Marriage, and Family Therapist

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KEYNOTE SPEAKER

Felicia Hill-Briggs, Ph.D., ABPP

Dr. Hill-Briggs is a clinical psychologist, neuropsychologist, and behavioral scientist. She is Professor of

Medicine at the Johns Hopkins School of Medicine, with joint appointments in the Johns Hopkins

Bloomberg School of Public Health, and the School of Nursing. She is Core Faculty of the Welch Center for

Prevention, Epidemiology & Clinical Research. Dr. Hill-Briggs is Senior Director of Population Health

Research and Development for Johns Hopkins HealthCare, LLC, and Co-Lead of the Behavioral, Social, and

Systems Science research community for the Johns Hopkins Institute for Clinical and Translational Research

(ICTR).

She is an international expert in behavior change and self-management of diabetes, hypertension, chronic

kidney disease, and related conditions. Dr. Hill-Briggs conducts clinical trials of individual-level and systems-

level interventions to improve disease outcomes modifiable through behavior change. A key contribution of

her work is effective intervention design and implementation for populations of health disparity, including

lower socioeconomic status groups, racial and ethnic minority groups, populations with low literacy and

health literacy, and persons with functional impairment and disability. She has received several awards for her

research and science dissemination including the Nelson Butters Award for Research Contributions to

Clinical Neuropsychology (National Academy of Neuropsychology), Tracey Orleans Outstanding Service

Award (Society of Behavioral Medicine), and Telly Awards (People’s Telly for Health Film/Video). Her work

extends globally to research and population health initiatives within Johns Hopkins Medicine International

collaborations in Trinidad and Tobago, Bermuda, Brazil, and Saudi Arabia.

Dr. Hill-Briggs is a native of Baltimore, Maryland and a graduate of the public school system. She graduated

magna cum laude from The American University, where she was a Rhodes Scholar nominee, and the first

student in university history to achieve two University Honors. She completed her M.S. and Ph.D. degrees in

Clinical Health Psychology and Neuropsychology at Penn State University. Prior to joining the Johns

Hopkins faculty in 1998, she served on the faculty of New York University Medical Center-Rusk Institute of

Rehabilitation Medicine. Dr. Hill-Briggs became the first African-American nationally to receive board

certification in the specialty of Rehabilitation Psychology. In 2015, she became the first African-American

non-physician to achieve the rank of full Professor at the Johns Hopkins School of Medicine.

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POSTER PRESENTATIONS- SESSION 1 (11:30 am – 12: 30 pm)

Session Guide:

Program Name Poster Board Numbers

INBT 1-14

DAASI-Thread 15-22

BME 23

HCOP 24-32

ICM 33-35

CTY 36-42

SARE 43-48

MCHC/RISE-UP-KKI 49-55

MCH-LEARN-KKI 56-60

PCCM 61-70

BSI 71-80

MERIT 81-94

# Name Program Title 1 Nicole Zambrana-

García INBT Characterization and Expansion of Human

Induced Pluripotent Stem Cell Derived Mural Cells

2 Christian Heil INBT Prostate Cancer Staging with Matrix Metalloproteinase-2 (MMP-2) Cleavable

Supramolecular Nanobeacons

3 Danielle Zamalin

INBT Evaluation of Apoptosis and Necrosis in Spheroid Models

4 Raymond Dengler INBT Characterizing Colloidal Surface Forces on the Potential Profile of Polymer-Coated

Silica Particles

5 Nicole Grub INBT Investigating the Interactions between VEGFR2 and EGFR

6 Nikolas Grotewold INBT Analyzing the Effects on Cell Motility of Inhibiting the RAS/MAPK and PI3K

Signaling Pathways

7 Paige Stanley INBT Protein Engineering Hfq for Modified Assembly and Activity

8 Mohammed Munim INBT High Density Droplet Platform for Sensitive Biomarker Detection

9 Jamal Keyes INBT PBAE Nanocarriers for siRNA Delivery to Achieve Gene Knockdown in Glioblastoma

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10 Jessica Gayle INBT Cell and Nuclear Volume During Adhesion and Detachment

11 Kyle Barrie INBT The Effects of Hyperthermia and Chemotherapy on Hepatocellular Carcinoma

12 Adrian Johnston INBT Development of an Inhalable Lung Sealant

13 Eliana Crentsil INBT The Effect of YAP Protein Expression on Cell Proliferation

14 Patrick Leggieri INBT 3D In Vitro Modeling of dhBMECs Under Shear Stress

15 Abdulla Williams DAASI-Thread

Outpatient Study

16 Tellvon Kilson & Darnell Boyd

DAASI-Thread

What We Do and How We Do It

17 Shamar Morgan & Myrikal Fields

DAASI-Thread

OCD & Panic Attacks

18 Davonta Ayers DAASI-Thread

Learning the Process

19 Jaden Roles DAASI-Thread

Thread Placement 2017

20 Montez Dorsey, Jr. DAASI-Thread

Artificial Heart and 3-D Printing

21 Davonta McNair DAASI-Thread

TBD

22 Jawaun Lewis DAASI-Thread

TBD

23 Sandhya Ramachandran &

Victor Wang

BME Edge Detection for MRI Stroke Images

24 Adiel Hernandez HCOP Impact of Translin Deletion on Dopamine Reward System

25 Ali Tamirat HCOP The Role of P2X4 Receptors in Prostate Cancer

26 Angel Boulware HCOP Psychosocial Adversity as a Determinant of Psychopathology in a Child Inpatient Sample

27 Sagar Chapagain HCOP Blue light stimulates food intake in Drosophila

28 Amber Follin HCOP Identifying genetic modifiers in a Drosophilia model of Inclusion Body

Myositis

29 Courtney Gainous HCOP How probiotics influence behavior and mental health: a pre-clinical study

30 Mario Garcia Duarte HCOP 3D Printed Thermo-Responsive Hydrogel for RV-PA Conduit

31 Sarah Gebken HCOP Mechanism of Tau Pathological Spreading in a New Mouse Model of Alzheimer’s Disease

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32 Adiel Hernandez HCOP Impact of Translin Deletion on Dopamine Reward System

33 Pierce Perkins ICM Alzheimer's Dementia

34 Dorothy Ucheomumu ICM Brain Structures and Volumes Associated with Schizophrenia

35 Akunna Mezu ICM Stroke Detection in Brain MRI:Creating an Automated Tool for Personalized Medicine

36 Isabella Lorence CTY Research Internship

Stroke detection in brain MRI: creating an automated tool for personalized medicine

37 Lydia Wang CTY Research Internship

Phoneme Analysis Hearing Test

38 Arianna Parkhideh CTY Research Internship

Chaos in the School Environment: Teacher Perceptions and Measures

39 Rhea Krishnan CTY Research Internship

Understanding epigenetic regulation of histone modifications

40 Amy Tuo CTY Research Internship

Crocs Made of Blocks: The Impact of Semantic Information on Block Building

41 Alanna Sun CTY Research Internship

Nanopore Sequencing for the Detection of Plasmid Insertions and DNA Methylation

42 Raksha Krishnan CTY Research Internship

Lamina Associated Domains and Nuclear Architecture Investigated through

Immunofluorescence

43 Grace Ayole SARE Studying the Effect of PPGPP on Caulobacter Cell Wall Synthesis

44 Jacqueline Ndayizeye SARE Boosting Yeast Transformation Efficiency

45 Kiyea Milledge SARE Characterization of a Mitochondrial Disease Model

46 Michael Carpenter SARE Characterization of CRISPR Knockout Breast Cancer Cell Lines

47 Malik Buck SARE Investigating the pathogenic mechanisms of CTM2C in a Drosophila Model

48 Victoria Gillam SARE Identifying and Localizing Necklace Olfactory Receptors

49 Alexander Adames MCHC/RISE-UP-KKI

Physical Inactivity and Mortality Among Black Men

50 Adeyoola Adeniji MCHC/RISE-UP-KKI

Zika: Recent Discoveries and Future Response

51 Aaron Brown MCHC/RISE-UP-KKI

An Exploration of Malformation Disorders in the Brain: Polymicrogyria and Pachygyria

52 Loren Hampton MCHC/RISE-UP-KKI

Recruitment and Retention of Low Income Blacks for Intrusive Smoking Cessation

Studies

53 LaShai Jake MCHC/RISE-UP-KKI

Illicit Drug Use Among AI/AN Youth in Rural Communities - Using Project ECHO

54 Ann Johnson MCHC/RISE-UP-KKI

Diagnostic Category and Electronic Use in Preschoolers

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55 Aamna Kabani MCHC/RISE-UP-KKI

Prevalence of Psychiatric Diagnoses in Children After Traumatic Brain Injury and

Disparities in Functional Outcomes

56 Al-Hafis Adegun MCH-LEARN-KKI

Evaluating the Effectiveness of Obesity Intervention Programs among People with

Disabilities

57 Christian Campbell MCH-LEARN-KKI

The Association Between Preventive Health Service Use and All-cause Mortality Among

Black Men

58 Mabinty Conteh MCH-LEARN-KKI

Quitline Intervention Programs and It's Association with Quit Attempts

59 Thelma Ejimofor MCH-LEARN-KKI

Intimate Partner Violence (IPV) & Its Effects on Infant/Toddler Growth &

Development

60 Jernelle John MCH-LEARN-KKI

The Effects of Adversity on the Association between Parental Executive Function and

Child Behavior

61 Ashley Chan PCCM S-nitrosoglutathione reductase is essential for protecting female hearts from ischemia-

reperfusion injury

62 Raven Riordan PCCM Role of Galectin 3-mediated autophagy activation in LPS-induced inflammation

63 Mia Benavidez PCCM Cigarette Smoke Affects Localization and Activation of EGFR in Normal Human

Bronchial Epithelium

64 Micheal Munson PCCM Na+/H+ Exchanger Regulates CHOP Levels in Pulmonary Arterial Smooth Muscle

Cells During Pulmonary Hypertension

65 Danielle Firer PCCM Elucidating the Relationship Between Bitter Taste Receptor Agonists and the

Desensitization of B2AR

66 Michael Rohly PCCM Infection Associated Allograft Injury Following Lung Transplantation

67 Christian Roa PCCM Baseline Analysis of Cardiovascular Health in Rural Puno Peru in Cardiopulmonary

outcomes and Household Air Pollution trial (CHAP)

68 Zahna Bigham PCCM Shear Stress Induced Calcium Influx in Rat Lung Microvascular Endothelial Cells

69 Michelle Moats PCCM IL10 deficiency promotes macrophage-driven senile emphysema

70 Natalie Pino PCCM Interactions of OSA, Pregnancy, and Fetal Health

71 Laeticia Hollant PCCM Acid-Base Regulation of The Acute Allergic Response in The Airways

72 Brady Bunkelman Basic Science Institute

Towards a xMD-Based Cell Specific RNA-seq of Human Kidney

13

73 Briyana Chisholm Basic Science Institute

High Mobility Group A2 (HMGA2) Protein Dysregulates Genes Involved in DNA

Replication, Recombination, & Repair, Cell Survival, Cancer & Metabolism

74 Taylor Coleman Basic Science Institute

Isolation and Expression of Borrelia burgdorferi Decorin Binding Protein A for

Human T-cell Stimulation Assay

75 Edward deRamon Basic Science Institute

Keratan Sulfate as a Potential Therapeutic for Airway Inflammatory Diseases

76 Monica Duran Martinez

Basic Science Institute

Unraveling the Genetic Interactions Between Trisomic and Disomic Genes that

Cause Atrioventricular Septal Defect in Down Syndrome

77 Cera Hassinan Basic Science Institute

Comparing patterns of variation in controls (ExAC) vs. pathogenic variants for autism

associated syndromes (HGMD)

78 Daria Ivenitsky Basic Science Institute

The Role of Somatic L1 Insertions in Early Human Miscarriages

79 Noel Jackson Basic Science Institute

Investigating the mechanism of Glypican 4 and 6 release by GDE2 and GDE3

80 Clara (Jingxian) Liu Basic Science Institute

Activities of beta-lactam combinations and computational screening for clinically selected mutations in transpeptidases

81 Gian Molina Castro Basic Science Institute

Spatial and temporal dynamics of oligodendrocytes during gray matter

remyelination

82 Destiny Battle MERIT Health

Leadership Academy

Detecting PD-L1 in the tissue of cancer-bearing mice

83 Genesis Cisneros MERIT Health

Leadership Academy

The effect of myoelectric and sEMG signals on controlling a virtual prosthetic arm

84 Danielle Cook MERIT Health

Leadership Academy

Rescuing insulin resistance with DHT in the setting of AR inhibition

85 Nymaurie Cowles MERIT Health

Leadership Academy

Gut microbiome and colorectal cancer

86 Dy'Mon Fleming MERIT Health

Leadership Academy

The role of lumican in innate immune response

14

87 Martiera Kelly MERIT Health

Leadership Academy

The Essence Project: The impact of enviromental and physiological factors on

sexual assault and HIV

88 Diamond Maye MERIT Health

Leadership Academy

Exportin-1 and DNA damage

89 Davia McKenzie MERIT Health

Leadership Academy

The effect of myoelectric and sEMG signals on controlling a virtual prosthetic arm

90 Zauria Minson MERIT Health

Leadership Academy

Affect of Atm as a DNA damaging agent against BCL-xL

91 Mariama Patterson MERIT Health

Leadership Academy

Patients who receive tracheostomies while in palliative care

92 Rwaida Saeed MERIT Health

Leadership Academy

Correlating PTEN and ERG status between African American men and European

American men

93 Nemah Saeed MERIT Health

Leadership Academy

Macrophages & ASPN in prostate cancer

94 Mercedes Thompson MERIT Health

Leadership Academy

Effect of Sinibis virus and antibody treatment on neuronal cytoskeletal proteins

95 Ki'Juana Land MERIT Health

Leadership Academy

Location of SENP2

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ORAL PRESENTATIONS

1:00 pm – 2:00 pm

East Auditorium

West Auditorium

Time Name of Student Program Title 1:00 pm Kelvin Moore, Jr. KKI (Center

for Diversity) The Role of Parental Insurance in Perception of

PrEP Utilization

1:10 pm Rachel Pan FARMS CRISPR/Cas9 corrects various HBB gene mutations in human iPSCs with high fidelity and

minimal off-target effects 1:20 pm Davonta McNair DAASI TBD

1:30 pm Pierce Perkins ICM Alzheimer's Dementia

Time Name of Student Program Title 1:00 pm Victoria Gilliam SARE Identifying and Localizing Necklace Olfactory

Receptors

1:10 pm Mercedes Thompson MERIT Health

Leadership Academy

Effect of Sinibis virus and antibody treatment on neuronal cytoskeletal proteins

1:20 pm Nicole Zambrana-García

INBT Characterization and Expansion of Human Induced Pluripotent Stem Cell Derived Mural Cells

1:30 pm Joshua Bell PCCM My Experience as a Johns Hopkins Intern

16

POSTER SESSION 2 (2:00 pm – 3:00 pm)

Session Guide:

Program Name Poster Board Numbers Pulmonary and Critical Care Medicine

(PCCM) 1-8

MCHC/RISE-UP-KKI 9-15

MCH-LEARN-KKI 16-20

PLLUSS- KKI 21-23

Hopkins Center for Health Disparities Solutions- KKI

24-27

FARMS 28-34

JHIBS 35-47

CTY 48-53

BSI 54-63

MERIT 64-74

CIS 75

HCOP 76-83

INBT 84-85

# Name Program Title 1 Reuben Ryan Cano PCCM Validation of a Tool For Assessing Pulmonary

Procedure Competence

2 Raúl Torres PCCM Chemotherapy Resistance in Cancer

3 Kiara Whitaker PCCM African Ancestry and its association with telomere length and BMI in self-reported European and

African American Subjects from the GeneSTAR Study

4 Alexis Carey PCCM Associations Between Black Carbon Exposure and FeNO Levels in Baltimore City Youth

5 Joshua Bell PCCM Allergic Sensitization and Allergen Exposure Among COPD Patients in Baltimore

6 Tristan Vulcain PCCM Impact of diet and indoor air pollutants on asthma severity in inner city children in Baltimore

7 Chantal Lemoine PCCM Response to indoor air pollution among allergic and non-allergic children with asthma living in

Baltimore City

8 Nyerovwo Okifo PCCM Association of Neighborhood Deprivation with Asthma Morbidity among African-American Head-

Start Children in Baltimore, Maryland

9 Adebosola Karunwi

MCHC/RISE-UP-KKI

Event Related Potential Of Practicing Novel, Praxis-Like Movements: Physiological Effects of

Repetition

17

10 Krystal La Flora MCHC/RISE-UP-KKI

Telehealth Services in Howard County Schools

11 Adetoyosi Obikoya MCHC/RISE-UP-KKI

A Comparison of Maternal and Paternal Assessments of Children’s Problem Behaviors

12 Maya Reyes MCHC/RISE-UP-KKI

Impacting Health Equity by Improving the Cultural Competency of Providers

13 Riley Smith MCHC/RISE-UP-KKI

Mindfulness in Obsessive-Compulsive Disorder: A Randomized Controlled Trial

14 Carumey Stevens MCHC/RISE-UP-KKI

The Role of the “Black Church” in Seeking Mental Health Services

15 Ashley Tejada MCHC/RISE-UP-KKI

Does an Immigrants’ Socioeconomic Status Affect Their Happiness?

16 Nadia Moore MCH-LEARN-KKI The variation in Executive Function abilities in children with a history of Prematurity and Attention Deficit Hyperactivity Disorder

17 Zanaeh Rogers MCH-LEARN-KKI Co-occurring PTSD and High Risk Alcohol Use among predominantly African American Women in

Baltimore City

18 Nya Ferguson MCH-LEARN-KKI

HIV Knowledge and Sex Risk Behavior Adherence from African American Women in Baltimore City

19 Sarah Tayel MCH-LEARN-KKI

Assessing Regional Disparities in Mental Health Treatment Access Amongst Children Aged 2-17

20 Karissa Avignon MCH-LEARN-KKI

Intimate Partner Violence Safety Strategies in Latina Immigrant Women

21 Kelvin Moore, Jr. PLLUSS- KKI The Role of Parental Insurance in Perception of PrEP Utilization

22 Dylan Balter PLLUSS- KKI An Examination of Racial Disparities in Inpatient Consultations

23 Bria Goode PLLUSS- KKI Suicidal Ideation and Attempts Among Among African American Youth

24 Elijah Boswell Hopkins Center for Health Disparities Solutions- KKI

The Association between Life Expectancy and Race in Professional Athletes

25 Destiney Taylor Hopkins Center for Health Disparities Solutions- KKI

The Association of Chronic Kidney Disease Risk Factors on All-Cause Mortality Among Black Men

26 Diana Lopez Hopkins Center for Health Disparities Solutions- KKI

The Association Between Education and All-Cause Mortality among Black Men

18

27 Danielle Gaskin Hopkins Center for Health Disparities

Solutions

Racial Disparities in Mortality Among High Status Populations

28 Zachary Baker FARMS The role of c-Abl in Neuroinflammation and Neurodegeneration

29 Rochelle Shih FARMS Effects of Differentiation on Migratory Properties on Glial Progenitors

30 Haesoo Moon FARMS The role of c-abl in alpha-synuclein-induced Parthanatos:Effacy of Nilotinib in Parkinson's

prevention

31 James Gentry FARMS Functional ground state pluripotency is characterized by global epigenetic changes on

lineage promoters

32 Kyra Seiger FARMS Optimization of a transcription factor-free system of maintaining PAX7 expression in induced

myogenic stem cells

33 Rachel Pan FARMS CRISPR/Cas9 corrects various HBB gene mutations in human iPSCs with high fidelity and

minimal off-target effects

34 Taylor Leposa FARMS Analysis of secreted nanoluciferase as a potential method for measuring cell viability in vitro and in

vivo

35 Anita Cooke JHIBS Exosomes Released from Astrocytes in Response to TNFα Disrupt Dendritic Branching in Neurons

36 Ashlee Hegie JHIBS Stroke Center Certification

37 Fayla Guerin JHIBS Contamination using BRIEF-A and no Contamination using BRIEF-A

38 Laxaviera Elphage JHIBS To Do Or Not To Do: Action Suppression During Conflict Resolution

39 Khandi Harrison JHIBS Visual Dysfunction in Children with Multiple Sclerosis and Healthy Controls

40 Kira Hunt JHIBS Symptom's Effect on Multitasking in Spinocerebellar Ataxia

41 Devante Kerr JHIBS Dopamine's Involvement in Salt Preference in Drosophila Melanogaster

42 Mah Noor JHIBS Stroke Detection in Brain MRI: Creating an Automated Tool for Personalized Medicine

43 Eryka Parham JHIBS The Study of Antiretroviral Therapy on the Blood-Brain Barrier

44 Denille Smith JHIBS Potential Therapeutic Targets for C9orf72-Associated ALS

45 Daimyn Wilson JHIBS Detection of Citrullinated PAD2 in the Brain of Patients with Multiple Sclerosis

46 Tiffany Green JHIBS The Effect of Don-Prodrug on Stress-Induced Depressive Symptom

47 Stefany Zelaya JHIBS The Opioid Epidemic

19

48 Joseph Cho CTY Student Research Program

The Effect of Exposures on Mitochondrial DNA Copy Number (mtDNA-CN)

49 Arjun Jain CTY Student Research Program

Actin Dynamics are Required for Coronavirus-Induced Syncytia Formation

50 Benjamin Pang CTY Student Research Program

Neurophysiology Markers and Recovery Predictors Following Repeated Traumatic Brain Injuries

51 Erick Huang CTY Student Research Program

Transcriptional Profiling of the Antidepressant Ketamine and its Metabolite (2R,6R)-

hydroxynorketamine in Mouse Hippocampus Cells

52 Connor Hogan CTY Student Research Program

Detection of Polymorphic and Individual Splicing Variations from Multi-Sample RNA-Seq Data Sets

53 Paul Moon CTY Student Research Program

Does Platelet Concentration Affect Platelet-Monocyte Aggregates and the Susceptibility of

CD16+ Macrophages to HIV Infection

54 Brooke Mounsey Basic Science Institute

Isolating GMF-β Protein & Investigating its Role in Nerve Repair

55 Natasha Navejar Basic Science Institute

Seeing with sound: How bats use echolocation to find hidden objects

56 Simosenkosi Nkomboni

Basic Science Institute

Immunolabeling of Synaptic Proteins in the Cochlea

57 Christina Padorani Basic Science Institute

Mitochondrial CaMKII and Pathologic ProROS Signaling: ROS-Induced ROS Release

58 Katherine Quintin Basic Science Institute

Modulating Inflammasome Activity by using FcyRIIa

59 Stephan Quintin Basic Science Institute

c-Abl and PARIS (ZNF746) as α-synuclein Targets in Dopaminergic Neurodegeneration: Validation

strategies using genetic and preclinical animal models of Parkinson’s Disease (PD)

60 James Sooknanan Basic Science Institute

Development of a Reporter System to Track Adipose - Derived Stem Cell Fate During

Vascularized Bone Regeneration

61 Alec Stepanian Basic Science Institute

Neuromodulation for intractable self-injurious behavior associated with autism spectrum disorder:

a translational study

62 Phong Truong Basic Science Institute

Global genetic and epigenetic alterations induced by endogenous IDH1-R132H/WT in human glial

cells

63 JaNiece Walker Basic Science Institute

Alu Exons: The Hidden Transcripts

64 Shakaiya Buckner MERIT Health Leadership Academy

Introduction to the world of clinical trials

20

65 Oumaima Driwech MERIT Health Leadership Academy

Calprotectin can starve the fungal pathogen Candida albicans of iron (Fe)

66 Londyn Gordon MERIT Health Leadership Academy

HIV risk among African American women

67 Kaysha Harper MERIT Health Leadership Academy

Location of SENP2

68 Monnyae Lucas MERIT Health Leadership Academy

Review of transplants

69 Shatera McNair MERIT Health Leadership Academy

Blocking the mid-gut receptor in the Anopheles stephensi mosquito

70 Ashley Ruano MERIT Health Leadership Academy

Effects of MTORC1 activity mutated with RHEBS16H

71 Oumou Sall MERIT Health Leadership Academy

Reconstructing the Adenovirus genome for simplified engineering

72 Jayme Savoy MERIT Health Leadership Academy

Investigating the role of CCLR-17D3 in drosophila germline stem cell maintenance

73 Amaya Simpson MERIT Health Leadership Academy

A dual plasmid system for labeling and kiling cells in co-culture

74 Eseni Tafah MERIT Health Leadership Academy

Prostate cancer metastasis

75 Yan Fu Center For Imaging Science

Marmoset Brain Registration

76 Bryan Itzep HCOP Dysregulation of microRNA biogenesis: Exploring the Lin28/ Let-7 Axis in Fragile X Syndrome

77 Lina Jowhar HCOP Biological and Phylogenetic Analysis of human H1N1 influenza viruses collected during 2015-16 in

Baltimore, MD and Taipei, Taiwan

78 Sunny Kwok HCOP A Computational Model of the Interactions between VEGF Receptor-2, Neuropilin-1, and

VEGF-A

79 Ashley Kyalwazi HCOP Neocortical layer 6 corticothalamic neurons innervation patterns in the thalamus

80 Dexter Manglicmot HCOP New Lamin Mutations and Prelamin A Processing

81 Edward Robinson HCOP Comparison of MCI with normal ageing using FDG-PET and brain structure volumes

21

82 Khalida Saalim HCOP Investigation of the Association between Glutaminase Expression and Clinical Outcomes in

Ovarian Cancer

83 Angela Sas HCOP Motivators, barriers, and facilitators to weight loss and behavior change among limited English

proficiency Latino adults in Baltimore City: A qualitative analysis

84 Matthew Tang INBT Arduino Controlled Bioprinting Platform

85 Marisa Ngbemeneh INBT Therapeutic Variability of Bevacizumab in Non-Small Cell Lung Adenocarcinoma

22

Scholarship Winners

Danielle Cook

Medical Education Research Initiative for Teens (MERIT)

Oumaima Driwech

Medical Education Research Initiative for Teens (MERIT)

Diamond Maye

Medical Education Research Initiative for Teens (MERIT)

Eryka Parham

Johns Hopkins Internship in Brain Science Program (JHIBS)

Jayme Savoy

Medical Education Research Initiative for Teens (MERIT)

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2017 HOPKINS C.A.R.E.S PROGRAM DESCRIPTIONS

Basic Science Institute Summer Internship: The Summer Internship Program (SIP) provides experience in research laboratories to students of diverse backgrounds, including underrepresented minority students, students from economically disadvantaged and underserved backgrounds and students with disabilities that have completed one - two or more years of college. The purpose of this exposure to biomedical and/or public health research is to encourage students to consider careers in science, medicine and public health. Biophysics Research for Baltimore Teens: Biophysics for Baltimore Teens (BRBT) is a new initiative, which will give Baltimore city teens a chance to do basic biomedical research in Johns Hopkins biophysics labs on both the Homewood and JHMI campuses. BRBT is offered through the Johns Hopkins Program in Molecular Biophysics (PMB) and PMB graduate students on both campuses will mentor BRBT interns. The interns’ exposure to laboratory research will be augmented with a weekly course in basic laboratory skills taught by graduate students and overseen by PMB faculty. CTY Student Summer Research Program: This program, sponsored by the Simons Foundation, invites high achieving, academically advanced high school students to participate in a residential research experiences across disciplines at both the Johns Hopkins University and School of Medicine. This six-week residential program pairs students with research mentors through a highly selective process, which considers both student and mentor skills and interests. Students attend career and research seminars and participate in a journal club sponsored by each host lab. Centro SOL Programa de Verano para Jóvenes: Summer program for Spanish/English bilingual high school students in Baltimore City. The program’s goal is to expose bilingual high school students to the medical field by offering meaningful opportunities to work with JHU School of Medicine faculty in clinical settings that serve Latino patients with limited-English proficiency. Patients with limited English proficiency (LEP) frequently have difficulties navigating the healthcare system, explaining their illness, understanding their providers’ recommendations, and participating fully in the development of a treatment plan. In this project, we want to capitalize on the strength of bilingual youth in our community. Students who are fluent in both Spanish and English will be invited to apply to the program. Following orientation, students will be placed in various clinical settings, to get exposure to various health professions, and where they can utilize their Spanish language skills to assist Latino patients with limited-English proficiency in various scenarios, such as registering for care, guiding them to various places in the hospital, greeting them and providing information at the entrance or information desks throughout Bayview Hospital. In addition, students will shadow Johns Hopkins Hospital Spanish language interpreters. This experience will allow them to appreciate the importance of professional medical interpretation during clinical encounters and give them an opportunity to pursue further training in this area if they are interested. Students will meet weekly with faculty preceptors to reflect on their experiences and provide feedback to our program. We see bilingual youth as a unique resource with enormous potential to succeed in STEM (Science, Technology, Engineering, and Math) careers under the right guidance. Through this pilot program, we will expose motivated Baltimore youth to careers in medicine,

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mentor them at a leading medical institution, and empower them to pursue further training that capitalizes on their Spanish language skills, while improving services to our Latino patients. Diversity and Academic Advancement Summer Institute (Thread): The Diversity and Academic Advancement Summer Institute (DAASI) is a partnership between Johns Hopkins School of Medicine Office of Student Pipeline Programs and Thread (formerly Incentive Mentoring Program). The goals are to three fold: (1) Academic Assistance: Provide a comprehensive, engaging curriculum to bolster participants’ academic self-confidence and capabilities; (2) Service, Life Skills, and Team Work: Create opportunities for participants to learn important life and professional skills through work opportunities and service learning experiences; and (3) Visualizing Success: Expose them to science and health educational pathways so that they may visualize the possibility of pursuing careers in science. The Foundation for Advanced Research in the Medical Services (FARMS): FARMS offers opportunities in the Institute for Cell Engineering (ICE) in one of our four program areas: Vascular Biology, Stem Cell Biology, Immunology or Neuroregeneration. Program participants may participate in a broad array of projects from computational biology, gene regulatory networks, immune system development, lymphoid malignancies, molecular and cellular mechanisms of oxygen regulation, molecular and cellular signals controlling neurodegeneration, neurogenesis, single cell biology, stem cell modeling, gene and stem cell therapies, MRI cell tracking techniques, or stem cell engineering. The rich environment and guidance by our faculty helps prepare students for successful careers as independent research scientists. Interns are expected to participate in all student related activities in ICE, conduct research and write a small progress report at the end of their internship or present their work in a poster session at the end of the summer. Health Career Opportunities Program (HCOP): The Health Careers Opportunity Program summer internship provides experience in research laboratories to students from economically or educationally disadvantaged backgrounds that have completed one - two or more years of college. The purpose of this exposure to biomedical and public health research is to encourage students to consider careers in the health care workforce. Students in the HCOP division work in labs in both School of Medicine and the Bloomberg School of Public Health. Institute for Computational Medicine: Founded in 2005, the mission of the Institute for Computational Medicine is to develop mechanistic computational models of disease, personalize these models using data from individual patients, and apply them to improve disease diagnosis and treatment. ICM researchers work in four different application areas: Computational Molecular Medicine seeks to understand the function of highly interconnected molecular networks in health and disease. This knowledge is applied to enhance discovery of molecular disease networks, detection of disease, discrimination among disease subtypes, prediction of clinical outcomes, and characterization of disease progression. Computational Physiological Medicine seeks to develop highly integrative mechanistic models of biological systems in disease, spanning from the levels of cells to tissues and organs. These models are personalizes using patient data, and apply them to improve disease diagnosis and treatment. Computational Anatomy is an interdisciplinary area of research focused on quantitative analysis of variability in biological shapes in health and disease. It is applied to imaging data to develop anatomic biomarkers for disease diagnosis. Computational Healthcare analyzes large-scale data sets from the electronic health record to discover new ways of improving individualized patient care. Our interdisciplinary labs offer students the opportunity to work with faculty in these four different research areas. These internships provide a unique

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opportunity to gain research experience in the emerging discipline of computational medicine, and would be of great benefit to students interested in pursuing graduate research in this area, or in attending medical school. Institute for NanoBiotechnology Research Experience for Undergraduates (INBT): The Institute for NanoBiotechnology at Johns Hopkins University offers undergraduate students from colleges and universities around the country a chance to participate in research projects in the exciting and rapidly growing area of Nanobiotechnology, a place where biology, medicine, and nanotech meet. For more information, visit http://inbt.jhu.edu/education/undergraduate/reu/. The Johns Hopkins Internship in Brain Science Program (JHIBS): Project Pipeline

Baltimore: The long-term goal of the JHIBS program is to significantly increase the pool of

qualified under-represented professional candidates from Baltimore in the neurosciences and mental

health medicine through an eight-week summer research and enrichment experience that targets

high school juniors and seniors. The program will provide the necessary exposure, knowledge, and

career-long mentoring, to help propel students toward a trajectory as a STEM professional. The

program has been in existence for nine years funded by the Cohen Foundation and beginning in

2014, jointly with a grant from the National Institutes of Mental Health.

Kennedy Krieger Institute Hopkins Center for Health Disparities Solutions: The Summer Internship program at the Hopkins Center for Health Disparities Solutions (HCHDS) accepts students from the Diversity Summer Internship Program at the Johns Hopkins School of Public Health and students from the Center for Diversity in Public Health Leadership Training at the Kennedy Krieger Institute. The eight-week summer program enables minority high school and undergraduate students to participate in research and academic activities, as well as receive mentoring. At the end of the eight weeks, each student produces a technical report that summarizes his/her summer experience. The HCHDS collaborates with the Center for Diversity in Public Health Leadership Training at the Kennedy Krieger Institute, which offers four funded summer internship programs. Maternal and Child Health-Leadership Education, Advocacy, and Research Network (MCH-LEARN): The Maternal and Child Health-Leadership Education, Advocacy, and Research Network (MCH-LEARN) will provide up to 45 undergraduate freshman and sophomore students from historically disadvantaged and underrepresented populations in the maternal and child healthcare (MCH) field with a comprehensive integrative MCH learning experience over the next 5 years. MCH-LEARN leverages a leadership learning network formed by (1) Kennedy Krieger Institute Leadership Education in Neurodevelopmental Disabilities (KKI LEND) Program, (2) Historically Black Colleges and Universities, (3) Johns Hopkins Schools of Medicine Leadership Education in Adolescent Health program and Bloomberg School of Public Health, Department of Family, Population and Reproductive Health, (4) Parents’ Place of Maryland, and the (5) Maryland Center for Developmental Disabilities. MCH-LEARN will build on the existing recruitment and training infrastructure created by three Centers for Disease Control and Prevention, Office of Minority Health and Health Equity-funded public health leadership programs to create a successful science-based practice and MCH-focused mentorship program for undergraduates from historically disadvantaged populations. MCH-LEARN activities include: (1) MCH-LEARN Seminars addressing (a) Healthy People 2020 Goals using a life course and social determinants model, (b) leadership and professional development and (c) guided discussion of KKI LEND seminars; and

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(3) a 10-week Summer Institute with three MCH learning externships (clinical, research, community advocacy). Each student will create an individual development plan. The overarching goal of MCH-LEARN is to increase the number of students from historically disadvantaged and/or underrepresented populations who enter graduate school in MCH fields. Students will develop and present an MCH topic at the end of the Summer Institute based on Healthy People 2020 Goals and submit an abstract to and be sponsored to attend the Association of Maternal & Child Health Programs Annual Conference. All MCH-LEARN didactic experiences will emphasize cultural competency, health disparities issues, and strategies to promote health equity focused, especially among children and youth with special health care needs. Maternal Child Health Careers/Research Initiatives for Student Enhancement- Undergraduate Program (MCHC/RISE-UP): The MCHC/RISE-UP is a 10-week summer public health leadership program designed for undergraduates in their junior and senior year and recent baccalaureate degree students (within 12 months of the MCHC/RISE-UP orientation) who are interested in learning more about preventing health disparities and promoting health equity and have a cumulative GPA of at least 2.5 on a 4-point scale. MCHC/RISE-UP is a national consortium of institutions including the Kennedy Krieger Institute (KKI; lead institution), Maryland Center for Developmental Disabilities, Johns Hopkins University School of Medicine, Nursing, and Public Health, University of Southern California, California State University-LA, and University of South Dakota Sanford School of Medicine Center for Disabilities. Three public health leadership tracks are offered: (1) clinical (KKI only), (2) research, and (3) community engagement and advocacy. Public Health Leadership and Learning Undergraduate Student Success (PLLUSS) Program: The PLLUSS Program is a 10-week public health leadership and research program. The PLLUSS Program is for undergraduate sophomore and junior students minoring or majoring in public health with at least a 3.0 GPA on a 4-point scale. Students must complete sufficient course credit hours during the program for a minor in public health. The PLLUSS program is conducted at three collaborative research sites: (1) Kennedy Krieger Institute (KKI) and Johns Hopkins Medical Institutions, (2) University of Cincinnati and the National Institute for Occupational Safety and Health (UC-NIOSH), and (3) California State University-Los Angeles. PLLUSS Program students will participate in public health research, education on health disparities and urban health issues, professional development, and community health promotion activities. Students will be encouraged to produce peer-reviewed publications and attend a national public health meeting. Students will receive mentorship with the goal of successful acceptance and completion of graduate or professional school in the public health area.

Medical Education Research Initiative for Teens (MERIT): MERIT aims to eliminate health

care disparities by transforming underrepresented high school students into health care leaders. To

accomplish these goals, MERIT provides seven years of academic, professional, and social support.

Scholars are selected during their sophomore year of high school and participate in intensive

MERIT programming until graduation including weekly Saturday sessions focused on academic

enrichment and college admissions guidance, paid summer internships in hospitals and laboratories,

and longitudinal mentoring. After high school, they become MERIT alumni and receive continued

guidance throughout college. Health care disparities will only be eliminated if the workforce mirrors

the communities we serve. MERIT Scholars’ voices are not represented now, but one day, they will

be poised to influence critical decisions.

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Pulmonary and Critical Care Medicine Summer Internship Program: The Division of Pulmonary and Critical Care Medicine hosts undergraduate students each summer as part of an NIH-funded program to enhance diversity in biomedical sciences. Students from around the United States and Puerto Rico join faculty for a ten-week, research-focused experience that extends from Memorial Day weekend through the first week of August. Students are matched with mentors based on their interests. Students work on specific research projects under the supervision of their mentor. Projects span a broad range of research, from the basic science of endothelial or epithelial cell biology to asthma epidemiology. In addition to the research experience, students participate in a weekly journal club, during which they present primary research articles to their peers and members of the faculty. Students also attend a seminar series featuring faculty members from Johns Hopkins and the NIH. This forum provides students with the opportunity to interact with faculty members and hear different perspectives on issues related to career development. Students interested in clinical medicine are given the opportunity to “round” with the Johns Hopkins Medicine residents, providing a glimpse of life in clinical medicine as a resident at an academic institution. Summer Academic Research Experience (SARE): SARE is an 8-week outreach program that seeks to develop exceptional high school students from the greater Baltimore area by introducing them to academic research with a secondary emphasis on STEM and health-related professions. We provide our scholars with a unique exposure to modern scientific research, combined with additional tutoring to fortify basic academic skills. Students spend 70% of the time working in research labs and 30% of the time working on academic skills, including science, writing, and mathematics. This

is a paid internship and we request that ⅔ of the stipend be set aside for college.

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2017 HOPKINS C.A.R.E.S ORGANIZING COMMITTEE

Lori Brando, PhD: Assistant Professor and Program Coordinator, Stanley Summer Scholars Program

Amanda Brown, PhD: Director, Johns Hopkins Internship in Brain Science

Gerri Cole, PhD: Chair, Hopkins C.A.R.E.S. Summer Symposium and Academic Program Manager,

Office of Student Pipeline Programs

Ashley Cooper: Marketing Administrator, Strategic Marketing and Outreach

Amanda Fabian: Assistant Program Manager, Center for Talented Youth Program

Jasmine Griffin: Office Assistant, Summer Internship Program

Tahirah Hall: Administrative Supervisor, Summer Internship Program Coordinator for Pulmonary and

Critical Care Medicine Summer Internship Program

Jessica Harlan: Senior Program Evaluation Specialist, Johns Hopkins School of Medicine

Jamie Hickman: Administrative Services Coordinator, Center for Diversity in Public Health Leadership

Training

Joyce Hoebing: Administrator, School of Medicine

Casey Jacobs: Academic Program Administrator, Biophysics for Baltimore Teens

Cathryn Kabacoff: Director, Summer Academic Research Experience

Neekta Khorsand: Program Coordinator of Professional Development, Thread

Brittany Kiser: Marketing Project Coordinator, Strategic Marketing and Outreach

Stephanie Landicho: Executive Director, MERIT

Camille Mathis: Academic Program Administrator, Institute of NanoBio Technology

Corrin McBride Hunt, PhD: Program Manager, Center for Talented Youth Summer Programs

Evelyn McCann: Administrative Secretary, Office of Graduate Student Affairs/Office of Student

Pipeline Programs

Jenese McFadden, DM, MS, MBA: Program Manager, Center for Diversity in Public Health

Leadership Training

Christine Schutzman: Academic Program Coordinator, Institute of NanoBioTechnology

Erika Sulecki: Program Coordinator, MERIT

Karen Swisher: Administrative Coordinator, Institute for Cell Engineering

Monica Guerrero Vazquez: Program Coordinator, Centro SOL

Catherine Will: Academic Program Manager, Summer Internship Program

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HOPKINS C.A.R.E.S SPONSORS

We are grateful for the financial support, which made the Hopkins C.A.R.E.S.

Summer Symposium a success: Office of the Vice Dean for Education, Office of

Student Pipeline Programs, Summer Internship Program Basic Science Institute, The

Johns Hopkins Internship in Brain Science Program (National Institute of Mental

Health R25-MH10071), Pulmonary and Critical Care Medicine Summer Internship

Program and Thread.