3D Bioprinting

• 3D Bioprinting

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3D bioprinting

1 '3D bioprinting' is the process of generating spatially-controlled cell

patterns using 3D printing technologies, where cell function and

viability are preserved within the printed construct. The first patent

related to this technology was filed in the United States in 2003 and

granted in 2006.


3D bioprinting - Process

1 Some of the methods that are used for 3D bioprinting of cells are photolithography, magnetic

bioprinting, stereolithography, and direct cell extrusion


3D bioprinting - Applications

1 The company utilizes its NovoGen MMX Bioprinter

for 3D bioprinting


Magnetic 3D Bioprinting - Terminology

1 'Magnetic 3D bioprinting' is a methodology that employs

biocompatible magnetic nanoparticles to print cells into 3D

structures or 3D cell cultures


Magnetic 3D Bioprinting - General Principle

1 There are several advantages to using magnetic 3D bioprinting over other 3D printing modalities such as

extrusion, photolithography, and stereolithography


Magnetic 3D Bioprinting - History

1 The first commercially available 3D bioprinting system is being commercialized by Nano3D Biosciences, Inc. The first application of this

system is for high-throughput and high-content drug screening.Timm, D. M. et al.

[http://www.nature.com/srep/2013/131021/srep03000/full/srep03000.html?WT.ec_id=SREP-

20131022 A high-throughput three-dimensional cell migration assay for toxicity screening with

mobile device-based macroscopic image analysis]. Sci. Rep. 3, 3000 (2013)


Magnetic 3D Bioprinting - Process

1 Results employing Magnetic 3D Bioprinting were recently published

in Scientific Reports in October 2013.


Magnetic 3D Bioprinting - Application

1 This has been demonstrated by the BiO Assay which combines the

benefits of 3D bioprinting in building tissue-like structures for study with

the speed of magnetic printing.


Magnetic 3D Bioprinting - Users

1 The target users for magnetic 3D bioprinting are in the pharmaceutical and CRO

industries, where this system can be integrated early in the drug discovery

process as a compound screen for toxicity and efficacy. In the future, magnetic 3D

bioprinting could be applied to the field of regenerative medicine and organogenesis.

Overall, magnetic 3D bioprinting is an effective tool to create faithful models of

native tissue.


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3D Bioprinting