350 PATENT ABSTRACTS

OH OH O

H

1

OH 014 0

Streptomyces sp., NRRL 12049. The A-39183 antibiotics are closely related antibiotics. The in- dividual A-39183 factors are separated by chromatography. The A-39183 factors are anti- bacterial agents which have activity against Staphylococcus and Streptococcus species that are penicillin resistant. The A-39183 factors are also active against both gram-positive and gram- negative anaerobic bacteria, and are ionophores.

4409332

C O L L A G E N - E N Z Y M E C O N J U G A T E S T H A T EXHIBIT NO

I N F L A M M A T O R Y R E S P O N S E AND M E T H O D FOR MA K IN G

T H E S A M E

Steven Jefferies, James L Gutmann, Barry Heat- field

Collagen polymers are rendered non- inflammatory by complexation with alkaline phosphatase according to the procedure dis- closed. Applications of these non-inflammatory collagen complexes include the production of non-inflammatory collagen sutures, collagen soft tissue replacements !ncluding wound and burn coverings and arterial vessel replacements, collagen drug delivery devices, and vitreous replacement for opthalmologic therapy. Gels composed of the collagen-alkaline phosphatase conjugate plus calcium hydroxide are useful as an agent in endodontic therapy. Structural dur- ability and stabilization of the anti- inflammatory properties of the material are enhanced by crosslinking with giutaraldehyde or other crosslinking agents. Glutaraldehyde also acts to sterilize and disinfect the collagen con- jugate prior to in-vivo use.

~ 1 ~ 2 0

3 - A M I N O - ( I ) - B E N Z A Z E P I N - 2 - O N E - I -ALKANOIC ACIDS

Jeffrey W H Watthey assigned to Ciba-Geigy Corporation

Variously substituted l-carboxymethyl-3- (carboxymethylamino)-2,3,4, 5-tetrahydro- i H- (l)benT~Tepin-2-ones and functional derivatives are angiotension converting enzyme inhibitors and are useful as antihypertensive agents. Syn- thesis of, compositions and methods of treat- ment utilizing such compounds are included.

440932.7

P R O C E S S AND RE A G E N T F O R THE D E T E R M I N A T I O N OF T H E

B I O L O G I C A L ACTIVITY OF H E P A R I N IN P L A S M A

Knut Bartl, Helmut Lill, Pete Rocschlau, Joachim Ziegenhorn, Wilzhofen, Federal Republic Of Germany assigned to Boehringer Mannheim GmbH

Method and reagent for the determination of the biological activity of heparin in plasma by adding thrombin or Factor Xa as the proteolytic enzyme and a chromogen substratc of the latter and measuring the dye liberated from the