PATENT ABSTRACTS 313

456066O

F I X A T I O N S U P P O R T F O R M I C R O O R G A N I S M S

decreased levels of which are related to respiratory distress syndrome, are disclosed. The antibodies are useful for prediction and dia- gnosis of respiratory problems in newborns.

Gille Geirnaert, Saint Palais sur Mer. France as- signed to Argiles & Mineraux AGS-BMP

A ceramic support for the fixation of micro- organisms thereto consists of a silico-aluminate having 5-25~o magnesia and an average granulometry of 5-300 microns, with the coarsest grains being no more than two times the dia- meter of the finest grains, and preferably less than 1.5 times the diameter of the smallest grains. This support, which is suitably obtained by calcining a mixture o f kaolinic clay and talc or magnes ium carbonate and containing no more than 50~ cordierite, then grinding and sintering to the desired granulometric distribution, is par- ticularly desirable in the fixing thereto of hybridomas to produce monoclonal antibodies, or biological catalysts.

4561974

A P P A R A T U S F O R T H E A N A E R O B I C F I L T R A T I O N O F

W A S T E W A T E R

Jacques Bernard, Jean-Marie Rovel, Roger Nicol, Claude Prevot, Saint German en Laye, France assigned to Degremont

An apparatus for the anaerobic filtration o f waste water includes a filter of filling material through which the waste water to be treated is passed from the bot tom to the top. The filter in- cludes upper and lower superposed layers of fil- ling material separated by an intermediate layer of material. The lower layer is in the form of an ordered arrangement of the material thereof. The upper and intermediate layers each include a loosely packed arrangement of the material thereof.

4562003

M O N O C L O N A L A N T I B O D I E S A G A I N S T A L V E O L A R

S U R F A C T A N T P R O T E I N

John Lewicki assigned to California Bio- technology Inc

Monoclonal antibodies specific for a protein as- sociated with a lung surfactant complex,

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D I A G N O S T I C D E V I C E I N C O R P O R A T I N G A

B I O C H E M I C A L L I G A N D

Christopher R Lowe, Fergus G P Earley. New- market. United Kingdom assigned to National Research Development Corporation

A device useful in diagnostics in which a bio- chemical species is attached to the surface of a sensor, especially to the gate of a field effect transistor. In such a B I O C H E M F E T it has been a problem to attach two or more biochemical species to the surface of the sensor, especially to the gates of a multi-gated FET. It has now been found possible to bond a group having a photo- activatable function covalently to the sensor sur- face, photo-expose the resultant modified surface selectively, e.g. through a mask, and bond the biochemical species, e.g. a hapten, anti- gen, antibody, lectin or enzyme, to the photo- activated function. In this way the biochemical species becomes attached in selected areas only. In view of the success of this technique realized under conditions of miniaturization, the inven- tion makes possible printed circuits for proteins. In addition to the device are the process o f manu- facture thereto, use for diagnostic purposes and a diagnostic kit of the device and a partner capable of binding to the biochemical species.

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R A D I O L A B E L L E D S U B S T R A T E S F O R A S S A Y I N G M A M M A L I A N

E N Z Y M E S

James W Ryan, Alfred Chung assigned to University of Miami

Compounds which are substrates for mam- malian enzymes, especially proteolytic and pep- tidase enzymes, are disclosed. These compounds, in general, have the general formula X-T, W-Y or X-(Pep)-Y, wherein X is a radiolabelled ben- zoyl or hydroxyphenylpropanoyl group, T is the -NH residue of a known chromogenic or fluorogenic substrate comprising at least one amino acid group which may be substituted with other organic groups, Y is a radiolabelled ben-