PATENT ABSTRACTS

said particles including particles of HBsAg in morphologic form not found in nature, said HBsAg contains particles being flaments, branched filaments, closed circular or closed cir- cular branched filaments.

4639372

C O C C I D I O S I S V A C C I N E

Peter K Murray, Stefan Galuska assigned to Merck & Co Inc

Sporozoites of coccidia fail to develop in chickens which are immune and many are blocked from penetrating host cells. Although previous attempts to immunize chickens with non-viable coccidial antigens have been unsuc- cessful it has been discovered that extracts from sporozoites or sporulated oocysts of E. tennella induce high levels of protective immunity. These extracts contain at least 15 polypeptides many of which are associated with the surface of the sporozoite and induce good immune responses. Antibody to these polypeptides blocks sporozoite-host cell penetration in vitro and neutralizes sporozoites in vivo. One or more of these polypeptides may be used as an antigen to protect against coccidiosis.

4639512

C O N J U G A T E S O F H A P T E N E S A N D M U R A M Y L - P E P T I D E S ,

E N D O W E D W I T H I M M U N O G E N I C A C T I V I T Y A N D C O M P O S I T I O N S C O N T A I N I N G

T H E M

Francoise Audibert, Claude Carelli, Louis Chedid, Pierre LeFrancier, Michel Level, Jean Choay, Neuilly sur Seine, France assigned to A- gence Nationale de Valorisation de la Recherche

The invention relates to an immunogenic princi- ple containing a specific antigen determinant of a predetermined native antigen. This immuno- genic principle is constituted by a conjugate bet- ween a hapten bearing said antigenic site and a muramyl-peptide, essentially in the absence of supporting macromolecules, this conjugate having an immunogenic effect not only against itself, but also with respect to the native antigen carrying said antigenic site.

4642291

187

C E L L S U R F A C E A N T I G E N S O F H U M A N A S T R O C Y T O M A

J Gregory Cairncross, M Jules Mattes, H Richard Beresford, Anthony P Albino, Alan N Houghton, Kenneth 0 Lloyd. Lloyd Old, Lon- don, NY, Canada assigned to Sloan-Kettering Institute for Cancer Research

Method of forming an antibody producing hybridoma cell line by fusing a myeloma cell line with splenocytes derived from BALB/c mice im- munized with human astrocytoma tumor cells, the hybridoma cell line formed, and the mono- clonal antibodies generated by said hybridoma cell line. A method of phenotyping astrocytoma tumor cells comprising determining the reaction of said cells to various monoclonal antibodies to astrocytoma tumor cells is also provided.

4642293

N O V E L H Y B R I D O M A C E L L L I N E P R O D U C I N G M O N O C L O N A L

A N T I B O D I E S A G A I N S T L A M I N I N A N D A P R O C E S S F O R T H E

P R O D U C T I O N T H E R E O F

Albert E Chung assigned to University of Pitts- burgh

The invention relates to a novel hybridoma con- tinuous cell line that produces a monoclonal antibody of the lgG type to the glycoprotein GP- 2, a subunit of the basement membrane compo- nent laminin. The hybridoma cell line is formed from a spleen cell from a Lewis rat, which has been immunized with a basement membrane antigen, fused with a mouse myeloma cell.

4642333

I M M U N O L O G I C A L L Y R E A C T I V E N O N - G L Y C O S Y L A T E D A M I N O

A C I D C H A I N S O F G L Y C O P R O T E I N B O F H E R P E S

V I R U S T Y P E S 1 A N D 2

Stanle Person

Plasmids are constructed containing the nucleotide sequence for selectively expressing immunologically active amino acid chains of glycoprotein B of HSV-I and HSV.2 and chains are prepared to serve in vaccines.