PATENT ABSTRACTS 365

4650675

O L I G O N U C L E O T I D E C O N J U G A T E S

Yves Borel, B Davi Stollar, Helina Borel, Paul M Gallop assigned to The Children£3 s Medical Center Corporation

Conjugate composed of an oligonucleotide covalently bonded to a carrier.

4650676

A N T I G E N S A N D M O N O C L O N A L A N T I B O D I E S R E A C T I V E

A G A I N S T M E R O Z O I T E S O F E I M E R I A S P P .

Robert H Schenkel, Pallaiah Thammana, Rosie B Wong assigned to American Cyanamid Com- pany

Monoclonal antibodies against merozoites and sporozoites of Eimeria tenella are obtained by use of hybridoma technology. Specific antigens for use as vaccines in the prevention and treat- ment of eoccidiosis and hybridoma cultures pro- ducing monoelonal antibodies are described.

4650756

M O N O C L O N A L A N T I B O D I E S T O C E L L S U R F A C E A N T I G E N S O F

H U M A N R E N A L C A N C E R

Lloyd J Old, Kenneth O Lloyd, Herbert Oettgen, Willet Whitmore, Jerzy Szkudlarek, Connie Finstad, Donna Morrissey, Shun-ichir Ogata, Ryuzo Ueda assigned to Sloan Kettering In- stitute for Cancer Research

The preparation and use of monoclonal anti- bodies to human renal tumor cells is described. The monoclonal antibodies bind to glycoproteins of 160Kd, 120Kd and l l5Kd, a glycolipid, a HLA heavy chain, group A blood and group B blood antigens.

4652440

M E T H O D O F S T A B L Y R A D I O L A B E L I N G A N T I B O D I E S

W I T H T E C H N E T I U M A N D R H E N I U M

Chang H Paik, Richard C Reba, William C Eckelman

99 mTc-labeling of antibodies and antibody fragments, either unconjugated or conjugated to DTPA, is effected in the presence of molar excess of free or carrier-bound DTPA to substantially completely inhibit direct technetium binding to non-stable binding sites on the antibody. The resultant 99mTc-labeled antibody has a stable label and is useful for, inter alia, tumor imaging by gamma scintigraphy and/or tumor therapy. Rhenium-labeling can be similarly effected.

4652447

M E T H O D S A N D C O M P O S I T I O N S U S I N G M O N O C L O N A L

A N T I B O D Y T O H U M A N H E L P E R T C E L L S

Patrick C Kung, Gideon Goldstein assigned to Ortho Pharmaceutical Corporation

Hybrid cell line for production of monoclonal antibody to an antigen found on all normal human helper T cells. The hybrid is formed by fusing splenocytes from immunized CAFI mice with P3X63AggU1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.

4652448

U S E O F M O N O C L O N A L A N T I B O D I E S A G A I N S T B A C T E R I A L A D H E S I N S

Peter L Sadowski assigned to Molecular Gene- tics Inc

Monoclonal antibodies specific for surface anti- gens of bacteria which act as adhesins between prokaryotic and eukaryotic cells and, in par- ticular, K-99 pill, and methods for production thereof are described. These monoclonal anti- bodies may be used for the prophylactic and therapeutic treatment of diseases induced by adhesin-bearing pathogens in animals and