PATENT ABSTRACTS

tritiated proline and tritiated thymidine are for- ced through respective liver biopsies, and there- after the respective liver biopsies are evaluated for collagen synthesis and DNA synthesis, respectively, utilizing autoradiographic techni- ques.

4675287

M O N O C L O N A L A N T I B O D Y D I R E C T E D T O H U M A N

G A N G L I O S I D E G D 2

Ralph A Reisfeld, Grego Schulz assigned to Scripps Clinic and Research Foundation

A non-human, mammalian monoclonal recep- tor produced and secreted by a hybridoma having the ATCC accession number HB 8568 and methods of preparing and using same, as well as diagnostics utilizing the receptor are dis- closed. The monoclonal receptor reacts with cells such as human neuroectodermal tumors having ganglioside GD2 antigen expressed on their cel- lular membrane surfaces.

4675291

H U M A N C U L T U R E D C E L L L I N E

Yuichi Yamamura, Tadamitsu Kishimoto, Satoru Nakai, Yoshikatsu Hirai, Takarazuka, Japan assigned to Otsuka Pharmaceutical Co Ltd

This invention provides a novel cultured cell line which is derived from human T leukemic cells and which produces a colony-stimulating factor (CSF). This invention also provides a process for preparing such human cultured cell line, and a process of producing a CSF from such cell line.

4677057

D I A G N O S T I C A S S A Y F O R T H E P R E S E N C E O F

A P O L I P O P R O T E I N S A S S O C I A T E D W I T H P L A S M A

H I G H D E N S I T Y L I P O P R O T E I N S

Linda K Curtiss, Thomas S Edgington assigned to Scripps Clinic and Research Foundation

Monoclonal receptors that immunologically bind to human apolipoprotein A molecules, par- ticularly apo-A-I and apo-A-ll, are described as

399

are their methods of use and articles of manufac- ture containing them.

4677058

D E T E C T I N G M A L I G N A N T C E L L S W I T H M O N O C L O N A L

A N T I B O D I E S S P E C I F I C T O T Y P E IV C O L L A G E N A S E E N Z Y M E

Kar Tryggvason, Lance Liotta, 90230 Oulu 23, MD, Finland

Basement membrane collagen degrading en- zymes are provided which are useful for the detection of malignant cells with metastatic ac- tivity. Means for detecting such cells are also provided.

4677061

T - C E L L L Y M P H O C Y T E S U B S E T M O N I T O R I N G O F

I M M U N O L O G I C D I S E A S E

Lynn M Rose, Edward A Clark, Jeffrey A Led- better assigned to Genetic Systems Corporation

Methods and compositions are provided for determining a change in status of a multiple sclerosis victim. Particularly, the ratio of helper or suppressor T cell subsets having specific sur- face markers associated with proliferation is determined, where a particular ratio value is as- sociated with a change in status.

4 6 7 7 ~ 3

H U M A N T U M O R N E C R O S I S F A C T O R

David F Mark, Alice M Wang, Martha Ladner, Abla Creasey, Leo S Lin, Janelle Van Arsdell as- signed to Cetus Corporation

Human tumor necrosis factor (TNF) has been prepared using recombinant methods. A human promyelocytic leukemia cell line has been in- duced using an improved induction procedure, and the TNF purified to homogeneity. Methods, vectors, and cells useful in obtaining human TNF in practical amounts are disclosed. Muteins having N-terminal deletions, which muteins have superior biological activity, are also disclosed.