4th International Workshop on Biology, Prevention and Treatment of Relapse after Hematopoietic Stem Cell Transplantation

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www.relapse-after-hsct.com

Michael BishopThe University of Chicago Medicine/USA

Nicolaus Kröger University Hospital Hamburg/DE

Sergio GiraltMemorial Sloan Kettering Cancer Center/USA

Alan Wayne Children‘s Hospital Los Angeles/ USC Norris Comprehensive Cancer Center/USA

The Organizing Committee has been working hard to make the Fourth International Workshop on the Biology, Prevention and Treatment of Relapse after Hematopoietic Stem Cell Transplantation a truly valuable experience for all participants. We shall be delighted to welcome you to the beautiful city of Chicago.

Relapse and disease progression are the leading causes of treatment failure for most hematologic malignancies treated with both allogeneic and autologous hematopoietic stem cell transplantation (HSCT). This symposium continues to grow and evolve from achievements of the first three Workshops, as we have witnessed tremendous progress in our understanding and treatment of relapse in the past 10 years. As such, the planned objectives of the Fourth Workshop are designed to present the latest scientific and clinical advances related to relapse after HSCT and to provide a forum for the presentation of ongoing laboratory, translational, and clinical research specifically related to this field. The educational content of this conference is relevant for medical and pediatric hematologists-oncologists, hematopoietic stem and immune cell translational and basic scientists, hematopathologists, physicians-in-training (Fellows/Residents/Post Docs), advance practice providers, pharmacists, oncology nurses and other associated allied health professionals. The workshop will feature internationally recognized speakers from a multidisciplinary, diverse group comprised of basic and translational scientists and clinical investigators.

The workshop will include formal didactic presentations and informal discussion panels. It will also offer investigators interested in the field the opportunity to present their work in dedicated oral and poster sessions.

4TH INTERNATIONAL WORKSHOP ON BIOLOGY, PREVENTION AND TREATMENT OF RELAPSE AFTER HEMATOPOIETIC STEM CELL TRANSPLANTATION

AIMS OF THE WORKSHOPPrimary Aim: To review the state of the science and basic, translational and clinical research related to relapse after both allogeneic and autologous HSCT.

• Update the current state of the science relative to biology and clinical study of relapse related to both autologous and allogeneic HSCT.

• Provide a forum for the presentation of ongoing laboratory and translational research specifically related to relapse following HSCT.

• Provide a forum to present ongoing clinical trials that are specific to the study of and treatment of relapse following HSCT.

• Provide an overview of the potential role of CAR T-cells and other cellular therapies in the prevention and treatment of relapse following HSCT.

MAIN TOPICSEpidemiology of relapse Biology of relapse

• Microenvironment• Checkpoint blockade• HLA-loss• T-cell impairment• NK/CIK cells• Intrinsic tumor resistance

Methods to prevent and treat relapse• Tumor-specific T-cells• Checkpoint inhibitors• Genetically modified T-cells• CAR T-cells• NK/CIK cells• Vaccination• Antibodies (e.g., bispecific and polyclonal)• Hypomethylating agents• HDAC inhibitors• Immunmodulating drugs (ImiDs)• Small molecular and TKIs

Role of minimal residual disease• FACS• Next Generation Sequencing• Digital PCR

Clinical results and trials• Lymphoid Malignancies• Acute Leukemias• Multiple Myeloma• MDS and MPN

Workshops (Meet the Experts)• Basic Immunology for Transplant• Trial Design/Biostatistics• CRS• Regulatory• Junior Faculty/Fellows• MRD Methods and Monitoring

Poster Session

Exhibits

O V E R V I E W

AMA PRA Category 1 CreditTM

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the University of Chicago Pritzker School of Medicine and the Organizing Committee. The University of Chicago Pritzker School of Medicine is accredited by the ACCME to provide continuing medical education for physicians.

The University of Chicago Pritzker School of Medicine designates this live activity for a maximum of 14 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Nurses and other healthcare professionals will receive a Certificate of Participation. For information on the applicability and acceptance of Certificates of Participation for educational activities certified for AMA PRA Category 1 Credit™ from organizations accredited by the ACCME, please consult your professional licensing board.

ABIM MOC II:Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 14 MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

European Union of Medical Specialties: The American Medical Association (AMA) has an agreement of mutual recognition of continuing medical education (CME) credit with the European Union of Medical Specialties (UEMS).

International physicians interested in converting AMA PRA Category 1 Credit™ to EACCME credit should contact the UEMS.

ACCREDITATION

Levels OF SPONSORSHIPPlatinum – $50,000

• 320-sq.-ft., 16' x 20' exhibition space• Four exhibitor registrations (additional registrations available at reduced rates)• One full-page, back cover, color advertisement in the program booklet• Acknowledgement: workshop website, workshop program book, on-site signage, mobile app• Post-workshop mobile app push notification• Brochure in the participants‘ bags

Gold – $35,000• 160-sq.-ft., 8' x 20' exhibition space• Four exhibitor registrations (additional registrations available at reduced rates)• One half-page, inside front cover, color advertisement in the program booklet• Acknowledgement: workshop website, workshop program book, on-site signage, mobile app• Brochure in the participants‘ bags

Silver – $25,000• 80-sq.-ft., 8' x 10' exhibition space• Four exhibitor registrations (additional registrations available at reduced rates)• Acknowledgement: workshop website, workshop program book, on-site signage, mobile app• Brochure in the participants‘ bag

Classic – $15,000• 80-sq.-ft., 8' x 10' exhibition space• Two exhibitor registrations (additional registrations available at reduced rates)• Acknowledgement: workshop website, workshop program book, on-site signage, mobile app• Brochure in the participants‘ bags

SUPPORT OPPORTUNITIES

S U P P O R T

Friday Breakfast - INDUSTRIAL SYMPOSIUM (NON-CME-APPROVED) – $26,000 Opportunity to hold a non-CME-approved industrial symposium as part of the scientific program; the content and speakers are subject to approval by the Workshop Chairpersons

• 50 minutes to present approved content • Audiovisual equipment• 80-sq.-ft., 8' x 10' exhibition space• Two exhibitor registrations (additional registrations available at reduced rates)• Acknowledgement: workshop website, workshop program book, on-site signage, mobile app• Brochure in the participants‘ bags

The expenses (travel, accommodations and registration) of the sponsors, chairpersons and speakers of the industrial symposium are additional and the responsibility of the supporter.

Saturday Breakfast - INDUSTRIAL SYMPOSIUM (NON-CME-APPROVED) – $26,000 Opportunity to hold a non-CME-approved industrial symposium as part of the scientific program; the content and speakers are subject to approval by the Workshop Chairpersons

• 50 minutes to present approved content • Audiovisual equipment• 80-sq.-ft., 8' x 10' exhibition space• Two exhibitor registrations (additional registrations available at reduced rates)• Acknowledgement: workshop website, workshop program book, on-site signage, mobile app• Brochure in the participants‘ bags

The expenses (travel, accommodations and registration) of the sponsors, chairpersons and speakers of the industrial symposium are additional and the responsibility of the supporter.

Continental Breakfast (Sole Support) – $18,000• 80-sq.-ft., 8' x 10' exhibition space• Two exhibitor registrations (additional registrations available at reduced rates)• Acknowledgement: workshop website, workshop program book, on-site signage, mobile app• Brochure in the participants‘ bags• Cocktail napkins and signage at event with logo

Coffee Breaks (Sole Support) (3 available) – $7,500• Includes a table at break area for brochures (table in exhibits is not included)• One exhibitor registration (additional registrations available at reduced rates)• Acknowledgement: workshop website, workshop program book, on-site signage, mobile app• Brochure in the participants‘ bags• Signage at event with logo

Lunch, strolling at exhibits (Sole Support) (2 available) – $35,000Opportunity to support a lunch in the exhibit area for all participants of the workshop

• 160-sq.-ft., 8' x 20' exhibition space• Two exhibitor registrations (additional registrations available at reduced rates)• One half-page, inside back cover, color advertisement in the program booklet• Acknowledgement: workshop website, workshop program book, on-site signage, mobile app• Brochure in the participants‘ bags• Cocktail napkins and signage at event with logo

WELCOME RECEPTION (Sole Support) – $36,000 Opportunity to support the welcome reception for all participants of the workshop

• Company logo on the official invitation to the welcome reception• 160-sq.-ft., 8' x 20' exhibition space• Four exhibitor registrations (additional registrations available at reduced rates)• One half-page, inside front cover, color advertisement in the program booklet• Acknowledgement: workshop website, workshop program book, on-site signage, mobile app• Brochure in the participants‘ bags• Cocktail napkins and signage at event with logo

Faculty Dinner (Sole Support) – $15,000 Opportunity to support the dinner for faculty and speakers attending the workshop

• Company logo on the official invitation to the faculty dinner• Two exhibitor registrations (additional registrations available at reduced rates)• Acknowledgement: at dinner, workshop website, workshop program book, on-site signage, mobile app• Brochure in the participants‘ bags• Signage at event with logo

Gala Event (Sole Support) – $40,000 Opportunity to support the off-site dinner for all ticketed participants of the workshop

• Company logo on the official invitation to the gala event• Invitations for all company representatives • Formal recognition at gala event• 160-sq.-ft., 8' x 20' exhibition space• Two exhibitor registrations (additional registrations available at reduced rates)• Acknowledgement: at event, workshop website, workshop program book, on-site signage, mobile app• Brochure in the participants‘ bags• Signage at event with logo

S U P P O R T

Workshop Lanyards (Sole Support) – $5,000This opportunity is initially available to Platinum and Gold supporters; otherwise available on a first-come, first-served basis

• Opportunity to brand the lanyards (lanyards are provided by the organizer)• Lanyards are provided by the organizer• Brochure in the participants‘ bags• Acknowledgment: workshop website, workshop program book, on-site signage, mobile app

Tote Bags (Sole Support) – $10,000This opportunity is initially available on a first-come, first-served basis

• Opportunity to brand the tote bags (tote bags are provided by the organizer)• One exhibitor registration (additional registrations available at reduced rates)• Brochure in the participants‘ bags• Acknowledgment: workshop website, workshop program book, on-site signage, mobile app

Brochure Insert – $2,500• Company brochure to be inserted into the participants‘ bags• Acknowledgment: workshop website, workshop program book, on-site signage, mobile app

Mobile App (Sole Support) – $10,000Opportunity to support mobile app for all participants of the workshop

• One exhibitor registration (additional registrations available at reduced rates)• Brochure in the participants‘ bags• Acknowledgment: workshop website, workshop program book, on-site signage, mobile app

Note Pads and Pens (Sole Support) – $5,000 Opportunity to sponsor note pads and pens for all participants of the workshop (note pads and pens are provided by the organizer)

• Brochure in the participants' bags• Acknowledgment: workshop website, workshop program book, on-site signage, mobile app

Confirmed FacultyCharalambos Andreadis, UCSF

Peter Bader, University Hospital for Children and Adolescents, Frankfurt

Michael Bishop, University of Chicago, Medicine

Ivan Borrella, John Hopkins

Jennifer Brudno, NCI

Charles Craddock, University of Birmingham

Marcos de Lima, Case Western

Peter Dreger, University of Heidelberg

John DiPersio, Washington University

Tim Fenske, MCW

Terry Fry, University of Colorado

Tom Gajewski, University of Chicago, Medicine

Luca Gattinoni, NCI

Sergio Giralt, Memorial Sloan Kettering Cancer Center

Ron Gress, NCI

Boglarka Gyurkocza, Memorial Sloan Kettering Cancer Center

Mehdi Hamadani, MCW

Mary Horowitz, CIBMTR/MCW

Xiao-Jun Huang, Peking University People’s Hospital & Peking University Institute of Hematology

Steven Hunger, CHOP/U Penn

John Koreth, DFCI

Jochem Kolb, Ludwig Maximilian University of Munich

Nicolaus Kröger, University Hospital Hamburg

Ola Landgren, MSKCC

Marcela Maus, MGH

Richard Maziarz, OHSU

Phil McCarthy, Roswell Park

Sattva Neelapu, MDACC

Marcelo Pasquini, MCW

Steven Pavletic, NCI

Michael Pulsipher, CHLA/USC

Noopur Raje, MGH

Alessandro Rambaldi, University of Milan

Stanley Riddell, University of Washington

Christoph Schmid, Klinikum Augsburg

Hans Schreiber, University of Chicago, Medicine

Nirali Shah, NCI

Christian Steidl, British Columbia Cancer Agency

Monica Thakar, MCW

Luca Vago, Ospedale di San Raffaele Istituto

Marcel van den Brink, MSKCC

Alan Wayne, Childrens Hospital Los Angeles, USC Norris Comprehensive Cancer Center

John Welch, Washington University

Speakers subject to change

S P E A K E R S

Friday September 21, 2018 7:00 – 8:00 Breakfast Symposium (Tentative)8:00 – 8:10 Welcome and Introduction8:10 – 8:40 Session I: The Epidemiology of Relapse8:40 – 10:30 Session II: Biology of Relapse (Part 1)

8:40 – 8:55 Immune Reconstitution following HSCT

8:55 – 9:10 T-Cell Exhaustion

9:10 – 9:25 Human Leukocyte Antigens

9:25 – 9:40 Tumor-specific mutant proteins as targets for immunotherapy

9:40 – 9:55 Tumor microenvironment

9:55 – 10:10 Microbiome

10:10 – 10:30 Panel Discussion and Questions

10:30 – 11:00 Break11:00 – 12:20 Session III: Biology of Relapse (Part 2)

11:00 – 11:15 Mechanisms of Immune Privilege in Lymphoid Malignancies

11:15 – 11:30 Microenvironment in Myeloma

11:30 – 11:45 Clonal Evolution of AML/MDS

11:45 – 12:00 lonal Evolution of ALL

12:00 – 12:20 Panel Discussion and Questions

12:25 – 1:25 Lunch Symposia/Special Interest

1:30 – 2:50 Session IV: Monitoring for Relapse

1:30 – 1:45 Monitoring for Relapse in Non-Hodgkin Lymphoma and Hodgkin Lymphoma

1:45 – 2:00 Monitoring for Relapse in Multiple Myeloma

2:00 – 2:15 Monitoring for Relapse in Acute Myeloid Leukemia

2:15 – 2:30 Monitoring for Relapse in Acute Lymphoblastic Leukemia

2:30 – 2:50 Panel Discussion and Questions

2:50 – 3:20 Break3:20 – 5:10 Session V: Methods for Prevention of Relapse (Part 1)

3:20 – 3:35 Maintenance Therapy after Autologous HSCT for MCL and FL

3:35 – 3:50 Maintenance Therapy after Autologous HSCT for HL

3:50 – 4:05 Choice of Allogeneic vs Autologous HSCT in early relapse NHL and double hit lymphoma

4:05 – 4:20 Single vs Tandem vs Auto-Allo in Multiple Myeloma

4:20 – 4:35 Maintenance and Consolidative Therapy after Autologous HSCT for Myeloma

4:35 – 4:50 Cellular immune therapy (MILs, DCs and CAR T) after Autologous HSCT for Myeloma

4:50 – 5:10 Panel Discussion and Questions

5:10 – 6:00 Session VI: Best Abstracts 6:00 – 7:30 Welcome Reception and Poster Viewing

Saturday September 22, 2018 7:00 – 8:00 Breakfast Symposium (Tentative)8:00 – 9:50 Session VII: Methods for Prevention of Relapse (Part 2)

8:00 – 8:15 Choice of Conditioning Regimen in Allogeneic HSCT for AML

8:15 – 8:30 Choice of Donor in Allogeneic HSCT for Acute Leukemias

8:30 – 8:45 Maintenance Therapy after Allogeneic HSCT for AML and MDS

8:45 – 9:00 Conditioning Regimens for ALL

9:00 – 9:15 Prophylactic DLI after Allogeneic HSCT for Leukemia

9:15 – 9:30 CAR T-Cells as a Bridge to Allogeneic HSCT or Maintenance Therapy after ALL

9:30 – 9:50 Panel Discussion and Questions

9:50 – 10:20 Break10:20 – 11:55 Session VIII: Methods for the Treatment of Relapse (Part 1)

10:20 – 10:35 Allogeneic HSCT vs. CAR T for Relapsed DLBCL after Autologous HSCT

10:35 – 10:50 Second Autologous HSCT versus Allogeneic HSCT in Relapsed Myeloma

10:50 – 11:05 DLI (+/- chemo) versus Second Allogeneic Transplant in relapsed AML

11:05 – 11:20 Choice of Donor in Second Allogeneic Transplant in Relapsed Leukemia

11:20 – 11:35 Relapse in the Setting of Active GVHD

11:35 – 11:55 Panel Discussion and Questions

12:00 – 1:00 Lunch Symposia/Special Interest1:00 – 2:35 Session IX: Methods for the Treatment of Relapse – CAR T-Cells

1:00 – 1:15: CAR T-Cell Therapy in NHL

1:15 – 1:30 CAR T-Cell Therapy in B-ALL

1:30 – 1:45 CAR T-Cell Therapy in Multiple Myeloma

1:45 – 2:00 CAR T-Cell Donor Lymphocyte Infusions

2:00 - 2:15 Relapse after CAR T-Cell Therapy

2:15 – 2:35 Panel Discussion and Questions

2:35 – 3:40 Session X: CIBMTR/EBMT Special Session on Cellular Immunotherapy

2:35 – 2:50 Current status of cellular therapy

2:50 – 3:05 Economics of cellular therapy

3:05 – 3:20 CIBMTR/EBMT Cellular Therapy Registry

3:20 – 3:40 Panel Discussion and Questions

3:40 – 4:00 Session XI: Summary and Future Directions4:00 Adjourn

S C H E D U L E

GENERAL INFORMATIONVENUEInterContinental Chicago Magnificent Mile, 505 North Michigan Avenue, Chicago, IL 60611 For hotel room reservations, go to conference registration: www.relapse-after-hsct.com/registration Rooms fill up quickly.

WORKSHOP SUPPORT/REGISTRATION/EXHIBITION Our conference planning partner is MOC&CO, www.mocandco.com. Phone: 630.338.8517•Email: HSCTconference@mocandco.com Our exhibit partner is J&J Exhibits.

LIABILITY AND INSURANCE The workshop organizer cannot accept liability for personal accidents, loss or damage to private property of participants, either during or indirectly arising from the Relapse Workshop. Participants are advised to secure their own personal travel and health insurance for their trip.

All exhibitors and sponsors are required to provide a certificate of insurance. Details will be provided in your sponsor and exhibitor kit.

TERMS AND CONDITIONS• Support items are allocated on a first-come, first-served basis.• All support and exhibition prices quoted are in U.S. Dollars.• All payments must be received before the beginning of the workshop. Should the company fail

to make the payment prior to the commencement of the workshop, the organizer reserves the right to cancel the company‘s participation and benefits.

• Time slot allocation will be based on level of support and approval of the organizing committee.• The exhibitor agrees to abide by ACCME Standards for Commercial Support as stated at

www.accme.org: SCS 4.2: • Product-promotion material or product-specific advertisement of any type is prohibited in or

during CME activities. The juxtaposition of editorial and advertising material on the same products or subjects must be avoided. Live (staffed exhibits, presentations) or enduring (printed or electronic advertisements) promotional activities must be kept separate from CME.

• Live, face-to-face CME, advertisements and promotional materials cannot be displayed or distributed in the educational space immediately before, during or after a CME activity. Providers cannot allow representatives of Commercial Interests to engage in sales or pro-motional activities while in the space or in the place of the CME activity.

• The workshop organizer reserves the right to accept or decline offers of support and applications for exhibition space.

The workshop organizer reserves the right to amend the published floorplan, should it be deemed necessary, for the benefit of the exhibition as a whole.

I N F O R M A T I O N

EXHIBITIONThe exhibition will be held at the InterContinental Chicago Magnificent Mile. The exhibition floor plan is de-signed to maximize exposure to the participants. All lunches and the welcome reception will be held in the exhibition area.

Exhibition space will be available on a first-come, first-served basis, with priority given to Platinum and Gold supporters.

The standard booth size is 8' x 10'.

Companies that have exhibits only will be acknowledged as exhibitors only.

Exhibition space rental is priced according to size and includes:

• 8' High back wall• 3' High side rail• One - 6' Skirted table• Two - Padded Chairs• One - Wastebasket• One - 7" x 44" Booth ID Sign• One exhibitor registration per booth

• Additional exhibitor registrations available for $300 per person• General cleaning of public areas

Additional exhibition equipment and services may be ordered by means of the form on the following pages of this brochure.

sponsor/Exhibitor Registration Form This must be returned to: MOC&CO-Conference Planning COmpany before June 30, 20184th International Workshop on Biology, Prevention and Treatment of Relapse after Hematopoietic Stem Cell Transplantation

Email: HSCTconference@mocandco.com •Fax: 630.443.7003

September 21-22, 2018 • InterContinental Chicago

_________________________________________________________________________________ Company

_________________________________________________________________________________ Contact _________________________________________________________________________________ Department_________________________________________________________________________________ Address _________________________________________________________________________________ City/State/Zip Code _________________________________________________________________________________ Phone Email_________________________________________________________________________________ Invoice Address (if different)

Order No./PO No./Tax No., if necessary _____________________________We will send an invoice with payment instructions to the email designated above.

Categories of Sponsorship ¨ Platinum $50,000 ¨ Silver $25,000 ¨ Gold $35,000 ¨ Classic $15,000

Support Opportunities¨ Industrial Symposium (Non-CME-approved) $26,000¨ Breakfast, each $18,000¨ Lunch, each $35,000¨ Coffee break, each $ 7,500¨ Welcome Reception $36,000¨ Faculty Dinner $25,000¨ Gala Event $40,000¨ Lanyards $ 5,000¨ Tote bags $10,000 ¨ Mobile app $10,000¨ Note pads and pens $ 5,000¨ Brochure insert $ 2,500

R E G I S T R A T I O N

Exhibition (standard booth size of 80 sq. ft.)Please note, space is limited; sponsors will have priority on securing space.

¨ 8' x 10' Booth - $6,000¨ 8' x 20' Booth - $12,000

Includes company profile in the program booklet, the booth area, 1 table, 2 chairs during the exhibi-tion, 1 exhibitor registration (8' x 10') or 2 exhibitor registrations (8' x 20'), set-up and tear-down time as well as a general cleaning.Once you have registered for your sponsorship and/or exhibits, you will receive an exhibit booklet with further details from our exhibit partner, J&J. Please note, the InterContinental cannot receive freight; all freight must go through the exhibit company.Freight will move in the evening of September 20. Exhibitors will have access to set up their booths from 7am to 11am on September 21. Exhibits will be open September 21 for lunch and welcome reception. On September 22, the Exhibits will be open for lunch; concluding at 1:30pm. Tear-out must be complete by 4pm on September 22. Due to time constraints, please keep this in mind when designing your exhibit.There is no entitlement to a specific exhibition space. Booth space will be available on a first-come, first-served basis, with priority given to Platinum and Gold sponsors.

Staff/ParticipantsRegistration pass for 1 (8' x 10') or 2 (8' x 20') included in the exhibitor fee, which also entitles the participant(s) to attend the scientific program.Additional staff _____ person(s) at $300 each

General SponsoringBecome a sponsor of the event and design your individual sponsorship. Please feel free to contact us so that we may provide you with a personal proposal according to your needs and wishes.We will support the event with: $_________________________________________________________

Booking (binding)Once we have received your registration form, the reservation will be confirmed. The amount for all booked items is payable by credit card or bank transfer and will be contained in a confirmation email with invoice.

My signature confirms my booking, and I agree to the terms and conditions as stated above.

____________________________________________________________________________ Signature Date

Fax or email two-page completed registration form to: email - HSCTconference@mocandco.com

fax - 630.443.7003

R E G I S T R A T I O N

www.relapse-after-hsct.com

Registration and ContactOur conference planning partner is

www.mocandco.comPhone: 630.338.8517Email: HSCTconference@mocandco.com

Exhibit PartnerJ&J Exhibits

LocationInterContinental Chicago 505 North Michigan Avenue, Chicago, IL 60611Hotel Reservationswww.relapse-after-hsct.com/registration

Organizers of the Scientific WorkshopMichael BishopSergio GiraltNicolaus KrÖgerAlan Wayne

Local Contact: Michael BishopEmail: mbishop@medicine.bsd.uchicago.edu

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