Contents

Editorial

EICHMANN, K.: Idiotypes, Subject and Object of Irmmmological Research 95 VAITH, P., and G. UHLENBRUCK: The Thompsen Agglutination Pheno·

menon: A Discovery Revisited 50 Years Later .......... 1

Original Papers

BAKACS, T., E. KLEIN, E. YEFENOF, P. GERGELY, and M. STEINITZ: Human Blood Lymphocyte Fractionation with Special Attention to their Cytotoxic Potential . . . . . . . . . . . . . . . . . . . . . . . 121

BARASOAIN, J., J. M. ROJo, and A. PORTOLES: Transfer of Antigen Anti­bacterial ImmlUlity by «Immuni» RNA from Animals Treated with P8eudomona8 Lipopolysaccharide . . . . . . . . . . . . . . . . . 34

BUTLER, G. H., and L. J. BREJ\'NER: Characterization of the Serwn Protein Inhibitor of the V.D.R.L. Test . . . . . . . . . . . . . . . . . . 442

CORNAIN, S., and E. KLEIN: Characteristics and in vitro Growth Influencing Effects of the Spleen Cell Population in a Methylcholanthrene Induced Mouse Sarcoma System . . . . . . . . . . . . . . . . . . . . . 101

DROEGE, W., PREM PAL SINGH, and O. LUDERITZ: Surface Carbohydrate Composition of Murine Thymocytes and of Lymph Node Cells from Normal and Athymic (Nude) Mice ................. 243

GOUDSWAARD, J., A. NOORDZIJ, R. H. VAN DAM, and J. A. VAN DER DONK: Quantification of Turkey ImmlUloglobulins IgA, IgM and IgG in Serum and Secretions . . . . . . . . . . . . . . . . . . . . . .. 248

GRACIA-PARDO, A.: Structure of Immunoglobulin D; Evidence for the Absence of an Extra Disulfide Bridge in the Fc Fragment . . . . . . 218

HASKOVA, V., J_ KASLIK, I. l"tIHA, I. MATL, and J. ROVENSKY: Simple Method of Circulating Immune Complex Detection in Hmnan Sera by Polyethylene Glycol Precipitation. . . . . . . . . . . . . . . . . 399

HENKE, J., and W. UNGAR: HLA-Antigens in Idiopathic Haemochroma-tosis (i.h.) Preliminary Report . . . . . . . . . . . . . . . . . . 41

HESS, G., J. WAGNER, vV. ARNOLD, R. H. PURCELL, and K. H. MEYER ZUM BUSCHENFELDE: Anti-HBc Titers in HBeAG and Anti-HBe Positive

Asymptomatic HBsAg Carriers . . . . . . . . . . . . . . . . . . 208 HUGET, R. P., H.-D. FLAD, and H. G. OPITZ: Promotion of L 1210 Tumor

Growth by Macrophages . . . . . . . . . . . . . . . . . . . . . 433 ISIDYAMA, H., K. OKUYAMA, K. MASUDA, and J. YASUDA: Effect of Hwnan

ImmlUloglobulin Preparations on Fc Rosette Formation between Anti­D-Coated Erythrocytes and Lymphocytes . . . . . . . . . . . . . 387

KIRCHNER, H., M. KOCHEN, H. M. HIRT, and K. MUNK: Immlmological Studies of HSV-Infection of Resistant and Susceptible Inbred Strains of Mice ............................. 147

KOFLER, R., and G. WICK: ImmlUlofluorescent Localization of Thyro­globulin - Autoantibody Producing Cells in Various Organs of Obese Strain (OS) Chickens. . . . . . . . . . . . . . . . . . . . . . . 88

476 . Contents

KRAMl'<IER, P., B. A. TAYLOR, and K. EWHl'<iANN: Genetics of the Idiot:;rpe of Strain AKR Antibodies to Group A Streptoeoeeal Carbohydrate; further Evidence for a Low Degree of Homology in the V H Chromosomal Region ............................. 284

KUHNEl'<IUND, 0., J. HAVLICET, and \Y. KOHLER: Type·Speeific and Non· Specific Reactions of Purified M Protein Preparations . . . . . . . . 197

LINKE, R. P.: Antigenic Differenee between Serum Amyloid Protein SAA and its Low Molecular Weight Derivate SAAL Revealed by an Anti· Amyloid A Antisenml at Different Temperatures . . . . . . . . . . 169

MAUFF, G., G. HAUPTMANN, H. W. HITZEROTH, F. GAUCHEL, and R. SCHERZ: The Nomenclature of Properdin Factor B Allotypes . . . . . . . . . 115

MEUER, S., S. BECKER, U. HADDING, and D. BITTER·SUERlVIANN: The Anaphylatoxic Peptide C3g of Guinea Pig Cornplement 1. Purification, Physiochemical and Antigenetic Properties. . . . . . .. 135

NAGASE, F., 1. NAKASHIMA, N. KATO, and K. YAGI: Studies of the Im­meme Response in Chickens I. Effect of Various Immunization Procedures on the Primary and Secondary Antibody Responses to Bovine Serum Albumin . . .. 2.56

NAGASE, F., 1. NAKASHIM.-\, N. KATO, and K. YAGI: Studies on the Im­mune Response in Chickens II. Functions of Carrier-Reactive Cells in Anti-Hapten Responses . . . 268

NEWMAN, R. A., W. M. GLOCKNER, and G. UHLENBRUCK: Carbohydrate Composition of Peripheral, Cultured and Leukaemic HlU11an Lympho­cyte Plasma Membranes . . . . . . . . . . . . . . . . . . . . . 186

NEWl'<iAN, R. A., G. UHLENBRUCK, K. SCHUMACHER, A. VON MILL, and D. KARDUCK: Interaction of Peanut Agglutinin with Human Lymphocytes. Binding Properties and Topology of the Receptor Site . . . . . . . . 451

NORTHOFF, H., A. KLUGE, and K. RESCH: Antibody Dependent Cellular Cytotoxicity (ADCC) against Human Erythrocytes, Mediated by Blood Group Alloantibodies: A Model for the Role of Antigen Density in Target Cell Lysis . . . . . . . . . . . . . . . . . . . . . . . . . . . 15

REYERO, C., J. G. THALHAMMER, G. RESZLER, and W. STOCK: Develop­ment of Peripheral Band T Lymphocytes in Piglets . . . . . . . . . 409

RUHL, H., H. SCHOLLE, G. BOCHERT, and W. VOGT: Activation of Lympho­cyte Subpopulations in Patients with Chronic Lymphocytic Leukemia. 75

SCHUMACHER, K., G. UHLENBRUCK, B. P. CHATTERJEE, G. STEINHAUSEN, P. VAITH, and A. VAN MIL: A New Group of Mitogenic Lectins from Invertebrate Sources . . . . . . . . . . . . . . . . . . . . . . 62

SCHENKEL-BRUNNER, H., and H. KOTHBAUER: Hemagglutinins in Female Fish Gonads: Comparative Investigations on Perch (Pe-rca fluviatilis) Gonads of Different Stages of Development. . . . . . . . . . . . . 155

SETHI, K. K., and H. BRANDIS: Characteristics of Soluble T-Cell Derived Factor(s) which Can Induce Non-immune Murine Macrophages to Exert Anti-toxoplasma Activity . . . . . . . . . . . . . . . . . . . . 226

SORG, C., C. L. GECZY, A. F. GECZY, G. J. HAMMERLING, and M. GATELY: Evidence that la-Antigens are not Secreted by Antigen or Mitogen Stim­ulated Mouse or Guinea Pig Lymphocytes . . . . . . . . . . . . . 44

SUESSMUTH, \Y., and W. DROEGE: Inhibition of a Primary DNA-Synthesis Response by Trinitrobenso-Sulfonate ((TNBS) Activated Suppressor Cells. Characterisation of the Inhibitory cells . . . . . . . . 416

TILL, G., V. LENHARD, and D. GEMSA: Chemotactic Activity of Lectins in vitro. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 173

WICK, G., S. SCHWARZ, and P. U. MULLER: No Development of Experi­mental Autoimmune Thyroiditis in Nude Mice. . . . . . . . . . . . 162

Contents . 477

Short Communication

PROKOP, 0., and W. KOHLER: Haptoglobins are Antibody-like Proteins 407 WRANN, M., H. SCHENKEL-BRUNNER, and H. KOTHBAUER: Blood-Group A

and H Specific Structures in Toad (Bu/o) Spawn. Comparative Studies on Three Species (B'ulo uufo, Bufo viridi8, Bulo calamila) ...... 471

Book Reviews

AHLQUIST, J.: Endocrine Influences on Lym.phatic organs, immlme response inflammation and autoimmunity. Reviewed by K. FEDERLIN, Gie13en 195

CROWELL, R. L., H. FRIEDMAN, J. E. PRIER (Eds.): Tumor Virus Infections and Innnlmity. - Reviewed by K. E. SCH~"-EWEIS, Bonn ....... 195

EIJSVOOGEL, V. P., D. Roos, W. P. ZEIJLEMAKER (Eds.): Leukocyte Mem­brane Determinants Regulating Immune Reactivity. Reviewed by H. N ORTHOFF, Heidelberg. . . . . . . . . . . . . . . . . . . . . . 295

EMOND, R. T. D.: Farbatlas del' Infektionskrankheiten. Reviewed by H. BRANDIS, Bonn. . . . . . . . . . . . . . . . . . . . . . . . . 196

HIJMANS, W., and M. SCHAEFFER (Eds.): Fifth International Conference on Immunofluorescence and Related Staining Techniques. . . . . . . 94

Abstracts

ADES, E. VV., and C. lYI. BALCH: A molecular approach delineating surface markers on human T lymphocytes. . . . . . . . . . . . . . . . . 297

ANDERSON, A. 0., N. D. ANDERSON, and J. D. WHITE: Basic mechanisms of lymphocyte recirculation in Lewis rats. . . . . . . . . . . . . . 298

ANDERSSON, L. C., and C. G. GAHMBERG: Surface glycoprotein patterns of normal and malignant human lymphocytes. . . . . . . . . . . . . 298

ARNDT, R., R. STARK, and H.-G. THIELE: Serological and molecular characterization of an antigenic structure common to peripheral T lymphocytes and neuraminidase treated thymic lymphocytes of the rat 299

Ax, W., 1. DIONYSIUS, and K. D. HUNGERER: In vivo and in vitro interaction of Trypano8oma cruzi with mouse macrophages and heart rnuscle cells (with film) . . . . . . . . . . . . . . . . . . . . . . . . . . . 300

BAST, B. J. E. G., R. MANTEN-SLINGERLAND, R. E. BALLIEUX, and D. CATTY: Multiple Ig classes on rabbit lymphocytes .......... 300

BENNER, R., A. VAN OUDENAREN, and J. J. HA..AIJlIiAN: The facilitating influence of the thymus upon bone marrow antibody formation. . . . 301

BERTSCHMANN, M., K. J. CLEl\1ETSON, E. PEDRINIS, H. COTTIER, and E. F. LUSCHER: The stimulation of a T cell response in the syngeneic host by the P-815 mastocytoma cell and the isolation of a tumor-associated antigen which has some H-2 antigen characteristics . . . . . . . . . 302

BOYD, R. L., and H. A. VV ARD: Antigenic changes associated with chicken B lymphocyte development. . . . . . . . . . . . . . . . . . . . 303

BURKERT, M., H. STEIN, H. BOUMANN, and K. LENNERT: Demonstration of intracytoplasmic immunoglobulin, lysozyme and albumin and iso­electric focusing pattern of tissue immllloglobulin in so-called reticulum-cell sarcoma (immunoblastic or large-cell lymphoma) . . . . . . . . . 303

BUTCHER, E., R. SCOLLAY, and I. VVEISSMAN: Lymphocyte interaction with high endothelial venules: lack of species specificity . . . . . . . 304

478 . Contents

CHEERS, CH., I. F. C. McKENZIE, and T. E. MANDEL: Genetics and me· chanisms of resistance/susceptibility to an intracellular bacterial in­fection. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 305

COOPER, E. L., H. R. MACDONALD, and B. SORDAT: Separation of earth­worm coelomocytes by velocity sedimentation. . . . . . . . . . . . 305

CURTIS, A. S. G., M. DAVIES, and P. C. VVILKINSON: New evidence on con-trol mechanisms in lymphocyte traffic . . . . . . . . . . . . . . . 306

DELuCA, D., G. W. W AER, and J. J. MARCHALONIS: Codistribution of Fab determinants and antigen on the surface of antigen binding lymphocytes of mouse thymus . . . . . . . . . . . . . . . . . . . . . . . . 307

DIERICH, M. P., and B. LANDEN: Identity of lytnphocyte C 3 receptors and receptors for C 5 . . . . . . . . . . . . . . . . . . . . . . . . . 307

DIERICH, M. P., and B. LANDEN: Lymphocyte C3 receptors and lytnpho­cyte membrane complement components cooperate in binding of EAC to lytTlphocytes . . . . . . . . . . . . . . . . . . . . . . . . . 308

DROEGE, vV., vV. SUSSMUTH, and R. FRANZE: The regulation of various types of cell-mediated immlme responses against TNP·modifitd syngeneic cells in vivo by different classes of suppressor cells. . . . . . . . . . 309

DWYER, J. M., M. WADE, and M. THAKUR: Use of purified T cells labdlul with IndimnIII to develop an isotope dilution assay for T cell mass . . . 309

EIJK, R. V. vV. VAN, and P. F. MUHLRADT: Carbohydrate incorporation into glycoconjugates of mouse thymocytes during Con A stimulation. Involvement of two subpopulations . . . . . . . . . . . . . . . . 310

EISENTK"-L, A., D. NAOHTIGAL, and M. FELDMAN: Studies of allospecific suppressor cells in culture . . . . . . . . . . . . . . . . . . . . 311

FELTKAMP, C. A., TH. M. FELTKAlIfP·VROOM, J. KOUDSTAAL, P. V. HEERDE, H. SPIELE, C. B. DE GRAAFF·REITSlIIA, and Lytnphoma Research Group: MUltidisciplinary study of non·Hodgkin lymphomas, electron micro· scopial, immlmological and enzyme·histochemical aspects ....... 312

FERNANDES, G., R. BOCKMAN, and R. A. GOOD: Inhibit,ion of T killer· cell generation in vitro: A Inacrophage function attributable to prostaglandin 312

FLORENSOV, V. A.: Evolution of lymphatic t,issue and the primary structure of lymph nodes. . . . . . . . . . . . . . . . . . . . . . . . . 313

GABISON, D., and G. BERKE: Endogenous innIl1.moglobulin·like IigIlt chains detectcd on the surface of lymphocytes involved in graft rejection. . 314

GASTKElIIPER, N. A., A. S. "VUBBENA, and P. NIEUWENHUIS: Germinal cen· tres and the B·cell system: a search for the germinal centre precursor cell in the rat. . . . . . . . . . . . . . . . . . . . . . . . . . 314

GAUDECKER, VON, B., and H. K. MULLER·HERlIIELINK: Ontogenetic diff",r· entiation of epithelial and non.epithelial cells in the human thymus . . 315

GElIISA, D., M. SEITZ, W. GRIlIIM, "V. KRAMER, and G. TILL: Conditions contributing to prostaglandin release from macrophages . . . . . . . 316

GERDES, J., U. KLATT, H. STEIN, and H. HERRlIIANN: Inhibition of C3b· and C3d.receptor activity by xenoantisera prepared by immunization with cell-bound C 3.receptor protein . . . . . . . . . . . . . . . . 317

GLOBERSON, A., H. RABINOWICH, T. UlIHEL, Y. REISNER, and N. SHARON: Characterization of reactive and suppressive cells in the mouse ernbry. onic liver by peanut agglutinin (PNA) . . . . . . . . . . . . . . . 317

HANAOKA, M., S. SHIRAKAWA, and K. TAKATSUKI: Adult T cellleukem.ia. Histopathological paUerns of lytnphoid tissues . . . . . . . . . . . 380

HANNA, M. G., JR.: Specific immunotherapy of established viscerallTlicro· metastases by BCG·tumor cell vaccine, alone or as an adjunct to surgery 318

HANNA, N., and D. NELKEN: Adjuvant induced non.specific suppressor cells and their effect on in vitro and in vivo lytnphoid responses . . . 319

Contents· 479

HAYRY, P. , and E. v. WILLEBRAND: Participation of lymphoid and n on· lymphoid cells in immune destruction of organ a llografts. . . . . . . 319

HEUER, J., E. KOLBCH, J. OBERBARNSCHEIDT, and R. STUMPF : The role of suppressor T cells in low zone tolerance. Can we make a decision be­tween deletion and suppression models? . . . . . . . . . . . . . . 320

HOEFSMIT, E. C. M., B. M. BALFOUR, E. YV. A . KAMPERDIJK, and J. CVE­TANOV: Cells containing Birbeck granules in the lymph and the lymph node ........ . .............. . ... ... 321

HOLUB, M., L. JAROSKovA, H. FISCHER, and E . POLANovA: Neoformation of lymphatics in the mouse omentum . . . . . . . . . . . . . . . 321

HOUBA, V., R. F. STURROCK, and A. E. BUTTERWORTH: Significance of the local formation of immune complexes within granuloma in Schistoso-miasis .. . . . . . .. .... .. . .... .. . ..... . 382

HlThiPHREY, J. H.: Marginal zone and mal'ginal sinus macrophages - a dis­tinct population. . . . . . . . . . . . . . . . . . . . . . . . . 323

HURTENBACH, U., E. FERBER, and H. C. BAUER: Antisera cause drastic changes in plasma membrane bound enzyme activities of rat thymocytes 322

INCEFY, G. S., G. GOLDSTEIN, and R. A. GOOD: Effect of thymopoietin, a t hymic peptide, on the functiona l activities of human thymocytes.. 324

JANKOVIC, B. D ., L. POPESKOVIC, and K . ISAKOVIC: Cation-induced im-munosuppression . . . . . . . . . . . . . . . . . . . . . .. 325

JAROSKovA, L., V. VIKLICKY, M. HOLUB, 1. TREBICHAVSKY, and R. STEPANKovA: Mast cells in local antibody formation and allograft re ­jection. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 325

JOHANNSEN, R ., H. H. SEDLACKEK, and F. R. SEILER: Immunological characteristics of neoan tigens expressed on the cell surface after neura­minidase treatment . . . . . . . . . . . . . . . . . . . . . . . 326

KAUFMANN, S. H. E., and H. HAHN: R egulation of d elayed type hyper-sensitivity to sheep red blood cells : demonstration of suppressor T cells and of a soluble suppressor factor . . . . . . . . . . . . . . . . . 327

KLAUS, G. G. B.: The role of antigen-antibody complexes in generating im­m unological memory and autoan ti-idiotypic immunity . . . . . . . . 327

KLINKERT, W., and C_ SORG: Chemical ch aracterization of radiolabeled lym­phocyte activation products of guinea p ig associated with macrophage migration inhibitory activity . . . . . . . . . . . . . . . .. 328

KOLB, H.: Interactions between neuraminidase-treated lymphocytes and liver cells. . . . . . . . . . . . . . . . . . . . . . . . . . . . 329

KONIG, W., N. FRICKHOFEN, and H . TESCH: Generation of an eosinophilo­tactic factor from human PMNs by various mechanisms of cell activation 329

KOWNATZKI, E., G. TILL, and D. GEMSA : Lymphocytes are stimulated by histamine to release an inhibitor of eosinophil chemotactic migration. . 330

LAFFERTY, K. J., and A. BOOTES: Transplantation of functional thymic epithelium to normal allogeneic mice . . . . . . . . . . . . . . . 330

LAFFERTY, K. J., H. S. WARREN, and J. A. WOOLNOUGH: A mediator ac-ting as a costimulator for the development of cytotoxic responses in vitro ... ........ . . ..... .... . .... . . . 331

T./AGE-STEHR, J., and T. DIAMANTSTEIN: D emonstration of cell-mediated autoimmunity and induction of suppressive control m echanisms . . . 331

L ALA, P. K., S. GARNIS, L. KAIZER, S. JACOBS, and V. SANTER: Character­i7.ation of lymphocytes invading experimental tumors . . . . . . . . 332

LAPP, W. S., and H . KIRCHNER: Graft-versus-host induced immunosup-pression associated with an increased t hymic mitogen response 333

LAUKEL, H. , W. D. GASSEL, and K . HAVEMAl'-.'N: Colony stimulating activ ity of human spleen cell culture supernatants . . . . . . . . . . . . . 333

480 . Contents

LEENE, W., and P. J. M. ROHOLL: Two subpopulations of cortisone-resistant lymphoid cells in the rabbit thymus. . . . . . . . . . . . . . . . 334

LEHlI1.ANN, H ., and M. SCHLAAK: Posttransfusion hepatitis (PTH): frequen-cy, serological type and possible role of preexisting anti-HBs in pro­tecticn. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 335

LINNA, T. J., and K. M. LAM: Transfer of natural tumor resistance by lymphoid cells in Marek's disease (JIVIV) . . . . . . . . . . . . . . 335

LOHLER, J ., and F. LEHlVlANN-GRUBE : Imnnillopathological alterations of lymphatic tissues in mice infected with lymphocytic chorimeningitis virus ... .... .... . ............. . .... 336

LOUIS, J. A., T. KOBAYAKAWA, and P. H. LAMBERT: Polyclonal antibody synthesis and autoantibody formation during murine experimental trypanosomiasis. . . . . . . . . . . . . . . . . . . . . . . . . 383

MACPHERSON, G. G., and H. W. STEER: The traffic of mononuclear phago­cytes through the intestinal wall of rats . . . . . . . . . . . . . . 337

MERTELSMANN, R., B. KOZlNER, D. FILIPPA, B. D. CLARKSON, and M. A. S. MOORE: Correlation of biochemical and immunological markers in human malignant lymphomas with conventional morphology and clinical fea-tures ... .. ..... .. ...... .. .......... 337

MEYER, E. M., W. SCHLAKE, and E. GRUND MANN : Histoll1orphometrica l , autoradiographical and enzyme-histochemical analysis of BCG-induced alterations in lymphoid tissues . . . . . . . . . . . . . . . . . . 338

MINK, J. G., W. B. VAN MUISWINKEL, A. M. M. DE LA.AT, and R. BENNER: Preleukemic AKR mice are selectively IgA·deficient. . . . . . . . . 339

MONNER, D. A., and P. F. MUHLRADT : Characterization of thymus extracts which stimulate incorporation of galactose into glycoconjugates of rat bone marrow cells. . . . . . . . . . . . . . . . . . . . . . . . 340

MOREIN, B. , A. HELENIUS, K. SIMONS, and V. SCHIRRlVB.CHER: Active im­munization with purified viral proteins and its il'nprovement by present-ing them as complex or into artificial liposomes . . . . . . . . . . . 340

MOROZ, C. , B. KUPFER, and SH. GILER: Circulating human T cell subset with a r eversible E-rosetting capacity in cancer and nonl1als - hypo -thesis on the regulatory mechanism influencing their role in Cl\U 341

MORRISON, W. J., G. E. ROELANTS, T. W. PEARSON, and M. MURRAY: Ge­netic control of susceptibility to T. congolense infection in inbred strains of mice .. . ............. . ............ 341

MULLER-HERMELINK, H. K., H.-D. WOTTGE, and VV. MULLER·RuCHHOLTZ: Permanent abolition of reactivity to m.ajor histocompatibility antigens r equires elimination of prethymic precursor cells . . . . . . . . . . . 342

l\1YRVIK, Q. N., P. RACZ, and K. TENNER-RACZ: Light and electron micro­scopic characteristics of sinus reactions and cellular traffic in the hilar lymph node complex (HLNC) in rabbits tilldergoing a pulmonary CMI reaction . . . . . . . .. .................. 343

NAYAK, R., M. DE SOUSA, and R. A. GOOD: Immunopathology of M. le­premurium (MLM) infection in B6, C3HAn and (C3H X B6) F, mice inoculated intravenously. . . . . . . . . . . . . . . . . . . . . 343

NEUMANN, CR., and C. SORG: Different cellular site for the production of murine macrophage migration inhibitory factor and il'nmune interferon (type II). . . . . . . . . . . . . . . . . . . . . . . . . . . . 344

NIEDERMEYER, W., Z. FISRELSON, and G. BERKE: Freeze-etching of contact regions between cytotoxic T lymphocytes and target cells . . . . . . 345

OPFERKUCR, ~T ., , ,y. HORN, F . FALKENBERG, and S. H. E KAUFMANN: Modulation of the immune response by pretreatment of antigen with complement . . . . . . . . . . . . . . . . . . . . . . . . . . 345

Contents 0 481

QpSTELTEN, Do, Do VA,," DER HEIJDEN, Ro STIKKER, and Po NIEUW'ENHIDS: Germinal centres and the B cell system: B cell differentiation in rabbit (appendix) germinal centres 0 0 0 0 0 0 0 0 0 • • • • • • • • • • • 346

PABST, R., and F. TREPEL: Lymphocyte production and organ distribution of newly formed lyrnphocytes after selective 3H-deoxycytidine labelling of mesenteric lymph nodes .......... 347

PEARSON, T. VV., G. E. ROELANTS, L. B. LUNDIN, and Ko S. MAYOR-"\V ITHEY: Suppressor cells in trypanosomiasis . . . . . . . . . . . 0 348

PEKAREK, J., J. KREJci, J. SVEJCAR, and L. HOZPRbrovA.: Some charac-teristics of the antigen-dependent migration inhibition factor . . 0 • • 348

PETIT, A., G. LUFFAU, and P. PERY: Isolation and study of some biologic properties of an allergen from Nippostrongylus brasiliensis . . . . . . 349

POELS, L. G.: Plasmodium be1'ghe'i infection in mice: a model for immune complex disease and auto-immtmity. . . . . . . . . . . . . . . 0 350

POLAK, L., and C. HINCK: Induction of tolerance to DNCB-contact sensi­tivity in guinea pig fetuses . . . . . . . . . . . . . . . . . . . . 350

POPPEMA, S., Ho HALLE, and J. D. ELEMA: Alkaline phosphatase positive lymphoma, functional and morphological aspects . . . . . . . . . , 351

POTWOROWSKI, E. F., T. A. SEE MAYER, H. P. BOLANDE, and W. S. LAPP: Graft-versus-host induced immtmosuppression associated with thyrnic microenvironment changes . . . . . . . . 0 • • • • • 0 • • • • 0 352

HAZIN, E., and A. GLOBERSON: The effect of various prostaglandins on plasma membrane receptors and function of mouse macrophages . . . 352

HEMOLD, H. G., and A. D. MEDNIS: Macrophage associated serine protein-ases inactivate pH 5-lVIIF but not pH 3-MIF . . . . . . . . . . . . 353

RESKE-KuNZ, Ao B., M. P. SCHEID, and E. A. BOYSE: Correlation ofimmuno­genetic and histological changes in immunodeficient mutant hr/hr mice 354

HODER, J. C., J. K. BALL, and S. K. SINGHAL: Some T cell lymphomas are immtmocompet,ent. . 0 • • • • • • • • • 0 • • • • • • • • • • 0 354

RODER, J. C., D. BEI,L, and S. K. SINGHAL: The control of autoreactive lymphoeytes by a receptor blockade mechanism in vitro . . . . 355

HODER, J. C., and R. KIESSLING: Target-effector cell interaction in the mouse nat1U'al killer cell system. . . . . . . . . . . . . . . . . . 356

HOELANTS, G. E., T. W. PEARSON, K. So MAYOR-WITHEY, and L. Bo LUN­DIN: Changes in spleen cell populations in trypanosomiasis . . . . . . 357

HUITENBERG, E. J., A. ELGERSMA, and Co H. J. LAMERS: Thymus-depen­dence and kinetics of intestinal mast cells and globule leucocytes. . . 357

SAINTE-MARIE, G.: Morphology and physiology of the structures of the lymph node related to lymphocyte traffic. . . . . . . . . . . . . . 359

SCHAUENSTEIN, K., G. VVICK, and R. PFEILSCHIFTER: Evidence for surface antigen(s) specific for a subpopulation of peripheral Band T lympho-cytes in the chicken. . . . . . 0 • • • • • • • • • • • • • • • • 359

SCHIRRMACHER, V., and G. SHANTZ: Tumor metastases and cell-mediated imn1unity in a syngeneic murine tumor model system: increase in meta­stasizing property associated with decreased immunogenicity and ability to induce cytotoxic T cells in vitro . . . . . . . . . . . . . . . . 360

SCHLAAK, M., P. SCHRODER, and J. C. VVULF: Cell cooperations in the mi­togen-induced transformation of human blood lymphocytes (MITL) . . 361

SCHMIDT, D., and M. Ho PARWARESCH: Isoelectric focusing pattern of acid phosphatase in normal splenic tissue, in the lysosomal fraction of viable splenic lymphocytes and in cases of hairy cell leukemia. . . . . 0 • 0 361

SCHUMANN, Go, A. F. BROWNBILL, and CH. MORONI: Are endogenous C­type viruses and their antigens physiologically required for the regu­lation of the humoral immune response? . . . . . . . . . . . . . . 362

482 . Contents

SCHViTENK, H. U., E . STEIGENBERGER, and S. TRINCEK: Pregnancy-asso· ciated-glycoprotein (cx2-PAG) in the sera of children with malignancies 362

SEDLACEK, H. H., H. J. BENGELSDORFF, and F. R. SEILER: Approaches to effective tumor uml1.1llotherapy with cells and the enzyme neuraminidase 363

SHOHAT, B., and N. TRAININ: Effect of thymic humoral factor (THF) in vitro on bone marrow and blood cells from B, T and null cell acute lymphatic leukemia (ALL) . ... ... .... ... .. .... 364

SMALL, M.: Effects of T cells on syngeneic tumor growth in vivo: tumor inhibition by mature lymphocytes and enhancem.ent of the san'le tumors by immature T cells. . . . . . . . . . . . . . . . . . . . . . . 364

SMITH, M. E., and W. L. FORD: Effect of metabolic inhibitors on migration of lymphocytes across specialized vascular endothelium . . . . . . . 365

SMITHYlIiAN, A. M., K. CARR, D. FORlI'I..i\.N, and R. G. WHITE: Separation of germinal centres from chicken spleen. . . . . . . . . . . . . . . . 366

SlIiITHYMAN, A. M., G. MUNN, F. A. FILIPPA, B. KOZH,"ER, C. T. C. TAN, and M. DESOUSA: Spleen cell populations in Hodgkin's disease (HD) 366

DESOUSA, M., A. FREITAS, B. HUBER, H. CANTOR, and E. A. BOYSE: Mi-gratory patterns of the Ly subsets of T lymphocytes in the mouse. 367

STEELE, E. J.: Ontogeny of spontaneous rosette forming cells in mice 367 STEELE, E. J., and A. J. CUNNINGHAM: Self antigens as possible stimulators

of natural antibodies. . . . . . . . . . . . . . . . . . . . . . . 368 STEIN, H., G. TOLKSDORF, and K. LENNERT: Definition of germinal center

cell -derived lymphomas by analysis of complement receptor subtypes and morphologic criteria . . . . . . . . . . . . . . . . . . . . . 368

STOCKINGER, H., V. ROHRICH, and W. KONIG: Inhibition of lymphocyte proliferation during parasitic infection with Nipposi1'ongylus bmsiliensis 369

STREJAN, G. H., and W. D. COLBY: Carrier-induced unresponsiveness of antihapten IgE antibody formation in mice. . . . . . . . . . . . . 369

SZENBERG, A.: Isolation and partial characterization of immunoglobulu'l from the surface of mouse thymus cells and cultured thymoma cells . . 370

TAYLOR, C. R., R . J. LUKES, and J. G. VAN DER TWEEL: Biology oflympho-ma transformation. . . . . . . . . . . . . . . . . . . . . . . . 371

TEW, J. G., T. MANDEL, A. BURGESS, and J. D. HICKS: The antigen binding dendritic cell of the lymphoid follicles: evidence indicating its role in the maintenance and regulation of serum antibody levels . . . . . . . . 371

THaNES, J., and H. STEIN: Characterization of an IgG-Fc-receptor protein isolated from human B-prolymphocytic and B-chronic lymphocytic leukemia cells . . . . . . . . . . . . . . . . . . . . . . . . . . 372

TREVES, A. J., M. FELDlI'I..i\.N, and H. S. KAPLAN : In vivo activity of lympho· cytes sensitized by antigen-fed macrophages : inhibition of lymphoma growth ... .. ... ..... .. . ...... ....... 372

VAN DEN TWEEL, J. G., C. R. TAYLOR, J. MCCLURE, and A. L. GOLDSTEIN: Detection of thymosin in thymic epithelial cells by an immunoperoxidase method ...... . ...... . ..... . . ....... 373

VADAS, M., J. DAVID, A. BUTTER"VORTH, V. HOUBA, and N. PISANI: Com­parison of the ability of human eosinophils and neutrophils to induce antibody-dependent damage to the larval stage of schistosoma mansoni in vitro . . . . . . . . . . . . . . . . . . . . . . . . . . . . 374

V AINIO, 0., M. K. VILJANEN, and A. TOIVANEN: Germinal center formation in BSA-tolerant chickens. . . . . . . . . . . . . . . . . . . . . 374

VELDlI'I..i\.N, J. E., W. KUIJPERS, and TH. M. FELTKAlIfP-VROOM: Middle ear transplantation: a new concept in clinical otology . . . . . . . . . . 379

VOSE, B. M.: Flllctional activity of human tumour-infiltra ting macro­phages. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 375

Contents . 483

WACHSMUTH, E. D.: Local cellular reactions follo"IV-mg i. c. injection of various adjuvants in rats and guinea pigs , . . . . . . . . . . . . 381

WARREN, H. S., J. A. 'VOOLNOUGH, C. P. DENARO, and K. J. LAFFERTY: Cytotoxic T cell responses to a syngeneic tumour: conditioILs for primary activation in vitro and biological effect in vivo . . . . . . . . . . . 376

\VOTTGE, H.-U., H. K. MULLER-HERMELINK, and 'V. MfuLER-RuCHHOLTZ: Survival and immunological responsiveness of rat-mouse bone marrow chimeras. . . . . . . . . . . . . . . . . . . . . . . . . . . . 376

WROGEMANN, K., M. J. WEIDEMANN, B. PESKAR, H. J. STAUDINGER, and H. FISCHER: Macrophage-lymphocyte interaction follm~-mg concanavalin A-stimulation as monitored by chemiluminescence. . . . . . . . . . 377

YAP, K. L., and G. L. ADA: Role of cell mediated immmuty in recovery from influenza virus infection. . . . . . . . . . . . . . 377

ZAN-BAR, I., and S. STROBER: Characterization of suppressor T cells in tolerant mice. . . . . . . . . . . . . . . . . . . . . 379