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Actinomycetes
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Actinomycetes (order)
Three genera
Actinomyces species Nocardia species Streptomyces species
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Gram Positive Filamentous Bacteria
GENUS OXYGEN GRANULE ACIDFAST
Mycobacteria aerobe no yes
Actinomyces ANAEROBE YES no
Nocardia aerobe sometime
PARTIALLY
Streptomyces aerobe YES no
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Actinomycosis
A chronic suppurative and granulomatous disease of the cervico-facial, thoracic or abdominal areas
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Actinomycosis
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Ecological Niche
Actinomyces
Endogenous (man and animals)
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CLINICAL SPECIMENSActinomyces
Pus
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Sulphur
granules
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Drug of Choice
Penicillin
(large doses)
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Serological Test
None available
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Nocardiosis
Subcutaneous infections, pulmonary infections, and brain abscesses
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Ecological Association
SoilEndogenous ?
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Geographic Distribution
World wide
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Nocardiosis
N. asteroides – Pulmonary
N. brasiliensis - Abscesses
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Clinical Specimens
Sputum Pus Biopsy tissue
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Serological Test
None available
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Drug of Choice
Sulfamethoxazole-Trimethoprim
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STREPTOMYCOSIS
Streptomyces species
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Mycetoma
Streptomyces species
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Ecological Association
Soil
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Streptomyces may invade bone
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Clinical specimens
Pus Biopsy material
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Serological Test
None available
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Treatment
Surgical debridement Sulfa drugs Amphotericin B
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