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Activated protein-C

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Propagation FXIa. Platelets. Activated protein-C. IXa/VIIIa. Thrombin activated fibrinolysis inhibitor. FVIIa/TF initiation. FXa/Va. Fibrinolysis. Factor XIIIa. Fibrinogen. Fibrin. Coagulation cascade: Central role of thrombin. VBWG. Reactivation of coagulation cascade. - PowerPoint PPT Presentation

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Activatedprotein-C

Thrombin activatedfibrinolysis inhibitor

Fibrinolysis

Coagulation cascade: Central role of thrombin

FibrinFibrinogen

FactorXIIIa

PlateletsPropagationPropagation

FXIaFXIa

FXa/VaFXa/VaFVIIa/TFFVIIa/TFinitiationinitiation

IXa/VIIIaIXa/VIIIa

Clot formation and stabilization

Inhibition of fibrinolysisThrombin

Reactivation of coagulation

cascadeVessel wall endothelial

lining

VBWG

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