Activatedprotein-C
Thrombin activatedfibrinolysis inhibitor
Fibrinolysis
Coagulation cascade: Central role of thrombin
FibrinFibrinogen
FactorXIIIa
PlateletsPropagationPropagation
FXIaFXIa
FXa/VaFXa/VaFVIIa/TFFVIIa/TFinitiationinitiation
IXa/VIIIaIXa/VIIIa
Clot formation and stabilization
Inhibition of fibrinolysisThrombin
Reactivation of coagulation
cascadeVessel wall endothelial
lining
VBWG