Advanced Statistics for Interventional

Cardiologists

What you will learn• Introduction• Basics of multivariable statistical modeling• Advanced linear regression methods• Hands-on session: linear regression• Bayesian methods• Logistic regression and generalized linear model• Resampling methods• Meta-analysis• Hands-on session: logistic regression and meta-analysis• Multifactor analysis of variance• Cox proportional hazards analysis• Hands-on session: Cox proportional hazard analysis• Propensity analysis • Most popular statistical packages• Conclusions and take home messages

1st day

2nd day

There are only 10 attitudes towards binary numbers:

There are only 10 attitudes towards biostatistics:

There are only 10 attitudes towards binary numbers:

either you understand them or not

There are only 10 attitudes towards biostatistics:

either you practice it or you ignore it

Standard statistics is just like standard PCI

• Keep on criss-crossing between published papers, your own data, your own analyses and chit-chat with colleagues or (even would-be) expert: it helps a lot on the long-term

• Nobody was accomplished and quick the first time he took a guiding (or even diagnostic!) catheter in hand: now look at yourself and what you have done in interventional cardiology!

• Keep focused and work on what you like and what you need

Adanced statistics is just like advanced PCI

• For any advanced technique, the best initial approach is partnering with an expert and learn case by case

• Even if you are experienced with a given approach, you might need supervision for other similarly complex techniques

• Advanced statistics is all too similar: learn to enjoy the road and pursue as much as possible open collaboration and constructive criticisms

Helpful books• Multivariable Analysis: A Practical Guide for Clinicians, by Katz, 2006• Regression Methods in Biostatistics: Linear, Logistic, Survival, and Repeated

Measures Models, by Vittinghoff, Glidden, Shiboski, and McCulloch, 2007• Introduction to Analysis of Variance: Design, Analysis & Interpretation, by Turner

and Thayer, 2001• Bayesian Approaches to Clinical Trials and Health-Care Evaluation, by

Spiegelhalter, Abrams, and Myles, 2004• Applied logistic regression, by Hosmer and Lemeshow, 2000• An Introduction to the Bootstrap, by Efron and Tibshirani, 1994• Monte Carlo Simulation, by Mooney, 1997• Systematic Reviews in Health Care: Meta-Analysis in Context, by Egger, Davey

Smith, and Altman, 2001• Survival Analysis, by Klein and Moeschberger, 2005• A Step-by-Step Approach to Using SAS for Univariate and Multivariate Statistics, by

O'Rourke, Hatcher, and Stepanski, 2005• Discovering Statistics Using SPSS, by Field, 2005

Helpful websites• http://faculty.vassar.edu/lowry/anova1u.html: I use it routinely to do ANOVA online• http://home.clara.net/sisa/index.htm: thorough but easy going, focused on analyses and

sample size computations• http://members.aol.com/johnp71/javastat.html: with many useful links for statistical

analyses and sample size computations• http://www.angelfire.com/wv/bwhomedir/: thorough personal webpage (Bruce Weaver’s)

full of links for advanced statistical methods• http://www.bayesian.org/: for those witha genuine interest in Bayesian analysis• http://www.cdc.gov: provides Epi-Info and StatCalc freewares• http://www.cytel.com/: provides trial programs for exact analyses• http://www.geocities.com/CollegePark/Quad/2435/: tips and tricks for Monte Carlo• http://www.metcardio.org: for those with a specific interest in meta-analyses• http://www.quantitativeskills.com/sisa/statistics/twoby2.htm: I use it routinely to do chi-

square and Fisher exact tests online• http://www.randomization.com: ideal to create your own randomization lists• http://www.resample.com/content/software/excel/download.shtml: provides tools for

home-made resampling analyses• http://www.statsdirect.com/: provides trial program for bootstrap• http://www.virtualstatistician.com/link-63.html: very comprehensive, sometimes too

focused on methods and dry

Questions?

And now…

For further slides on these topics please feel free to visit the

metcardio.org website:

http://www.metcardio.org/slides.html