HIGH PURITY TUBING, HOSE, & FITTINGS

SANITARY HOSE ASSEMBLIES

MOLDED SILICONE & TPE COMPONENTS

SINGLE USE MANIFOLD ASSEMBLIES

VERIGENICS™ RFID SOLUTIONS

PRODUCTS AND SERVICES

PURITY IN FLUID FLOW SYSTEMS®

TUBING & HOSE

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APSH – Braid Reinforced SiliconeHose: Polyester Braiding; 10 stock sizesfrom .063” I.D. to 1” I.D.

APSH-DB – Double Braid ReinforcedSilicone Hose: Polyester Braiding; 3 stocksizes from 1/2” I.D. to 1” I.D.

APST – Silicone Tubing:44 stock sizes from .030” I.D. to 1” I.D.

APSPG – Silicone Pump Tubing:11 stock sizes from .031” I.D. to 1/2” I.D.

A highly flexible hose constructed of virgingrade fluoropolymer overbraided with atightly-woven fabric and double spiral steelwire. All materials are sanctioned by the FDAfor food contact surfaces. White FEP core isUSP Class VI approved.

Rubber-CoveredFEP Hose

APFOS-WC – White PTFE Core,Convoluted I.D.: 6 stock sizes from1/2” I.D. to 4” I.D.

APEWF – Wire-Reinforced, EPDMRubber Core: 6 stock sizes from 3/4” I.D.to 4” I.D.

APSM – 4-Ply, Mandrel-Wrapped SiliconeHose: Polyester Mesh Fabric; Smooth O.D.;8 stock sizes from 1/2” I.D. to 4” I.D.

APSW – 4-Ply, Wire-Reinforced, Mandrel-Wrapped Silicone Suction Hose: PolyesterMesh Fabric; Smooth or Convoluted O.D.; 8stock sizes from 1/2” I.D. to 4” I.D.

Silicone Tubing & Hose

EPDM Hose

Low volatile grade, platinum cured silicone meets USP Class VI, FDA CFR 177.2600, ISO 10993, European Pharmacopoeia 3.1.9,and 3-A standards. All tubing cores are extruded in a clean room and are animal derived ingredient free.

APFOS-W – White PTFE Core,Smooth I.D.: 6 stock sizes from 1/4” I.D.to 1-1/2” I.D.

Stainless SteelOverbraidedPTFE HoseConstructed of virgin grade white PTFE witha series 300 stainless steel wire braidreinforcement. Also available with a blackconductive PTFE core. Can be configuredwith a silicone or rubber jacket.

Excellent chemical resistance properties makethis hose ideal for many demanding applications.

APFRC-W-FLX – Smooth White FEPCore: 5 stock sizes from 1/2” I.D. to 2” I.D.

This highly engineered formulation of highpurity tubing has been developedfor fluid transfer in thebiopharmaceutical industry.

• Sterile weldable and heat sealable• Provides excellent life in peristaltic pumps• Proven to have a cleaner profile than

competitive products• Eliminates the need to incorporate sections

of silicone tubing into bag filling andsampling applications

• Extensive validation and extractables testportfolios available

• Gamma irradiatable and autoclavable

BiopharmaceuticalGrade Tubing

APAF-BP – Biopharmaceutical Tubing:15 stock sizes from 1/8” I.D. to 1” I.D.

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FITTINGS

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Sanitary

Female Bevel Seat

Male I-Line

Mini Tri-ClampTri-ClampElbow

Female JIC Swivel

Tube AdapterTube and Pipe Weld Adapters

Flange Compression

Plastic Barbed

Weld End

Male JIC x FNPTMale JIC x MNPT

Adapters

JIC

Female I-Line

Tri-Clamp®Male Bevel Seat

Cam & Groove

Female C&G(Swivel shown)

Male C&G

Pipe Thread

Female Pipe

Male Pipe

Stainless Steel Flange RetainerFlange (sold separately) available in: 304 & 316 StainlessSteel or Powder Coated Carbon Steel

Thermobarb® FDA PPPolypropylene Barbed Fitting

Contact us about fabricating

your completeHose Assemblies

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All AdvantaPure® Fittings are made of high quality 316L Stainless Steel. Most are available in sizes from 1/4” I.D. to 4” I.D. Sanitary Fittings, manufactured with a 15 Ra finish or better, meet 3-A standards. Electro-Polishing services are also available.

Eliminate production stoppages for sterilization, reduce the risk of contamination, andincrease efficiency by incorporating single use systems from AdvantaPure®. Single usesystems, or SUS, simplify cleaning validations—use once and discard—and are wellsuited for single-use processes such as batch filling and sampling.

Each system is custom made using platinum-cured, Class VI silicone tubing and hoseor Class VI biopharmaceutical TPE tubing for peristaltic pump applications. Addfittings, stoppers and container closures (see page 6), filters, bags, bottles, labels andtracking options, and other components.

Single use systems are not intended for implantation or continuous steam applications.

SINGLE USE SYSTEMS

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Tubing and HoseSilicone Tubing and HoseLow-volatile grade, platinum-cured siliconetubing and braid-reinforced silicone hose isclean-room manufactured by AdvantaPure forpharmaceutical and biotech applications.

Both the tubing (called APST) and hose (APSH) haveundergone extensive physical, chemical, and biologicaltesting and meet USP Class VI, FDA CFR 177.2600, ISO10993, European Pharmacopoeia 3.1.9, and 3-A standards.

APST size range: .030” through 1” I.D. (.76mm through 25.40mm I.D.)APSH size range: .063” through 1” I.D. (1.59mm through 25.40mm I.D.)

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BioPharmaceutical TPE TubingAdvantaFlex addresses the need for a flexible,translucent, sterilizable, heat sealable, andweldable biopharmaceutical tubing for fluidprocessing. The unique properties of AdvantaFlexhelp it outlast similar tubing tested in peristaltic pumps by 6-10 times.

AdvantaFlex is ideal for aseptic tubing welds, as iteliminates costly aseptic connectors and multiple contactsurfaces. The tubing is made from FDA-approvedingredients and meets various ISO and USP standards, includingClass VI, as well as European Pharmacopoeia 3.2.2.1 standards.

Size range: 1/8” to 1” I.D. (3.18mm to 25.40mm I.D.)

Supplied as silicone fittings attacheddirectly to silicone tubing or hose,AdvantaPure’s Molded SiliconeAssemblies are well-suited forapplications involving aseptic transfer,sterile processing, and other criticalapplications in the pharmaceutical,biomedical, and high purity

industries. The assembliesreduce installation time, improve cleanliness, and retainthe many benefits of silicone.

Molded Silicone Assemblies areavailable from AdvantaPure in miniand standard Tri-Clamp® fittingstyles and are supplied with malegaskets molded directly to the face ofthe fitting. Straight-through and step-up bore configurations are producedin sizes up to 1” tube I.D. Protectivebackup cups, offered in polysulfone orseries 304 stainless steel for extradurability, provide a stable clampingsurface and safeguard the fittingsduring installation and use.

Molded Silicone AssembliesDeveloped for biopharmaceuticalapplications, the AdvantaTube®

Sterile Welder and Heat Sealer havebeen designed to optimally work inAdvantaFlex® TPE tubingapplications. The AdvantaTubeWelder makes sterile tubing weldsquickly, reliably, and easily, includingwet, dry, or fluid filled tubing.

The AdvantaTube Sealer offers acompact design, simple operation,reliability, and portability — theremote sealing head uses a 10 footcord allowing you to seal at thelocation that's convenient for you. TheAdvantaTube Sealer does not breaksterility as it seals fluid-filled tubing.

Welding and Sealing Systems

Molded Manifold AssembliesSingle use molded manifolds provide a seamless transition between tubing and connections for acontinuous, leak-proof flow. Molded connections made using platinum-cured silicone or AdvantaFlexBiopharmaceutical TPE include Y, T, cross, reducer, Tri-Clamp®, and mini Tri-Clamp styles. Connectionsizes differ depending on style and material. Size range: .188” to 1” I.D. (4.76mm to 25.40mm I.D.)

Molded manifolds can be used with avariety of containers, vessels, biobags,etc. for batch filling and samplingneeds in drug and vaccine production.

SINGLE USE SYSTEMS

Available in mini and standard Tri-Clamp fitting styles, moldedends are supplied with male gaskets molded directly to the faceof the fitting. Protective backup cups provide a stable clampingsurface and safeguard the fittings during installation and use.

For more information call: 1-888-755-4370 5

Part of our high purity manufacturing suite, the AdvantaPure® Mold Shop features a clean room environment to produce a varietyof molded components suitable for any number of applications in the pharmaceutical, biomedical, and biotechnology industries.Our molded products are custom made to meet your application’s specific requirements, documented lot traceable, and certified tobe free of animal-derived ingredients. Contact your AdvantaPure representative for more details.

BioClosure® SystemsHigh Purity Container ClosuresManufactured from USP Class VI, platinum- cured silicone elastomer that’s free of animal-derived ingredients, AdvantaPure’s BioClosure Systems offer the utmost in purity. They’re cleanroom manufactured, biologically safe, and work with vessels of glass, metal, or plastic.Stoppers, caps, inserts for True Unions and GL45’s, and other styles, with or without tubing, areavailable. Stopper sizes range from 2 to 12. Other items are custom manufactured.

Use as a disposable item to reduce cross contaminationrisks, cleaning requirements, and validation time and costs.

Standard size bottle stoppers are available with tubingalready attached to speed your installation, reduce multipleproduct inventories, and save labor costs.

AdvantaFlex tubing can be an excellent alternative to silicone for many applications, especially forperistaltic pump use. It is ideal for aseptic tubing welds and is heat sealable. Molded components made fromAdvantaFlex Biopharmaceutical Grade TPE allow for one material contact surface throughout the system, whileproviding a seamless transition between tubing and connections for a continuous flow.

BioPharmaceutical Grade TPE

Select from a number of different crevice-free connections

SINGLE USE SYSTEMS

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DocuLink® (patent pending) is aservice designed to save time andeffort during document retrieval. Itidentifies a single use system on theproduct itself, not only on the bagfrom which it was removed, by use ofa permanently-affixed label at asilicone connector, which can handle

clean-in-place (CIP), steam-in-place (SIP), autoclave, andgamma irradiation processes.

DocuLink can list the individualpart number and lot number toallow quick lookup ofdocuments such as certificatesof compliance and certificatesof analysis. It can also be linkedto an online data managementsite (optional) for quickdocument retrieval.

Overmolded Endsare available in Tri-Clamp® and mini Tri-Clampstyles in Hytrel® and polypropylene materials.Size range: 1/8” to 1-3/16” hose I.D. (3.18mm to 30.16mm hose I.D.)

FiltersChoose from a varietyof styles, sizes, andmanufacturers for yoursingle use system.

Barbed fittingscome in Y, T, elbow, and reducer styles. Materialsinclude polypropylene, polyethylene, and PVDF.Size range: 1/8” to 1” hose I.D.(3.18mm to 25.40mm hose I.D.)

Pinch Clampsof polypropylene or polyester squeeze tubing closedanywhere along a line. One piece construction.Sizes fit up to 3/4” tubing O.D. (19.05mm tubing O.D.)

Aseptic Connectorsreduce contamination risksand keep processingsystems pure. Several easy-to-use styles are available.

Quick Connectsoffer on-the-spot connectionsand come in several materials.Dependable and secure.

Connections, Filters, Bottles

BottlesLaboratory and samplingbottles can also be incor-porated into your system.Select from HPDE andother materials.

AdvantaPass™ (patent pending)permits aseptic transfer of fluidsbetween the walls of pharmaceuticalmanufacturing suites. It supports the separation of different classes of clean rooms and lessens the riskto environments.

The system provides a reliablemethod for transferring fluidswithout physically moving bins andtotes, thereby eliminating the riskof breakage and spillage during bintransfer. It's a practical, safe andeasy way to move large volumes ofliquids from one room to another.

Contact one of our technical salesrepresentatves to discuss yourapplication requirements.

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What really sets AdvantaPure® apart from other manufacturers is our ability and willingness to offer various services to create acustom part from stock material. This benefits you in two ways—fast delivery and low cost. Contact a helpful AdvantaPure SalesRepresentative to discuss your needs.

SERVICES

For more information call: 1-888-755-4370 7

By combining our broad line of stocktubing, hose, and fittings, theoptimum hose assembly for yourapplication can be fabricated quickly.Let our Fabrication Team handle theassembly labor for you, so youreceive a finished, pressure-tested,ready-to-install product. We can alsoprovide choices for non-entrapmenthose assemblies, where conveyedmaterials contact only the pure inner-core of the assembly—from end toend—providing a seamless transitionand higher flow rates.

Hose AssembliesHose Identification Systems

High Purity Silicone Hosewith Sanitary Stainless

Steel Fittings

AdvantaPure offers various Hose Identification methods thatmay be used together or individually.

• AdvantaLabel® - Silicone hose labeling systemuses permanently-vulcanizedsilicone to encase a label andcolor stripes to the outside ofsilicone tubing and hose forquick, easy-to-readidentification.

• Laser-Etched Collars -Stainless steel collars areetched using precise lasertechnology for sharper andmore legible text and images.

• Color Tracer Braid -Incorporated into flexible, braid-reinforced silicone hose, thecolored braid material offers aquick and easy way todifferentiate between lines.

• Color 4 Ply Silicone Hose -Four-ply, mandrel-wrappedsilicone hose, with or without astainless steel reinforcing wire,is an excellent choice forpressure applications.

• Laser-Etched Tags -Sharper and more legible thantraditional acid-etched parts orhandwritten labels, laser-etchedtags are inexpensive, easy toattach to hoses, and work wellfor existing installations.

Special coverings offer additional protection from high temperatures orpressures, excessive friction, kinking or crushing, etc. Available materialsinclude Stainless Steel Armor, Rubber, Silicone, Polypropylene or Kynar®

braid, and more.

Special Hose Coverings

Stainless SteelArmor

Silicone CoveredStainless Steel Braid

Have your products gamma irradiated before they arrive at your location and save theadditional inventorying, transportation costs,and transit time.

A number of AdvantaPure's silicone andAdvantaFlex products, particularly thosedesigned for single use, are available withvalidated sterility assurance of 10-6 per ISO 11137method VDmax.

Gamma Irradiation Services

Introducing Verigenics™, a division of NewAge® Industries Inc. Previouslymarketed under the AdvantaPure® high purity products line, Verigenics offerssolutions to enable medical device, pharmaceutical and other regulated companies totrack and authenticate consumables, assets and equipment. Verigenics products useRFID (radio frequency identification) technology to provide enhancements such as

increased safety for providers and patients, brand loyalty, increased productivity, inventory visibility and improved product security. Contact Verigenics directly at – Phone: 888-322-5131; Email: info@verigenics.com; Website: www.verigenics.com

RFID SOLUTIONS

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NewAge® Industries AdvantaPure®

145 James Way, Southampton, PA 18966-3817Phone: 888-755-4370 (toll free) • 215-526-2151Fax: 888-258-4293 (toll free) • 215-526-2167Website: www.advantapure.comE-mail: sales@advantapure.com

©2013 NewAge® Industries, Inc. Specifications are subject to change without notice. AdvantaPure products are produced by NewAge Industries, Inc.AdvantaFlex®, AdvantaLABEL®, AdvantaPass™, AdvantaTube®, BioClosure®, DocuLink®, GammaTag®, Hose Track®, P•E•T Process Equipment Tracking®,Purity in Fluid Flow Systems®, NewAge Industries AdvantaPure®, NewAge®, the "N" logo, and Verigenics™, are trademarks of NewAge Industries, Inc.Kynar® is a registered trademark of Atochem North America, Inc. • Tri-Clamp® is a registered trademark of Alfa Laval Inc.All other trademarks are the property of their respective owners.

The Hose Track® Hose Lifecycle Analysis System is a unique, revolutionary hose assembly trackingsystem. Hose Track helps users minimize the risk of contamination and hose failure and the costlyrepercussions associated with batch waste and production stoppages. It offers an excellent way formanufacturing and maintenance personnel to monitor hose assembly cleaning, usage rates, andreplacement. (U.S. Patents 7,195,149 and 7,328,837. Other U.S. and foreign patents pending.)

Calendar & Manual Log Methods for replacing critical processcomponents can be unreliable, increasing the risk of productcontamination and wear related failure.

RFID Tags attached to process equipment are scanned by areader/writer to track wear related events and update thecomputer database.

A P•E•T System provides a detailed audit trail to assist in thevalidation process, and consolidates documents by electronicallylinking to notes, cleaning schedules, files, certifications, drawings,installation instructions, warning notices, and other protocols.

RF IDENTIFICATION AND HOSE LIFECYCLE ANALYSIS SYSTEM

GammaTag® – the industry's firstgamma-radiation-resistant read/write RFIDtag is available exclusively from AdvantaPure.Ideal for use on products where gamma sterilization is required.

The same RFID technology developed for hoses can be used for other components in the process chain—valves, filters, vessels, biobags,and more. Track usage and cleaning cycles to ensure timely maintenance and replacement... before parts begin to fail, risk product integrity,and waste time and labor. It’s a logical approach to tracking all critical process components. (U.S. Patents 7,195,149 and 7,259,675. OtherU.S. and foreign patents pending.)

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