Aging Skin - vitafoods.eu.com · MYTH Busting around Beauty from Within 1. Ingested COLLAGEN will go to the skin and lead to tissue repair --- MAYBE, but needs help 2. Vitamin C is

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Aging Skin


MYTH Busting around Beauty from Within

1. Ingested COLLAGEN will go to the skin and lead to tissue repair

2. Vitamin C is the best ANTOXIDANT for Skin Health

3. Only additional SUBSTRATES are needed for Skin Repair and Anti-aging


Core Drivers of Compromised Skin Health

1• Sunlight / UV Radiation / Mitochondria

2• Generation of Free Radicals & Oxidants

3• Chronic Inflammation

4• Disrupted Control of Breakdown vs. Repair Processes


If you ingest COLLAGEN does that Guarantee Matrix Repair?

Collagen that is ingested must go through the following steps:

• Digestion from the protein into peptides then into amino acids.

• The amino acids must be absorbed from the gut into the circulation

• Fibroblasts within target skin must then reconstruct the protein from the individual amino acids within the circulation using specific enzymes.

A complicated process of Digestion, Absorption & Reconstruction


Collagen: Form & Structure

• There are 28 different types of collagen in humans, although 3 dominate

• How the different forms are constructed varies between tissues, reflecting the application & purpose

• Do animal forms reflect the consumer needs at the specific location?

Most forms of collagen in supplements come from fish scales or rooster combs.

Does that match consumer needs?


The Matrix: More than Collagen

A multitude of other structural elements that are needed to create a functional matrix:

➢ Collagens

➢Fibronectin (glycoprotein)

➢ Tenascins (C, R, X and W)

➢ Elastin

➢ Vitronectin

➢ Decorin

➢ Integrin

➢ Laminin

➢ Glycosaminoglycan (GAG)


Matrix Repair is Dictated by Processes not Substrate Availability

The availability of substrates (amino acids) are not the critical drivers of a healthy matrix.

What is critical is the presence of active processes (enzymes) that reconstruct the MATRIX.

Processes are regulated at gene expression level.


UV Radiation & Skin Health

*Fibroblasts: Cells that make up the dermis and produce collagen and hyaluronic acid.

The ideal antioxidant would be: potent, work in lipids, restore

balance to cell decision making via gene expression (transcriptomics).

Astaxanthin vs. Vitamin CAdapted with permissionTominaga K. et al. 2017. J. Clin. Biochem. Nutr. Vol 61(1): 33-39


What is occurring during Oxidative Stress & UV Exposure

SKIN IS ACTIVATING MEDIATORS OF INFLAMMATION, ENZYMES & PROCESSES THAT DEGRADE THE DAMAGED MATRIX

THIS IS REGULATED BY GENE SWITCHES (TRANSCRIPTOMICS)

AT THE SAME TIME, ALL PROCESSES THAT REPAIR & GROW THE SKIN MATRIX ARE

SWITCHED OFF


Human fibroplasts were pre-incubated with vitamin C/astaxanthinfor 72 hours prior to exposure to UV radiation.

Astaxanthin vs Vitamin C Collagen Production

Tominaga et al., 2009 Food Style 21 13(1):25-9. A0070

Astaxanthin restores Collagen Genesis in Human Fibroblasts

Free Radicals generated by UV Radiation suppresses Collagen production. Astaxanthin but NOT Vitamin C can restore collagen production

Free RadicalsOxidants

Mitochondrial Health

Inflammation

Wrinkles, Fine Lines, Age Spots

Inflammation & Aging

Redox-sensitive Transcription Factors“The Gene Switches”

Astaxanthin


Events associated with UV Radiation, Oxidants & Inflammation

Free Radicals generated from UV radiation, affect gene switches

A family of enzymes that degrade proteins (MMPs) drives matrix protein breakdown

Degradation of matrix glycosaminoglycans (eg chondroitin) is dictated by ACANS

Collagen & matrix formation (eg COLA2) processes are SHUT DOWN

Suppression of the Pro-inflammation Gene Switch NF-kB by a Herbal Leucine MixtureEffect of Collagen and Glycosaminoglycan Production

Matrix production & breakdown are events that are in opposition by gene switches. Inflammation drives them in opposing directionsAkhtar et al. BMC Complementary and Alternative Medicine 2011, 11:66 http://www.biomedcentral.com/1472-6882/11/66

Enzymes that degrade the

matrix (MMPs) are turned on

at the gene level by

oxidants during Inflammation

Akhtar et al. BMC Complementary and Alternative Medicine 2011, 11:66 http://www.biomedcentral.com/1472-6882/11/66


What about other Fibrotic Diseases?Inappropriate (excess) collagen production is a hallmark of various fibrotic disease states, e.g., Non-Alcoholic Fatty Liver Disease (NAFLD).

Intriguingly the anti-inflammatory botanicals that help to restore balance to gene expression display the ability to limit fibrosis.

Astaxanthin may help promote collagen formation in aging skin while limiting fibrosis in fatty liver disease.

The Key is to RESTORE BALANCE in how one uses genetic resources. Here natural products & nutrition has a lot to offer

https://www.mdpi.com/2072-6643/10/9/1298

https://www.mdpi.com/2072-6643/10/9/1298


MYTH Busting around Beauty from Within

1. Ingested COLLAGEN will go to the skin and lead to tissue repair --- MAYBE, but needs help

2. Vitamin C is the best ANTOXIDANT for Skin Health --- NO, it is weak & too polar

3. Only additional SUBSTRATES are needed for Skin Repair and Anti-aging --- Busted, repair and health reflects a balance in processes that are controlled at the gene expression level not the relative presence of substrate

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Aging Skin - vitafoods.eu.com · MYTH Busting around Beauty from Within 1. Ingested COLLAGEN will go to the skin and lead to tissue repair --- MAYBE, but needs help 2. Vitamin C is