Albuterol’s Effect on the β2-Adrenergic

ReceptorEnna van den Akker

Albuterol Intro

• One in twelve Americans suffer from asthma• 3.7% of Americans diagnosed with Bronchitis in the past year. • Used to increase lung function• Medicine for asthma and bronchitis• Ligand for a β2-adrenergic Receptor• Results in smooth muscle relaxation and bronchodilation

With Albuterol Albuterol

GDP

Adenylyl Cyclase

ATP

cAMP

Protein Kinase A

Calcium Channel Calcium Activated Potassium Channel

Ca2+

Ca2+

Ca2+

Myosin Light chain Kinase

Myosin Light chain Phosphatase

GTP

P

K

G-Proteinβ2-Adrenergic Receptor

Without Albuterol

GDP

Adenylyl Cyclase

ATP

cAMP

Protein Kinase A

Calcium Channel Calcium Activated Potassium Channel

Ca2+

Ca2+

Ca2+

Myosin Light chain Kinase

Myosin Light chain Phosphatase

GTP

K

G-Proteinβ2-Adrenergic Receptor

Conclusion

Causes of bronchodilation and smooth muscle relaxation• Decreased cellular concentration of calcium• Opening of potassium channels• Inactivation of myosin light chain kinase

Works citedImages adapted from:

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