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ALCOHOLIS
M
Sosa, Diane
Valera, Erllyne
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ALCOHOL (Ethanol)
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Stomach: 20%
SI: 80%
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Liver: >90%
METABOLISM
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Liver: >90%
METABOLISM
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EFFECTS OF ACUTEALCOHOLINTOXICATIONThe greater the DOSE, the
greater
the EFFECT
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FRONTALLOBE:
"lannin#
For$in#Ieas
Ma%in#e!isions
Sel&'Control
CEREBRALCORTEX:
!ontrolsenses aninhiitory
!enters
CEREBELLUM:
Coorinatio
nBalan!e
HYPO-THALAMU
S:Bloo
"ressreHn#er Thirst
ADH HIPPO-CAMPUS
:Me$ories
MEDULLA:HR
Te$*eratr
e
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CEREBRALCORTEX:
!ontrolsenses aninhiitory
!enters
Tal%ati+e
In!rease sel&'!onen!eLoss o& inhiition"oor -#e$ent
Cannot thin% !learly
BAC: !1-!"EUPHORIA
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FRONTALLOBE:
"lannin#
For$in#Ieas
Ma%in#e!isions
Sel&'Control
CEREBRALCORTEX:
!ontrolsenses aninhiitory
!enters
"leasre
NaseaE$otional arosal"oor reasonin#
Loss o& ne $otors%ills
BAC: !#-!1EXCITEMENT
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FRONTALLOBE:
"lannin#
For$in#Ieas
Ma%in#e!isions
Sel&'Control
CEREBRALCORTEX:
!ontrolsenses aninhiitory
!enters
CEREBELLUM:
Coorination
Balan!e
Moo S.in#s
An#erSanessMania
Loss o& e*th
*er!e*tionIna**ro*riate so!ialeha+ior
BAC: !11-!2CONFUSION
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FRONTALLOBE:
"lannin#
For$in#Ieas
Ma%in#e!isions
Sel&'Control
CEREBRALCORTEX:
!ontrolsenses aninhiitory
!enters
CEREBELLUM:
Coorination
Balan!e
A##ressionRe!e sensations
De*ressionSlrre s*ee!hLa!% o& alan!e
Loss o& te$*eratre
re#lation
BAC: !21-!$STUPOR
MEDULLA:
HR Te$*eratre
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FRONTALLOBE:
"lannin#
For$in#Ieas
Ma%in#e!isions
Sel&'Control
CEREBRALCORTEX:
!ontrolsenses aninhiitory
!enters
CEREBELLUM:
Coorinatio
nBalan!e
HYPO-THALAMU
S:Bloo
"ressreHn#er Thirst
ADH HIPPO-CAMPUS
:Me$ories
MEDULLA:HR
Te$*eratr
e
/n!ons!iosnessLoss o& laer
!ontrolDi0!ltyreathin#
BAC: !$1-!%COMA
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FRONTALLOBE:
"lannin#
For$in#Ieas
Ma%in#e!isions
Sel&'Control
CEREBRALCORTEX:
!ontrolsenses aninhiitory
!enters
CEREBELLUM:
Coorinatio
nBalan!e
HYPO-THALAMU
S:Bloo
"ressreHn#er Thirst
ADH HIPPO-CAMPUS
:Me$ories
MEDULLA:HR
Te$*eratr
e
BAC: &!%DEATH
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EFFECTS OFCHRONIC ALCOHOLINTOXICATION
TOLERANCE
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TOLERANCE
• De!rease in rain sensiti+ity toal!ohol &ollo.in# lon#'ter$
e1*osre
• Boy2s aiity to ADA"T – In!rease !on!entrations o& the
LIVER
EN34MES
– Learn to &n!tion ner in5en!e o&
al!ohol
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MANAGEMENT
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MOTIVATED TO CHAN6E7
• Treat$ent &or al!oholis$ !an e#in
only .hen the al!oholi! a!!e*ts tosto* rin%in#8 –
DETOXIFICATION
–
REHABILITATION – MAINTENANCE
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• MEDICATIONS9 –
Ben:oia:e*ines – Dislra$
– Naltre1one
ABSTINENCE
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'!TO BE CONTINUED
THIN; e&ore yoDRIN;7
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ALCOHOLISM
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O/0*n+Metaolites a!!$lates &ro$
al!ohol $etaolis$ an *ath.ays
a
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W0 3+045*0+677/3/*0+ 8,53 *755*3+045*63!W0 ,+ 0+, +9+706
W0 3+045*7 ;0
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M+045*0+6 77/3/*0+8,53 *755* 3+045*63
NADH
It2s o1ii:e &or$ (NAD>) is neee yBeta'o1iation,
6ly!olysis, Citri! A!iCy!le
NADP=
It2s re!e &or$ (NAD"H) is neee y
"entose "hos*hate "ath.ay H2O
Al!ohol is a ireti!
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M+045*7 ;0
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05 d+>+*5;3+n0 58.;5?*.7+3
It lo.ers the !on!entration o& "yr+ate
a+ailale &or 6l!oneo#enesis
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W. ,+ *755*76 ;,5n+ 05 ?5/0 007@
U,7 A7dGOUT
W0 6 W+,n7@+ 5,6@59
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W+,n7@+6 +n7+;*5;0.
an 5,6@59 6.nd,53+ arei03n B1 !o$$ona$on# al!oholi!s!
W0 6 W+,n7@+-5,[email protected],53+ W. d5+6 0 d+>+*5; n7,5n7
*755*63
WERNICES ORSAOFF
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Nero*sy!hiatri!synro$e !hara!teri:e
y eha+ioralanor$alities an
$e$ory i$*air$ents
Tria o& a!te $ental
!on&sion, ata1ia, ano*hthal$o*le#ia
WERNICE SENCEPHALOPATH
Y
ORSAOFFPSYCHOSIS
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R5*+ 58 T3n+
There are $a-or en:y$es thatreire Thia$ine as a
!o&a!tor9
Trans%etolase "yr+ate Dehyro#enase
Al*ha'%eto#ltarate Dehyro#enase
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YOU
