“Letthy%food%be%thy%medicine,%and%thy%medicine%be%thy%food.” EV... · 2015. 9. 25. · o Red Palm Oil naturally contains high levels of valuable minor constituents: Tocotrienols

Your Preferred Partner In Palm Nutraceutical Excellence

WH Leong, CEO, ExcelVite Sdn. Bhd.

Strictly Private & Confiden3al

“Let thy food be thy medicine, and thy medicine be thy food.”


Red Palm Oil – The Most Nutritious Oil

•   ExcelVite – Brief Introduction •  Our Process and Products •  About Red Palm Oil

§ Crown Jewels in Red Palm Oil •  Challenges and Opportunities •   EVSpectra™ Red Palm Oil Concentrate



Ø   1994 – Formerly known as Carotech. First & only integrated plant in the world to commercially extract tocotrienols (“Super Vitamin E”) and mixed carotene, from crude palm oil (Elaeis guineensis)

Ø   Protected by US Patents and scientifically-substantiated with human clinical studies (flagship product : Tocotrienols)

Ø   2007 – the only GMP-certified tocotrienol producer in the world

Ø   2012 – the only FDA-inspected tocotrienol producer in the world

Ø   Current leading & largest producer of tocotrienol and mixed carotene in the world

Ø   Experienced and proven management (20 years)



Virgin Crude Palm Oil

(Elaeis guineensis)

Extrac?on & Reac?on Process

Molecular Dis?lla?on (Ultra-‐High Vacuum / Low Temperature)

Biodiesel -‐ Oleochemical &

Glycerine

Full Spectrum Palm Tocotrienol / Tocopherol

Complex

Palm Mixed Carotene Complex

Palm Phytosterol Complex

Red Palm Oil Concentrate

•   Dietary Supplements / Pharmaceu?cals •   Food & Drink •   Cosme?c, Personal Care Products



Palm Tree Palm Fruits Virgin Red Palm Oil

& 1.  EVNol™ - Natural Full Spectrum Tocotrienol Complex

2.  EVNol SupraBio™ – Bioenhanced Natural Full Spectrum Tocotrienol Complex

3. EVTene™ - Natural Mixed-Carotenes Complex

4. EVRol™ - Naturel Phytosterol Complex

5. EVSpectra™ - Natural Red Palm Oil Concentrate



Malaysian Red Palm Oil o   The oil palm (Elaeis guineensis) originates from

West Africa o   Has not been genetically-modified (NON-GMO) o   Red Palm Oil naturally contains high levels of

valuable minor constituents:

Tocotrienols + Tocopherol (600 – 1000ppm)

Carotenoids (500 – 700 ppm)

Phytosterols (326 – 527 ppm)

Squalene (200 – 500 ppm)

Phospholipids (5 – 130 ppm)

Without these valuable minor constituents, Red Palm Oil will just be another ordinary cooking oil



Malaysian Red Palm Oil

Tocotrienol

•   Belongs to the vitamin E family


Carotenoids (Alpha Carotene & Beta Carotene)

•   Pro-Vitamin A

The Crown Jewels of Red Palm Oil



Tocotrienol


1st Crown Jewel of Red Palm Oil


Ø  There are 8 forms of natural vitamin E Tocopherols (Major source : Soybean) Tocotrienols (Major source : Palm)

Ø  All published papers on vitamin E (35,354) listed in PubMed – Less than 1% related to tocotrienol ! (Source: PubMed)

R1

R1

R2

R2 Methyl Group R1 R2

Alpha-‐ CH3 CH3

Beta-‐ CH3 H

Gamma-‐ H CH3

Delta-‐ H H



Methyl Group R1 R2

Alpha- CH3 CH3

Beta- CH3 H

Gamma- H CH3

Delta- H H TOCOPHEROL (T)

TOCOTRIENOL (T3)

HO R1

R2 CH3

CH3

HO R1

R2

There are 8 forms of natural vitamin E : Tocopherols (Major source : Soybean) Tocotrienols (Major source : Palm)



Vitamin E Composition in Red Palm Oil -   78% mixed tocotrienols (α,β,γ,δ) -   22% α-tocopherol



Human Clinical Studies

Cancer Research

(Breast Cancer / Prostate Cancer)

Heart Health (Carotid stenosis /

Cholesterol Health / Arterial

Compliance)

Skin Nutrition

(Super antioxidant / anti-

aging / scar reduction /

accumulation in skin)

Neuro Protection (Brain Health -

Stroke/ Cognition / Alzheimer’s Disease /

White Matter Lesions)

Liver Health

(NAFLD / Liver Stiffness / Metabolic Syndrome)


Ø  Total published papers on vitamin E (35,354) listed in PubMed – Less than 1% related to tocotrienol ! (Source: PubMed)


71 120

12 27 27

243

672

0

100

200

300

400

500

600

700

800

Brain Health Heart Health Liver Health Skin Health Radiation Cancer Others

Num

ber

of p

aper

s

Indications

Number of Published Research Papers (Pubmed, total on tocotrienols = 1172 as at 22 July 2015)



B r a i n H e a l t h •  Non-antioxidant property – regulate key checkpoints to minimize neuronal cell degeneration and death; induces arteriogenesis and increases secondary blood supply to stroke-affected area. •  Via Antioxidant property.

H e a r t H e a l t h •  Regulates down-degradation of HMG CoA-Reductase •  Potent antioxidant property

L i v e r H e a l t h •  Anti-inflammatory function.

S k i n H e a l t h •   Antioxidant, anti-aging, anti-inflammatory functions

C a n c e r •  Growth arrests, antiproliferative and apoptotic effects.

•  Suppression of carcinogenesis. •  Potent antioxidant property – free radical scavenging

R a d i a t i o n P r o t e c t i o n •  Potent antioxidant activity (ROS and RNS scavenging)

•  Growth arrests, antiproliferative and apoptotic effects.




Carotenoids


2nd Crown Jewel of Red Palm Oil


Distribution of Carotenes in Carrot & Red Palm Oil

32% α-Carotene

β-Carotene

Others

63%

5%

34%

60%

6%

< 100 ppm 500 – 700 ppm

•   Carotenoid composition of red palm oil is similar to carrots •   > 60% beta-carotene and >30% alpha-carotene •   Including other natural carotenoids (gamma carotene & lycopene)




Comparison of Various Sources of Carotene


Alpha-, and Beta-Carotene Total Publications : ~ 13,712 Nutrition

Heart Health Skin

Cancer

Animal Health

Papers ~2606

Papers ~427

Papers ~3,050

Papers ~525

Papers ~1139

All papers on “Carotenoids” =

71,912 (as at 28 July

2015)




Today, RPO is harvested from 3 main regions:

Peninsular Malaysia

Borneo

Indonesia



Challenges •   Sustainability

?   Environmental impact ?   Wild life losing habitat ?   Is Malaysian Red Palm Oil sustainably produced

•   Peninsular Malaysia ü  Existing Crop Land > 25 years ü  > 50% forest cover ü  Plantations and Smallholders – RSPO members ü  Governed by Stringent Rules & Regulations – Monitored by MPOB Enforcers

•   Other regions ?   Sustainability Policies Not Well Defined

•   Negative studies on vitamin E (alpha-tocopherol) and beta-carotene – mainly synthetic or single isoform




Opportunities ü  Red Palm Oil has more vitamin E and carotenes than any

other vegetable oils •   Olive, corn, sunflower, safflower oils do not contain carotenoids •   Vitamin E (tocotrienols + tocopherol) content in Red Palm Oil is

significantly higher than all these other oils •   Red Palm Oil is also significantly higher in Vitamin E content

compared with vegetable sources of vitamin E

ü  Red Palm Oil has the highest Retinol Equivalents (RE) compared to carrots (15x), leafy vegetables (44x), apricots (120x), tomatoes (300x), bananas (1000x), and orange juice (3750x).




Opportunities ü  Improves nutritional value of end products – possible for

RDA claims on products ü  Boosts nutritional content with all the naturally existing

minor components ü  Availability of published research studies in the area of

vitamin A deficiency, heart disease, and cancer

Food manufacturers are eliminating the use of synthetic colors (Southampton Study) – Red Palm Oil fits right into

the latest “Coloring Food with Food” trend




Red Palm Oil



Opportunities – Red Palm Tocotrienols

2012 $290m

2015 $376m

é 29.6%

Ø  Market value of natural vitamin E (ingredient / raw mat) (Source: Frost & Sullivan)

Huge Opportunities for tocotrienols as the “Super Vitamin E”

Ø  Large body of science demonstrated efficacy of red palm tocotrienols (EVNol™ and EVNol SupraBio™) in health areas covering brain, heart, liver, skin & hair.

Ø  Clinical studies show red palm tocotrienols are bioavailable and bioefficient.



Opportunities – Palm Carotenoids

2014 $306m

2020 $446m

é 45.8%

Ø  Market value of natural coloring market (Source: Future Market Insights)

Ø  Growing demand for natural food colorings by manufacturers and consumers

Ø  Alpha- and beta-carotenes are precursors of vitamin A Ø  Apart from imparting color to foods, palm carotenoids provide

essential nutritional benefits to children and women in terms of overcoming vitamin A deficiency, as well as improving the immune system.



EVSpectra™ - Red Palm Oil Concentrate

Ø  Launched in response to demand from the dietary supplement industry. Ø  EVSpectra™ allows manufacturers to offer all the goodness and benefits of

red palm oil in a softgel dosage form ü Convenience ü  Lower oil (triglyceride) intake, hence reduced calorie

Ø  EVSpectra™ is 100 times more concentrated than red palm oil Ø  Provides phytonutrients tocotrienol and carotenoids of 2 tablespoon (28g)

or red palm oil in one 250mg softgel capsule

Ø  The ratio of total vitamin E to total mixed carotenoids is 2:1 – exactly the same as found in red palm oil



Corporate Website

www.excelvite.com

Tocotrienol Educational Website

www.tocotrienol.org




GMP Manufacturing Facility : ExcelVite Sdn. Bhd. Lot 56442, 7 ½ Mile, Jalan Ipoh/Chemor, 31200 Chemor, Perak, Malaysia U.S. Sales Office: ExcelVite Inc. 21, Balmoral Court, 08817 Edison, New Jersey [email protected] Australia : [email protected] General Enquiries: [email protected] www.excelvite.com www.tocotrienol.org


Documents

“Letthy%food%be%thy%medicine,%and%thy%medicine%be%thy%food.” EV... · 2015. 9. 25. · o Red Palm Oil naturally contains high levels of valuable minor constituents: Tocotrienols