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“The Global In Vitro Fertilization Market”
Dr. Peter Svalander
Presentation outline
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The Total Fertility Rate is declining below the replacement rate (2.1) to sustain population levels
2015
These new demographics may threaten living standards …
• Falling productivity and increasing dependency will reduce potential GDP growth from 2.1% to 1.3% a year
• Age-related spending as a proportion of GDP in will increase:• Pensions: 7.4% (2000) to 10.8% (2050)• Health care: 6.0% (2000) to 9.3% (2050)
• As a consequence of ageing, share of EU in global output is expected to decrease:
• EU from 18% (2000) to 10% (2050)• US from 23% (2000) to 26% (2050)
Grant J, et al
Rand Corporation Report, ESHRE 2006
ARTAssisted Reproductive Technology
IVFIn Vitro Fertilization
IVFEmbryoFreezing
PGD ICSI IVMEmbryoImaging
IVA
History of IVF
U.K. Australia U.K. Belgium Denmark Japan
IVF: In Vitro Fertilization
PGD: Pre-implantation Genetic Diagnostics
ICSI: Intracytoplasmic Sperm Injection
IVM: In Vitro Maturation
IVA: In Vitro Activation
Australia
1978 1984 1990 1991 1994 2009 2013
For IVF, Embryo Freezing, PGD, ICSI, IVA: Dates above indicate first baby born
Last major innovation in IVF
In Vitro Fertilization (IVF)
IVF
Intra Cytoplasmic Sperm Injection (ICSI)
Heffner LJ
NEJM, 2004; 351:1927-1929
Fertility declines and birth defects increase with age
Maternal Age at Delivery (yr)
Risk of Down’s
Syndrome
Risk of Any Chromosomal Abnormality
20 1/667 1/526
25 1/1200 1/476
30 1/952 1/385
35 1/378 1/192
40 1/106 1/66
45 1/30 1/21
* Modified by Hook et al, JAMA 1983; 249:2034-8
Risk of Down Syndrome and Chromosomal Abnormalities at
Live Birth, According to Maternal Age*
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Fertile women who plan on becoming mothers in their 30s and 40s should freeze their eggs
Infertility will affect 1 in 3 women havingchildren in their late 30s.
Egg freezing when young will allow women to choose number of babies to have and when.
Women are much more likely to achieve their desired family size.
Source: Martin Varsavsky, personal communication
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30% of couples who undergo IVF never get to have a baby with their own eggs
n=2678
n=1360
n=836
n=1290
Source: Malizia, B.A. et al. 2009. Cumulative Live-Birth Rates after In Vitro Fertilization. N Engl J Med, 360:236-43.
Source: https://www.youtube.com/watch?v=isRaHszrPc4
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