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“The  future  is  already  here  —    it's  just  not  very  evenly  distributed”  

               William  Gibson  

Jonathan  Sheldon,  PhD  Global  Vice  President  Healthcare  Health  Sciences  Global  Business  Unit  February  25,  2016  

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Safe  Harbor  Statement  The  following  is  intended  to  outline  our  general  product  direcUon.  It  is  intended  for  informaUon  purposes  only,  and  may  not  be  incorporated  into  any  contract.  It  is  not  a  commitment  to  deliver  any  material,  code,  or  funcUonality,  and  should  not  be  relied  upon  in  making  purchasing  decisions.  The  development,  release,  and  Uming  of  any  features  or  funcUonality  described  for  Oracle’s  products  remains  at  the  sole  discreUon  of  Oracle.  

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The  Healthcare  Storm  

       

Precision  Medicine   Healthcare  

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Copyright  ©  2016,  Oracle  and/or  its  affiliates.  All  rights  reserved.    |  

The  Healthcare  System  is  Broken  

•  700,000  emergency  department  visits    and  120,000  hospitalizaUons  are  due    to  ADEs  annually    

•  At  least  40%  of  costs  of  ambulatory  (non-­‐hospital  seangs)  ADEs  are  esUmated  to  be  preventable  

•  $290  billion  annual  cost  of  MedicaUon    non-­‐adherence  

•  836,000  of  7  million  30  day  hospital  readmissions  annually  are  preventable  

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hgp://www.cdc.gov/MedicaUonSafety/basics.html  NaUonal  Quality  Forum,  PrevenUng  Readmissions  whitepaper  Nov  2010    New  England  Healthcare  InsUtute  (NEHI)  whitepaper:  Thinking  Outside  the  Pillbox,  August  2009  

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The  Shim  Total  Public  and  Private  Accountable  Care  Organiza=ons,  2011  to  January  2015  

64   70   72   84  

174  219  

322   336  

447   458  472   490  

621   633  647   657  

744  

0  

100  

200  

300  

400  

500  

600  

700  

800  

Q1  2011  

Q1  2012  

Q1  2013  

Q1  2014  

Q1  2015  

Total  A

COs  

1  2  

2   1  

3  

7  

3  

5   3  

4  

27  

1  

9   25  

7  

1   6  

5  

0%  

10%  

20%  

30%  

40%  

50%  

60%  

70%  

80%  

90%  

100%  

Clinic   IDN   Standalone  

6   5   4   3   2   1   0  

Aggressiveness  of  Organiza=ons’  PHM  Efforts  

How  many  types  of  risk-­‐bearing  programs  are  organizaUons  engaging  in?  

Source:  “PopulaUon  Health  Management  PercepUon  2015:  Which  Vendors  Stand  Out?”  KLAS  report,  June  2015  

Number  of  Program  Types  

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klasrpt_Pop_Health_PercepUon_2015_-­‐_Full_Report  

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The  Healthcare  Storm:  Precision  Medicine  Can  Fix  It  

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Lower    Cost  

Improve  Outcomes  

Precision  Medicine  

Healthcare  

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Precision  Medicine:  Delivering  on  the  Promise  Life  Sciences  PerspecUve     Healthcare  PerspecUve    

137  

73%  42%  

13%  

A  New  Landscape  for  the  Pharmaceu=cal  Industry  PMC  research  illustrates  the  biopharmaceuUcal  industry’s  deep  commitment  to    personalized  medicine.  

of  all  drugs  in  development  are  

personalized  medicines.  

of  oncology  drugs  in  development  are  

personalized  medicines.  

Personalized  medicines  represent  13%  of  all  approved  medicines.  

approved  medicines  have  genomic  informaUon  in  

their  label.  

Source:  Biopharmaceu2cal  Companies’  Personalized  Medicine  Research  Yields  Innova2ve  Treatments  for  Pa2ents.  PMC/PhRMA,  2015.  

30%  

Heart  Pa=ent  Hospitaliza=on  Rate  Documented  when  geneUc  informaUon  was  used  in  dosing  warfarin  

15%  

Colorectal  Cancer  5-­‐year  Survival  Rate  Following  discovery  of  molecular    receptors  associated  with  tumor  growth  

2x  

Myelogenous  Leukemia  5-­‐year  Survival  Rate  Following  introducUon  of  imaUnib,  a  targeted  therapy  

34%  

Chemotherapy  Use  If  women  with  breast  cancer    received  geneUc  tesUng    prior  to  treatment  

$604M  

Colorectal  Cancer  Costs  If  metastaUc  colorectal  cancer    paUents  received  geneUc  tesUng    prior  to  treatment  

17K  

Strokes  Prevented  If  a  geneUc  test  was  used  to    properly  dose  blood  thinners  

Personalized  Medicine  Improves  Health  Outcomes  

Personalized  Medicine  Can  Make  The  Health  System  More  Efficient  

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hgp://www.personalizedmedicinecoaliUon.org/Userfiles/PMC-­‐Corporate/file/PMC_2015_annual_report.pdf  

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NaUonal  Interest      

China  Qatar  

Great  Britain  

United  States  

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Our  PerspecUve:    Precision  Medicine  Enables  PopulaUon  Health    

Precision  Medicine     PopulaUon  Health  

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Oracle  Healthcare:  A  Solid  FoundaUon  Built  to  Scale    •  Enterprise  grade  •  Fit  for  Purpose  •  Flexible    

MulU-­‐Structured  Data  Sources  

Data  Management    

ApplicaUon  Enablement    

Oracle  Healthcare    Founda=on    

PRIVACY      SECURITY    

AcquisiUon    

AggregaUon      

Integrity    

OrganizaUon    

Readmission    Preven=on    

Chronic  Disease    Care  Gaps  

Risk    Stra=fica=on    

Performance      Quality  Tracking  

Cost    Analysis  

Precision  Medicine    

Financial  Clinical   Admin   Omics  

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Precision  Medicine  is  Becoming  the  New  Norm  

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