ARCHIVES - BMJ

DECEMBER 1992 VOL 67 NO 12

ARCHIVES OFDISEASE IN

CHILDHOODThe Journal of the British Paediatric Association

Annotations

Original articles

Types of psychiatrictreatment

Statistics fromthe inside

Current topics

Personal practiceReferees and staffLetters to the editorIndexArchivist

1417 The place of computed tomography and lumbar puncture in suspected bacterialmeningitis DavidH Mellor

1420 Sleep problems Gregory Stores1421 Routine discharge examination of babies-is it necessary? PH T Cartlidge1423 Do maternal and intrauterine factors influence blood pressure in childhood? PH Whincup,

D G Cook, 0 Papacosta1430 Management and outcome of severe head injuries in the Trent region 1985-90

A C Elias-Jones, J A G Punt, A E Turnbull, et al1436 Long term effects of periconceptional multivitamin supplements for prevention of neural

tube defects: a seven to 10 year follow up MonicaHolmes-Siedle,3JenniferDennis,RH Lindenbaum, et al

1442 A randomised trial of low dose folic acid to prevent neural tube defects PeadarN Kirke,LeslieE Daly, J Harold Elwoodfor the Irish Vitamin Study Group

1447 Immunohistochemical features of the portal tract mononuclear cell infiltrate in chronicaggressive hepatitis Giorgio Senaldi, Bernard Portmann, AlexP Mowat, et al

1454 Bronchial responsiveness and lung function in infants with lower respiratory tract illness overthe first six months of life JaneR Clarke, Amanda Reese, Michael Silvernan

1459 Association of perinatal events, epilepsy, and central nervous system trauma with juveniledelinquency Paula Rantakallio, Markku Koiranen, Jyrki Mottonen

1462 Urinary protein/creatinine index in follow up of patients with Wilms' tumour afternephrectomy C Mpofu, J R Mann

1467 Teachers' perceptions of epilepsy M J Bannon, C Wildig, P WJones1472 Growth hormone deficiency during puberty reduces adult bone mineral density S L Hyer,

DA Rodin,J H Tobias, et al1475 Hazards of parenteral treatment: do particles count? J WL Puntis, KM Wilkins,

PA Ball, et al1478 Sinusitis-induced subdural empyema Ruth Skelton, Wirginia Maixner, David Isaacs1481 Familial pancreatic enzyme insufficiency G Owen, P WBuss, HR Jenkins, et al1483 Thrombolysis with low dose tissue plasminogen activator E Doyle,J Britto, J Freeman, et al1484 Fatal encephalitis/encephalopathy in primary human herpesvirus-6 infection YAsano,

T Yoshikawa, YKajita, et al1486 Recovery of protein from urine specimens collected in cotton wool G C Smith, CM Taylor

1488 (11) Drug treatment Michael Prendergast

1495 8. Size, power, and confidence MJ R Healy1498 The ethics ofcardiopulmonary resuscitation. I. Background to decision making

J M Davies, BM Reynolds1502 The ethics of cardiopulmonary resuscitation. II. Medical logistics and the potential for good

response JM Davies, BM Reynolds1506 Suitability of the paediatric setting for hospitalised adolescents M L Gillies,

WLI Pary-Jones1510 Factitious illness: recognition and management DM Eminson, RJ Postlethwaite1517151915211441, 1446BMJ PUBLISHING GROUP

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VOLUME 67 * CONTENTS

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FETAL AND NEONATAL EDITIONOriginal articlesCatabolic effect of dexamethasone in the preterm baby K G Brownlee, P C Ng,M Jf Henderson, et alDexamethasone increases plasma amino acid concentrations in bronchopulmonary dysplasia A F Williams, MJonesDexamethasone treatment during ventilator dependency: possible life threatening gastrointestinal complicationsElizabeth A O'Neil, WalterJ Chwals, MichaelD O'Shea, et alLow dose intraventricular fibrinolytic treatment to prevent posthaemorrhagic hydrocephalus A Whitelaw,R PA Rivers, L Creighton, et alSymmetrical thalamic lesions in infants M Eicke,j Briner, U Willi, et alEvaluation of techniques for delivery of steroids to lungs to neonates using a rabbit model Christopher O'Callaghan,John Hardy,3Julie Stammers, et alDelivery of therapeutic aerosols to intubated babies Jonathan Grigg, Shmuel Arnon, TraceyJones, et alTreatment of severe persistent pulmonary hypertension of the newborn with magnesium sulphateYousefK Abu-Osba, Omar Galal, Khader Manasra, et alMeasurement of plasma volume in neonates M YAnthony, S R Goodall,M Papouli, et alIgG subclasses compared in maternal and cord serum and breast milk A Gasparoni, A Avanzini,F Ravagni Probiser, et alReduced use of surface cultures for suspected neonatal sepsis and surveillance S RM Dobson, D Isaacs,A R Wilkinson, et alCandida strains from neonates in a special care baby unit A M Sharp, F C Odds, E G V EvansEnterobacteriaceae and neonatal necrotising enterocolitis M R Millar, P MacKay,M Levene, et alGentamicin: influence of dosing on pharmacokinetics, nephrotoxicity, and antibacterial activity H Skopnik,R Wallraf, B Nies, et alCyclical fluctuations in cerebral blood volume L N Livera, YA B D Wickramasinghe, S A Spencer, et a!Neonatal renal candidal bezoar VK Rehan, D C Davidson

Obstetrics for paediatricians65 Rhesus haemolytic disease MartinJ7 Whittle

Current practice69 Respiratory support using patient triggered ventilation in the neonatal period A Greenough, A D Milner

Perinatal lessons from the past72 Dr William Cadogan (1711-1797) of Bristol and the management of infants PM Dunn74 Book reviews

Annotation75 Psoriasis in childhood 3rulian Verbov

Original articlesCo-morbidity associated with fabricated illness (Munchausen syndrome by proxy) CN Bools, B A Neale,S R MeadowComparison of BCG vaccination at birth and at third month of life Ibrahim Ildirim, Nihat Sapan, Bulent CavusogluConditions accounting for substantial time spent in hospital in children aged 1-14 years Jane Henderson,MichaelJ7 Goldacre,JennieM Fairweather, et alCongenital hypothyroidism detected by neonatal screening: relationship between biochemical severity and earlyclinical features DB Grant, I Smith, P W Fuggle, et alRelationship between urinary and serum growth hormone and pubertal status E C Crowne, WHB Wallace,SM Shalet, et alLimited joint mobility in subjects with insulin dependent diabetes mellitus: relationship with eye and kidneycomplications SatishK Garg, H Peter Chase, Guillermo Marshall, et alFailure to prevent nicotine addiction in young people with diabetes E A Masson, IA MacFarlane, CJ Priestley, et alDo doctors recognise eating disorders in children? RachelJ Bryant-Waugh, Bryan D Lask, Rosamund L Shafran, et alTrial of intensive compared with weekly speech therapy in preschool children J7ean Barratt, Peter Littlejohns,J'ulie ThompsonHome parenteral nutrition in chronic intestinal failure WM Bisset, P Stapleford, S Long, et alA biotinidase Km variant causing late onset bilateral oral neuropathy V Th Ramaekers, TM Suormala, M Brab, et alBeta glucuronidase and hyperbilirubinaemia in breast fed infants of diabetic mothers L Sirota,M Ferrera,N Lerer, et alAxillary and rectal temperature measurements in infants CJ Morley, P H Hewson, AJ Thornton, et alStreptococcus associated toxic shock C Torres-Martinez, D Mehta, A Butt, et alImplantable intravenous access device L L Goldsworthv, HM DalyPaediatric psychotherapy: a service in a general outpatient clinic Susan Vas Dias, Sheila A McKenzieCoeliac disease and lymphangiectasia VojislavN Perisic, George KokaiPositive end expiratory pressure via a portable system in thoracic dystrophy S Edees, A Moulden, RJ WinterCurrent topic

138 HIV infection in children D Gibb, M L NewellRegular review

142 Medium chain acyl-CoA dehydrogenase deficiency E H Touma, C CharpentierPersonal practice

146 Lower oesophageal pH monitoring-a useful clinical tool DavidM Tappin, Caroline King, James Y PatonStatistics from the inside

149 3. Estimation MJ7 R Healy151 Letters to the editor

Book reviewsMeeting in 1992Instructions to authors

No 2 FEBRUARY 1992 Annotations157 Antibiotic choices for meningitis beyond the neonatal period Nj Klein, R S Hevderman, M Levin159 Fibreoptic bronchoscopy in infants de Blic, P Scheinmann

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Original articles162 Fourteen cases of imposed upper airway obstruction M P Samuels, W McClaughlin, R RJacobson, et al171 Combined effect of infection and heavy wrapping on the risk of sudden unexpected infant death Ruth Gilbert,

Peter Rudd, PJeremy Berry, et al178 A clinical study of Noonan syndrome M Sharland,M Burch, WM McKenna, et al184 Desmopressin for bed wetting: length of treatment, vasopressin secretion, and response J H C Evans, S R Meadow189 Twin peaks, extramarital conceptions, and virgin births: is there a connection? M Murphy, V Seagroatt192 Controlled study ofPseudomonas cepacia and Pseudomonas maltophilia in cystic fibrosis G Gladman, PI Connor,

R F Williams, et al196 Prospective evaluation of the Paediatric Risk of Mortality (PRISM) score Ganapathy Balakrishnan, Tom Aitchison,

David Hallworth, et al201 Surgical treatment of hyperinsulinaemic hypoglycaemia L Spitz, R K Bhargava, DB Grant, et al206 Consultation time, workload, and problems for audit in outpatient clinics James WPartridge211 Clinical review of idiopathic versus hepatitis B surface antigen related forms of membranous glomerulonephritis

Seza Ozen, Umit Saatci, Aysin Bakkaloglu, et al214 Inhaled frusemide against cold air induced bronchoconstriction in asthmatic children J Seidenberg,J Dehning,

H von der Hardt218 Persistent gastrointestinal symptoms after correction of malrotation S P Devane, R Coombes, V VSmith, et al222 Rehabilitation and outcome after severe head injury R Scott-Jupp, N Marlow, N Seddon, et al227 Post-traumatic tremor in head injured children S L77ohnson, DMB Hall229 Energy intake and basal metabolic rate during maintenance chemotherapy S A Bond, A M Han, S A Wootton, et al233 Fever associated with teething LJ7aber, IJ Cohen, A Mor234 Growth patterns after surgery for virilising adrenocortical adenoma A TSalt, M O Savage, D B Grant

Types of psychiatric treatment237 Types of psychiatric treatment: overview PhilipJ Graham

Special report240 Asthma: a follow up statement from an international paediatric asthma consensus group

Statistics from the inside249 4. Sampling distributions MJ R Healy

Looking back251 Decline and fall of the tubercle bacillus: the Newcastle story 1882-1988 FJ WMiller, Mary D Thompson256 Letters to the editor

No 3 MARCH 1992 Annotations257 The urgency of immersions John Pearn258 Reactive amyloidosis Joel David, Patricia Woo

Original articles262 Congenital retinal dystrophies: a study of early cognitive and visual development MarilynM Black,

PatriciaM Sonksen266 Memory after treatment for acute lymphoblastic leukaemia J Rodgers, P G Britton, R G Morris, et al269 What consistency of food is best for children with cerebral palsy who cannot chew? R D Croft272 Gut regulatory peptides and intestinal permeability in acute infantile gastroenteritis G R Lawson, R Nelson,

M F Laker, et al277 Increased plasma tumour necrosis factor-( concentration in atopic dermatitis S Sumimoto, M Kawai,

Y Kasaiima, et al280 Interleukin-2 production of lymphocytes in food sensitive atopic dermatitis Hiroatsu Agata, Naomi Kondo,

Osamu Fukutomi, et al285 Inhaled budesonide for chronic wheezing under 18 months of age V Noble, N R Ruggins, M L Everard, et al289 Bronchodilators for treatment of mild bronchiolitis: a factorial randomised trial Elaine E L Wang, Ruth Milner,

Upton Allen, et al294 The intensive care unit in paediatric oncology D Heney, IJ Lewis, L Lockwood, et al299 Pulse oximetry reference values at high altitude Juan Manuel Lozano, Olga Rebeca Duque, Tatiana Buitrago, et al302 Narcolepsy M R Allsopp, Z Zaiwalla307 Postnatal encephaloclastic porencephaly-a new lesion? J H Cross, CJI Harrison, P R Preston, et al312 Effect of positioning on the breathing pattern of preterm infants Ruth Heimler,3Jeanne Langlois,.DanielJ Hodel, et al315 An indirect calorimetry system for ventilator dependent very low birthweight infants J S Forsyth, Anna Crighton320 Positive end expiratory pressure in acute and chronic respiratory distress A Greenough, V Chan, M F Hird324 Randomised trial of nutrition for preterm infants after discharge A Lucas, NJ Bishop, FJ King, et al328 Varicella zoster virus DNA in throat swabs of vaccines T Ozaki, H Miwata, Y Asano, et al330 Advantages ofworking in the developing world CJ C Williams

Commentary-DavidMorley332 Measuring compliance with inhaled medication in asthma J A P Coutts, NA Gibson,J Y Paton

Contemporary history334 A girl in my arms: a story of a paediatrician from Vukovar Branka Sipek

Types of psychiatric treatment336 (2) Individual psychotherapy J7udith Trowell

Personal practice340 Management of chronic constipation Graham S Clavden

Current topic345 The provision of safe surgery for children John D Atwell, PaulM Spargo350 Letters to the editor

353 Spring books

FETAL AND NEONATAL EDITIONNo 4 APRIL 1992 Original articles

357 Patterns of metabolic adaptation for preterm and term infants in the first neonatal week 7M Hawdon,M P Ward Platt, A Avnsley-Green

366 Pulmonary and systemic arterial pressure in hyaline membrane disease Jonathan R Skinner, RichardJ7 Boys,Stewart Hunter, et al

374 Central venous pressure in the ventilated neonate 7onathan R Skinner, David WA Milligan, Stewart Hunter, et al378 Phosphatidylcholine composition of endotracheal tube aspirates M R Ashton, A D Postle, M A Hall, et al



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383 Turnover of exogenous artificial surfactant M R Ashton, A D Postle, M A Hall, et al388 Plasma hypoxanthine: a marker for hypoxic-ischaemic induced periventricular leucomalacia? GA B Russell,

GJeffers, R W I Cooke393 Somatosensory evoked potentials and outcome in perinatal asphyxia NA Gibson, M Graham, M I Levene399 Blood leucocyte count in the human fetus NP Davies, A G S Buggins, RJ M Snijders, et al404 Fetal leucocyte count in rhesus disease N P Davies, A G S Buggins, R M Snijders, et al407 Plethysmographic validation of near infrared spectroscopic monitoring of cerebral blood volume

YA B D Wickramasinghe, L N Livera, S A Spencer, et al412 Postnatal evolution of slow variability in cerebral blood flow velocity Heather Coughtrey, 7anet M Rennie,

DavidH Evans416 Intravenous aminophylline and cerebral blood flow in preterm infants Maura McDonnell, NK Ives, P L Hope419 Upper airway patency during apnoea of prematurity CJ Upton, A D Milner, GM Stokes425 Caffeine or theophylline for neonatal apnoea? J EM Scanlon, K C Chin,ME I Morgan, et al429 Randomised trial of continuous nasogastric, bolus nasogastric, and transpyloric feeding in infants of birth weight

under 1400 g PD Macdonald, CH Skeoch, H Carse, et al432 Risk factors for necrotising enterocolitis: the influence of gestational age PhilipJ Beeby, Heather3Jeffery436 Capillary plasma elastase (xi-proteinase inhibitor in infected and non-infected neonates R L Rodwell, KM Taylor,

D I Tudehope, et al440 Breathing pattern abnormalities in full term asphyxiated newborn infants P Sasidharan443 Intracardiac thrombus formation with rapidly progressive heart failure in the neonate: treatment with tissue type

plasminogen activator B Van Overmeire, PJ Van Reempts, KJ Van Acker446 Respiratory timing in intubated neonates with respiratory distress syndrome M South, CJ Morley448 Intraventricular haemorrhage after aspiration of ventricular reservoirs N E Moghal,M W Quinn, M I Levene, et al

Perinatal biology450 Prenatal treatment with thyrotrophin releasing hormone to prevent neonatal respiratory distress Francis de Zegher,

Bernard Spitz, Hugh DevliegerRegular review

455 On the horizon: neonatal lung transplantation N ScottAdzickCurrent topics

458 Neonatal nurse practitioners-a view from perfidious Albion? M A Hall, S L Smith,J EJackson, et alCommentary-L O'Hagan

463 Vascular compromise in newborn infants D T GaultCommentary-M L Chiswick

Perinatal lessons from the past468 Scevole de Ste Marthe of France (1536-1623) and The Paedotrophia PM Dunn

470 Letters to the editor

No 4 APRIL 1992 Annotation473 Neonatal BCG immunisation Antonia Clarke, Peter Rudd

Original articles475 Immunogenicity and safety of PRP-T conjugate vaccine given according to the British accelerated immunisation

schedule R Booy, S A Taylor, S R M Dobson, et al479 Raised serum soluble interleukin-2 receptor concentrations in cystic fibrosis patients with and without evidence of lung

disease ElifDagli,'illA Warner, CR Besley, et al482 Respiratory status and allergy after bronchiolitis M Murray,M S C Webb, C O'Callaghan, et al488 Bronchial responsiveness in an area of air pollution resulting from wire reclamation J Y Wang, TR Hsiue, H I Chen491 Atopy, bronchial responsiveness, and symptoms in wheezy 3 year olds NicolaM Wilson, Stephen B Phagoo,

MichaelSilverman496 Enhanced allergic sensitisation related to parental smoking R Ronchetti, E Bonci, R Cutrera, et at501 Middle aortic syndrome: clinical and radiological findings A Sumboonnanonda, B L Robinson, WM W Gedroyc, et al506 Vesicoureteric reflux and renal scars in asymptomatic siblings of children with reflux RajkoB Kenda,JurijF Fettich509 Vulvovaginitis: causes and management AM Pierce, CA Hart513 Growth in patients with isolated gonadotrophin deficiency Z Dickerman, A Cohen, Z Laron517 Fetal haemoglobin and early manifestations of homozygous sickle cell disease K Bailey,J S Morris, P Thomas, et al521 Sinus histiocytosis with massive lymphadenopathy DavidK Stones, Charmaine Havenga524 T cell immunodeficiency in dyskeratosis congenita B W Lee, HK Yap, T C Quah, et al527 Anal abnormalities in childhood myotonic dystrophy-a possible source of confusion in child sexual abuse

W Reardon, HE Hughes, S H Green, et al529 Sonographic detection of the lead point in intussusception M D Stringer, S NJ Capps, S M Pablot530 Tuberculin skin reactivity four years after neonatal BCG vaccination L P Ormerod,J M Garnett531 Association of high fever and short bacterial excretion after salmonellosis A Sahib El-Radhi, Timo Rostila,

Timo Vesikari

Statistics from the inside533 5. Data structures MJ R Healy

Types of psychiatric treatment536 (3) Counselling parents in child behaviour therapy R McAuley

Practice abroad543 Paediatric illness in Hong Kong and Britain D P Davies

Personal practices550 Chronic fatigue syndrome: a joint paediatric-psychiatric approach Margaret I Vereker556 Human milk banking at Sorrento Maternity Hospital, Birmingham S E Balmer, B A Wharton

Current topic560 Paediatrics in the accident and emergency department BM Phillips, WJ Robson

Controversy-a review of a report565 Physical signs of sexual abuse in children Margaret A Lvnch567 Letters to the editor

No 5 MAY 1992 Annotations569 Diabetes in puberty D B Dunger571 'Personal child health records' held by parents Aidan Macfarlane572 Medulloblastoma Clifford C Bailev



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Original articles574 Profile of bronchial responsiveness in children with respiratory symptoms J B Clough,3t D Williams, S T Holgate580 Drug delivery from holding chambers with attached facemask Mark L Everard, Andrew R Clark, Anthony D Milner586 Drug delivery from jet nebulisers Mark L Everard, AndrewR Clark, AnthonyD Milner592 Role of infection in the middle lobe syndrome in asthma Chaim Springer, Avraham Avital, Natan Noviski, et al595 HIV-I infection and perinatal mortality in Zimbabwe C GA Aiken600 Deaths at home and in hospital in Zimbabwe B HM Wolf,MO Ikeogu603 Intensive enteral feeding in advanced cirrhosis: reversal of malnutrition without precipitation of hepatic

encephalopathy CPJ Charlton, E Buchanan, CE Holden, et al608 Using steatocrit to determine optimal fat content in modular feeds M 0 Rawashdeh, D R Lloyd, J WL Puntis, et al613 Electrogastrography in non-ulcer dyspepsia S Cucchiara, G Riezzo, R Minella, et al618 Gaviscon and Carobel compared with cisapride in gastro-oesophageal reflux P Greally, FJ Hampton,

UM MacFadyen, et al622 Should audio recordings of outpatient consultations be presented to patients? George Rylance625 Chloroquine in idiopathic pulmonary haemosiderosis Andrew Bush, MaryN Sheppard,J7 0 Warner628 Abnormal serum IgG subclass pattern in Down's syndrome G Anneren, C GM Magnusson, G Lilja, et al632 Height and body proportions in child abuse JKH Wales, SM Herber, L S Taitz636 Home blood pressure monitoring in diabetes Caroline Gompels, Denis Savage640 Incidence of normal micturition in myelomeningocele patients I Reiner, MJones, S Donnell, et al641 Treatment of refractory ulcerative oesophagitis with omeprazole A M Dalzell, J WSearle, M K Patrick

Types of psychiatric treatment643 (4) Change the family, change the child? Christopher Dare

Current topics649 Intravenous volume replacement: which fluid and why? Lucinda Huskisson654 The autonomic nervous system-a role in sudden infant death syndrome T G Matthews

Regular review657 Biological role of lactoferrin Lourdes Sanchez, Miguel Calvo, JeremyHBrock


No 6 JUNE 1992 Annotations669 Paediatric cochlear implantation Kevin P Gibbin671 Detection of minimal residual disease in leukaemia Fay E Katz673 Stressful life events and childhood illness IanM Goodyer

Original articles675 The Scottish low birthweight study: I. Survival, growth, neuromotor and sensory impairment The Scottish Low

Birthweight Study Group682 The Scottish low birthweight study: II. Language attainment, cognitive status, and behavioural problems The

Scottish Low Birthweight Study Group687 Impaired motor function (clumsiness) in 5 year old children: correlation with neonatal ultrasound scans

Makolm Levene, Sheila Dowling, Margaret Graham, et al691 Postdischarge formula consumption in infants born preterm A Lucas, F King, NB Bishop693 Computed tomography findings in partial seizures A M B Minford, WI Forsythe697 Difficult and unlikeable parents Roy Meadow703 Asthma, inhaled corticosteroid treatment, and growth Titus K Ninan, George Russell706 Mononuclear cells subsets and coronary artery lesions in Kawasaki disease Susumu Furukawa, Tomoyo Matsubara,

Keijiro Yabuta709 Tartrazine in atopic eczema J Devlin, TJ David712 Dysmorphic features in offspring of alcoholic mothers I Autti-Ramo, E Gaily, M-L Granstrom717 Frontoethmoidal meningoencephalocele: a common and severe congenital abnormality in South East Asia

ChristopherGM Richards720 Early diagnosis and management of 5 (x-reductase deficiency I Odame,M D C Donaldson, AM Wallace, et al724 Salivary IgA antigliadin antibody as a marker for coeliac disease V Hakeem, R Fifield, HF Al-Bayaty, et al728 Late diagnosis of cryptorchidism: a failure of medical screening? A Sarmah731 Family characteristics and insulin dependent diabetes M Alison Metcalfe, J David Baum737 IgG antibodies in early Pseudomonas aeruginosa infection in cystic fibrosis SM Cordon,3t S Elborn, RJ Rayner, et al

Controversy741 The value of proximal small intestinal biopsy in the differential diagnosis of chronic diarrhoea A G Thomas,

A D Phillips,JI A Walker-SmithCommentary-R A F Bell, H Marcovitch

Types of psychiatric treatment745 (5) Dealing with the courts and parenting breakdown Claire Sturge

Chalienges751 Child health and paediatric care in Spain: where are we going? Angel Ballabriga

Statistics from the inside757 6. Data structures (continued) M R Healy760 Letters to the editor

761 Book reviews763 Instructions to authors

Archivist 723, 740, 759, 764

FETAL AND NEONATAL EDITIONNo 7 JULY 1992 Annotations

765 Do we need an Apgar score? Neil Marlow767 Metabolic acidosis in newborn infants J HI Walter

Original articles770 Fetal abnormality: an audit of its recognition and management-Northern Regional Survey Steering Group775 Potential impact of population screening for prenatal diagnosis of congenital heart disease Seamus Cullen,

Gurleen K Sharland, Lindsey D Allan, et al779 Cytomegalovirus prevalence in pregnant women: the influence of parity Pat A Tookey, Anthony E Ades,

Catherine S Peckham



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784 Skin temperature and heart rate rhythms in infants of extreme prematurity S W D'Souza, S Tenreiro, D Minors, et al789 Prediction of impaired metabolic adaptation by antenatal Doppler studies in small for gestational age fetuses

J M Hawdon,M P Ward Platt, S McPhail, et al793 Superior mesenteric artery blood flow velocity in necrotising enterocolitis S T Kempley, HR Gamsu797 Development of cutaneous microflora in premature neonates N Keyworth,M R Millar, K T Holland802 Complement activation in neonatal infection M Peakman, G Senaldi, G Liossis, et al808 Receiver operating characteristic curves for comparison of serial neutrophil band forms and C reactive protein in

neonates at risk of infection GA B Russell, A Smyth, R WI Cooke813 Neutrophil chemotaxis and adhesion in preterm babies R Carr, D Pumford, JM Davies818 Serum erythropoietin concentrations of symptomatic infants during the anaemia of prematurity Jill Meyer,

Alan Sive, PeterJacobs822 UK experience in neonatal extracorporeal membrane oxygenation GA Pearson, DJ Field, RK Firmin, et al826 New aerosol delivery system for neonatal ventilator circuits Mark L Everard, Julie Stammers, John G Hardy, et al831 Episodic bradycardia in preterm infants C J Upton, A D Milner, GM Stokes835 Cerebrovascular carbon dioxide reactivity and failure of autoregulation in preterm infants Alan C Fenton,

Kent L Woods, DavidH Evans, et al840 Traumatic neonatal intracranial bleeding and stroke Paul Govaert, Piet Vanhaesabrouck, Claudine de Praeter846 Athetoid cerebral palsy with cysts in the putamen after hypoxic-ischaemic encephalopathy MA Rutherford,

J M Pennock, DM Murdoch-Eaton, et al851 Regional cerebral blood blow velocity changes after indomethacin infusion in preterm infants N C Austin,

P W Pairaudeau, TK Hames, et al855 Randomised trial of umbilical arterial catheter position: Doppler ultrasound findings S TKempley, HR Gamsu

Special reports860 Screening for retinopathy of prematurity Alistair R Fielder, Malcolm I Levene868 Report of working group of the British Association of Perinatal Medicine and Neonatal Nurses Association in

categories of babies requiring neonatal care

Personal practice870 Use of sedatives and muscle relaxants in newborn babies receiving mechanical ventilation Malcolm I Levene,

Michael W QuinnCurrent topic

874 Mineral transport across the placenta SM Husain,M Z MughalPersonal view

879 Putting the clock back 30 years: neonatal care since the 1991 NHS reforms Catherine Pope, David Wild

Perinatal lessons from the past882 Dr Thomas Denman of London (1733-1815): rupture of the membranes and management of the cord PM Dunn885 Letters to the editor

887 Book reviews

No 7 JULY 1992 Annotations889 Angelman's syndrome Jill Clayton-Smith891 Psychological treatments for childhood asthma Bryan Lask

Original articles892 Cryptorchidism: a prospective study of 7500 consecutive male births, 1984-8 John Radcliffe Hospital Cryptorchidism

Study Group900 Birth weight and hospital admission before the age of 2 years Lesley Mutch, Hazel Ashurst, Alison Macfarlane905 Suspected child abuse: cost in medical time and finance C L Summers, EM Molyneux

Commentary-CJ HobbsResponse from the authors

911 Screening of hearing impairment in the newborn using the auditory response cradle SM Tucker,J Bhattacharya920 Growth of infants with neonatal growth hormone deficiency JM Wit, H van Unen925 Sleep related upper airway obstruction and hypoxaemia in sickle cell disease Martin P Samuels, Valerie A Stebbens,

Sally C Davies, et al930 Sequelae of haemolytic uraemic syndrome A Schlieper, P C Rowe, E Orrbine, et al935 Randomised trial of a ready-to-feed compared with powdered formula A Lucas, S Lockton, Peter S W Davies940 Management and response to treatment of Helicobacterpylori gastritis MJ Mahony,J I Wyatt,JM Littlewood944 Transient hypothyroxinaemia associated with developmental delay in very preterm infants WouterJf Meijer,

S Pauline Verloove-Vanhorick, Ronald Brand, et al948 Positive rolandic sharp waves in the EEG of the premature newborn: a five year prospective study Stephane Marret,

Dominique Parain, EmmanuelJeannot, et al952 Occurrence of suppurative lymphadenitis after a change of BCG vaccine Paul Hengster,J_org Schnapka,

Manfred Fille, et al956 JC virus associated meningoencephalitis in an immunocompetent girl Kim Blake, Deenan Pillay,

Wendy Knowles, et al958 Necrobacillosis with pancytopenia M Epstein, A DJ Pearson, SJ Hudson, et al960 Protein S deficiency: early presentation and pulmonary hypertension J O'Sullivan, R Chatuverdi, M K Bennett, et al

Current topics962 Myelodysplastic syndromes Ian M Hann967 Children of parents in prison Dora Black

Types of psychiatric treatment971 (6) Psychiatric treatment for children-the organisation of services Fiona Subotsky

Regular review976 Recent progress in intestinal transplantation Celia Ingham Clark980 Letters to the editor

Archivist 899, 904, 910, 919, 924, 934, 975

No 8 AUGUST 1992 Annotations981 Current status of definitive surgery for congenital heart disease B Sethia983 The molecular basis of nephrogenesis and congenital kidney disease J'onathan Bard

Original articles985 Haemorrhagic shock encephalopathy syndrome in the British Isles CJ7 Bacon, S M Hall



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994 Optimum method for administration of biosynthetic human growth hormone R Stanhope, A Albanese, L Moyle, et al998 Plasma and cerebrospinal fluid arginine vasopressin in patients with and without fever PM Sharples,J R Seckl,

D Human, et al1003 Cord blood lymphocyte responses to food antigens for the prediction of allergic disorders Naomi Kondo,

Yuki Kobayashi, Shinji Shinoda, et al1008 Risk of developing atopic disease after early feeding with cows' milk based formula D Gustafssom, TLowhagen,

K Andersson1011 Newly diagnosed diabetes: a study of parental satisfaction D N Lessing, P G F Swift,MA Metcalfe, et al1014 Prevention of exercise induced asthma by inhaled salmeterol xinafoate C P Green,3J F Price1018 Genetic risk for asthma, allergic rhinitis, and atopic dermatitis Sigrid Dold, Matthias Wjst, Erika von Mutius, et al1023 Early immune responses to Dermatophagoides pteronyssinus and atopic predisposition R G G Ruiz, DM Kemeny,

F Mariani, et al1027 Breast feeding and oral rehydration at home during diarrhoea to prevent dehydration A S G Faruque,

D Mahalanabis, A Islam, et al1030 Reversible cerebral shrinkage in kwashiorkor: an MRI study Geney D Gunston, Dawn Burkimsher, HesterMalan, et al1033 Reversible mitochondrial myopathy with cytochrome c oxidase deficiency MattiK Salo, Juhani Rapola,

Hannu Somer, et al1036 Recurrent parotitis Herman A Cohen, Samuel Gross, Moshe Nussinovitch, et al1038 Solitary mastocytoma causing recurrent blistering in infancy Colin S Munro, PeterM Farr1039 Pituitary gigantism P W Lu, M Silink, I Johnston, et al

Challenges1042 Paediatric care in Hungary Dezso Schuler

Types of psychiatric treatment1046 (7) Paediatric liaison ShirleyA Leslie

Current topics1050 Cerebral palsy-an increasing contributor to severe mental retardation Amanda Nicholson, Eva Alberman1056 Guidelines for management of idiopathic thrombocytopenic purpura O B Eden, J S Lilleyman on behalfofthe British

Paediatric Haematology Group

1059 Letters to the editor1060 Book reviews

Archivist 997, 1002, 1045

No 9 SEPTEMBER 1992 1061 James Spence Medallist 1992

Annotations1063 The radiological dating of injuries S Chapman1065 Fungal skin infections R7Hay

Original articles1068 Paediatric outpatient utilisation in a district general hospital R MacFaul, R Long1073 Audit of screening for congenital hypothyroidism POD Pharoah, M P Madden1077 How much nebulised budesonide reaches infants and toddlers? K C Lodrup Carlsen, K Nikander, K-H Carlsen1080 What do parents know about vitamins? ML B Ko, N Ramsell,J A Wilson1082 Effect of taurine supplementation on fat and energy absorption in cystic fibrosis M De Curtis, F Santamaria,

P Ercolini, et al1086 The value of serum IgG titres against Pseudomonas aeruginosa in the management of early pseudomonal infection in

cystic fibrosis MM Brett, Ej Simmonds, A TM Ghoneim, et al1089 Management of hypertensive emergencies J E Deal, TM Barratt, MJ Dillon1093 Early thrombocytopenia in HIV infection RM Beattie,7 Q Trounce, E G Hermione, et al1095 Thymopentin treatment in severe atopic dermatitis-clinical and immunological evaluations Kue-Hsiung Hsieh,

Men-Fang Shaio, Tung-Nan Liao1103 Policies for control of communicable disease in day care centres A Chouillet, H Maguire, Z Kurtz1107 Endocrine deficit after fractionated total body irradiation A L Ogilvy-Stuart, DJ Clark, WHB Wallace, et al1111 Is hearing assessed after bacterial meningitis? HM Fortnum, D Hull1112 Toxic shock-like syndrome caused by adenovirus infection K Bojang, M D S Walters1114 Accidental ingestion of 'Ecstasy' (3,4-methylenedioxymethylamphetamine) A R Bedford Russell, R H Schwartz,

S Dawling

Controversy1116 Avoiding chemotherapy related late effects in children with curable tumours C Ross Pinkerton

Types of psychiatric treatment1120 (8) Inpatient psychiatry units Jonathan Green

Current topics1124 Liver transplantation Judith Chiyende, Alex P Mowat1128 Hearing impairment after bacterial meningitis: a review HM Fortnum


1136 Book reviews

Archivist 1072, 1102, 1119, 1127, 1133

FETAL AND NEONATAL EDITIONNo 10 OCTOBER 1992 Annotations

1137 Herpes simplex virus infection in pregnancy David McIntosh, David Isaacs1139 Kidney function in the very low birthweight infant j TBrocklebank

Original articles1140 Renal function in sick very low birthweight infants: 1. Glomerular filtration rate Barrv H Wilkins1146 Renal function in sick very low birthweight infants: 2. Urea and creatinine excretion Barry H Wilkins1154 Renal function in sick very low birthweight infants: 3. Sodium, potassium, and water excretion Barry H Wilkins1162 Renal function in sick very low birthweight infants: 4. Glucose excretion Barry H Wilkins1166 Simultaneous measurement of preductal and postductal oxygen saturation by pulse oximetry in hyaline membrane

disease PD Macdonald, V YH Yu1169 Effect of patency of the ductus arteriosus on blood pressure in very preterm infants Nick Evans,james Moorcraft1174 Annual audit of neonatal morbidity in preterm infants R W I Cooke



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1177 Prediction of neurodevelopmental outcome in the preterm infant: short latency cortical somatosensory evokedpotentials compared with cranial ultrasound L S de Vries, P Eken, V Pierrat, et al

1182 Membrane humidification-a new method for humidification of respiratory gases in ventilator treatment of neonatesL Hanssler, W Tennhoff, C Roll

1185 Randomised controlled trial of colloid infusions in hypotensive preterm infants EF Emery, A Greenough, HR Gamsu1189 Cardiac tumours in intrauterine life AlisonMM Groves, Nuala LKFagg, Andrew C Cook, et al1193 Changes in the plasma aminogram of parenterally fed infants treated with dexamethasone for bronchopulmonary

dysplasia P C Ng,KG Brownlee, EJ Kelly, et al11% Coagulation screening tests in high risk neonates: a prospective cohort study B K Schmidt, P Vegh, M Andrew, et al1198 Clinical application of urine antigen detection in early onset group B streptococcal disease E D G McIntosh,

HE Ieffrey1201 Recovery of intralipid from lumbar puncture after migration of saphenous vein catheter Felix Odaibo,

Carlos A Fajardo, Catherine Cronin1204 Meconium ileus in the absence of cystic fibrosis Khoulood Fakhoury, Peter R Durie, Henry Levison, et al1207 Validation of a portable indirect calorimetry system for measurement of energy expenditure in sick preterm infants

GJ Shortland, PJ Fleming,3tH Walter1212 Fatal perinatal nephropathy with onset in intrauterine life RJ Scot,M Rochefort1214 When will my baby go home? PeterJ Powell, Colin VE Powell, Sally Hollis, et al1217 Intermittent ductal patency in healthy newborn infants: demonstration by colour Doppler flow mapping MK Lim,

KHanretty, A B Houston, et al1219 Neonatal meningococcal conjunctivitis associated with meningococcal meningitis M Ellis, AM Weindling,

D C Davidson, et al

Special report1221 Development of audit measures and guidelines for good practice in the management of neonatal respiratory distress

syndrome-Report of a Joint Working Group of the British Association of Perinatal Medicine and the Research Unit ofthe Royal College of PhysiciansControversy

1228 Surfactant replacement therapy-time for thought G McClureCommentary-ColinJ Morley

Current topic1231 Diagnosis and management of inborn errors of metabolism-an update J E Wraith

Personal practices1233 Initial experience of screening for retinopathy of prematurity D I Clark, C O'Brien, AM Weindling, et al1237 The unreactive fetal heart rate 7 S Smoleniec, D KJames

Perinatal lessons from the past1242 Felix Wurtz of Basel (1518-75) and clubfeet PeterM Dunn


No 10 OCTOBER 1992 Annotations1245 Drug abuse in children and adolescents: an update Harith Swadi1247 Consent to treatment in childhood AlexanderMcCall Smith1248 Molluscum contagiosum Allan S Highet

Original articles1250 Effects of oral and intramuscular vitamin K prophylaxis on vitamin K, PIVKA-II, and clotting factors in breast fed

infants EA M Cornelissen, LA A Kollee, R A DeAbreu, etal1255 Oscillations of body temperature at night PJBrown, R A Dove, CS Tuffnell, etal1259 Factors affecting the development of night time temperature rhythms M R Lodemore, S A Petersen, M P Wailoo1262 Paediatric cardiac transplantation with steroid-sparing maintenance immunosuppression J Au,J W Gregory,

I W Colquhoun, et al1267 Intravenous immunoglobulin in HIV-I infected haemophilic patients N Wagner, R Bialek, H Radinger, et al1272 Gastrointestinal complications of gastrocystoplasty B D Gold, P S Bhoopalam, RM Reifen, et al1277 Prepubertal height velocity references over a wide age range B Rikken,JM Wit

Commentary-R Stanhope1281 Bone age, social deprivation, and single parent families TJ Cole, AJ L Cole1286 Centiles for adult head circumference KM DBushby, TCole,J NS Matthews, eta!1288 Immunisation status in inner London primary schools HE Bedford,3t I Masters, Z Kurtz1292 An audit of preschool vision screening J3ohn WAllen, Bratati Bose1294 Microfollicular thyroid adenoma and congenital goitrous hypothyroidism A J Alabbasy, L Delbridge, R Eckstein, et al12% Oral hairy leukoplakia in vertically and horizontally acquired HIV infection D Nadal, B de Roche,M Buisson, et al

Current topic1298 Building a combined child health service Margaret R S Barker, RJ Purvis

Types of psychiatric treatment1302 (9) Consultative work in child and adolescent psychiatry Derek Steinberg

Statistics from the inside1306 7. Regression and correlation MJ R Healv

Regular review1310 Recent advances in understanding muscular dystrophy KM D Bushby

Personal practice1313 Investigation of metabolic disorders resembling Reye's syndrome Anne Green, SusanM Hall1318 Letters to the editor

1320 Autumn books

Archivist 1276, 1285

Correction1324 Early thrombocytopenia in HIV infection Beattie et al

No 11 NOVEMBER 1992 Annotations1325 Silent gastro-oesophageal reflux: how much do we miss? I WBooth1327 Excitatory amino acid neurotoxicity-a broader horizon for cerebral protection? Robert C Tasker



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Original articles1330 Psychological effects of sodium valproate and carbamazepine in epilepsy G Stores, P L Williams, E Styles, et al1338 Diagnostic significance of "mTc-dimercaptosuccinic acid (DMSA) scintigraphy in urinary tract infection

BJrakobsson, S Soderlundh, UBerg1343 Foregut motor function in chronic renal failure AM Ravelli, S E Ledermnann, WM Bisset, et at1348 Ultrasonographic assessment of the extent of hepatic steatosis in severe malnutrition J F Doherty, EJ3 Adam,

GE Griffin, et al1353 Delayed surgery for congenital diaphragmatic hernia: neurodevelopmental outcome in later childhood

Mark Davenport, Elise Rivlin, S W D'Souza, et al1357 Adult height in constitutionally tall stature: accuracy of five different height prediction methods E Ejloss,

R Temperli, PE Mullis1363 Incidence of hepatic hamartomas in tuberous sclerosis SJ3dzwiak,M Pedich, P Rajszys, et al1366 Increased resting energy expenditure in childhood asthma: does this contribute towards growth failure? S R Zeitlin,

S Bond, S Wootton, et al1370 Defective alloantigen-presenting capacity of 'Langerhans cell histiocytosis cells' Raymond CH Yu,Jenny F Morris,

Jon Pritchard, et al1373 Interleukin-2 in relation to T cell subpopulations in rheumatic heart disease MagdyM Zedan, Farha A El-Shennauy,

HelmyM Abou-Bakr, et al1376 Bronchoscopy in lipoid pneumonia M Kameswaran, S HAnnobil, B Benjamin, etal1378 Causes of death in children diagnosed with non-Hodgkin's lymphoma between 1974 and 1985 CM Robertson,

CA Stiller,J E Kingston1384 Antiphospholipid antibody associated thrombosis in juvenile chronic arthritis Roberto Caropali, Angelo Ravelli,

Barbara Ramengli, et al1385 Severe anaemia and ileocolic anastomotic ulceration A H Hamilton, JM Beck, GM Wilson, etal

Personal practice1387 Intercurrent illness in inborn errors of intermediary metabolism Marijorie A Dixon,J V Leonard

Types of psychiatric treatment1392 (10) Treatment of delinquents CarolSheldrick

Current topics1398 Should we use dexamethasone in meningitis? The Meningitis Working Party ofthe British Paediatric Immunology and

Infectious Diseases Group1402 African children in Britain Anne Nesbitt, MargaretA Lynch

Chalienges1406 Challenges for child health in Australia R Kim Oates1410 Letters to the editor1415 Book reviews

Archivist 1337, 1352, 1401

No 12 DECEMBER 1992 Annotations1417 The place of computed tomography and lumbar puncture in suspected bacterial meningitis DavidH Mellor1420 Sleep problems Gregory Stores1421 Routine discharge examination of babies-is it necessary? PH T Cartlidge

Original articles1423 Do maternal and intrauterine factors influence blood pressure in childhood? PH Whincup, D G Cook, 0 Papacosta1430 Management and outcome of severe head injuries in the Trent region 1985-90 A C Elias-J3ones,J A G Punt,

A E Turnbull, et al1436 Long term effects of periconceptional multivitamin supplements for prevention of neural tube defects: a seven to

10 year follow up Monica Holmes-Siedle, Jennifer Dennis, R H Lindenbaum, eta!1442 A randomised trial of low dose folic acid to prevent neural tube defects PeadarN Kirke, Leslie E Daly,

J Harold Elwoodfor the Irish Vitamin Study Group1447 Immunohistochemical features of the portal tract mononuclear cell infiltrate in chronic aggressive hepatitis

Giorgio Senaldi, Bernard Portmann, AlexP Mowat, et al1454 Bronchial responsiveness and lung function in infants with lower respiratory tract illness over the first six months of

life Jane R Clarke, Amanda Reese, Michael Silverman1459 Association of perinatal events, epilepsy, and central nervous system trauma with juvenile delinquency

Paula Rantakallio, Markku Koiranen, Jyrki Mottonen1462 Urinary protein/creatinine index in follow up of patients with Wilms' tumour after nephrectomy C Mpofu,J R Mann1467 Teachers' perceptions of epilepsy M J Bannon, C Wildig, P WJones1472 Growth hormone deficiency during puberty reduces adult bone mineral density S L Hyer, D A Rodin,

JH Tobias, et al1475 Hazards of parenteral treatment: do particles count? J WL Puntis, KM Wilkins, PA Ball, et al1478 Sinusitis-induced subdural empyema Ruth Skelton, Wirginia Maixner, David Isaacs1481 Familial pancreatic enzyme insufficiency G Owen, P WBuss, H RJenkins, etal1483 Thrombolysis with low dose tissue plasminogen activator E Doyle, J Britto,J Freeman, etal1484 Fatal encephalitis/encephalopathy in primary human herpesvirus-6 infection YAsano, T Yoshikawa, YKajita, et al1486 Recovery of protein from urine specimens collected in cotton wool G C Smith, CM Taylor

Types of psychiatric treatment1488 (11) Drug treatment Michael Prendergast

Statistics from the inside1495 8. Size, power, and confidence MJ3 R Healv

Current topics1498 The ethics of cardiopulmonary resuscitation. I. Background to decision making J M Davies, BM Reynolds1502 The ethics of cardiopulmonary resuscitation. II. Medical logistics and the potential for good response 7M Davies,

BM Reynolds1506 Suitability of the paediatric setting for hospitalised adolescents M L Gillies, W Ll Parry-Jones

151015171519

1521

Personal practiceFactitious illness: recognition and management DM Eminson, RJ PostlethwaiteReferees and staffLetters to the editorIndexArchivist 1441, 1446



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