Atropa BelladonnaAtropa Belladonnaand and

ScopolamineScopolamineMichelle PryceMichelle Pryce

Chemistry 211Chemistry 211

13 June 200813 June 2008

Atropa belladonna Scopolamine is derived

from the Atropa belladonna plant.

This plant is commonly known as the “Deadly Nightshade”.

The plant is a perennial herbaceous plant that can grow to over 5m in height.

Atropa Belladonna The leaves are dull,

but shiny green. They are similar in texture to poison ivy.

It produces purple, bell-shaped flowers.

The flowers then produce shiny black, sweet berries.

Atropa Belladonna Atropa belladonna also goes

by the following other names: dwale, banewort, devil's cherries, naughty man's cherries, divale, black cherry, devil's herb, great morel, and dwayberry.

The plant is native to Central and Southern Europe, North Africa, and Southwest Asia, it and has been successfully cultivated in North and South America as well as parts of Russia.

It is considered one of the deadliest plant in the Western Hemisphere.

Toxicity of Atropa Belladonna

Atropa belladonna is one of the most toxic plants found on Earth.

Children have been poisoned by eating as few as three berries.

Ingestion of a leaf of the A. belladonna can be fatal to an adult.

The root of the plant is generally the most toxic part of the plant. Belladonna leaves, if handled carelessly, can cause pus filled blisters on the hands.

Symptoms of A. belladonna poisoning include dilated pupils and blurred vision.

Also included are husky voice, hallucinations, loss of balance, a feeling of flight, staggering, a sense of suffocation, paleness followed by a red rash, flushing, extremely dry throat, constipation, tachycardia, urinary retention, and confusion.

Historic Uses of A. belladonna

Belladonna is Italian for ‘beautiful lady’ and was used cosmetically for hundreds of years.

Belladonna was used by women in order to dilate the pupils.

This produced a dreamy, intoxicated state that was considered the epitome of beauty at one time.

However, repeated use caused fuzzy vision and eventually blindness.

Medicinal uses of A. belladonna

Atropine— Used in ACLS protocol for

symptomatic bradycardia. Used to reverse effects of

nerve agent in chemical poisoning.

Used to treat organo-phosphate poisoning.

Used by ophthalmologists for pupil dilation in eye exams.

Scopolamine— Used to treat nausea and

vomiting. Used to treat motion

sickness and vertigo. Used to treat IBS,

enterocolitis, and duodenal ulcers to stop intestinal spasms.

Used in cold/flu medicines to help dry up excess mucus

Folklore and historical references

Some of the first anesthetics, dating back to the days of Pliny the Elder (1st century AD), were derived from the Atropa family of plants.

“Witches’ Brew” A tea made from the leaves of the plant produce hallucinations

in which the drinker thinks he thinks he is flying.

Devil’s Cherries According to folklore, the devil has exclusive right to use the

plant in any form. Anyone who uses the plant without the devil’s permission will be

visited and killed by the devil.

Historical references In Homer’s Odyssey, Circe’s

transformation of Odysseus’ fellows into pigs is attributed to hallucinations caused by A. belladonna.

Belladonna is the plant that poisoned the troops of Marcus Antonius during the Parthian wars.

According to the History of Scotland (1582), Macbeth poisoned an entire army with a drink containing an infusion of belladonna and alcohol.

Juliet of Romeo and Juliet took an infusion of belladonna to produce her death-like sleep.

Mentioned in Little Women as a sleeping aid.

Mentioned in the movies The Nightmare Before Christmas, Perfect Stranger, Robocop 2, and Practical Magic as ways to sedate or kill a nemesis and in the TV shows CSI and House as a way to commit criminal activities.

Scopolamine The name Scopolamine is

derived from Dr. J A Scopoli, a chemist, naturalist, and instructor of chemistry and metallurgy, who isolated some beneficial properties of A. belladonna while working in Slovenia in the 1750’s and 1760’s.

Dr. Scopoli was also a physician who was assigned to treat miners in the mines of Slovenia.

He was trying to isolate a cure for mercury poisoning when he isolated the derivative of scopolamine.

He did not find a cure form mercury poisoning, however, scopolamine is a very useful drug.

Today, it is used medicinally for treatment of motion sickness, gastrointestinal cramping, and recovery from anesthesia and surgery.

Other uses of scopolamine 1940’-1960’s- used by obstetrics in combination

with morphine a to produce a tranquilized ‘twilight sleep’ for mothers in labor.

Used in 1950’s by CIA and others in Project MKULTA, as an interrogation drug.

Used in 1950’s and 60 in Asthmador, a drug to treat asthma and bronchitis.

Used up to 1990 as OTC sleep aid. Used today illegally as date rape drug in

Colombia and Thailand.