Beginning of the chapterHeart health and genetics

(Cardiovascular Sensor)

39

SENSORS

CARDIOVASCULAR SENSOR

Cholesterol/TriglyceridesHomocysteineArteriosclerosisSudden cardiac arrest

SENSORS

CARDIOVASCULAR SENSOR

Predisposition to: Predisposition to:

1)1)High LDL cholesterol High LDL cholesterol

2)2)Low HDL cholesterol Low HDL cholesterol

1)1) Effect of omega-3 on HDL cholesterol Effect of omega-3 on HDL cholesterol

3)3)High triglyceridesHigh triglycerides

4)4)High homocysteine High homocysteine

1)1) Vitamin B2 positively effects the Vitamin B2 positively effects the

homocysteine levels homocysteine levels

5)5)Prolongation of the QT intervals Prolongation of the QT intervals

6)6)Effect of 26 drugsEffect of 26 drugs

22 genetic variations

CARDIOVASCULAR DISEASES

CARDIOVASCULAR DISEASES

Gene examples

CARDIOVASCULAR DISEASES

Gene examples

CARDIOVASCULAR DISEASES

Gene examples

CARDIOVASCULAR DISEASES

Gene examples

CARDIOVASCULAR DISEASES

Gene examples

CARDIOVASCULAR DISEASES

Gene examples

CARDIOVASCULAR DISEASES

Gene examples

CARDIOVASCULAR DISEASES

Genetic predisposition

SENSORS

CARDIOVASCULAR SENSOR

Cardiovascular disease

1) Prevention1) Prevention

2) Early detection2) Early detection

3) Better treatment3) Better treatment

CARDIOVASCULAR DISEASES

Counselling example

PreventionPreventionRegular exercisesRegular exercises

Do not smoke!Do not smoke!

As little alcohol as possibleAs little alcohol as possible

Low-fat dietLow-fat diet

Less animal, more plant foodsLess animal, more plant foods

Use vegetable oilsUse vegetable oils

Omega3 fish oil capsules have a negative impact on your cholesterolOmega3 fish oil capsules have a negative impact on your cholesterol

Early detectionEarly detectionRegular medical blood testsRegular medical blood tests

Submit to a Resting ECG examination before taking QT altering Submit to a Resting ECG examination before taking QT altering

medicationmedication

CARDIOVASCULAR DISEASES

High risk, what to do now?

Early detectionEarly detectionRegular medical blood testsRegular medical blood tests

Regular QT interval testsRegular QT interval tests

Measure the electrolyte level when performing extreme Measure the electrolyte level when performing extreme

sportssports

SENSORS

CARDIOVASCULAR SENSOR

Cardiovascular disease

1) Prevention1) Prevention

2) Early detection2) Early detection

3) Better treatment3) Better treatment

PHARMACOGENETICS

Various drugs and enzymes

DRUG D

3A42C192E9NAT2

DRUG C

2D6

DRUG B

2C9

DRUG A

1A2

break down

CARDIOVASCULAR DISEASES

Optimal medication

CARDIOVASCULAR DISEASES

Optimal medication

SENSORS

CARDIOVASCULAR SENSOR

Cardiovascular disease

1) Prevention1) Prevention

2) Early detection2) Early detection

3) Better treatment3) Better treatment

End of the chapterHeart health and genetics

(Cardiovascular Sensor)

39