Bioinformatics

Xin-Yi Chua

Peter Ansell, Chris Bowles,

Lawrence Buckingham, James M. Hogan,

Scott Mann, Paul Roe,

Jiro Sumitomo, Jan M. Weinert

www.mquter.qut.edu.au/bio

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Bioinformatics

Another Genomic Revolution

Bio 2.0: Navigate and Share the graph

Bringing ‘GIS’ to Comparative Genomics

Future Directions

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Bioinformatics

An explosion in genomic data

The rise of population genomics & proteomics

Alignment does not scale to the new BioScience

Comparative genomics

Gene regulation

Protein characterisation

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BLASTBLAST

3e-56

5e-56

9e -45

9.9

…

Results “Hits”

Reference gene

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Example ClustalW alignment

mammalian sulfatases: first 110 residues of the catalytic domain

Bioinformatics

We allow scientists to visualise the graphMake the topology fit the question

Visualisation is navigation

Let the graph answer the question Refine and test hypotheses

And then make the answer available Peer communities & link-based publication

Sharing the vision…

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Bioinformatics

The new ‘GIS’ – Genomic Information System

All about distances and what works for the user

Linking to data sources via Bio2RDF

Combining a collection of data sources together

Exploiting tags and ontologies

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SilverMap Blast component

Bio2RDF Bio2RDFBio2RDF

BlastDBBlastDB

TagsTags

TRN

Protein-protein interactions

User defined distance measures

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Bioinformatics

Future applicationsSupport user defined distances

Transcriptional Regulatory Network analyses

Protein-Protein interactions

Bringing our tools to the communityMaking SilverMap the lingua franca of genomic publication

The lab wiki and public web site

Integration, tagging and sharing of views

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