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DNA replication: Molecular mechanism indicates novel routes to block uncontrolled cell division&New mechanism for neurodegeneration found
Biology foldingProfessor: Lina María Martinez Ana María Ortiz GilIII Semester – MedicineUniversidad Pontificia Bolivariana2014
IntroductionIntroduction Over the years many
experiments have been executed in order to find the exact point where the process of duplicating the genetic material is regulated so they can have an initial point to start developing different ways to stop it.
These two studies reveal new discovering in the genetic field that will first, help us understand the importance of molecular researching nowadays; and second, let the world know that, by doing this experiments, science is everyday closer to the answers that the medical world is needing.
DNA replication: Molecular mechanism indicates novel routes to block uncontrolled cell division
In this study a group of scientists from MRC Clinical Sciences Centre perfom an experiment where, being based in previous theories, they revealed where does a crucial enzyme of the replication start processing the DNA helix..
DNA replication: Molecular mechanism indicates novel routes to block uncontrolled cell division
For a cell to divide it is necessary that the genetic material is duplicated so the
resulting cell has the same information as the
previous one. The process of dividing needs to have
specific machinery composed by proteins
and leaded by the helicase.
DNA replication: Molecular mechanism indicates novel routes to block uncontrolled cell division
The helicase captures the DNA into its ring
structure, unfolds and separates it so the next proteins can work on the
duplication process. Although this had been
perfectly known, the exact way it worked had
remained a mystery.
DNA replication: Molecular mechanism indicates novel routes to block uncontrolled cell division
By using sophisticated technology the research exposed the pinpoint of the helicase work.
Since it is a gated system, there’s a specific gate where the DNA enters the enzyme; the point is located between the connection of MCM2-5 and it’s in there where we could talk about a main check-point of the process that if it could be regulated the cancer cell growth would be inhibited.
DNA replication: Molecular mechanism indicates novel routes to block uncontrolled cell division
In my opinion, one of the most remarkable facts about this article is that they show how the cooperation between different studies is what allows the real success of a scientific process. And that is exemplified in this research where they accomplish the final objective of a long investigation.
New mechanism for neurodegeneration found
All the cells in the human body need proteins to develop any metabolic process they need to
survive. Even the protein production system itself is composed by a mechanism leaded by enzymes (which
are also proteins) that translate the genetic
material into new different proteins to be used in multiple processes.
New mechanism for neurodegeneration found
This group of scientists found, by experimenting
with sick mice, that neurodegeneration can be caused by a mutation in a gene that encodes one of
the most important proteins for the translation process in the neurological
system; the tRNA. The mutation impairs the protein production in
neurons.
New mechanism for neurodegeneration found
Besides revealing the mutation on the tRNA’s
gene, they found also that another defect is
necessary for neurodegeneration to
appear and proteins are also involved. In this case the neurological disease
requires another protein to be missing; the GTPBP2.
New mechanism for neurodegeneration found
Even if the study could accomplish the objective
of learning how the disease is caused in mice;
the same process in higher organisms as humans is harder to
understand since tRNAs are much more diverse
and there are more genes that could codify for the
enzyme.
New mechanism for neurodegeneration found
In my opinion, even if the study was not directly done
in humans; learning the pathophysiology of
determined diseases in simpler organisms
represents the foundations for future studies that aim to
get every time closer to human solutions.
DNA replication: Molecular mechanism indicates novel routes to block uncontrolled cell division
Since cancer is nowadays one of the main causes of morbimortality, this discovering is crutial in the long way to find a
real cure for the disease, which would certainly be
one of the greatest aacomplishments in
medical history.
DNA replication: Molecular mechanism indicates novel routes to block uncontrolled cell division
Showing the medical and scientific world the
importance of learning the molecular systems of
determined diseases, can encourage more scientists to keep on
working together to find new treatments and
cures.
New mechanism for neurodegeneration found
The study of neurological diseases has a huge medical utility since those
conditions are attacking giant
populations all over the world.
New mechanism for neurodegeneration found
As it’s been said before, neurodegeneration is
possibly the main cause of most of the neurological diseases that are being diagnosed nowadays.
That’s why the developing of these researches has an
inmense utility, since they’re everytime closer to
find a cure.
REFERENCESREFERENCES[http://www.sciencedaily.com/
releases/2014/07/140731200952.htm] Checked : August 4th 2014. “DNA replication: Molecular mechanism indicates novel routes to block uncontrolled cell division”
[http://www.sciencedaily.com/releases/2014/07/140724144251.htm] Checked: August 8th 2014. “New mechanism for degeneration found”