Biomedical Engineering ProgramOpening Session Rob Murphy, MD

Professor of Medicine and Biomedical Engineering

Director, Center for Global Health

Northwestern University

Chicago, USA

2Framework Programs for Global Health Innovation

Developing Innovative Interdisciplinary Biomedical Engineering Programs in Africa1. Partners

a. Northwestern University. Among the top five biomedical engineering programs in the United States with very strong presence in South Africa with goal to expand to East and West Africa.

b. University of Cape Town. Top ranked university in Africa with one of the oldest biomedical engineering programs (developed CT scanner). Partner of Northwestern for 8 years with joint training program.

c. University of Ibadan. Biomedical Engineering Program just starting and one of the key training sites in the new consortium.

d. University of Lagos. Biomedical Engineering Program in place for over one year and one of the key training sites in the new consortium.

e. Nigerian Institute for Medical Research. Para-statal institute focused on medical research including HIV and Tuberculosis

3Biomedical Engineering Program: Key Personnel: Leadership

1.Robert Murphy, MD• Principal Investigator and Professor of

Medicine and Biomedical Engineering, Director – Center for Global Health, Northwestern University

2.Matthew Glucksberg, PhD• Co-Program Director, Professor of Biomedical

Engineering and Director - Center for Innovation in Global Health Technologies (CIGHT), Northwestern University

3.Tania Douglas, PhD• Professor of Biomedical Engineering and

Director – Medical Imaging Research Unit, Site Program Director, University of Cape Town

4Biomedical Engineering Program: Key Personnel: Leadership

3. Adewale Coker, PhD• Professor of Environmental Health

Engineering, Director of the Biomedical Engineering Program, Site Program Director, University of Ibadan

4. Niyi Osuntoki, PhD• Senior Lecturer and Acting Head, Department

of Biomedical Engineering and Site Program Director, University of Lagos

5Biomedical Engineering Program: Key Personnel

Northwestern University• Kara Palamountain, MBA – Executive Director, Global Health

Initiative, Kellogg School of Management • David Kelso, PhD – Clinical Professor and founding Director, Center

for Innovation in Global Health Technologies

• Chad Achenbach, MD, MPH – Assistant Professor of Medicine and Biomedical Engineer

• Ellen Chadwick, MD – Professor of Pediatrics, Associate Director of Pediatric and Maternal HIV Infection

• Daniel Diermeier, PhD – Professor of Regulation and Competitive Practice, Director Ford Center for Global Citizenship

• Shannon Galvin, MD – Assistant Professor of Medicine and Associate Director, Center for Global Health

6Biomedical Engineering Program: Key PersonnelNorthwestern University

• Jamie Nicole Jones, MBA, PhD – Clinicial Assistant Professor of Entrepreneurial Practice and Director of Social Entrepreneurship

• Josh Leonard, PhD, - Assistant Professor of Chemical and Biologic Engineering, Co-Director Graduate Cluster in Biotechnology

• Robert Linsenmeier, PhD – Professor of Biomedical Engineering, Neurobiology and Ophthalmology, Associate Director for the VanNTH Engineering Research Center in Biomedical Educational Technologies

• Alicia Loffler, PhD, - Associate Vice President for Research and Executive Director, Innovation and New Venture Office (INVO)

• Babafemi Taiwo, MBBS – Associate Professor of Medicine and Director of Research in Africa

• Keith Tyo, PhD – Assistant Professor of Chemical and Biologic Engineering and Co-Director, Recombinant Protein Production Core

7Biomedical Engineering Program: Key Personnel

University of Cape Town

• Jonathan Blackburn, DPhil – South African Research Chair in Applied & Chemical Sciences and founder of Sense Proteomic and the Centre for Proteomic & Genomic Research (RSA)

• Willem Hanekom, MB, ChB – Professor and Director, South African

Tuberculosis Vaccine Initiative

• Lucy Linley, MBChB– Neonatologist, Head of Department Neonatology, Mowbray Hospital

• Mladen Poluta, – Senior Lecturer and Convener, Healthcare Technology Management Program

8Biomedical Engineering Program: Key Personnel

University of Ibadan

• Isaac Adewale, MD – Professor and Vice Chancellor, Co-Principal Investigator for Medical Education Partnership Initiative Nigeria and APIN PEPFAR Program.

• David Olaleye, MB, ChB – Professor of Virology and Principal Investigator for Medical Education Partnership Initiative

University of Lagos

• Sade Ogunsola, MB ChB, PhD– Professor of Medical Microbiology and Provost, College of Medicine, Chairman of the WHO Working Group on Infection Prevention and Control curriculum

9Biomedical Engineering Program: Key Personnel

Nigerian Institute for Medical Research

• Oni Idigbe, PhD – Adjunct Professor of Medicine (Northwestern) and Director of Research and former Director General

• Innocent Ujah, MBBS, ChB – Professor of Obstetrics and Gynaecology (Jos) and Director General

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Frameworks BME Program

1.Frameworks Biomedical Engineering GrantThe theme of our program involves the development of effective, affordable, and easy to use innovative biomedical devices that can advance diagnostic and treatment approaches that result in improved survival. Our cross-disciplinary approach involves three key areas of research which only together can lead to improved health and survival: 1) biomedical engineering, 2) medical evaluation, and 3) commercialization. This interdisciplinary training program will provide LMIC faculty and students with a unique comprehensive hands-on learning experience focused on developing innovative global health technologies.

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2. Frameworks AimsAIM 1: Establish new and enhance existing training

programs in biomedical engineering in sub-Saharan Africa. Through a combination of classroom, distance learning and field work, faculty and post-graduate students will be trained in identification and development of healthcare technologies appropriate for their local and regional settings.

AIM 2: Train biomedical engineers and medical doctors to evaluate newly developed testing and therapeutic devices. Trainees from our partner institutions focused on clinical research have already received valuable training through the existing MEPI and AITRP programs, however research projects utilizing their newly acquired skills have been limited. Selected trainees with biomedical and behavioral science backgrounds in adult and pediatric medicine will receive hands-on mentoring directed towards evaluating the newly developed technologies in AIM 1.

AIM 3: Train post graduates from business schools to scale up development and launch new healthcare products. Post-graduates in business will be instructed and mentored in defining the most appropriate medical technologies needed in their countries along with the tools needed to approve, finance, procure, distribute, use and maintain these medical technologies.

Frameworks BME Program

122. Frameworks Research Plan

Frameworks BME Program

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Planned eLearning Activities

2. Frameworks Distance Learning Components

1: Business Global Health Course. This will be a 10 week course, recorded via Articulate, of Professor Kara Palamountain at the Kellogg School of Management. The course will be put on-line, non-synchronous, and will be offered by CD. Following completion, students will be eligible for field work opportunities.

2: Polycom leadership/executive committee meetings. Key personnel from the partner institutions will meet bimonthly to discuss progress of trainees and development of products and its status.

3: Product presentation and training. Group presentations will be made by product development teams using Articulate or other video format.

4: Presentations of other courses. Live streaming, synchronous and asynchronous can be done for a variety of courses in intellectual property, contract negotiations, patent application procedures among others.

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Current Solution: Commercial Heating

PadUS Standard: Bair Hugger

Need | Pediatric Surgery Infant Warmer: US Standard and Current Solution

Proposed Solution: JoeyKare

Cost US$ 12,000 + $300/usage

US$30 US$300

Pro Effective; safe; approved Provides heat; inexpensive Effective regulated heat; safe; no disposables; battery backup; commercial potential

Con Expensive; highly electric dependent

No safety control; unregulated heat; requires electric

More expensive than pad

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Our Solution | JoeyKare

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Key Features

Temperature AdjustabilityTemperature MonitoringUser FeedbackAlarm System Multiple Fail SafesRobust Printed Circuit BoardQuick Set-Up TimeEfficient Heat ProductionEasy MaintenanceLow Cost

Device Temperature:27ºC

Device Temperature Risen Too High

Set Temperature:33ºC

Maintenance Check Required

Low Battery

17Background: Anal

Muscle Stimulator• Imperforate anus or high anal atresia occurs in 1:600

to 1:5000 births

• Treatment is surgical: Posterior sagittal anorectalplasty (PSARP) or pull-through anorectal reconstruction

• Complications can be debilitating, including fecal incontinence

• Identification of perianal musculature is critical in order to most effectively place the new anus

• The Pena Stimulator is effective, however it is very expensive – US$12,000 and generally not available in resource-limited settings

MS Nerve Stimulator

DS7A PSARP MuscleLocating ElectricStimulator

Device Layout

MS Nerve Stimulator Test

Thank you! 21

Questions? Interest?Specific ideas?