Embed Size (px)
Citation preview
BME Alliance Holds StudentDesign ChallengeMore than 500 undergrads participate in project as part of the Virtual Summer InternshipFull story pg 4
Case-Coulter TranslationalResearch Partnership Awards$1.1M in funding and support forpromising biomedical engineeringuniversity technologies.pg 7
A Visionary LeaderAs a forerunner in neuromodulation, HunterPeckham advocated interdisciplinarycollaboration and clinical research.pg 10
A Dynamic DuoAn engineer and nursecollaborate in the classroomand on research projects.pg 16
F a l l 2 0 2 0 | B i o m e d i c a l E n g i n e e r i n g
Also in this issue:
EXPLORE
Department of Biomedical Engineeringat Case Western Reserve University10900 Euclid Ave. | Cleveland, Ohio 44106-7207
[email protected] | P: (216)-368-4063 | F: (216)-368-4969
bme.case.edu
Biomedical Engineering at Case Western Reserve University
O c t o b e r 2 0 2 0F a l l 2 0 2 0 | B i o m e d i c a l E n g i n e e r i n g
BME Alliance Holds StudentDesign Challenge
4
A Visionary Leader: Profile ofHunter Peckham
10
Student Spotlight2
A Dynamic Duo: A Nurse andEngineer Collaborate
16
Grad Student OrganizationForms to SupportUnderrepresented Minorities
20
2020 Case-Coulter TranslationalResearch Partnership Awards
7
Faculty Highlights22
Faculty Directory25
CASE WESTERN RESERVEUNIVERSITY DEPARTMENT OF
BIOMEDICAL ENGINEERINGRANKED IN THE TOP 5
Letter from the Chairs1
@RKirschCWRU@DGeoffreyVince
geographically distributed across the U.S. and theworld. We were heartened by the response theinternship received and humbled by the opportunityto serve and educate the next generation ofbiomedical engineers.
In the midst of the pandemic, we continue to attracttop-notch talent to the BME Alliance. In August,renowned pain expert Carl Saab joined ClevelandClinic and the BME Alliance, with the goal of creatinga pain center. Michael Moffitt, a prominent medicaldevice developer from industry and an expert in painand movement disorders likewise joined CWRU andthe BME Alliance.
This newsletter describes some of the manyaccomplishments of our faculty, staff, students andalumni. For example, Hunter Peckham transitionedto Emeritus Professor and received the PritzkerAward from the Biomedical Engineering Society.Mark Griswold was elected a fellow of theInternational Academy of Medical and BiologicalEngineering (IAMBE). Anirban Sen Gupta, ColinDrummond, Anant Madabhushi and ShaninaKnighton received major grants and honors. TheCase-Coulter Translational Research Partnershipcontinues to be highly successful in assisting facultyin turning their discoveries into products. Ourstudents also received coveted awards andrecognition. Read on for more details!
As we close out this most unusual of years, we areproud of the work our researchers are doing and ofthe way our administrative team has continued toprovide excellent service. And, we look forward tocontinued growth and success of the BME Alliancebetween our two institutions!
FROM THE CHAIRSWelcome to our fall 2020 newsletter! It hascertainly been an interesting time since our spring edition, as we have evolved our culture and approaches in response to major public health and societal events. This evolution has included a significantly expanded approach to ensuringdiversity and fairness across all of our activities.For example, we have established a BME Diversity Committee, supported the graduate student-initiated Underrepresented Minorities inBiomedical Engineering group and appointed an Associate Chair for Diversity as part of an initiativeof the national BME Council of Chairs. Thisevolution has also included significant adaptationsof our teaching and research approaches inresponse to the COVID-19 pandemic.
Our educational activities have adopted carefully designed remote course delivery methods for the most part, with some in-person activities.Research activities have proceeded without interruption, albeit with some adjustments to maintain safety. Like many of you, we have allbecome experts in using online virtual meetings,using secure digital signatures and getting to know new students and colleagues before we even meet them in person!
The BME Alliance not only carried on, it went above and beyond. For example, we offered a Virtual Summer Internship that attracted more than 500 students from 50+ universities around the world. These interns benefited from presentations and discussions with many Cleveland Clinic and Case Western Reserve University faculty (including a roundtable with the two of us!) and competed in a design contest between teams with members
Robert F. KirschAllen H. and Constance T. Ford ProfessorChair of Biomedical EngineeringCase Western Reserve University
Geoffrey VinceThe Virginia Lois Kennedy EndowedChair in Biomedical Engineering andApplied TherapeuticsLerner Research InstituteCleveland Clinic
1
Daniel Shao, Junior, Systems Biology(BS), Computer Science (BA), Biology(Min), has been working onbioinformatics projects in the Centerfor Computational Imaging andPersonalized Diagnostics (CCIPD),including building a machine learningclassifier to predict patient survivalfrom breast tumor images.
Evan Vesper, Junior, ElectricalEngineering (BSE), BiomedicalEngineering (BSE), French (Min), hasbeen volunteering in the MotionStudy Lab at the Louis StokesCleveland VA Medical Center's APTCenter. Evan has also received one ofthe APT Center's highly competitiveWen Ko Summer Internships.
Established by Congress in 1986, the Barry GoldwaterScholarship and Excellence in Education Program isdesigned to attract outstanding students into careersin mathematics, the natural sciences and engineering.From a pool of 1,343 undergraduates nominated by461 institutions, the Goldwater Scholarship Foundationawarded 396 scholarships this year. Each institution isallotted four nominees, and this year two students inthe Department of Biomedical Engineering at CaseWestern Reserve University received the scholarship.
Student Spotlight
Goldwater Scholarship Top 10%
A paper by Ahmad Algohary, anewly minted PhD from the Centerfor Computational Imaging andPersonalized Diagnostics, is amongthe top 10% most downloadedpapers in the Journal of MagneticResonance Imaging (JMRI) in thepast 12 months.
"Radiomic features on MRI enablerisk categorization of prostatecancer patients on activesurveillance: Preliminary findings"
Algohary is mentored by AnantMadabhushi, Donnell InstituteProfessor of Biomedical Engineeringand Director of CCIPD.
MostDownloadedPapers in JMRI
2
23 undergraduate students were awarded Support of Undergraduate Research & CreativeEndeavors (SOURCE) Summer Research Funding. Each student received a scholarship to enhancetheir summer research experience at Case Western Reserve University. Congratulations to TanayAkolkar, Katelin Amann, Ketan Jolly, Henrik Hahamyan, Justin Kim, Hoa Le, Liam Matthews,Sargam Panpaliya, Yuliang (Bill) Ding, Lindsey Druschel, Luna Al Lababidi, Varoon Aluri, JosephJaster, Nikhil Madugula, Gabrielle McBroom, Avani Muchhala, Ananya Sahu, Vishal Senthilkumar,David Yo, Nora (Ningjing) Zhang, Xuetong Zhou and Evan Vesper.
Neptune Kidney Consortium AwardCatherine Jayapandian, SeniorResearch Associate in CCIPD, hasbeen awarded a one-year $57,500Career Enhancement Award from theNeptune Kidney Consortium for herproject entitled "Computational
ACM SIGHPC Computational & DataScience Fellowship
Pranjal Vaidya, graduate student inCCIPD, has been awarded the verycompetitive Association forComputing Machinery's SpecialInterest Group on High PerformanceComputing (ACM SIGHPC)
Nathaniel Braman, a newly mintedPhD advised by CCIPD DirectorAnant Madabhushi, has receivedthe 2020 Doctoral ExcellenceAward for Biomedical Engineeringfrom the School of Medicine.
2020 Doctoral Excellence Award
Braman's work focused on the development of newmeasurement and analysis techniques to extractinformation about a tumor and tumor environmentto determine the best treatment strategy forcancers of the breast and lung. On April 17, 2020,he defended his PhD dissertation entitled "NovelRadiomics and Deep Learning ApproachesTargeting the Tumor Environment to PredictResponse to Chemotherapy.”
SOURCE Summer Research Funding
Xin Li received the StrokeNetClinical Research and TrainingAward for 2020-2021. Li is apostdoctoral fellow in the lab ofEla Plow at Cleveland ClinicLerner Research Institute.
2020-2021 StrokeNet ClinicalResearch and Training Award
Beginning December 4, some of these projects can be viewed at SOURCE Virtual Intersections
Pathology-based Prognostic Predictor of Outcomefor FSGS." Jayapandian will be co-mentored byCCIPD Director Anant Madabhushi, and John Sedor, anephrologist in the Glickman Urological & KidneyInstitute at Cleveland Clinic.
Computational & Data Science Fellowship. Theaward includes $15,000 to support Vaidya towardthe completion of her PhD. Vaidya is mentored byCCIPD Director Anant Madabhushi.
Crain's Cleveland “Twenty in their 20s”Haojia Li, graduate student in CCIPD,was recognized in June as one ofCrain's 2020 "Twenty in their 20's" forher work in assessing theaggressiveness of breast cancer andthe most appropriate treatment by
analyzing tissue using deep learning, machinelearning and imaging processing. Li is mentored byCCIPD Director Anant Madabhushi.
3
If you want to encourage compliance withmask wearing on university campuses tohelp curb the spread of the coronavirus,who better to offer pioneering solutionsthan the students themselves? In August,125 teams of engineering students sharedshort video pitches of solutions theycreated during a student design challengedeveloped by the Biomedical EngineeringAlliance between Case Western ReserveUniversity and Cleveland Clinic as part ofits 2020 Virtual Summer Internship.
500+STUDENTS
BME Alliance Holds StudentDesign ChallengeMore than 500 undergrads participate in project aspart of the Virtual Summer Internship
50+UNIVERSITIES
4
students work through the design process, he ledweekly one-hour live seminars on all facets ofengineering design, from brainstorming andassessing user needs to creating a businessmodel and testing prototypes.
Williams also counseled many of the teams, eachof which included three to five students, as theyworked on solutions. These included physicalmasks, as well as innovations such as a rapidmask sterilizing system and interactive, web-based training courses to help studentsunderstand the role that masks play in stoppingthe spread of COVID-19 and what they can do tofacilitate mask wearing on campus.
Participants in the Virtual Summer Internshipwere energized by working on the summer-longdesign challenge. “It was very exciting to work ona project that has a direct application to thecurrent crisis in our world, where we are able tosee the potential benefits and positive outcomesour product could provide,” says Alexis Porco, afourth-year biomedical engineering student atthe University of Virginia.
Approximately 500 engineering undergrads fromtop universities around the world participated inthe 10-week Virtual Summer Internship, whichculminated in a small group-based designchallenge to develop, design and test a solutionto address the need for enhanced use ofpersonal protective equipment (PPE) –particularly on college campuses – to helpmitigate the coronavirus pandemic.
Posted on YouTube, the video pitches wereviewed nearly 60,000 times during a two-weekspan in August. The winning design, selectedbecause it received the most “likes,” was createdby students from Brazil, Peru and the UnitedStates. Jake Thomas, Astrid Puma Alvites, GiuliaHerszage Rocha and Sophia Hall designed theJ.A.G.S. Unforgettable Mask made from twolayers of 100% cotton material with a pocket inthe middle for a filter. The team aimed to tackletwo main problems with mask wearing –comfort and convenience – with its design. Thetriangular shape at the top and bottom lifts themask off the mouth, while providing a tight sealaround the chin and bridge of the nose.
The team aimed totackle two mainproblems with maskwearing – comfortand convenience.
Fostering Curiosity and Creativity“The mask-oriented project is both personal andtopical for students,” says Matthew Williams, anassistant professor of biomedical engineering atCase Western Reserve University whospearheaded the design challenge. “I was ratherimpressed by the thinking, overall curiosity andcreativity expressed by the students.” To help
Filling a Gap During a Disrupted SummerThe design challenge was just one component ofthe Virtual Summer Internship. The program alsofeatured live one-hour online sessions ledseveral times a week by professors, researchers,professional staff, entrepreneurs and others on ahost of topics related to biomedical engineeringcareers, research and technology.
5
Faculty from the Biomedical Engineering Allianceconceived of the program in late spring when itbecame apparent that the COVID-19 pandemicwas going to derail summer plans for mostuniversity students. “We were getting contactedregularly by BME students who had lost theirsummer internships and were looking for someway to replace them,” says Steve Fening,associate professor of biomedical engineering atCase Western Reserve University and director ofthe Case-Coulter Translational ResearchPartnership. “We sought to provide a non-traditional academic experience for students – notexactly like an internship in a company, butdifferent than a typical classroom.”
Fening spearheaded the Virtual SummerInternship alongside Robin Crotty, departmentmanager and supervisor of BME education in theBiomedical Engineering Department of ClevelandClinic’s Lerner Research Institute. “The bread andbutter of the BME Alliance are students. They arethe tie that binds us,” says Crotty. “We knew thesestudents had great summer opportunities lined upthat, through no fault of their own, weren’thappening anymore. To help these studentsachieve something this summer was so importantto us.”
this,” says Moton. “It definitely taught me bettercommunication skills, with both faculty andstudents around my age.”
Moton adds that the 35 online presentations“were so helpful for any student.” One well-received session was presented by Bolu Ajiboye,associate professor of biomedical engineering atCase Western Reserve University. Ajiboye sharedhis work as an investigator with the Cleveland FESCenter on implantable technology that restoreslimb movement to paralyzed patients, which wasfeatured in a documentary entitled I AM HUMANnow streaming on several venues.
“I was really blown away by the technology shownin that documentary and the possibilities forimplantable devices in the brain,” says AbigailHalsdorfer, an undergraduate mechanicalengineering major at Case Western ReserveUniversity who joined the live chat. “I found theethical questions regarding these devices verysignificant, and I think it is important for me toremember the ethical responsibility I have goingforward with whatever I ‘engineer.’”
It’s too soon to tell what impact, if any, the designchallenge solutions will have on the campuses ofparticipants in the 2020 Virtual SummerInternship. However, it’s clear that the program –likely a one-off event to fill a void in theseunprecedented times – made a significantimpression on students who joined in.
“The faculty at Case Western Reserve were sohelpful and had a genuine excitement for theprogram,” says Porco. “They offered great advicein a time when students needed it most. We aretruly grateful!”
Opening the Minds of Future Engineers
One of those students was Kelly Moton, abiomedical engineering major at Case WesternReserve whose internship in orthotics andprosthetics at the Walter Reed National MilitaryMedical Center was canceled. She served ascoordinator for the Virtual Summer Internship,organizing speakers, introducing online sessionsand interacting with students. “I learned a lotabout what really goes into running a program like
FIRST PLACE: J.A.G.S. Unforgettable Mask | 3,174 views | 911 likes
SECOND PLACE: The Perfect DIY COVID Mask | 4,407 views | 840 likes
THIRD PLACE: BamboGuard | 4,399 views | 835 likes
6
The Case-Coulter Translational Research Partnership, whichhelps to commercialize projects by clinicians and biomedicalengineering faculty that improve human health and well-being, has awarded more than $1.1 million in financial backingand other support for the most recent round of funding.
CASE-COULTERTRANSLATIONAL RESEARCH
PARTNERSHIP AWARDS
$1.1 MILLION IN FUNDING AND SUPPORT FOR PROMISINGBIOMEDICAL ENGINEERING UNIVERSITY TECHNOLOGIES
For more information, please visit bme.case.edu/cctrp.
7
10-liter Scale Production of BG34-200Immunotherapeutic Under cGMP Guidelines
A significant fraction of patients with solid tumorcancers in metastatic and advanced settings do notrespond to immunotherapies due to a lack of T-cell-inflamed tumor microenvironment. Thisbotanical-derived non-toxic BG34-200 moleculecan be intravenously injected to modulatemacrophages and create a tumormicroenvironment that is vital for the generation ofantitumor T-cell responses. The team is launching aclinical trial targeting canine metastaticosteosarcoma (OS) to collect key and gap data inpreparation for a first-in-human clinical trialtargeting pediatric and AYA OS.
Mei Zhang, Alex Huang
Drug-free Targeted Prostate Cancer Treatmentwith TNT - Targeted Nanobubble Therapy
Drug-free, low toxicity prostate cancer treatmentusing nanobubbles (NB) are targeted to theprostate specific membrane antigen (PSMA)biomarker overexpressed on prostate tumor cells.The nanobubbles are injected into thebloodstream and specifically seek out only thecancer cells. Once inside the target cell, the NBsremain trapped and can be excited with anultrasound pulse. Exposure to ultrasound resultsin collapse of the NB, leading to a highly focusedmechanical disruption of the cancer cells and celldeath. The approach, called TNT – targetednanobubble therapy - can fit into the existingclinical workflow and can be carried out withstandard clinical ultrasound equipment. TNT cantreat tumors without severe side effects, as it willbe effective only when NBs are sonicated and willdestroy only the cancer cells and not thesurrounding healthy cells.
Agata Exner, Lee Ponsky
TraumaChek: A Field-deployable DielectricCoagulometer for Comprehensive Assessmentof Trauma-induced Coagulopathy
TraumaChek® is a miniaturized, multichannel,portable, handheld blood coagulation analyzer forearly, rapid and comprehensive assessment oftrauma-induced coagulopathy to guide hemorrhagecontrol, transfusion and resuscitative managementof trauma at the point-of-injury by first respondersand at the point-of-care by hospital clinicians.
Anirban Sen Gupta, Sanjay Ahuja
8
Minimally Invasive Interfascicular Nerve Stimulation(MiiNS) System for Chronic Pain Management
This is a drug-free technology to provide targeted,comfortable, worry-free relief to people suffering from long-term pain. The discomfort and emotional stress from painaffects a person’s activity, sleep and ability to live a healthylife, leading to other serious health problems. The MinimallyInvasive Interfascicular Nerve Stimulation (MiiNS) technologyprovides a targeted, personally customized and comfortabletreatment without side effects, addiction or surgicalprocedures. MiiNS can be implanted by a doctor during asimple office visit to provide long-lasting pain relief.
Dustin Tyler, Jennifer Sweet
BAFF CAR-NK Cells for Therapyof B Cell Malignancies
BAFF CAR- NK cells can specificallykill B cell cancers in a very effectivemanner with minimum side effects.This is a potential curativetherapeutic strategy to addresspatients who are not responding tothe current treatment methods.
Reshmi Parameswaran, Pallavi Tiwari
PhotoSorb: Safe and Long-lasting Sunscreen
Every year, more than one million new cases ofskin cancer, including melanoma, arediagnosed in the United States. The primarycause is exposure to ultraviolet radiation (UV)from sunlight. Sunscreens can block UV, butincreasing concerns about the health andenvironmental risks of chemical sunscreensnow on the market underscores an urgentneed for safer, more effective alternatives. Ateam from biomedical engineering anddermatology at Cleveland Clinic is developing anovel sunscreen (PhotoSorb) that appears tobe safer and more stable than currentsunscreens, and also has the potential toactually prevent skin cancers.
Vijay Krishna, Edward Maytin
9
For nearly 50 years, Hunter Peckham has been a pioneer in thefield of rehabilitation engineering. He developed the firstcommercially-available neuroprosthesis for people with spinalcord injury (SCI) and has received 11 patents for functional neuralstimulation systems and neural prostheses. However, Peckham’strue gift as an innovator may not be his technical prowess, butrather his work as a bridge builder among people.
A Visionary LeaderAs a forerunner in neuromodulation, Hunter Peckham advocatedinterdisciplinary collaboration and clinical research.
Hunter Peckham,(middle) and JimJatich (right),circa 1986
10
“Hunter believes in people and the necessity of connectingpeople – especially those in disparate fields – to changethe world for the betterment of all humanity by innovatingand translating innovations into clinical practice andstandard of care,” says John Chae, MD, Vice President ofResearch and Sponsored Programs for the MetroHealthSystem and Co-Director of the MetroHealth RehabilitationInstitute alongside Peckham.
During his career, Peckham has collaborated with countlesspeople, from engineers and physicians to students andentrepreneurs. Working together, they transformed thefield of biomedical engineering and functional electricalstimulation. Although Peckham retired from Case WesternReserve University on June 30, 2020, his legacy lives on.
“Hunter invented the words, concepts and technology –and made clinical translation possible – by buildingcompanies, partnerships and collaborations acrossacademic, institutional and departmental lines,” saysMichael Keith, MD, an orthopaedic surgeon at MetroHealth.“He was the ambassador-at-large for engineering.”
Embedding a Lab within a Hospital
When Peckham was an undergraduate student inengineering at Clarkson College of Technology in the mid-1960s, biomedical engineering wasn’t a formal discipline.While studying mechanical engineering, he read a journalarticle that caught his attention. “It was about the Starr-Edwards aortic valve, one of the first artificial heart valvereplacements,” recalls Peckham. “I thought, ‘Wow! You canactually makes things that go into the body.’ That was aneye-opener.”
After earning his bachelor’s degree, Peckham began lookingfor educational institutions where he could receive trainingon medical devices such as valve replacements. “Case wasone of the few options,” he says. “Shortly after I arrived, theDepartment of Biomedical Engineering was created. I wasone of the first ‘test pilots’ of BME.” Peckham earned hismaster’s degree in mechanical engineering from the CaseInstitute of Technology in 1968 and his doctorate degree inbiomedical engineering in 1972 from Case WesternReserve University.
"He was theambassador-at-large forengineering"- Michael Keith
Orthopaedic surgeon atMetroHealth System
"Hunter believes inpeople and thenecessity ofconnecting people –especially those indisparate fields – tochange the worldfor the bettermentof all humanity."
- John ChaeVice President of Researchand Sponsored Programs forthe MetroHealth System andCo-Director of theMetroHealth RehabilitationInstitute
11
As a doctoral student, Peckham began research atHighland View Hospital that shaped the remainderof his career. In class, he was studying how tochange the properties of muscles by stimulatingthem, and he wondered if the technology could beused to help people with SCI. The rehabilitationhospital east of Cleveland, which later wasintegrated with MetroHealth, had a program tohelp SCI patients gain greater independence andfunctionality. With funding from a few smallgrants, Peckham set up a lab within the hospital.
“I was an anomaly at the hospital. At the time,people thought, ‘What’s an engineer doing on theunit?’” says Peckham. “The arrangement was amystery to many people, but the lab wasaccessible to people being treated for SCI andtheir nurses, doctors and therapists.”
Peckham teamed with clinicians and patientsfrom day one. Among those he worked with wasAlvin A. Freehafer, MD, a pioneer in tendontransfer surgery to restore partial function toparalyzed hands and arms. Peckham often joinedDr. Freehafer in the operating room. Theengineer’s research on mapping muscle propertieshelped the physician fine tune his surgicaltechniques and produce better patient outcomes.One of the biggest coups for Peckham’s programwas landing an award from the NIH’s NationalInstitute of Neurological Disorders and Stroke in1972.
Freehafer later introduced Peckham to Dr. Keith,and the two began collaborating in 1979 onfunctional electrical stimulation (FES) – theapplication of electrical currents to the nervoussystem to generate activity in paralyzed limbs. “Iprovided the problems to be solved, and Huntercreated new electronic devices that could beimplanted. He innovated new, safe ways ofanimating paralyzed muscles,” says Keith, whodeveloped surgical techniques to implant thedevices and influenced their design.
The work on implantable devices with Dr. Keithmarked a pivotal shift. “There is a big differencebetween studying how muscles move in response
Creating the FES Center
Peckham focused his research onneuromodulation for upper extremities,specifically the hand. With support from theDepartment of Veterans Affairs, the NIH, the Foodand Drug Administration and numerouscolleagues, Peckham developed the FREEHANDsystem. The neuroprosthesis sends electricalsignals to muscles in the hand, causing it to openand close. In 1986, the eight-electrode device wasimplanted in the first patient, Jim Jatich (below),who sustained a cervical-level spine injury fromdiving into a pool nearly a decade prior. Thesystem functioned well for 27 years until Jatich’sdeath in 2013.
to stimulation and creating a device that enables aperson to have function as a result of that,” saysPeckham. “I gravitated toward clinical researchwith human subjects that nobody else in theworld was doing.”
12
“To create a working device for someone like Jimand see how it changed his life – see him pick upthings – was tremendous,” says Peckham. ButJatich was more than just a clinical subject toPeckham. “He befriended Jim, and together theyshared knowledge,” says Keith. “Their relationshipinfluenced other practitioners to commit theircareers to persons with spinal cord injury."
Researchers and physicians who workedalongside Peckham in the 1970s and 1980s atHighland View Hospital moved to other facilities,such as the Louis Stokes Cleveland VA MedicalCenter. While Peckham focused on upperextremities, others concentrated on lowerextremities. Innovators in the field remained inclose contact, yet separate groups adopteddifferent approaches to their work. Then Peckhamhad an “aha” moment to create a center devotedto neuromodulation.
“We needed to consolidate efforts to build abetter environment with more cohesiveness inthe engineering development approach,” saysPeckham. The Cleveland FES Center was foundedin 1991 with three institutional partners: CaseWestern Reserve University, the Louis StokesCleveland VA Medical Center and MetroHealthMedical Center. Later, University Hospitals andthe Cleveland Clinic Neurological Institute joinedthe consortium. Peckham served as executivedirector of the center for more than 20 years.
Dedicated to introducing functional electricalstimulation into clinical practice, the FES Centerhas garnered national attention and attractedtop-notch researchers. Many of themsubsequently obtained faculty positions inbiomedical engineering at Case Western Reserve
Focusing on Technology Transfer
With a strong team in place at the FES Center,the researchers began attracting the attention oforganizations striving to commercialize cutting-edge technology. Between 2003 and 2010,Peckham was the principal investigator ongrants from the state of Ohio’s Biomedical andResearch Technology Transfer (BRTT) programand Biomedical Research and CommercializationProgram (BRCP). In 2013, he landed $3 million infunding from the Ohio Third Frontier program tocommercialize neuromodulation andneurostimulation technology platforms.
“At the time, it was hard getting money to dotranslational work. You had to be headstrong –and sort of crazy – like me,” recalls Peckham.“Getting that money from the state allowed thefaculty [at Case Western Reserve University] towork on things that were more translational.”Based upon the BRTT, the Department ofBiomedical Engineering received funding fromthe Coulter Foundation to support the Case-Coulter Translational Research Partnership(CCTRP) to advance biomedical products to themarketplace.
“At the time, it was hard getting money to do translationalwork. You had to be headstrong – and sort of crazy – like me."
- Hunter Peckham
University, including Robert Kirsch, current Chairof the Department of Biomedical Engineeringand Executive Director of the FES Center.
“The whole core of the neural engineering groupat Case is based on the kind of recruitment wewere able to do at the FES Center,”acknowledges Peckham. “That has had a long-lasting impact on the BME Department. Neuralengineering is a strength of the department.”
13
This was not Peckham’s first foray intocommercialization. In 1993, he foundedNeuroControl Corporation, which brought twoFood and Drug Administration-approvedproducts for people with SCI to market – theFREEHAND system and a bladder controlsystem. “In order to get technology to people,we needed to have a company partner with uson commercialization,” says Peckham.
NeuroControl raised $30 million in startupfunding from venture capitalists, andapproximately 300 people worldwide wereimplanted with the FREEHAND system. But in2002, the company folded. “Clinically, theproduct was changing lives for patients everyday. We proved we could do this,” says Peckham.“But we also proved the startup business modelwas wrong.”
Despite the company failing, Peckham says itvalidated the value of the technology, which inturn led to the grants from the state of Ohio andthe CCTRP. And he was not willing to give up oncommercialization. “If the startup model waswrong and no big company was going tocommercialize the product, then what modelwould work?” questioned Peckham. “That’s whenwe came up with the idea for a non-profit instituteoperating within the university.”
In 2013, Peckham launched the Institute forFunctional Restoration (IFR) at Case WesternReserve University. “The idea was to create anincubator model that would move this technologyfurther along the translational spectrum andreduce risks for a commercial partner with parallelinterests,” says Peckham. In 2018, the IFRreceived the Gold Electrode Award from NeurotechReports for being the most valuable nonprofit.
14
Although Peckham has retired as a professor from Case Western ReserveUniversity, he is not stepping away from his life’s work. He continues toserve as co-director of the MetroHealth Rehabilitation Institute and theInstitute for Functional Restoration. “I still have a tremendous commitmentto people with spinal cord injury and getting these neuromodulationsystems out,” he says.
Through the years, Peckham has collected numerous accoladesacknowledging his body of work. He received a Lifetime Achievement Awardfrom the North American Neuromodulation Society earlier this year and thesame award from the American Spinal Injury Association in 2015. He waselected to the National Academy of Engineering and is a fellow of theNational Academy of Inventors and the International Academy of Medicaland Biomedical Engineering.
Peckham has worn many hats: engineer, scientist, inventor, professor andentrepreneur. The list goes on. “I never had just one job. As my interestschanged and my skills developed, Case gave me the opportunity to do manydifferent things,” he says. “I tell young faculty that they can do virtuallyanything at Case Western Reserve University if they take the initiative.”
Hunter Peckham serves as an exemplar of just how far initiative can takeyou – and the tremendous impact it can have on the world.
Writing the Next Chapter in Neuromodulation
15
A Dynamic DuoAn engineer and nurse collaborate in the classroom and on research projects.
Graduate students at Case Western Reserve Universitywho enroll in the BioDesign course to learn aboutmedical device innovations are co-taught by twoexperts: Colin Drummond, a professor and assistantchair of the Department of Biomedical Engineering, andShanina Knighton, PhD, RN, an instructor and KL2Scholar with a primary appointment in the FrancesPayne Bolton School of Nursing. At first glance, it mayseem odd that a nurse teaches an engineering courseabout inventing and implementing new medical devicesand instruments. But one of the main purposes of theclass is to examine how innovations can address unmetclinical needs – something that Knighton became quitefamiliar with as a bedside nurse.
“Shanina and I come from two different places, and wearrive at BioDesign to teach together,” says Drummond.“Shanina has experience working on the frontlines inhealthcare, so she can provide feedback andperspective that really enriches the classroom.”
(Left) Shanina Knighton,PhD, RN, an instructorand KL2 Scholar with aprimary appointment inthe Frances Payne BoltonSchool of Nursing
(Below) Colin Drummond,a professor and assistantchair of the Departmentof Biomedical Engineering
16
Knighton has been teaching BioDesign alongsideDrummond since 2016 as an adjunct facultymember and is the first nurse to have anappointment in the Case School of Engineering.It’s a natural fit for the nurse, who is a problem-solver with research interests in infection controland the use of technology for self-managementof elderly and disabled patients. She came toCase Western Reserve University in 2013 for herdoctorate degree in nursing to pursue thoseinterests and further develop her idea for a novelpatient hand-cleaning system.
“I was attracted to Case because the university isfocused on innovation,” says Knighton. “FormerDean Mary Kerr told me about an awesomeengineer named Colin Drummond, who had anappointment in nursing at the time, who couldhelp push forward entrepreneurial endeavors.”She and Drummond hit it off right away, and forthe past seven years they have collaborated on amultitude of fronts, from research projects toinstructing and mentoring students.
A Commitment to PatientHand HygieneKnighton’s first interaction with Drummond wasas a student in the BioDesign course she nowco-instructs. She was the only nurse in a class ofmostly engineering and medical students.Knighton thrived in the course, which includedlots of interactive, hands-on projects. It alsofeatured a pitch competition to investors, whereKnighton presented the patient hand-cleaningsystem that ultimately became the focus of herdissertation research.
Knighton’s interest in patient hand hygienebegan as a clinical nurse on a pre/post-surgicalcare unit, where she worked for seven years.Informed by infection prevention theories fromtwo influential nurse pioneers – FlorenceNightingale and Virginia Henderson – Knightonrecognized gaps in knowledge surroundingpatient self-management of hand hygiene. She
proposed using verbal electronic audio reminders,in conjunction with a patient hand hygienebundle, to increase independent hand hygienepractices in older adults in acute care settings.
Impressed with the pitch, Drummond suggestedthat Knighton submit her business plan to theGalen/Brien Holder-Vision Graduate SchoolBusiness Plan Competition held by the School ofEngineering. She did so and won third place.
Drummond shared news of Knighton’s winningentry with leaders of the Frances Payne BoltonSchool of Nursing. “That really put me on theradar with the nursing school, getting recognitionfor something beyond being a nurse,” recallsKnighton. “From there on out, things took off. Idid more pitch competitions and collaboratedmore with Colin.”
Research Expands intoNew AreasThe crux of Knighton’s research for herdissertation – creating an easier way for patientsto clean their hands – escalated into broaderwork in design, development and evaluation oftechnology-based interventions that shecontinues today as a KL2 Scholar. Funded by theClinical and Translational Science Collaborative(CTSC), KL2 Scholars are trained and mentored toconduct team-based, multidisciplinary, patient-oriented clinical research. It aligns perfectly withKnighton’s mission.
A quick glance at just a few of the projectsKnighton has worked on recently with Drummondreveals her commitment to multidisciplinarywork. Between 2018 and 2019, she served as co-principal investigator on an Industrial Internet ofThings grant from the Institute for Smart, Secureand Connected Systems (ISSACS) at CaseWestern Reserve University to establish aninfrastructure to engage older adults as partnersto determine their unmet needs and simplifycare. Drummond was a collaborator on the grant.
17
pandemic, and something from the 1800s isbecoming news,” she says. “People should cleantheir hands!”
Drummond applauds Knighton’s efforts ininfection control. “Shanina has been on a decade-long journey about hand hygiene,” he says. “Sheknows it’s the right thing , and she has showngreat resiliency in finding funding sources thatsupport her strategy, not subordinating tosomebody else’s strategy.”
They both assert that the work is not simplyabout hand hygiene, but about its place within alarger context. Older patients may be afraid orunable to get up and clean their hands. Not onlycan that cause infection, but it can also contributeto immobility, which in turn can lead tofrustration, depression, further inactivity, muscleatrophy and risk of falls. “Western medicineencourages us to focus on one piece of theproblem, but not within the context of the biggerpicture,” says Knighton.
Understanding the big picture – the systemsview – makes the collaboration betweenKnighton and Drummond crucial. As a nurse, shehas invaluable clinical insight and day-to-dayexperience using many products designed bybiomedical engineers. Drummond “knows themarket and has the eye of an engineer,” she says.
Understanding the ‘SystemsView’ of Medicine
Earlier this year, Knighton and Drummondwrapped up work on a CTSC Pilot Award to createa virtual assistant system to enhance patient self-medication outcomes. Drummond was theprincipal investigator and Knighton the co-principal investigator. “My role on the team was tohelp develop patient and nurse clinical needs forvoice algorithms to detect medication use andpotential adverse medication interactions,” saysKnighton.
One of her latest endeavors is a multidisciplinaryproject including biomedical engineers, electricalengineers and physicians to develop a wearablesensor for COVID-19. When used in tandem withpredictive platforms, users of wearable devicescould be alerted when changes in theirphysiological metrics match those associated withCOVID-19 symptoms. A review of the work, whichis spearheaded by Dhruv Seshardi, a doctoralcandidate in bioelectronics and data analytics atCase Western Reserve University, was publishedin June in Frontiers in Digital Health.
Drummond and Knightonduring a working sessionfor the CTSC Pilot Award tocreate a virtual assistantsystem to enhance patientself-medication outcomes.
Knighton’s body of work, particularly in relation tothe importance of hand hygiene, has provedtimely this year. “We are in the middle of a
18
But Drummond isn’t your average biomedicalengineer. Prior to joining the BME Department in2015, he had a short stint in Case WesternReserve University’s School of Nursing becauseof his expertise in informatics. “That year hadsuch a profound impact on me,” he says. “I endedup really understanding the nursing perspective.”Afterward, he enrolled in continuing educationnursing classes that led to frontline clinical work,underscoring the practical relevance of hisresearch activity.
Drummond’s respect for nursing stems from histheory on care versus cure. “A lot of mybiomedical engineering colleagues are working oncures for illnesses, diseases and medicalconditions,” he says. “My bias on the translationalside is to focus on patient care, and that’s whatbrought me to nursing.”
Knighton praises Drummond’s patient-centeredfocus. “When you talk to Colin, it’s not like talkingto a regular engineer who wants to solve aproblem,” she says. “He brings a more humanizedapproach. He thinks about the patient.”
that are needed for care than physicians, so it’snatural for nurses to have innovative ideas.”
To help ensure that future biomedical engineersunderstand the valuable input nurses canprovide, Knighton has mentored more than threedozen students, many in the department’s SeniorDesign class. As a KL2 Scholar, she says her goalis to “create an engineering/nursing pedagogy bytaking the biomedical underpinnings and applyingthem to nursing in a practical manner.”
Knighton’s work on the hand hygiene system forolder adults demonstrates the validity of thisframework. In May, she received a UL1 PilotAward from NIH’s National Center for AdvancingTranslational Sciences to further develop thesystem. “We hope to have a viable prototypesometime this winter to start trialing insideclinical settings,” she says.
Drummond and Knighton exemplify thequintessential relationship betweeninterdisciplinary professionals. Spend an hourwith the two researchers, and it’s easy to seewhy they’ve successfully teamed up on so manyprojects. The passionate conversation movesseamlessly from details about current research tobig picture thinking about the healthcarelandscape. But it all boils down to one objective –improving patient care.
“The engineer wants to make sure devicesfunction and have all the necessary bells andwhistles. The nurse wants to know how they fitinto her workflow and facilitate patient care,”says Knighton. “We are all trying to solve thesame problem, and sometimes viewing the issuethrough a different lens allows us to createinnovative solutions.”
Nurse/Engineer PartnershipsMake SenseDrummond acknowledges the importance ofpartnering with physicians on solutions such asdiagnostic tools and therapeutics. But for hisprojects, focused on the care continuum, teamingwith nurses like Knighton is crucial. “Nurses comeup with the patient care plan for the day, providethe ongoing care and educate the patient,” hesays. “The nurse is closer to many of the tools
Many people have contributed to Shanina Knighton’s success along the way. While they could not all bementioned in this article, she would like to acknowledge her gratitude to following for their mentorship andexpertise: Patricia Higgins, Associate Professor in the Frances Payne Bolton School of Nursing; Curtis Donskey,Professor in the School of Medicine; Mary Dolansky, Sarah C. Hirsh Professor at the Frances Payne BoltonSchool of Nursing; Kurt Stange, Distinguished University Professor; David Aron, Professor in the School ofMedicine and Director of Program Research and Education at the Louis Stokes Cleveland VA Medical Center;and Robin Jump, Assistant Professor in the Department of Medicine Division of Infectious Diseases & HIVMedicine Department of Educational Programs in Clinical Research, Louis Stokes Cleveland VA Medical Center.
19
Victoria Laney, a second-year PhD student in theDepartment of Biomedical Engineering, isgrateful for early exposure to STEM fields andsupport to attend college. With parents workingfor the U.S. Department of State, Laney lived inseveral countries. She earned both a bachelor’sand master’s degree in engineering from JohnsHopkins University and has worked on severalresearch projects. But as a Black student, shealso understands the challenges of being aminority in university settings.
“Even with the advantages afforded to me by mypre-college education, I found that succeeding incollege was substantially harder as anunderrepresented minority,” says Laney. Someof the obstacles she has experienced are lack ofmentorship and assumptions by classmates thatshe is not as intelligent, therefore they avoidworking with her. To address these issues andothers, Laney helped launched a new graduatestudent-based organization at Case WesternReserve University in July calledUnderrepresented Minorities in BiomedicalEngineering (UMBE). The organization’s goalsinclude providing mentorship forunderrepresented minorities (URMs) on campus, engaging in outreach to the greater Cleveland
area and fostering a diverse environment thatbenefits both URMs and the BiomedicalDepartment as a whole.
“The barriers to education in STEM exist at manylevels, and I think by addressing some of themwe can increase diversity and become a moreequitable and innovative biomedical engineeringcommunity,” says Laney, who is president ofUMBE. Other members of the organization’sexecutive board include Kenya Alfaro, vicepresident; Emily Conlan, secretary; TahseenMinhaz, treasurer; Leah Roldan and SarahCarney, outreach chairs; and Shruti Raghunathanand Tesh Pierre, professionalism chairs. BoluAjiboye, associate professor of biomedicalengineering, serves as the faculty advisor.
As of mid-September, the UMBE had 20members and was working on recruitmentefforts. The organization also launched severalsocial media platforms to spread the word aboutthe group (Instagram and Twitter: @cwruumbe).
“I’m so proud that so many members of theBiomedical Engineering Department haveexpressed their support, and I hope we canmaintain the momentum,” says Laney. “I’mexcited to see the progress we can make.”
Grad Student Organization Forms toSupport Underrepresented Minorities
20
Victoria Laney | President Kenya Alfaro | Vice President
Emily Conlan | Secretary Tahseen Minhaz | Treasurer
Leah Roldan | Outreach Co-Chair Sarah Carney | Outreach Co-Chair
Shruti Raghunathan | Professionalism Co-Chair Tesh Pierre | Professionalism Co-Chair
Jay AlbertsJay Alberts, staff, Lerner Research Institute Department of Biomedical Engineering, and colleagues have developed the Ventilator Mode App to give providers real-time information about the model of ventilator
they are using. Providers enter the make and model of the ventilator into the app, which then shows a tutorial on how to use that particular device.
Mehdi AlilouMehdi Alilou, a research assistant professor in the Department of Biomedical Engineering and the Center for Computational Imaging and Personalized Diagnostics (CCIPD), was awarded a two-year, $383,000 early
career lung cancer grant from the Department of Defense Congressionally Directed Medical Research Programs (DOD CDMRP) Lung Cancer program. The funding will support his project, “Quantitative Vessel Tortuosity as Biomarker for Predicting and Monitoring Response to Immunotherapy for Non-Small Cell Lung Cancer from Routine CT Scans.”
Margot DamaserMargot Damaser, staff, Lerner Research Institute Department of Biomedical Engineering, was awarded the 2020 Urology Care Foundation Distinguished Mentor Award. The award pays tribute to her track record of
fostering the next generation of urologic research leaders by continually providing an excellent training environment and guidance to early-career investigators. Damaser was also honored as an International Continence Society Hall of Fame member in April.
Mark GriswoldMark Griswold, associate professor of the Department of Biomedical Engineering at the Case School of Engineering was elected a fellow of the International Academy of Medical and Biological Engineering (IAMBE).
The academy is made up of fellows who are recognized for their outstanding contributions to the profession.
Faculty Highlights
“...We seek to build upon the foundation of our current success in transforming students into engineers and further enrich the Senior Design capstone experience...”
Colin DrummondColin Drummond, professor and assistant chair of the Department of Biomedical Engineering at Case
Western Reserve University, received a renewal of an R25 research education grant from the National Institutes of Health for the undergraduate Senior Design course co-taught with Matthew Williams, assistant professor. The original 5-year R25 was led by Dustin Tyler, Kent H. Smith Professor II of Engineering. Drummond cites four research aims of the renewed 5-year, $216,000 R25: to enable and promote interactive and hands-on learning, to provide an interprofessional team environment, to develop non-technical skills and to establish concrete outcomes to disseminate the results of the training. “With these aims we seek to build upon the foundation of our current success in transforming students into engineers and further enrich the Senior Design capstone experience not only for the curriculum at our institution, but the capabilities of biomedical engineers across the field as well,” says Drummond.
22
Xiaojuan Li
Xiaojuan Li, staff, Lerner Research Institute Department of Biomedical Engineering, received a five-year, $3.2 million R01 award to develop MR T1 and T2 relaxation time imaging methods
to establish a platform for standardization and cross-validation of these measures. Li was also inducted into the AIMBE College of Fellows for outstanding contributions to advancing the quantitative imaging of musculoskeletal tissues and diseases.
Anant MadabhushiThe Pathologist released its 2020 Power List celebrating influential figures, thought leaders and opinion shapers in pathology and laboratory medicine. For the second year in a row, Anant Madabhushi, the
Donnell Institute Professor of Biomedical Engineering, and director of the Center for Computational Imaging and Personalized Diagnostics at CWRU, was named to the list.
Gordon McLennan and Anand RamamurthiLerner Research Institute Department of Biomedical Engineering has bid fond farewells to Gordon McLennan and Anand Ramamurthi. McLennan has moved on to the University of Colorado Anschutz Medical Campus, Aurora, Colo., to become the vice chair of clinical research, Department of Radiology (Interventional). Dr. Ramamurthi is now the P.C. Rossin Professor and chair of the Department of
Bioengineering in Lehigh University’s P.C. Rossin College of Engineering and Applied Science.
Ron MiduraRon Midura, Lerner Research Institute Department of Biomedical Engineering, has retired after many years at Cleveland Clinic. Midura and his team did pioneering work in the area of bone formation,
osteoporosis and the effects of mechanical unloading on the process of fracture healing, all toward a goal of building new diagnostic or therapeutic procedures for bone disorders. Midura will now become Emeritus Staff in the department.
Ela PlowEla Plow, assistant staff, Lerner Research Institute Department of Biomedical Engineering, and colleagues, were featured in the Congressionally Directed Medical Research Programs’ Spinal
Cord Injury Research Program book for their grant for a multi-site national spinal cord injury clinical trial. This publication is given to consumers, advocates and Congress to help highlight the research the program supports.
Carl SaabCarl Saab, a leader in the study of pain mechanisms and relief, has joined Cleveland Clinic Lerner Research Institute Department of Biomedical Engineering. His expertise is in brain mechanisms of
pain in animals and humans. At Cleveland Clinic, Saab will lead a collaborative research program into the biomarkers of pain and set up a comprehensive pain center.
Anirban Sen GuptaAnirban Sen Gupta, professor of biomedical engineering in the Case School of Engineering and co-founder of Haima Therapeutics, was awarded several grants this fall, totaling $8.6
million, from the U.S. Department of Defense (DOD). His lab, the Bioinspired Engineering for Advanced Therapies (BEAT) Laboratory, and Haima are teaming up on three DOD grants: one to advance freeze-drying of SynthoPlate™ artificial platelets for long-term storage and field-deployability, another to integrate SynthoPlate™ into freeze-dried plasma and a third to develop a whole blood surrogate with co-investigators from the University of Maryland. In addition, Sen Gupta is collaborating with Pedram Mohseni, professor of electrical engineering, and XaTek Inc. on a DOD grant to advance the use of the ClotChip™ point-of-care device for evaluating trauma coagulopathy. Sen Gupta was also appointed to the international editorial board of Biomaterials (Elsevier), a premier journal in the field of biomedical materials.
23
Rakesh ShiradkarRakesh Shiradkar, research assistant professor of the Center for Computational Imaging and Personalized Diagnostics and Biomedical Engineering in the Case School of Engineering, and his team
received one of seven annual pilot awards supported by the Clinical & Translational Science Collaborative (CTSC). The grant supports the team as they develop radiomics for prostate cancer patients on active surveillance: “Development of a Prostate Cancer Risk Stratification Nomogram Integrating Clinical Variables and MRI Derived Radiomic Signatures for Patients on Active Surveillance.”
Pallavi TiwariPallavi Tiwari, assistant professor of biomedical engineering at Case Western Reserve School of Medicine was selected as one of six winners of the third annual Johnson & Johnson Women in STEM2D
(WiSTEM2D) Scholars Award for her research in brain cancer. Each recipient, representing each of the STEM2D disciplines—science, technology, engineering, math, manufacturing and design—will receive a $150,000 grant and three years of mentorship.
Satish ViswanathSatish Viswanath and Pallivi Tiwari, assistant professors in biomedical engineering in the Case School of Medicine and lead researchers in the Center for Computational Imaging and
Personal Diagnostics, received a $1.15 million U01 research grant from the National Cancer Institute’s
Informatics Technology in Cancer Research program. Viswanath and Tiwari are developing artificial intelligence tools to help surgeons and oncologists identify the subtle, but critical differences between a recurring tumor and damaged non-cancerous tissue on post-operative MRI scans of certain cancer patients. Viswanath was also named one of Crain’s Cleveland Business 40 Under Forty honorees, celebrating leaders who are making a difference in their community.
Karl WestCleveland Clinic spinoff company Centerline Biomedical, which commercializes an endovascular surgery navigation system called the Intra-Operative Positioning System
(IOPS), has received pre-market clearance from the U.S. Food & Drug Administration and has successfully completed its first clinical case in the United States. The IOPS was invented by Karl West, staff scientist and director of medical devices at Lerner Research Institute Department of Biomedical Engineering, who is also a member of Centerline Biomedical’s Scientific Advisory Board. West also received the 2020 Auggie Award, recognizing advances in augmented and virtual reality, for Best Healthcare and Wellness Solution. In addition, the Holographic Interventional Therapy lab, led by West and Cleveland Clinic interventional radiologists Charles Martin, MD, and Gaurav Gadodia, MD, performed the world’s first in-human evaluation of the augmented reality surgical navigation platform technology for a percutaneous kidney tumor ablation. The team included Jeff Yanof, Sara Al-Nimer and Aydan Hanlon.
CENTER FOR COMPUTATIONAL IMAGING AND PERSONALIZED DIAGNOSTICS
REACHED 50 PATENTS“Treatment planning and evaluation for rectal cancer via image analytics”
Satish Viswanath, assistant professor of biomedical engineering; Anant Madabhushi, the Donnell Institute Professor of Biomedical Engineering; and Jacob Antunes, graduate student researcher
“Intra-Perinodular Textural Transition (IPRIS): A Three Dimensional (3D) Descriptor for Nodule Diagnosis on Lung Computed Tomography (CT) Images”
Mehdi Alilou, research associate; and Anant Madabhushi, the Donnell Institute Professor of Biomedical Engineering
24
FACULTY DIRECTORY
A. Bolu [email protected]
Jay Alberts [email protected]
James M. Anderson [email protected]
Suneel S. Apte [email protected]
James P. Basilion [email protected]
Jillian Beveridge [email protected]
Jeffrey R. Capadona [email protected]
Patrick Crago [email protected]
Margot Damaser [email protected]
Kathleen A. Derwin [email protected]
Colin K. Drummond [email protected]
Dominique M. Durand [email protected]
Steven Eppell [email protected]
Ahmet Erdemir [email protected]
Stephen D. Fening [email protected]
Aaron Fleischman [email protected]
Kiyotaka Fukamachi [email protected]
Chaitali Ghosh [email protected]
Miklos Gratzl [email protected]
Kenneth J. Gustafson [email protected]
Vincent C. Hascall [email protected]
Michael Jenkins [email protected]
Jan Jensen [email protected]
Efstathios (Stathis) Karathanasis [email protected]
Vijay Krishna [email protected]
Vinod Labhasetwar [email protected]
Xiaojuan Li [email protected]
Zheng-Rong Lu [email protected]
Dan Ma [email protected]
Anant Madabhushi [email protected]
Paul D. Marasco [email protected]
Edward V. Maytin [email protected]
Cameron McIntyre [email protected]
Gordon McLennan [email protected]
Ronald J. Midura [email protected]
J. Thomas [email protected]
George F. Muschler [email protected]
Kunio Nakamura [email protected]
P. Hunter [email protected]
Ela Plow [email protected]
Anand Ramamurthi [email protected]
Andrew Rollins [email protected]
Gerald Saidel [email protected]
Anirban Sen Gupta [email protected]
Sam Senyo [email protected]
Andrew Shoffstall [email protected]
Pallavi Tiwari [email protected]
Ronald Triolo [email protected]
Dustin Tyler [email protected]
Satish Viswanath [email protected]
Horst von Recum [email protected]
David Wilson [email protected]
Xin Yu [email protected]
Maciej Zborowski [email protected]
Robert F. [email protected]
Geoffrey [email protected]
Department of Biomedical Engineering10900 Euclid Ave.Cleveland, Ohio 44106-7207
bme.case.edu lerner.ccf.org/bme
@CWRUBMECWRU, Department of Biomedical Engineering @CWRUBME
#BMEalliance
