BME 354

Molecular Sensors and Nanodevices for BME Applications

Tim YehDepartment of Biomedical Engineering

University of Texas at Austin

Tim.Yeh@austin.utexas.edu

L1: Introduction

Tim Yeh (Hsin-Chih Yeh)• 1990-1994: B.S. in Mechanical Engineering

National Taiwan University, Taiwan• 1996-1998: M.S. in Mechanical Engineering

University of California, Los Angeles• 1998-2003: R&D engineering in optical MEMS industry

Optical Micromachines, San Diego, California• 2003-2008: Ph.D. in Mechanical Engineering

Johns Hopkins University, Baltimore, Maryland

• 2009-2012: Postdoc in a nanoscience center

Los Alamos National Laboratory

• 2012- : Assistant professor in BME at UT Austin

http://research.engr.utexas.edu/yeh/2

Human hair

Teaching Assistants

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Cong Liu

Expertise: Optical engineering, electrical engineering

Office: BME 5.202K

Email: cong.liu@utexas.edu

Office hour: T 3:45-4:45pm or by appointment

Allen Liu

Expertise: Biomaterials, tissue engineering

Office: BME 5.202K

Email: ylliu@utexas.edu

Office hour: M 5:30-6:30pm or by appointment

BME 354 Molecular Sensors and Nanodevices

Fall 2014 MWF 11am-12pm, CPE 2.206

Instructor: Professor Tim Yeh (Hsin-Chih Yeh)

Office hours: MF 12-1pm or by appointment, BME 5.202C

Please send me an email in advance if you are coming to my office.

Textbook (required):

Molecular Sensors and Nanodevices: Principles, Designs and Applications in Biomedical EngineeringJohn X.J. Zhang and Kazunori Hoshino, Elsevier 2014

References (optional):

Selected papers posted on BlackBoard.Micromachined Transducers Sourcebook, Kovacs, McGraw-Hill 1998 Fundamental of Microfabrication, Madou, CRC Press 2002Chemical Sensors and Biosensors, Eggins, Wiley 2002 Biomolecular Sensors, Gizeli and Lowe, Taylor and Francis 2002 Commercial Biosensors, Ramsay, Wiley 1998

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Prerequisites

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• BME 314. Engineering Foundations of Biomedical EngineeringFundamental biology (311C), physics (303K), chemistry (302), math (427K), and engineering (BME 102L, EE 319K)

• BME 352. Engineering BiomaterialsMechanical and chemical properties of biomaterialsElectronics (BME 221 Measurement and instrumentation lab)

• Desire to learn, common sense, being able to enjoy challenges, ability to work alone, curiosity, aptitude to modify and control sleep habits….

Grading Policy

25%

12.5%

12.5%

20%

30%

8 Homework assignments

Midterm 1

Midterm 2

Project presentation

Final exam

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Homework

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• Totally 8 homework assignments

• Assigned on Wednesday and due next Wednesday before class (i.e. 10:59am) – you have a week to work on HW assignments

• A deadline is a deadline – no late homework will be accepted

• Dropping the lowest HW grade? No

• Assignment extension?

• Ask the instructor before the assignment is due• Granted for medical and personal emergencies only• You may be asked to provide written proof

BlackBoard

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• Announcements

• Syllabus and schedule

• Course documents

–Lecture notes

–Rubric for project

presentation

–Articles (i.e. review

papers) to read

• HW assignments

• Communication

• My Grades

–Check your grades

Disability and Religious Holidays

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Check the syllabus

Academic Integrity

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• All students must follow the Code of Honor:

I affirm the solutions represented in my response to the following exam questions are solely mine. Information contained within has not been distributed or obtained from other sources.

• Cheating will be dealt with in as severe a manner as possible. You will fail this course if you cheat. Cheating includes, but is not limited to, copying and plagiarism. Please see the following points to clarify the above situations for this course.

1. Assignments and homework are to be the work of the individual student. Utilizing computer codes, notes, answer sheets, assignment banks, etc. that have not been explicitly authorized by the Instructor is considered cheating.

2. For the purposes of this course, plagiarism consists of, but is not limited to, any of the following: copying exact text from a published source without citation (> 10 words), inaccurately citing sources, paraphrasing text or ideas from a published source without citation (>3 sentences), copying text but changing only selected words without citation (>3 sentences), and constructing a text that is primarily another’s work (whether cited or not).

3. Students may be suspended or expelled permanently from the University for scholastic dishonesty.

Check the syllabus

Academic Integrity

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• Please check the following website for the official UT Austin policy:

http://deanofstudents.utexas.edu/sjs/acint_student.php

• It is OK to ask questions now about what constitutes cheating. It is

not OK later once an event has happened. Additionally, claiming

ignorance regarding cheating does not excuse an individual. It is up

to you to determine what constitutes academic dishonesty.

Check the syllabus

Class Goals

• To know the basic elements and major classes of molecular

sensors, nanodevices and biomedical microsystems (i.e.

Micro- Electro-Mechanical Systems, MEMS);

• To demonstrate an understanding of the fundamental

principles behind the operation of molecular sensors, nano-

devices and biomedical microsystems.

• To understand the unique requirements, environments, and

applications of molecular sensors, nano-devices and

biomedical microsystems.

• To gain an understanding of standard micro- and nano-

fabrication techniques for sensors

• To apply knowledge of the above to the design and manufacturing

of such microsystems.

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• Introduction (1 lecture)

• Principles of Molecular Sensors (1 lecture)

• Introduction to Silicon, MEMS, Microfabrication, Scaling Law (4 lectures)

• Microfluidics and Soft Lithography (5 lectures)

• Electrical Transducers: electrochemical sensors, FET-based sensors (4 lectures)

• Exam 1

• Optical Transducers and Optical Spectroscopy (6 lectures)

• Mechanical Transducers: cantilevers, acoustic biosensors, thermal sensors (4 lectures)

• Exam 2

• Introduction to Nanotechnology (7 lectures)

• Project presentation

• Final Exam

BME 354 Topics

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Class Schedule

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Class Schedule

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10/22-25 BMES conference in San Antonio

Your attendance is required during the project presentation!

• Focus on sensors, actuators, MEMS

– Journal of Microelectromechanical Systems (JMEMS)

– Journal of Micromechanics and Microengineering

– Sensors and Actuators A (Physical)

– Sensors and Actuators B (Chemical)

• Micro Total Analysis Systems (Micro-TAS)

– Lab on a Chip, Analytical Chemistry

– Biomedical Microdevices

• Nanotechnology, Nanomaterials

– Nature nanotechnology

– Nano Letters, Small, Nanotechnology

– Advanced materials, Advanced functional materials, biomaterials

– Nature materials

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Supporting Information: Journals

• Electrical Engineering

– IEEE journals, such as IEEE Electron Device Letters

– Journal of the Electrochemical Society

– Journal of the Vacuum Society

• Optics

– Nature photonics

– Optics express, Optics letters

– Proceeding of the SPIE– International Society for Optical Engineering

• Applied Physics

– Applied Physics Letters

– Journal of Applied Physics

– Physics Review series

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Supporting Information: Journals

– International Conference on Solid-State Sensors and Actuators, or

“Transducers”

• Large, international, alternate years, 91, 93, …, 11, 13, ..

– Solid-State Sensor and Actuator Workshop, or “Hilton Head”

• North American only, alternate years, 92, 94, …, 10, 12, ..

– Eurosensors

• European, alternate years, 92, 94, …, 10, 12, ..

– IEEE Micro Electro Mechanical Systems Workshop, or “MEMS”

• Single session, highly selective, international, annually

– Micro Total Analysis Systems, or “µTAS”

• Interantional annual

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Supporting Information: Conferences

• Theses

–University Microfilms International

(ProQuest Dissertations and Theses)

• Patents

– http://patent.womplex.ibm.com

– www.uspto.gov

• Websites (MEMS-talk)

– http://mems.isi.edu

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Supporting Information: Internet Resources

Questions?

Comments?

Suggestions?

Special requests?

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