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Hum Neurobiol. 1985;4(3):189-94.

Effect of benzodiazepine hypnotics on all-night sleep EEG spectra.Borbély AA, Mattmann P, Loepfe M, Strauch I, Lehmann D.

AbstractThe effect of a single, oral bedtime dose of the benzodiazepine hypnotics flunitrazepam (FR; 2 mg),flurazepam (FR; 30 mg), and triazolam (TR; 0.5 mg) on the sleep stages and the sleep EEG wasinvestigated in eight healthy, young subjects. In comparison to the placebo night, all drugs reduced thepercentage of stage 1 and REM sleep, increased stage 2, and decreased the number of stage shifts. ForFN and FR, some of these changes persisted in the postdrug night. All-night spectral analysis of the EEGshowed a reduction of low-frequency activity (0.25-10.0 Hz) in stages 2, 3 + 4 and REM sleep, changesthat persisted for all three drugs in the post-drug night. In the drug nights, activity in the spindle frequencyrange (11-14 Hz) was enhanced particularly in stage 2 and 3 + 4, activity in the high frequency range(17-25 Hz) particularly in REM sleep and stage 1. In the first third of the drug night, the depression oflow-frequency activity in stage 2 was either absent (FR) or less prominent (FN, TR) than in the followingpart of the night. The results demonstrate that benzodiazepine hypnotics induce specific changes in theEEG spectra which reflect the immediate and residual drug effects more sensitively than conventionalsleep scores.

PMID: 2866173 [PubMed - indexed for MEDLINE]

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Effect of benzodiazepine hypnotics on all-night sleep EEG spectra. - P... http://www.ncbi.nlm.nih.gov/pubmed/2866173

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