1
Our next-generation silicon neural probe technology offers exceptional performance for both acute and chronic experiments, encompassing: ...unrivalled in vivo longevity - record the neurons you want across many days to weeks in freely behaving animals. ...the only silicon neural probes on the market with minimized sensitivity to photo-electric artefacts making them the optimal choice for single unit recording + optogenetics. ...stabilised electrodes with typical 50 kOhm impedance; ~2x - 10x better than the competition! designed to fit our nano-Drives with guaranteed alignment with drive-axis and convenient co-alignment with fibre optics and fluidic cannulae. ...15 micron thin silicon neural probes with narrow shank-width for minimal tissue damage yet still able to withstand considerable stress without breaking. ...acute probes offering multiple re-uses across many months. Superior chronic stability... Optogenetics-safe... Best-in-class signal to noise ratio... Microdrive compatible... ... Ultra-thin yet robust... Long-term reusable... 200 mm 1 ms 0.2 mV Silicon Neural Probes: Features, Advantages & Benefits CAMBRIDGE NeuroTech Advanced Electrophysiology Systems 100 0 6 0 count trial 200 mV 473 nm; 15 ms 1.5 mW -10 0 20 10 30 (ms) 200 mm P series probe 125 core flat fibre Data courtesy of Max Liu and Anatol Kreitzer University of California, San Francisco -10 0 20 10 30 (ms) Data recorded from the p an Ai32 mouse line crossed to the Adora2A Cre line; a marker of indirect pathway medium spiny neurons (MSNs) which in turn express ChR2 - note photo-evoked spikes. Recorded with a P-series probe closely apposed to 125 core fibre optic cannula osterior striatum in the awake head-fixed mouse using Spike-sorted single unit data from freely behaving rat cortex - recorded 60 days post-implant and after 30 days in the same location. Data provided by Tahl Holtzman, Nick Donnelly, Jeff Dalley – University of Cambridge, UK I got beautiful 'multi-multi' single cell recordings using both your 32 channel and 64 channel probes in rodents. The recording quality was truly incredible with huge spikes all over the place; definitely some of the best recordings I have seen using silicon probes so far!! Nicolas Mallett, Lab Head, University of Bordeaux, France. Brain area: Striatum and globus pallidus; Species: Rats and Mice

CAMBRIDGE Silicon Neural Probes: NeuroTech Features, … · NeuroTech Advanced Electrophysiology Systems 37.98 38.38 36.78 38.58 100 0 6 0 37.38 37.78 count trial 200 m V 473 nm;

  • Upload
    others

  • View
    8

  • Download
    0

Embed Size (px)

Citation preview

Page 1: CAMBRIDGE Silicon Neural Probes: NeuroTech Features, … · NeuroTech Advanced Electrophysiology Systems 37.98 38.38 36.78 38.58 100 0 6 0 37.38 37.78 count trial 200 m V 473 nm;

Our next-generation silicon neural probe technology offers exceptional performance for both acute and chronic experiments, encompassing:

...unrivalled in vivo longevity - record the neurons you want across many days to weeks in freely behaving animals.

...the only silicon neural probes on the market with minimized sensitivity to photo-electric artefacts making them the optimal choice for single unit recording + optogenetics.

...stabilised electrodes with typical 50 kOhm impedance; ~2x - 10x better than the competition!

designed to fit our nano-Drives with guaranteed alignment with drive-axis and convenient co-alignment with fibre optics and fluidic cannulae.

...15 micron thin silicon neural probes with narrow shank-width for minimal tissue damage yet still able to withstand considerable stress without breaking.

...acute probes offering multiple re-uses across many months.

Superior chronic stability...

Optogenetics-safe...

Best-in-class signal to noise ratio...

Microdrive compatible......

Ultra-thin yet robust...

Long-term reusable...

200 m

m

1 ms

0.2

mV

Silicon Neural Probes:Features, Advantages & Benefits

CAMBRIDGENeuroTech

Advanced Electrophysiology Systems

37.98

38.38

36.78

38.58

100

06

0

37.38

37.78

coun

ttr

ial

200 m

V

473 nm; 15 ms1.5 mW

-10 0 2010 30 (ms)

200 m

m

P seriesprobe

125 coreflat fibre

Data courtesy of Max Liu and Anatol Kreitzer

University of California, San Francisco

-10 0 2010 30 (ms)

Data recorded from the p an Ai32 mouse line crossed to the Adora2A Cre line; a marker of indirect pathway medium spiny neurons (MSNs) which in turn express ChR2 - note photo-evoked spikes. Recorded with a P-series probe closely apposed to 125 core fibre optic cannula

osterior striatum in the awake head-fixed mouse using

Spike-sorted single unit data from freely behaving rat cortex - recorded 60 days post-implant and after 30 days in the same location. Data provided by Tahl Holtzman, Nick Donnelly, Jeff Dalley – University of Cambridge, UK

I got beautiful 'multi-multi' single cell recordings using both your 32 channel and 64 channel probes in rodents. The recording quality was truly incredible with huge spikes all over the place; definitely some of the best recordings I have seen using silicon probes so far!!Nicolas Mallett, Lab Head, University of Bordeaux, France.Brain area: Striatum and globus pallidus; Species: Rats and Mice