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CANCER Cells can lose control of cell division & growth or cell death Cells can lose control of cell division & growth or cell death If they grow unchecked, they form tumours If they grow unchecked, they form tumours

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TUMOURS Tumours are groups of cells Tumours are groups of cells can be benign or malignant Benign tumours divide for a period then stop. They can be removed by surgical or laser methods Benign tumours divide for a period then stop. They can be removed by surgical or laser methods Malignant tumours never stop dividing, they cause angiogenesis (blood vessels grow into them). This provides them food and oxygen to allow them to keep growing. It also allows the cancer to spread. Malignant tumours never stop dividing, they cause angiogenesis (blood vessels grow into them). This provides them food and oxygen to allow them to keep growing. It also allows the cancer to spread.

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CANCER Cancers Cancers begin as a primary tumour. However, cells break away from the primary tumour and - travelling in blood and lymph - establish metastasesmetastases metastases metastasesin other locations of the body. Many Many tumours is more difficult to target treatment then a single tumour.

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Cancer Statistics

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Scottish Statistics

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Cancers follow from faulty (mutated) genes Faulty genes can be inherited Faulty genes can be inherited Exposure to agents which damage DNA increase the chances of a mutation occurring e.g Exposure to agents which damage DNA increase the chances of a mutation occurring e.g Chemicals e.g. cigarette smoke Radiation e.g UV, Xray, Gamma rays In addition, damage to repair and checking systems will increase the chances of cancer In addition, damage to repair and checking systems will increase the chances of cancer

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CAUSES OF CANCER The The development of cancer is associated with a variety of risk factors Tobacco Tobacco Sunlight Sunlight (UV irradiation) Body Body weight Physical Physical activity Diet Diet Hormones Hormones Occupations Occupations Infections

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Tobacco

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Sunlight Exposure

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Diet

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Body Weight

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Physical Activity

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Hormones

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Occupation

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Infection

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http://news.bbc.co.uk/1/hi/health/8102621.s tm http://news.bbc.co.uk/1/hi/health/8102621.s tm http://news.bbc.co.uk/1/hi/health/8102621.s tm http://news.bbc.co.uk/1/hi/health/8102621.s tm In fact, scientists estimate about a third of the most common cancers could be prevented if people ate healthily, maintained a healthy weight and were regularly physically active In fact, scientists estimate about a third of the most common cancers could be prevented if people ate healthily, maintained a healthy weight and were regularly physically active

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2 sets of genes control cell division: Proliferation genes (proto- oncogenes) speed it up Tumour suppressor (anti-proliferation) genes slow it down Cancer, uncontrolled cell division, can result from too much speeding or too little slowing.

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GENE MUTATIONS When When proto-oncogenes become mutated they are called ONCOGENES. An An oncogene is similar to its non-mutated counterpart, but it is more active or produced in an unregulated way. ONCOGENES ONCOGENES STIMULATE CELL DIVISION Extension Extension Extension material

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TUMOUR SUPPRESSOR GENES & CANCER Tumour suppressor genes (antiproliferation genes) suppress cell division Tumour suppressor genes (antiproliferation genes) suppress cell division They can also become mutated They can also become mutated Causing uncontrolled cell division Causing uncontrolled cell division Animation

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GENETICS OF CANCER Cancers due to oncogenes only require mutation in one copy of the gene (the mutated version has dominance heterozygotes get cancer). Cancers due to oncogenes only require mutation in one copy of the gene (the mutated version has dominance heterozygotes get cancer). Cancers due to antiproliferation gene mutation require mutation in both copies (the mutated versions are recessive homozygotes get cancer). Cancers due to antiproliferation gene mutation require mutation in both copies (the mutated versions are recessive homozygotes get cancer).

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CANCER TREATMENTS CANCER TREATMENTS Surgeryphysical removal of cancer cells Surgeryphysical removal of cancer cells Radiotherapydamages DNA, killing cell Radiotherapydamages DNA, killing cell Chemotherapyoften inhibit aspects of cell cycle, killing cell. Rapidly dividing cells are more severely affected than slow dividing cells, so cancerous cells can be killed whilst limiting damage to less rapidly dividing cells (side effects) Chemotherapyoften inhibit aspects of cell cycle, killing cell. Rapidly dividing cells are more severely affected than slow dividing cells, so cancerous cells can be killed whilst limiting damage to less rapidly dividing cells (side effects)

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PACLITAXEL blocks a cell's ability to break down the mitotic spindle during mitosisspindle mitosis

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COLCHICINE Inhibits the development of spindles as the nuclei are dividing. spindles

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VINBLASTINE bind to tubulin, thus preventing the cell from making the spindlestubulin spindles

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Web Sites http://www.ncbi.nlm.nih.gov/books/bv.fcgi?call=bv.View..ShowSection&rid=gnd.section.99 http://www.ncbi.nlm.nih.gov/books/bv.fcgi?call=bv.View..ShowSection&rid=gnd.section.99 http://www.biology.iupui.edu/biocourses/N100/2k4 ch8mitosisnotes.html http://www.biology.iupui.edu/biocourses/N100/2k4 ch8mitosisnotes.html http://www.cancerquest.org

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