cceHUBAn Environment for Collaborative Cancer Research

Ann Christine CatlinCCE Annual Retreat

May 26, 2010

clinical data observational & scientific data

decision supportintegrative & predictive tools

Sample Collection

Clinical Patient

Data

Laboratory Analysis

Visual Analytics

Predictive Modeling

Data &

Tools

Sample Collection

Clinical Patient

Data

Predictive Modeling

Laboratory Analysis

Visual Analytics

CCE Research WorkflowSharing Data, Tools, Analysis & Knowledge

cceHUBBuilding “Community” for Cancer Care Engineering Research

cceHUB development begins

cceHUB goes online

what does cceHUB offer today ?

June 2008

20

April 2009

2

May 2010

26

Clinical DataStatistics on cceHUB Sample and Patient Tracking

DatabaseTotal

PatientsDiagnosis

% DataLifestyle% Data

Cancer/Polyp Patients

2 / 3 blood draws

Treatment% Data

patients 171 99% 70% 25 / 66 18 / 3 33%

First patient CCE001 enrolled on April 2, 2009Most recent patient CCE203 enrolled on May 25, 2010Maximum patients enrolled on a single day September 23, 2009 = 9Downtime April 2009 – May 2010 during enrollment transfer

cceHUB = 4 hoursOncore = 21 days

DatabaseTotal

SamplesTotal

AliquotsDistributed IUSCC Labs

Transferred Purdue

Distributed Purdue Labs

samples 192 3748185 x 2 Klaunig 185 x 1 Xu 169

53 x 2 Raftery70 x 1 Teegarden 65 x 1 Adamec

Clinical Data ContributionData Entry and Processing: Support for the Clinical Workflow

Clinical Data ViewsData View & Search: Support for Clinical Data Exploration

Laboratory DatasetsStatistics on cceHUB Dataset Upload and Tracking

RepositoryAdamec Global

Proteomics

KlaunigComet Assay

KlaunigAnti-

Oxidant

Xu Lipidomics

Raftery NMR

Metabolomics

datasets 65 mzXML 1 spreadsheet1 CSV

1 spreadsheet1 CSV

1 spreadsheet1 CSV

1 spreadsheet1 CSV

samples 65 55 119 46 53

aliquots 92 106

First dataset uploaded from Xu Laboratory January 5, 2010Most recent dataset uploaded from Adamec Laboratory April 12, 2010Largest file uploaded 190900067bytes April 9, 2010 < 4 seconds transfer time

Percent files tracked to patient clinical data 100%Percent files tracked to instrument, laboratory, preparation protocol, samples 100%Percent files available from repository to view, search, process, analyze 100%

Data Repository UploadData Annotation and Tracking: Support for the Laboratory Workflow

Data Repository ViewsData View & Search: Support for Laboratory Data Exploration

Community ViewingStatistics on cceHUB Data View and Search

April - May2010

Clinical Data Viewer

Data RepositoryViewer

Sample Acquisition Workflow

Visits 12,948 3,180 2,577

Modeling ToolscceHUB Tools: Support for Modeling Workflow

Modeling ToolscceHUB Tools: Decision Support for Physicians

Data Analysis SharingAnalyzing, Browsing & Exploring the Data

Using cceHUBWho’s at the Website?

OneYear

Web Hits Visitors Visits

Core Users Core Tool Users

4/09-4/10 1,550,658 10,443 29,855 2540 62

OneYear

Core Users Core Tool Users

4/09-4/10 2540 62

USA 42% 100%

Asia 28%

Europe 21%

Other 9%

Education 90% 86%

Industry 4% 5%

Government 5% 5%

Using cceHUBWho’s Using our Website the Most?

Population Models

Integrative Models

Analysis Models

Clinical Team

ToolDeveloper

Visualization Tools

hub login easherer lin43 elcinicten dcregar baaraa apattath

# logins 294 103 94 159 333 37

cceHUB wall-time

12093hours

2329 hours

5023 hours

1156 hours

4660 hours

499hours

cceHUB interaction

3833 hours

39 hours

63 hours

1032 hours

214 hours

246 hours

workspace wall-time

11985 hours

2329 hours

5023 hours

4408 hours

499hours

workspace CPU time

1993 hours

89 hours

1737 hours

tools used 5 3 1 5 2

acc # logins = 1409tools used = 12workspace wall-time = 7218 hours

HUBzero-PoweredLeveraging a Powerful Research Environment

• User Groupsauthorization, secure data, access control, specialized analysis tools

• Community-Shared Resources publications, teaching materials, web-based contribution, linkage, tags, search

• Portal to Toolsshared development, execution power, analysis & visualization in your browser

• Community feedbackratings, usage statistics, wikis, blogs

• Workflowsserve all research groups, cover complete biological data life-

cycle

• Massive Datasetsannotate, upload, link to clinical date, archive, backup, share

• Clinical Datalink to hospital database, shared across communitycontribute, view, search

• Knowledgeshare across community data, workflows, models, results

• Analysis Toolsdata access, replay

Data SupportcceHUB Brings New Data Technology to the HUB

Genomics Project with Notre Dame

Genomics Project with Notre Dame

cceHUB plus

We have the technology!

Prostate Cancer Project with

Purdue Center for Cancer Research

Prostate Cancer Project with

Purdue Center for Cancer Research

The Next PhaseCollaborative Knowledge Acquisition with Shared Data and Shared Analysis

Tissue Project with

MD Anderson

Tissue Project with

MD Anderson

Thymoma Project with

Yale University Medical School

Thymoma Project with

Yale University Medical School

The Next PhaseWhat Do You Want cceHUB To Do For You ?

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