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Cellular Basis of Learning and MemoryBIPN 148
Spring 2006April 3-June 9, 2006
This course will examine the cellular and molecular mechanisms that underlie learning and memory. Topics covered will include the role of the hippocampus in learning and memory, neurotransmitter systems and receptors involved in learning and memory, and biochemical mechanisms of synaptic plasticity. Emphasis will be placed on discussing experiments from the primary literature. A solid background in cell and molecular biology is expected.
Prerequisites: BILD 1; BILD 2; BIBC 100/102; BIPN140 highly recommended.
Times: MWF at 4:00Location: CSB 001Web Site: http://www.biology.ucsd.edu/classes/bipn148.SP06/
Recommended Text Ghosh and Scanziani Lecture NotesLecture notes are available for purchase through University Readers at http://www.universityreaders.com/students
Grading: Weekly Quizzes: 30%Group paper and presentation: 30%Final Exam: 40%Grading is on a curve.
Discussion Sessions/TA office hours (optional): Pacific Hall 1115Wednesdays at 5:00Fridays at 3:00
Contact Information
Professors: Anirvan Ghosh, Pacific Hall 1123, [email protected], 822 4142.Massimo Scanziani, CMG 2nd Floor, [email protected], 822 3839
TEACHING ASSISTANTS: Will Barkis ([email protected]) and Mark Chen ([email protected])
HUMAN MEMORY
DECLARATIVE(EXPLICIT)
NONDECLARATIVE(IMPLICIT)
FACTS EVENTS
PROCEDURAL (SKILLS AND
HABITS)
PRIMING SIMPLE CLASSICAL
CONDITIONING
NONASSOCIATIVELEARNING
EMOTIONAL RESPONSES
SKELETAL MUSCULATURE
MEDIAL TEMPORAL
LOBE
STRIATUM NEOCORTEX AMYGDALA CEREBELLUM REFLEXPATHWAYS
Subdivisions of Human Memory
Milner B, Squire LR, Kandel ER: "Cognitive neuroscience and the study of memory". Neuron 1998, 20:445-468.
QuickTime™ and aTIFF (LZW) decompressorare needed to see this picture.
Ivan Pavlov
Classical Conditioning(an example of implicit memory)
Implicit Memory: Pavlovian Associative Conditioning
Conditioned Stimulus
UnconditionedStimulus
Conditioned Stimulus
UnconditionedResponse
ConditionedResponse
TRAINING
CONTEXTUAL TEST CUED TEST
•Animal is placed in novel context•Hears a tone•Receives foot shock
•Animal is returned to same context•Test for freezing behavior
•Animal is placed in modified context•Hears a tone•Test for freezing behavior
Implicit Memory: Fear Conditioning
0.0
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0.4
0.6
0.8
1.0
LiCl NaClgr
ams
blue
berr
y ba
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Implicit memory: Conditioned Taste Aversion
DAY 1
DAY 2
1st Exposure to Food Item
2nd Exposure to Food Item
Injection of LiCl or NaCl
Grams Ingested on 2nd Exposure(LiCl treated group compared to NaCl treated
control)
A B
Implicit Memory: Neophobia
DAY 1
DAY 2
1st Exposure to Food Item
A
Grams Ingested(1st exposure compared to second exposure)
B
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0.6
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1st intake 2nd intakegr
ams
blue
berr
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2nd Exposure to Food Item
QuickTime™ and aTIFF (LZW) decompressorare needed to see this picture.
Hermann Ebbinghaus(Distinction between short-term
and long term memory)
Ebbinghaus Test
ZOGMIFXELRICDAJNEQSORYANQIJGEB
Memorize this set of words
Wait for 1 minute
(keep the words in mind!)
Write down the words in sequence
Did anyone get all 10 right?
Sensory Information
Working Memory/Short term Memory(Minutes)
Long Term Memory(Hours/Days/Years)
By testing subjects after various delays Ebbinghaus developed the concept of short-term and long term memory
Working Memory Requires Frontal Lobe Function
Declarative Memory Required the Hippocampus