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Topic 1: 1 point• What are the four
components of repair?
• Angiogenesis• Migration and proliferation of
fibroblasts• Deposition of ECM• Remodeling
Topic 1: 2 points• By 3-5 days of tissue repair, what
specialized tissue appears?
Granulation Tissue
Topic 1: 3 points• What are the two major
factors that induce angiogenesis?
• bFGF (basic fibroblast growth factor)• VEGF (vascular endothelial growth
factor)
Topic 1: 4 points• What are the three phases of cutaneous
wound healing?
InflammationProliferationMaturation
Topic 1: 5 points
This is the simplest type of cutaneous wound repair; healing of a clean, uninfected surgical incision that is then approximated by surgical sutures
Healing by primary intention; primary
union
Topic 2: 1 point
This type of cell replaces neutrophils around 48-96 hours during tissue repair
Macrophage
Topic 2: 3 points
What are the factors that influence wound healing?
NutritionMetabolic statusCirculatory status
Hormones Infection
Mechanical factorsForeign bodies
Size, location, and type of wound
Topic 2: 4 points
Excessive formation of collagen that develops following thermal or traumatic injury can give rise to this
Hypertrophic Scar
Topic 2: 5 pointsThe signaling mechanism by which the cells
respond to the signaling molecules that they themselves secrete
Autocrine Signaling
Topic 3: 1 pointThis signaling mechanism occurs when one cell
type produces the ligand and then acts on adjacent target cells that express the appropriate receptor
Paracrine signaling
Topic 3: 2 pointsThis signaling mechanism occurs when hormones
synthesized by cells of endocrine organs act on target cells distant from their site of synthesis
Endocrine signaling
Topic 3: 3 points
These receptors transmit signals into the cell through trimeric GTP-binding proteins, contain seven transmembrane α-helices, and constitute the largest family of plasma membrane receptors
G-Protein Coupled Receptors
Topic 3: 4 points
This type of growth occurs by enlargement of the lobes of the liver that remain after the operation
Compensatory growth or compensatory hyperplasia
Topic 3: 5 pointsThis is the most abundant glycoprotein in the
basement membrane and it contains binding domains for both ECM and cell surface receptors
Laminin
Topic 4: 1 point
This substance provides resilience and lubrication to connective tissue (notably for the cartilage in joints) and its concentration increases in inflammatory diseases
Hyaluronan
Topic 4: 2 pointsThese are represented by pale platelet and fibrin deposits
alternating with darker red cell-rich layers. It signifies that a thrombus has formed in flowing blood
Lines of Zahn
Topic 4: 3 pointsThese are thrombi on heart valves
resulting from blood-borne bacteria or fungi
Vegetations
Topic 4: 4 pointsThese are the consequences of shock
The consequences are impaired tissue perfusion and cellular hypoxia