Path JeopardyCellular Responses

Path is Lots O’ Fun

1 1 1 1

2 2 2 2

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Topic 1: 1 point• What are the four

components of repair?

• Angiogenesis• Migration and proliferation of

fibroblasts• Deposition of ECM• Remodeling

Topic 1: 2 points• By 3-5 days of tissue repair, what

specialized tissue appears?

Granulation Tissue

Topic 1: 3 points• What are the two major

factors that induce angiogenesis?

• bFGF (basic fibroblast growth factor)• VEGF (vascular endothelial growth

factor)

Topic 1: 4 points• What are the three phases of cutaneous

wound healing?

InflammationProliferationMaturation

Topic 1: 5 points

This is the simplest type of cutaneous wound repair; healing of a clean, uninfected surgical incision that is then approximated by surgical sutures

Healing by primary intention; primary

union

Topic 2: 1 point

This type of cell replaces neutrophils around 48-96 hours during tissue repair

Macrophage

Topic 2: 2 points

This is the most important fibrogenic agent in cell proliferation

TGF-B

Topic 2: 3 points

What are the factors that influence wound healing?

NutritionMetabolic statusCirculatory status

Hormones Infection

Mechanical factorsForeign bodies

Size, location, and type of wound

Topic 2: 4 points

Excessive formation of collagen that develops following thermal or traumatic injury can give rise to this

Hypertrophic Scar

Topic 2: 5 pointsThe signaling mechanism by which the cells

respond to the signaling molecules that they themselves secrete

Autocrine Signaling

Topic 3: 1 pointThis signaling mechanism occurs when one cell

type produces the ligand and then acts on adjacent target cells that express the appropriate receptor

Paracrine signaling

Topic 3: 2 pointsThis signaling mechanism occurs when hormones

synthesized by cells of endocrine organs act on target cells distant from their site of synthesis

Endocrine signaling

Topic 3: 3 points

These receptors transmit signals into the cell through trimeric GTP-binding proteins, contain seven transmembrane α-helices, and constitute the largest family of plasma membrane receptors

G-Protein Coupled Receptors

Topic 3: 4 points

This type of growth occurs by enlargement of the lobes of the liver that remain after the operation

Compensatory growth or compensatory hyperplasia

Topic 3: 5 pointsThis is the most abundant glycoprotein in the

basement membrane and it contains binding domains for both ECM and cell surface receptors

Laminin

Topic 4: 1 point

This substance provides resilience and lubrication to connective tissue (notably for the cartilage in joints) and its concentration increases in inflammatory diseases

Hyaluronan

Topic 4: 2 pointsThese are represented by pale platelet and fibrin deposits

alternating with darker red cell-rich layers. It signifies that a thrombus has formed in flowing blood

Lines of Zahn

Topic 4: 3 pointsThese are thrombi on heart valves

resulting from blood-borne bacteria or fungi

Vegetations

Topic 4: 4 pointsThese are the consequences of shock

The consequences are impaired tissue perfusion and cellular hypoxia

Topic 4: 5 pointsThis lesion in the maternal pulmonary

microvasculature contains squamous cells, lanugo hair, fat from vernix caseosa, and mucin

Amniotic Fluid Embolism