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B IO Q UEST P ROGRAMMING 2014-15 B REAKTHROUGHS BioQuest is an educational program of Center for Infectious Disease Research www.cidresearch.org/bioquest-academy With our new branding as the Center for Infectious Disease Research (www.cidresearch.org), our scientists are now able to use system’s biology approaches to make transformative scientific advancements that lead to the prevention and treatment of infectious diseases. Education has been an integral part of our mission since we commenced operations nearly 40 years ago. Starting at the high school level, we foster a continuum of training and engagement with students to inspire tomorrow’s biomedical pioneers. The BioQuest Academy (www.cidresearch.org/bioquest-academy) program fosters global health interest and builds capacity through teacher trainings with curricular resources aligned to the latest standards and an array of connected student programs (Site Explorations, BioQuest Academy and teacher training). Read ahead to learn how we inspired and educated our community during the 2014-15 school year. Education The Site visit begins the entry into a STEM career. This year the BioQuest program served thousands of learners in its 11 th year of operations through broad programming (e.g., web-based curriculum, community speaking/outreach and social-mediated mentoring), half-day Site Explorations, (a half day of mentored touring and learning with hands-on curriculum), teacher trainings, and immersive summer programming through the BioQuest Academy and connected internships. 2014-15 BioQuest programming’s noteworthy education outcomes include: 522 students experienced Site Explorations 2014-15 school year, with 70% of visitors indicating that immersive experiences like Site Explorations were very important in increasing their comprehension of classroom science content. 62% of visitors were female and 52% reported to be from ethnicities and races underrepresented in STEM fields. In exit surveys, 79% stated that the visit increased their interest in a future career in science. Attending BioQuest Academy is a fun way to get an education in infectious disease content, biotech skills and biomedical theory, and can also be a game-changing experience for rising high school seniors. Thirty six of 2014 BioQuest summer Academy students are off to schools such as Yale University, Brown University, Cornell University, Stanford University, University of Washington (UW), Scripps College, and UC San Diego. 91% of our 276 older alumni have already graduated from college (79% in STEM fields) — 23 are pursuing post-baccalaureate studies, seven are practicing nurses and 53 of them have returned to work in CIDResearch programs as interns and technicians! In a well attended Teacher training workshop, 36 teachers from local area school experienced new curriculum on Innovative vaccines for infectious disease, where they used a system’s biology based modeling approach to develop vaccines for HIV, Malaria and Ebola. Encouraging diversity As we move forward, we are focusing our efforts to increase diversity in our Academy classrooms and Site visits. Through a directed approach, we were able to encourage the largest pool of under-served students groups to apply for this year’s Academy and the students with exceptional potential were selected from this pool to participate and train this summer. We are proud to say that our 2015 Academy classroom comprised of 64% of students from under-served groups. These classrooms were wonderfully blended where our preliminary results show significant knowledge gains in under-served students who interact with well-served students. We are pairing these target student populations with like minded scientist-mentors from our Center to begin a long-term support network for underserved students to stay in STEM careers. Inventing curriculum The integration of infectious disease research, immunology and systems biology is accelerating the rate of vaccine development at CIDResearch. Our teacher training, and Bioquest Academy curriculum are going through a redesign process to to keep pace with the newly developed technologies and strategies used in our research facilties.

Center for Infectious Disease Research Site … our new branding as the Center for Infectious Disease Research (), our scientists are now able to use system’s biology approaches

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BIOQUEST PROGRAMMING 2014-15 BREAKTHROUGHS

BioQuest is an educational program of Center for Infectious Disease Research www.cidresearch.org/bioquest-academy

WithournewbrandingastheCenterforInfectiousDiseaseResearch(www.cidresearch.org),ourscientistsarenowabletousesystem’s biology approaches to make transformative scientific advancements that lead to the prevention and treatment ofinfectious diseases. Education has been an integral part of ourmission sincewe commenced operations nearly 40 years ago.Starting at the high school level, we foster a continuum of training and engagement with students to inspire tomorrow’sbiomedical pioneers. TheBioQuest Academy (www.cidresearch.org/bioquest-academy) program fosters global health interestandbuildscapacitythroughteachertrainingswithcurricularresourcesalignedtothelateststandardsandanarrayofconnectedstudent programs (Site Explorations, BioQuest Academy and teacher training). Read ahead to learn how we inspired andeducatedourcommunityduringthe2014-15schoolyear.EducationTheSitevisitbeginstheentryintoaSTEMcareer.ThisyeartheBioQuestprogramservedthousandsoflearnersinits11thyearofoperations through broad programming (e.g., web-based curriculum, community speaking/outreach and social-mediatedmentoring),half-daySiteExplorations,(ahalfdayofmentoredtouringandlearningwithhands-oncurriculum),teachertrainings,and immersive summer programming through the BioQuest Academy and connected internships. 2014-15 BioQuestprogramming’snoteworthyeducationoutcomesinclude:• 522studentsexperiencedSiteExplorations2014-15schoolyear,with70%ofvisitors indicatingthat immersiveexperiences

like Site Explorationswere very important in increasing their comprehensionof classroom science content. 62%of visitorswerefemaleand52%reportedtobefromethnicitiesandracesunderrepresentedinSTEMfields.Inexitsurveys,79%statedthatthevisitincreasedtheirinterestinafuturecareerinscience.

• Attending BioQuest Academy is a funway to get an education in infectious disease content, biotech skills and biomedicaltheory, and can also be a game-changing experience for rising high school seniors. Thirty six of 2014 BioQuest summerAcademy students are off to schools such as Yale University, Brown University, Cornell University, Stanford University,UniversityofWashington(UW),ScrippsCollege,andUCSanDiego.91%ofour276olderalumnihavealreadygraduatedfromcollege(79%inSTEMfields)—23arepursuingpost-baccalaureatestudies,sevenarepracticingnursesand53ofthemhavereturnedtoworkinCIDResearchprogramsasinternsandtechnicians!

• InawellattendedTeachertrainingworkshop,36teachersfromlocalareaschoolexperiencednewcurriculumonInnovativevaccines for infectiousdisease,where theyuseda system’sbiologybasedmodelingapproach todevelopvaccines forHIV,MalariaandEbola.

EncouragingdiversityAs wemove forward, we are focusing our efforts to increase diversity in our Academy classrooms and Site visits. Through adirectedapproach,wewereabletoencouragethelargestpoolofunder-servedstudentsgroupstoapplyforthisyear’sAcademyandthestudentswithexceptionalpotentialwereselectedfromthispooltoparticipateandtrainthissummer.Weareproudtosay that our 2015 Academy classroom comprised of 64% of students from under-served groups. These classrooms werewonderfullyblendedwhereourpreliminaryresultsshowsignificantknowledgegainsinunder-servedstudentswhointeractwithwell-servedstudents.Wearepairingthesetargetstudentpopulationswithlikemindedscientist-mentorsfromourCentertobeginalong-termsupportnetworkforunderservedstudentstostayinSTEMcareers.InventingcurriculumTheintegrationofinfectiousdiseaseresearch,immunologyandsystemsbiologyisacceleratingtherateofvaccinedevelopmentatCIDResearch.Ourteachertraining,andBioquestAcademycurriculumaregoingthrougharedesignprocesstotokeeppacewiththenewlydevelopedtechnologiesandstrategiesusedinourresearchfacilties.

BIOQUEST PROGRAMMING 2014-15 BREAKTHROUGHS

BioQuest is an educational program of Center for Infectious Disease Research www.cidresearch.org/bioquest-academy

Wearegrateful forthetremendoussupportfromour individual,community,philanthropicandcorporatepartners.Together,wearegeneratingacriticalthinkingscienceandtechnologymindedworkforceforthe21stcentury.Thankyoutoallforyoursteadfastsupport.IndividualsAnonymousArielAbromovPeterMyler&AlexaAllenPaulAndersonPeterAskovichMarionAvrilLauraAustinEllenSisk&TimBlairAnnaBranAlexander&WendyBrzeznyFrancisco&CarmenBritoRobert&TheresaBritschgiDavid&VirginiaBroudyJeanneBrovoldVictoriaBukerSaraCarbonettiLindsayCarppIgorCestariJohnChambersIIIWonjongMoon&HeeJinChangKimberlyChoiKristinCohenElizabethCromwellLisabethCronSamDanzigerAudreyDavisTimDaweAmyDeRocherMattDonelanChrisEnglinKatyHoran&DanFilonowichJoAnn&BarryFormanEmilyGlennJoleneGlennMatthewGrayRobertoGuirnaloaAnkeHarupaToni&MichaelHatzakis,JrAnnHerbigEricHoughland

TerryMeersman&CarmendelaHozKent&LouiseIrwinBryanJensenPeter&JuneJiangPam&KimKaiserGarrettKlinichKarenKuterChristopherR.LarsonSallyLyons-AbbottNickiAnnMarkleChristinaMcCormickKyleMinchSusan&IsaacMorgenszternBethanyNorthquistSusan&StephenPapineauMarilynParsonsMonicaPetersenIsabellePhanGarrettPoshustaSallyQuySrikumarRangarajanChrisReadLynettRobertsonMaryJeanRyanBrandonSack

SowmyaSampathTracySaveriaSuzanneScheeleDrs.JaneBiddle&KenSeamonLeslieSebastianAarthiSekarSmithaShankarGenieShethErickaSjogrenDonSodoraAnnaSokolovRobinStacyTeamTrioTetyanaStolyarSandhyaSubramanianRosaSuenVasudhaSundaravaradanPattyTaagenEthanThompsonEltonVasconcelosMarissaVignali&FernandoVilaBrianWaughKatherineWeybrightJessicaWinklerGrantorsAmgenFoundationByron&AliceLockwoodFoundationFosterFoundationKeyBankFoundationRobertsonFamilyFoundationCommunityPartnersCareerandTechnicalEducation,OSPICentralWashingtonUniversityCommunityCenterforEducationResults(CCER)YakimaFarmWorkersClinicDO-IT,UWExcellentSchoolsNowFredHutchGEARUPGenomeSciences,UWInfectiousDiseaseResearchInstitute.InitiativetoMaximizeStudentDiversity,UWInstituteforSystemsBiologyMakingConnections,UWNorthshoreSchoolDistrictNorthwestAssociationforBiomedicalResearchOfficeofSuperintendentofPublicInstructionPacificScienceCenterRainierScholarsSeattlePublicSchoolsScienceEducationPartnershipSouthKingCo.STEMNetworkTechnologyAccessFoundationUniversityofWashingtonWashingtonGlobalHealthAllianceWashingtonMESAWashingtonStateTuberculosisAdvisoryCouncil

WashingtonStateUniversityWashingtonSTEMWenatcheeSchoolDistrictYMCABlackAchieversSchoolsServed(2015)BainbridgeHighSchoolBallardHighSchoolBethelHighSchoolCBTechSkillcenterClevelandHighSchoolColumbiaRiverHighSchoolDecaturHighSchoolEphrataHighSchoolGigHarborHighSchoolGlacierPeakHighSchoolGlideHighSchool(OR)HighlineHighSchoolIngrahamHighSchoolInternationalCommunitySchoolKentridgeHighSchoolMosesLakeHighSchoolMountTahomaHighSchoolNewStartHighSchoolNorthKitsapHighSchoolOrtingHighSchoolSeattlePreparatorySchoolToppenishHighSchoolTESLAstemHighSchoolWashingtonHighSchool