Certificate of Analysis

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QA: Jeff Park

QC:

Zoey Tseng

Date:

Sep. 14, 2015

CAS 941685-27-4 Batch No. B15S0913

Product Name 4-(1H-pyrazol-4-yl)-7-((2-

(trimethylsilyl)ethoxy) methyl)-7H-pyrrolo[2,3-d]pyrimidine

Batch size 800 g

MFG. Date Sep.13, 2015 Retest Date Sep.13, 2017

TESTING ITEM SPECIFICATION RESULT

Appearance White powder Conforms

Identification 1H-NMR spectrum Conforms

Purity HPLC

≥95% 98.01%

Storage Keep in a cool and dry place at room temperature

Result Correspond

4-(1H-pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy) methyl)-7H-pyrrolo[2,3-d]pyrimidine

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=====================================================================Acq. Operator : 2015-09 Seq. Line : 11Acq. Instrument : Instrument 1 Location : Vial 92Injection Date : 9/14/2015 3:24:37 PM Inj : 1 Inj Volume : 1 µlDifferent Inj Volume from Sequence ! Actual Inj Volume : 0.7 µlAcq. Method : D:\DATA\RAW DATA\2015-09\DEF_LC2015-09-1412-59-40\LC-12MIN-ACID.MLast changed : 9/6/2015 8:47:13 AM by 2015-09Analysis Method : D:\DATA\RAW DATA\2015-09\DEF_LC2015-09-1412-59-40\LC-12MIN-ACID.MLast changed : 9/14/2015 3:41:39 PM by 2015-09 (modified after loading)Method Info : Instrment: Agilent 1100HPLC Column:C18 4.6*150mm 5um Mobile phase:A=0.02% CF3COOH in Water B=ACN Gradient: 10%-90%B in 6min Flow Rate: 1mL/min

min0 2 4 6 8 10

mAU

0

200

400

600

800

1000

*DAD1 B, Sig=254,16 Ref=off (D:\DATA\RAW DATA\2015-09\DEF_LC2015-09-1412-59-40\092-1101.D - D:\DATA\RAW DATA\2015-09\DE

6.4

05

9.1

58

9.5

15

11.

242

===================================================================== Area Percent Report ===================================================================== Sorted By : SignalMultiplier : 1.0000Dilution : 1.0000Use Multiplier & Dilution Factor with ISTDs

Data File D:\DATA\RAW DATA\2015-09\DEF_LC2015-09-1412-59-40\092-1101.D

Instrument 1 9/14/2015 3:41:50 PM 2015-09 Page 1 of 2

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Signal 1: DAD1 B, Sig=254,16 Ref=off Signal has been modified after loading from rawdata file! Peak RetTime Type Width Area Height Area # [min] [min] [mAU*s] [mAU] %----|-------|----|-------|----------|----------|--------| 1 6.405 BB 0.0619 4657.47656 1133.94214 98.0105 2 9.158 BB 0.0916 12.38730 1.91217 0.2607 3 9.515 BB 0.0860 22.02720 3.56841 0.4635 4 11.242 BB 0.1549 60.12518 5.70784 1.2653 Totals : 4752.01625 1145.13056 ===================================================================== *** End of Report ***

Data File D:\DATA\RAW DATA\2015-09\DEF_LC2015-09-1412-59-40\092-1101.D

Instrument 1 9/14/2015 3:41:50 PM 2015-09 Page 2 of 2

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01234567891011121314f1 (ppm)

-5.0E+07

0.0E+00

5.0E+07

1.0E+08

1.5E+08

2.0E+08

2.5E+08

3.0E+08

3.5E+08

4.0E+08

4.5E+08

5.0E+08

5.5E+08

6.0E+08

09-14-2015400MHz/DMSO-d6

9.00

2.00

2.12

2.01

0.99

1.00

0.95

1.95

0.94

-0.119

0.796

0.816

0.836

2.500

3.390

3.498

3.518

3.538

5.619

7.091

7.100

7.717

7.726

8.349

8.669

8.738

13.409

NN

NOSi

CH3CH3

CH3

NHN

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