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Copyright © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins
Copyright © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins
Chapter 8
Disorders of Fluid, Electrolyte, and Acid-Base Balance
Chapter 8
Disorders of Fluid, Electrolyte, and Acid-Base Balance
Copyright © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins
Fluid DistributionFluid Distribution
• Intracellular compartment
• Extracellular compartment
– Interstitial spaces
– Plasma (vascular) compartment
– Transcellular compartment
Copyright © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins
Distribution of WaterDistribution of Water
Copyright © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins
ScenarioScenario• An athlete ran a marathon even though he felt ill…• After the race he collapsed. He was pale with a low blood
pressure and sunken eyes. One knee and ankle were badly swollen, and his abdomen was distended with fluid. The doctor diagnosed appendicitis and dehydration.
Question:• What has happened to his:
– Blood osmolarity?– Cell size? – Transcellular fluid volume? – Vascular compartment volume?
Copyright © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins
Forces Moving Fluid In and Out of CapillariesForces Moving Fluid In and Out of Capillaries
Copyright © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins
Question Question
What forces work to keep blood in the capillary?
a. Capillary colloid osmotic pressure (COP) & tissue COP
b. Capillary hydrostatic pressure & tissue COP
c. Capillary hydrostatic pressure & tissue hydrostatic pressure
d. Capillary COP & tissue hydrostatic pressure
Copyright © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins
Answer Answer
d. Capillary COP & tissue hydrostatic pressure
Hydrostatic pressure can be thought of as “pushing pressure,” and osmotic pressure can be thought of as “pulling” pressure. Pressure in the capillary that pulled/kept fluid in (capillary COP) and pressure pushing fluid out of the tissue (tissue hydrostatic pressure) would result in more fluid in the capillary.
Copyright © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins
SodiumSodium
• Normal level is 135–145 mEq/L
• Regulates extracellular fluid volume and osmolarity
Question:
• Why would “retaining sodium” cause high blood pressure?
Copyright © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins
ScenarioScenarioIt's a very hot day and you fall down the stairs on the way to
see the doctor about your hepatitis and renal disease.
• Explain why you have edema in your sprained ankle and foot.
Copyright © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins
Controlling Blood OsmolarityControlling Blood Osmolarity
• High osmolarity causes:
– Thirst increased water intake
– ADH release water reabsorbed from urine
• Low osmolarity causes:
– Lack of thirst decreased water intake
– Decreased ADH release water lost in urine
Copyright © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins
Question Question
Tell whether the following statement is true or false:
Increased levels of ADH decrease urine output.
Copyright © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins
Answer Answer
True
ADH prevents diuresis by causing more water to be absorbed in the kidney tubules. If more water is absorbed, there is less water left to eliminate as waste, decreasing urine output.
Copyright © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins
Dehydration Due to HypodipsiaDehydration Due to Hypodipsia
• A common problem in elderly people
Scenario:
• Dr. Bob thinks it could be treated with ADH given in a nasal spray
• Dr. Bill thinks renin injections would be better
Question:
• What is your evaluation of these two theories?
Copyright © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins
ADH ImbalancesADH Imbalances
• Diabetes insipidus (DI)
– Neurogenic
– Nephrogenic
• Syndrome of inappropriate ADH (SIADH)
• Which will cause hyponatremia?
Copyright © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins
Sodium ImbalancesSodium Imbalances
• Hyponatremia (<135 mEq/L)
– Hypertonic
– Hypotonic (dilutional)
• Hypernatremia (>145 mEq/L)
– Water deficit
– Na+ administration
Copyright © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins
ScenarioScenario
• A man with hypernatremia was severely confused.
Question:
• The doctor said this was due to a change in the size of his brain cells. Why would this happen?
• A medical student suggested giving him a hypotonic IV. Why?
• The doctor said that might worsen the change in his brain cell size, and that his blood osmolarity should be corrected very slowly. Why?
Copyright © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins
PotassiumPotassium
• Normal level is 3.5–5.0 mEq/L
• Maintains intracellular osmolarity
• Controls cell resting potential
• Needed for Na+/K+ pump
• Exchanged for H+ to buffer changes in blood pH
Copyright © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins
What Will Happen to Blood K+ Levels When the Client Has:What Will Happen to Blood K+ Levels When the Client Has:
• Hyperaldosteronism?
• Alkalosis?
• An injection of epinephrine?
• Convulsions?
• Loop diuretics?
Copyright © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins
The Basics of Cell FiringThe Basics of Cell Firing
• Cells begin with a negative charge— resting membrane potential
• Stimulus causes some Na+ channels to open
• Na+ diffuses in, making the cell more positive
Threshold potential
Resting membrane potential stimulus
Copyright © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins
The Basics of Cell Firing (cont.)The Basics of Cell Firing (cont.)
• At threshold potential, more Na+ channels open
• Na+ rushes in, making the cell very positive: depolarization
• Action potential: the cell responds (e.g., by contracting)
Threshold potential
Resting membrane potential stimulus
Action potential
Copyright © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins
The Basics of Cell Firing (cont.)The Basics of Cell Firing (cont.)
• K+ channels open
• K+ diffuses out, making the cell negative again: repolarization
• Na+/K+ ATPase removes the Na+
from the cell and pumps the K+ back in
Threshold potential
Resting membrane potential stimulus
Action potential
Copyright © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins
Blood K+ Levels Control Resting PotentialBlood K+ Levels Control Resting Potential
• Hyperkalemia raises resting potential toward threshold
– Cells fire more easily
– When resting potential reaches threshold, Na+ gates open and won’t close
Threshold potential
Normal resting membrane potential
Hyperkalemia
Copyright © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins
Blood K+ Levels Control Resting Potential (cont.)Blood K+ Levels Control Resting Potential (cont.)
• Hypokalemia lowers resting potential away from threshold
– Cells fire less easily
Threshold potential
Normal resting membrane potential Hypokalemia
Copyright © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins
Question Question
What effect does a potassium level of 7.5 mEq/L have on resting membrane potential (RMP)?
a. RMP becomes less negative, and it takes a greater stimulus in order for cells to fire.
b. RMP becomes less negative, and it takes less of a stimulus in order for cells to fire.
c. RMP becomes more negative, and it takes a greater stimulus in order for cells to fire.
d. RMP becomes more negative, and it takes less of a stimulus in order for cells to fire.
Copyright © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins
Answer Answer
b. RMP becomes less negative, and it takes less of a stimulus in order for cells to fire.
A potassium level of 7.5 mEq/L is considered hyperkalemic. In hyperkalemia, RMP is moved closer to the threshold (it becomes less negative). Because RMP is nearer to the threshold, a weaker stimulus will cause the cell to fire (a lesser distance must be overcome).
Copyright © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins
CalciumCalcium
• Normal level is 8.5–10.5 mg/dL
• Extracellular: blocks Na+ gates in nerve and muscle cells
• Clotting
• Leaks into cardiac muscle, causing it to fire
• Intracellular: needed for all muscle contraction
• Acts as second messenger in many hormone and neurotransmitter pathways
Copyright © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins
Copyright © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins
Scenario:Scenario:
• A man with metastatic cancer complains of bone pain and sudden weakness.
Question:
• Why did the doctor measure:
– PTH?
– Calcium levels?
– Vitamin D levels?
Copyright © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins
MagnesiumMagnesium
• Normal level is 1.8–2.7 mg/dL
• Cofactor in enzymatic reactions
– Involving ATP
– DNA replication
– mRNA production
• Binds to Ca2+ receptors
• Can block Ca2+ channels
Copyright © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins
Extracellular Calcium Controls Nerve FiringExtracellular Calcium Controls Nerve Firing
• Hypercalcemia
– Blocks more Na+ gates
– Nerves are less able to fire
• Hypocalcemia
– Blocks fewer Na+ gates
– Nerves fire more easily
• Which would cause Trousseau sign?
Copyright © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins
Question Question
Tell whether the following statement is true or false:
Both hyperkalemia and hypercalcemia cause cells to fire more easily.
Copyright © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins
Answer Answer
False
Recall that hyperkalemia cause cells to fire more easily by moving RMP closer to the threshold. Hypercalcemia, on the other hand, blocks more sodium gates. If less sodium enters the cell, it cannot depolarize as quickly (it is less likely to fire). Hypocalcemia blocks fewer sodium gates–cells depolarize more quickly (they are more likely to fire).
Copyright © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins
Copyright © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins
Acid (H+)Acid (H+)
• Normal value: pH = 7.35–7.45
• Blocks Na+ gates
• Controls respiratory rate
• Individual acids have different functions:
– Byproducts of energy metabolism (carbonic acid, lactic acid)
– Digestion (hydrochloric acid)
– “Food” for brain (ketoacids)
Copyright © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins
Respiratory or Volatile AcidRespiratory or Volatile Acid
• CO2 + H2O H2CO3 (carbonic acid)
• H2CO3 H+ + HCO3- (bicarbonate ion)
• An increase in CO2 will cause
– Increases in CO2 (increased PCO2)
– Increases in H+ (lower pH)
– Increases in bicarbonate ion
Copyright © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins
Respiratory Acidosis and AlkalosisRespiratory Acidosis and Alkalosis
• CO2 + H2O H2CO3 H+ + HCO3- (bicarbonate ion)
Respiratory acidosis Respiratory alkalosis
Increased PCO2
Increased carbonic acid
Increased H+ = low pH (<7.35)
Increased bicarbonate
Decreased PCO2
Decreased carbonic acid
Decreased H+ = high pH (>7.45)
Decreased bicarbonate
Copyright © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins
Question Question
Tell whether the following statement is true or false:
Serum levels of pH and CO2 levels are directly proportional.
Copyright © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins
Answer Answer
False
As blood levels of CO2 increase, pH becomes more acidic (decreases).
Copyright © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins
Respiration and Buffers Adjust Blood pHRespiration and Buffers Adjust Blood pH
Scenario:• A woman was given an acidic IV. Soon she began to
breathe more heavily. Why?• When her blood was tested, it had:
– Slightly lowered pH– Low bicarbonate– Low PCO2
– Slightly increased K+
• Her urine pH was slightly lowered• Why?
Copyright © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins
Buffer SystemsBuffer Systems
Copyright © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins
Metabolic Acid ImbalancesMetabolic Acid Imbalances
• Metabolic acidosis
– Increased levels of ketoacids, lactic acid, etc.
– Decreased bicarbonate levels
• Metabolic alkalosis
– Decreased H+ levels
– Increased bicarbonate levels
Copyright © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins
Metabolic Acidosis and AlkalosisMetabolic Acidosis and Alkalosis
• Increased metabolic acids raise H+ levels
• Some H+ combines with bicarbonate, decreasing it
• Breathing adjusts CO2 levels to bring pH back to normal
Metabolic acidosis Metabolic alkalosis
Increased H+ = low pH (<7.35)
Decreased bicarbonate
Heavier breathing causes decreased PCO2
Decreased H+ = high pH (>7.45)
Increased bicarbonate
Lighter breathing causes increased PCO2