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Overview Energy and matter Atoms, molecules, and chemical bonds Importance of organic and inorganic
nutrients and metabolites Structure and function of carbohydrates,
lipids, proteins, and nucleic acids Enzymes and ATP help run the metabolic
reactions of the body
Energy
The capacity to do work (put matter into motion)
Types of energy Kinetic – energy in action Potential – energy of position; stored (inactive)
energy Energy is easily converted from one form to
another During conversion, some energy is “lost” as
heat
Why is chemistry important to anatomy and physiology?
Chemistry is the science that deals with matter
Matter is anything that takes up space and has mass
Smallest stable units of mass are atoms
Elements vs. Molecules
Elements are atoms of one particular type (from the periodic table)
Molecules are groups of atoms that contain more than one element
Elements found in the body
13 principal elements Oxygen (O) Carbon (C) Hydrogen (H) Nitrogen (N) Calcium (Ca), phosphorus (P), potassium (K),
sulfur (S), sodium (Na), chlorine (Cl), magnesium (Mg), iodine (I), and iron (Fe)
13 trace elements (e.g. zinc, manganese)
Elements with unfilled electron shells are reactive
To become stable they form chemical bonds.
Three main types of chemical bonds Intramolecular:
Ionic bonds (charged atoms resulting from the gain or loss of electrons)
Covalent bonds (electrons are shared) Intermolecular
Hydrogen bonds
Ionic and covalent bonds
Molecules: atoms held together by covalent bonds
Salts: molecules held together by ionic bonds
Q: What are the strongest type of bonds?
Importance of water
The body is mostly water (~2/3rds of total body weight) so all chemical reactions in the body occur in water
Covalent bonds are much stronger than ionic bonds in water
Water properties
Water can dissolve organic and inorganic molecules making a solution
Water is needed for chemical reactions Water can absorb and retain heat Water is an effective lubricant
Mixtures and Solutions
Mixtures – two or more components physically intermixed (not chemically bonded) Solutions – homogeneous mixtures of
components Colloids (emulsions) – heterogeneous mixtures
whose solutes do not settle out Suspensions – heterogeneous mixtures with
visible solutes that tend to settle out
Essential Molecules
Nutrients: essential molecules obtained from food
(you have to eat them to get them) Metabolites:
molecules made or broken down in the body
Organic vs. inorganic
Organic molecules: Always contain carbon with hydrogen, and
sometimes oxygen Often soluble in waterInorganic: Electrolytes, minerals, and
compounds that do not contain carbon with hydrogen.
Important examples: oxygen, carbon dioxide, water, inorganic acids and bases, salts
Vitamins and Minerals
Vitamins and minerals are essential nutrients that are required in very small amounts for healthy growth and development.
Examples? They cannot be synthesized by the body
and are essential components of the diet.
Vitamins
Organic substances necessary for metabolism
There are 13 known vitamins (e.g. A, B1, D, K)
Some are fat soluble while others are water soluble
Are Coenzymes that help carry out the reactions of metabolism
Minerals
Inorganic compound (often salts or elements) necessary for proper body function
Can be bulk or trace minerals Are Cofactors in metabolic reactions
Electrolytes
Inorganic ions (usually minerals) that conduct electricity in solution
Electrolyte balance is maintained in all body fluids; imbalance seriously disturbs vital body functions
Biological Macromolecules
Life depends on four types of organic macromolecules:1. Carbohydrates
2. Lipids
3. Proteins
4. Nucleic acids
Can you think of an example of each?
1. Carbohydrates
Contain carbon, hydrogen and oxygen in a ratio of 1:2:1
Account for less that 1% of body weight
Used as energy source Called saccharides
Polysaccharides
Starch Glycogen Cellulose
All are long strings of glucose molecules
Difference lies in how they are bonded together
Polymers
A polymer is any molecule made up of several repeating units. Starch is a polymer of glucose.
2. Lipids
Contain carbon, hydrogen, and oxygen but the ratio of C:H is 1:2 (much less O)
May also contain other elements, phosphorous, nitrogen, and sulfur
Form essential structures in cells Are important energy stores
Lipids: Triglycerides (Fats and Oils)
Consist of 3 fatty acids and glycerol Insulation Energy protection
Q: What ‘s the difference between saturated and unsaturated?
Protein Structure
Proteins are the most abundant and important organic molecules
Basic elements: carbon (C), hydrogen (H), oxygen (O),
and nitrogen (N) Basic building blocks:
20 amino acids
Figure 2–20a
Protein Structure – 4 levels
Primary: amino acid sequence
Secondary: Hydrogen bonds form spirals or pleats
Tertiary: Secondary structure folds into a unique shape
Quaternary: several tertiary structures together
Shape and Function
Protein function is based on shape Shape is based on sequence of amino
acids Denaturation:
loss of shape and function (due to heat, pH change or other factors)
Protein Functions
support: structural proteins
movement: contractile proteins
transport: transport proteins
buffering: regulation of pH
metabolic regulation: enzymes
coordination and control: hormones
defense: antibodies
Proteins: Enzymes
Enzymes are catalysts: proteins that lower the activation energy of a
chemical reaction are not changed or used up in the reaction
Other factors that speed up reactions: Increased temperatures Smaller particles Higher concentrations
Figure 2–7
Activation Energy
Chemical reactions in cells cannot start without help
Activation energy gets a reaction started
Energy In, Energy Out
Exergonic reactions: produce more energy than they use
Endergonic reactions: use more energy than they produce
KEY CONCEPT
Most chemical reactions that sustain life cannot occur unless the right enzymes are present
How Enzymes Work
Substrates: reactants in enzymatic reactions
Active site: a location on an enzyme that fits a
particular substrate
Figure 2–21
Active siteAmino acids
Enzyme (E)Enzyme-substratecomplex (E-S)
Internal rearrangementsleading to catalysis
Dipeptide product (P)
Free enzyme (E)
Substrates (S)
Peptide bond
H2O
+
How EnzymesWork
4. Nucleic acids
Contain C, H, O, N, and P
DNA and RNA are nucleic acids
Nucleotide consists of Sugar Phosphate group Nitrogenous base
A nucleotide: ATP
Energy storage for cells
Many enzymes use ATP
Provides a way to run reactions that are otherwise endergonic (require energy)
Figure 2.24
Solute Solute transported
Contracted smoothmuscle cell
Product made
Relaxed smoothmuscle cell
Reactants
Membraneprotein
P Pi
ATP
PX X
Y
Y
+
(a) Transport work
(b) Mechanical work
(c) Chemical work
Pi
Pi
+ADP
ATP is the energy currency of the cell