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Chemosensors of Ion and Molecule Recognition
NATO ASI Series Advanced Science Institutes Series
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The Partnership Sub-Series incorporates activities undertaken in collaboration with NA TO's Cooperation Partners, the countries of the CIS and Central and Eastern Europe, in Priority Areas of concern to those countries.
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Series C: Mathematical and Physical Sciences - Vol. 492
Chemosensors of Ion and Moleeule Recognition
edited by
J. P. Desvergne Laboratoire de Photochimie Organique. Universite Bordeaux I. Talence. France
and
A. W. Czarnik Irori Quantum Microchemistry. La Jolla. California. U.S.A.
Springer-Science+Susiness Media, SV.
Proceedings of the NATO Advanced Research Workshop on Chemosensors of Ion and Molecule Recognition Bonas, France August 31-September 4,1996
A C.I.P. Catalogue record for this book is available from the Library of Congress.
ISBN 978-94-010-5759-2 ISBN 978-94-011-3973-1 (eBook) DOI 10.1007/978-94-011-3973-1
Prinfed on acid-free paper
All Rights Reserved © 1997 Springer Science+Business Media Dordrecht Originally published by Kluwer Academic Publishers in 1997 Softcover reprint of the hardcover 1 st edition 1997 No part of the material protected by this copyright notice may be reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording or by any information storage and retrieval system, without written permission from the copyright owner.
This book contains the proceedings of a NATO Advanced Research Workshop held within the programme of activities of the NATO Special Programme on Supramolecular Chemistry as part of the activities of the NATO Science Committee.
Other books previously published as a result of the activities of the Special Programme are:
WIPFF, G. (Ed.), Computational Approaches in Supramolecular Chemistry. (ASIC 426) 1994. ISBN 0-7923-2767-5
FLEISCHAKER, G.R., COLONNA, S. and LUISI, P.L. (Eds.), Self-Production of Supramolecular Structures. From Synthetic Structures to Models of Minimal Living Systems. (ASIC 446) 1994. ISBN 0-7923-3163-X
FABBRIZZI, L., POGGI, A. (Eds.), Transition Metals in Supramolecular Chemistry. (ASIC 448) 1994. ISBN 0-7923-3196-6
BECHER, J. and SCHAUMBURG, K. (Eds.), Molecular Engineering for Advanced Materials. (ASIC 456) 1995. ISBN 0-7923-3347-0
LA MAR, G.N. (Ed.), Nuclear Magnetic Resonance of Paramagnetic Macromolecules. (ASIC 457) 1995. ISBN 0-7923-3348-9
SIEGEL, JAY S. (Ed.), Supramolecular Stereochemistry. (ASIC 473) 1995. ISBN 0-7923-3702-6
WILCOX, C.S. and HAMILTON A.D. (Eds.), Molecular Design and Bioorganic Catalysis. (ASIC 478) 1996. ISBN 0-7923-4024-8
MEUNIER, B. (Ed.), DNA and RNA Cleavers and Chemotherapy of Cancer and Viral Diseases. (ASIC 479) 1996. ISBN 0-7923-4025-6
KAHN, O. (Ed.), Magnetism: A Supramolecular Function. (ASIC 484) 1996. ISBN 0-7923-4153-8
ECHEGOYEN, L., KAIFER ANGEL E. (Eds.), Physical Supramolecular Chemistry. (ASIC 485) 1996. ISBN 0-7923-4181-3
TABLE OF CONTENTS
Preface
Organizing Cornmitee
List of participants
1. H. T. Luong Modification of cyclodextrins to control their guest-host chemisti)' and their application as chemosensors
R Y. Tsien New fluorescent readouts for protein interactions, gene expression, and membrane potential
M. M. G. Antonisse, R 1. W. Lugtenberg, R J. M. Egberink, J. F. J. Engbersen, and D. N. Reinhoudt
Chemical sensors based on field effect transistors; selective recognition of cations and anions
S. Shinkai Aqueous sugar sensing by boronic-acid-based artificial receptors
O. S. Woifbeis, C. Huber, and T. Werner Solid state supramolecular optical sensors
L. Fabbrizzi, G. Francese, M. Liccelli, P. Pallavicini, A. Perotti, A. Poggi, D. Sacchi, and A. Taglietti
Fluorescent chemosensors which take profit from the metalligand interaction
D. Diamond, T. Grady, S. O'Neill, and P. Kane Recognition, transduction and immobilisation- A holistic approach to sensor development
A. Ueno, H. Ikeda, and 1. Wang Signal transduction in chemosensors of modified cyclodextrins
vii
ix
x
xi
1
17
23
37
61
75
91
105
T. W. Bell and Z. Hou Hydrogen bonding chemosensors for metabolites and nucleotides 121
T. M. Swager New approaches to sensory materials: Molecular recognition in conjugated polymers. New transduction methodology 133
A. P. De Silva, H. Q. N. Gunaratne, T. Gunnlaugsson, A. 1. M. Huxley, 1. T. Rademacher, and T. E. Rice
Higher generation luminescent PET (photoinduced electron transfer) sensors 143
W. K. Hartmann, M. A. Mortellaro, D. G. Nocera, and Z. Pikramenou Chemosensing of monocyclic and bicyclic aromatic hydrocarbons by supramolecular active sites 159
E. U. Akkaya Squaraine-based long wavelength fluorescent chemosensors for ions
J. Yoon, N.E. Ohler, D.H. Vance, W.D. Aumiller and A.W. Czarnik A fluorescent chemosensor with selectivity for Hg(II). Chelatoselectivity via ligand immobilization
B. Valeur, F. Badaoui, E. Bardez, 1. Bourson, P. Boutin. A. Chatelain, I. Devol, B. Larrey, J. P. Lefevre, and A. Soulet
Cation-responsive fluorescent sensors
F. Fages Fluorescent, siderophore-based hydroxamate chelators for the detection of transition-metal ions
Author index
Subject index
viii
177
189
195
221
241
243
PREFACE
In the broad field of supramolecular chemistry, the design and hence the use of
chemosensors for ion and molecule recognition have developed at an extroardinary rate.
This imaginative and creative area which involves the interface of different
disciplines, e.g. organic and inorganic chemistry, physical chemistry, biology,
medicine, environmental science, is not only fundamental in nature. It is also clear that progress is most rewarding for several new sensor applications deriving from the
specific signal delivered by the analyte-probe interaction.
Indeed, if calcium sensing in real time for biological purposes is actually
possible, owing to the emergence of efficient fluorescent receptors, other elements can
also be specifically detected, identified and finally titrated using tailored chemosensors.
Pollutants such as heavy metals or radionuclides are among the main targets since their
detection and removal could be envisioned at very low concentrations with, in addition,
sensors displaying specific and strong complexing abilities. Besides, various species of
biological interest (or others, the list is large) including sugars and other micellaneous
molecules such as oxygen and carbon dioxide can be actually probed with optodes and
similar devices.
The present volume in which the key lectures of the workshop are collected
gives a survey of the main developments in the field.
The success of the workshop mainly came from the high quality of the lectures,
the invited short talks, the two posters sessions and the many very lively discussions
which without doubt will produce positive outcomes.
The workshop and therefore this monograph would not have been possible
without the generous financial support from the NATO Science Committee to whom
the organizers and the attendees are greatly indebted.
We would also like to thank the members of our research group for their assistance in organizing the meeting. Special thanks go to Mrs Simon and to the staff of
the CMteau de Bonas who offered us not only remarkable facilities for the scientific
session but also an outstanding social programme in a friendly atmosphere.
Jean-Pierre Desvergne Anthony W. Czarnik
February 1997
ORGANIZING COMMITTEE
Dr. Anthony Czarnik Senior Director, Chemistry IRORI Quantum Microchemistry 11025 N. Torrey Pines Rd., STE 100 LA JOLLA CA 92037 [email protected]
Dr. Jean-Pierre Desvergne Director of Research, CNRS Laboratoire de Photochimie Organique Universite Bordeaux I 351, COUTS de la Liberation F 33405 TALENCE, Cedex FRANCE [email protected]
Professor A.P. de Silva School of Chemistry Queen's University of Belfast David Keir Building Belfast BT 9 5AG N. IRELAND chg 123 [email protected]
x
Tel: 11619546 1300 Fax: 1/6195463082
Tel: 33/(0)5 56 84 62 79 Fax: 33/(0)5 56 84 66 45
Tel: 44/1232 245133 ext 4422 Fax: 44/1232 382117
LIST OF PARTICIPANTS
KEY SPEAKERS:
Canada
France
Gennany
Italy
Dr. John H. T. Luong Biotechnology Research Institute National Research Council Canada 6100 Royalmount Avenue Montreal, Quebec H4P 2R2 CANADA [email protected]
Tel: 115144966175 Fax: 115144966265
"Modification ofCyclodextrins to Control Their Guest-host Chemistry and Application as Chemosensor"
Professor Henri Bouas-Laurent Laboratoire de Photochimie Organique Universite Bordeaux I 351, Cours de la Liberation 33405 Talence, Cedex FRANCE "Conference Welcome"
Dr. Frederic Fages Laboratoire de Photochimie Organique CNRS UA348 351 Cours de la Liberation 33405 Talence, Cedex FRANCE [email protected]
Tel: 33/(0)5 56 84 62 72 Fax: 33/(0)5 56 8466 45
Tel: 33/(0)5 56 84 89 42 Fax: 33/(0)5 56 8466 45
"Fluorescent, Siderophore-Based Hydroxamate Chelators for the Detection of Transition Metals Ions"
Professor Bernard Valeur Laboratoire de Chimie Generale Conservatoire National des Arts et Metiers 292, rue Saint-Martin F-75141 Paris Cedex 03 FRANCE [email protected]
Tel: 33/(0)1 40 27 23 89 Fax: 33/(0)1 40 27 23 62
"Cation-Responsive Fluorescent Sensors in Solution and in Microheterogeneous Media"
Professor Otto Wolfbeis University of Regensburg Institute for Analytical Chemistry, Chemo- and Biosensors 93040 Regensburg GERMANY otto. [email protected]
Tel: 491941 943 4066 Fax: 491941 943 4064
"Complete Mass-Transfer is Required in Indicator-Based Optical Sensors"
Professor Luigi Fabbrlzzi Dipartimento di Chimica Generale Universita di Pavia Via Taramelli 12, 1-27100 Pavia ITALY [email protected]
Tel: 39/38 250 7329 Fax: 39/38 252 8544
"Fluorescent Chemosensors Which Take Profit From The Metal-Ligand Interaction"
xi
xii
Japon
Netherlands
Turkey
United Kingdom
United States
Professor Akihiko Ueno Department of Bioengineering Tokyo Institute of Technology 42S9 Nagatsuta, Midori-ku Yokohama 226, JAPAN [email protected]
Tel: 81145 924 5757 Fax: 81/4S 923 0374
"Signal Transduction in Chemosensors of Modified Cyclodextrlns"
Professor Seiji Sldnkai Fax: 81192 642 3611 Department of Chemical Science and Technology Faculty of Engineering Kyushu University Hakozaki, Higashi-ku Fukuoka812 [email protected] "Aqueous Sugar Sensing by Boronic acid-Appended Artificial Receptors"
Professor David N. Relnhoudt Tel: 31153 4892981 Department of Chemical Technology Fax: 31/53 4894645 Technische Twente Hogeschool P.O. Box 217 7500 AE Enschede NETHERLANDS van=der=Ploeg%Secr"/[email protected] "Chemical Sensors Based on Field Effect Transistors; Selective Recognition of Cations and Anions"
Professor Engin U. Akkaya Department of Chemistry Middle East Technical University Ankara, 06S31 TURKEY [email protected]
Tel: 90/312 210 5126 Fax: 90/312 2101280
"Squaraine-based Long Wavelength Fluorescent Chemosensors for Ions"
Professor AP. de SUva "Higher-Generation Luminescent PET Sensors"
Professor Thomas BeD Tel: 11702 7841842 Department of Chemistry 1 216 Fax: In02 7846804 University of Nevada RENO NV 89557-0020 [email protected] "Hydrogen-Bonding Chemosensors for Metabolites and Nucleotides"
Dr. Anthony Czarnik "Fluorescent Chemosensors: Challenges, Insights and Opportunities"
Professor Daniel Nocera Department of Chemistry Michigan State University EAST LANSING Ml 48824 [email protected]
Tel: 115173559715 ext. 180 Fax: 11517353 1793
"Optical Supramolecules: Chemical Sensing to Planes, Trains and Automobiles"
Professor Timothy Swaler Department of Chemistry Massachusetts Institute of Technology CAMBRIDGE MA 02139 [email protected]
Tel: 116172534423 Fax: 11617 253 7929
"New Approaches to Sensory Materials: Molecular Recognition In Conducting Polymers"
Professor Roger Y. Tsien Howard Hughes Medical Institute 310 Cellular and Molecular Medicine, M-047 School of Medicine University of California, San Diego LA JOLLA CA 92093-0647 [email protected]
Tel: 116195344891 Fax: 116195345270
"Fluorescent Sensors of Protein-Protein Interaction, Gene Expression and Membrane Potential"
xiii
Participants from NATO countries:
Belgium
France
Dr. Jean-Louis Habib JIwan UCUCICO-CHOP I Place Louis Pasteur B 1348 Louvain-Ia-Neuve, BELGIUM [email protected] "Fluorescent Probes Supported on Silica Matrix"
Martial Archenault CYLERGIE L 'Oree d'Ecully Chernin de la F orestiere 69130 EcullyCedex, FRANCE
Tel: 32/10 47 27 16 Fax: 32/10 47 30 09
Tel: 33/(0)4 78 43 39 56 Fax: 33/(0)4 78 43 30 59
"Development and Application of a Chlorine Amperometric Microsensor the Drinking Water Monitoring"
Dr Jean-Pierre Desvel"Jlle "Complexing and Photophysical Properties of Some Fluorescent Coronands"
Damien Marquis Laboratoire de Photochirnie Organique Universite Bordeaux I 351, Cours de la Liberation 33405 Talence Cedex, FRANCE
Tel: 33/(0)5 56 8462 79 Fax: 33/(0)5 56 84 66 45
"Complexing and Photophysical Properties of Some Fluorescent Coronands"
Sylvie Debnond Institut de Chimie de la Matiere Condensee Chateau de Brivazac, Avenue du Dr. Schweitzer 33608 Pessac Cedex, FRANCE [email protected]
Tel: 33/(0)5 56 86 62 70 Fax: 33/(0)5 56 8426 49
"Cation-delayed and Cation-triggered Photoinduced Intramolecular Charge Transfer in Fluorescent Probes"
Michel Lamotte Laboratoire de Photochirnie Organique Universite Bordeaux I 351, Cours de la Liberation 33405 Talence Cedex, FRANCE [email protected]
Dr. Rene Lapouyade Institut de Chimie de la Matiere Condensee Chateau de Brivazac, Avenue du Dr. Schweitzer 33608 Pessac Cedex, FRANCE [email protected]
Tel: 33/(0)5 56 84 63 16 Fax:33/(0)5 56 84-66 45
Tel: 33/(0)5 56 84 62 70 Fax: 33/(0)5 56 84 26 49
"Cation-delayed and Cation-triggered Photoinduced Intramolecular Charge Transfer in Fluorescent Probes"
xiv
Gennany
Rachel MeaJe ENS Cachan, PPSM-CNRS URA 1906 61, avenue du President Wilson 94235 Cachan Cedex, FRANCE [email protected] "Development of Calcium Sensitive Latex"
Robert Pamu ENS Cachan, PPSM-CNRS URA 1906 61, avenue du President Wilson 94235 Cachan, Cedex FRANCE [email protected] "Photophysics of Calcium Green in Cells"
Laetitia Schoutteten ENS Cachan, PPSM-CNRS URA 1906 61, av du President Wilson 94235 Cachan, Cedex FRANCE [email protected] "Photophysics of Calcium Green in Cells"
Zouhair Asfari E.C.P.M., Lab. de Chimie des Interactions 1, rue Blase Pascal 67008 Strasbourg Cedex, FRANCE [email protected]
Tel: 33/(0)1 47402705 Fax: 33/(0)1 474024 54
Tel: 33/(0)1 47 40 27 26 Fax: 33/(0)1 47402454
Tel: 33/(0)1 47402705 Fax: 33/(0) I 47 40 24 54
Tel: 33/(0)3 88 41 68 00 Fax: 33/(0)3 88 60 45 39
"Calix[4]-bis-crowns and Calix[4]-bis-aza-oxa-crowns: from Receptors Design to Molecular Machinery. "
Juergen Buegler University of Reg ens burg Anorg. Chemie/Prof Dr. Henri Brunner 93040 Regensburg GERMANY Juergen. [email protected]
Tel: 49/(0)9419434096 Fax: 49/(0)941 943 4439
Prof Kurt E. Geckeler Tel: 4917071 29724 80 University ofTuebingen Fax: 4917071 84801 Institute of Organic Chemistry Auf der Morgenstelle 18 0-72076 Tuebingen, GERMANY [email protected] "Chemical Sensors Based on Polymers for the Detection of Organic Solvents"
Christian Haider Tel: 491941 943 4060 University of Regensburg Fax: 49/941 9434064 Institute for Analytical Chemistry, Chemo- and Biosensors 93040 Regensburg GERMANY [email protected]
Guenther Hennrich Tel: 49/941 9434054 University of Regensburg Institute for Analytical Chemistry, Chemo- and Biosensors 93040 Regensburg GERMANY [email protected]
Christian Huber University of Regensburg Institute for Analytical Chemistry, Chemo- and Biosensors 93040 Regensburg GERMANY [email protected]
Ute Kosch University ofRegensburg Institute for Analytical Chemistry, Chemo- and Biosensors 93040 Regensburg GERMANY [email protected]
Matthias Nl&ccmann Vorlaenderweg 60 0-48151 Muenster, GERMANY [email protected]
Ralf Oesterelch University of Regensburg Institute for Analytical Chemistry, Chemo- and Biosensors 93040 Regensburg GERMANY [email protected]
Erika Prlncsheim University of Regensburg Institute for Analytical Chemistry, Chemo- and Biosensors 93040 Regensburg GERMANY [email protected]
Mario SlIDdor Anorganisch-chemisches Institut Technische Universitat Milnchen Lichtenbergstr. 4 85747 Garching GERMANY [email protected]
Ewald Terpetschnl& University of Regensburg Institute for Analytical Chemistry 93040 Regensburg GERMANY [email protected]
UweTrebbe Melchersstrasse 69 0-48149 Muenster, GERMANY [email protected]
Tobias Werner University of Regensburg Institute for Analytical Chemistry, Chemo- and Biosensors 93040 Regensburg GERMANY Tobias. [email protected]
Tel: 491941 9434059 Fax: 491941 9434055
Tel: 4919419434017 Fax: 4919419434064
Tel: 49/2519801965 Fax: 491251 9801999
Fax: 4919419434064
Tel: 491941 943 4010 Fax: 491941 943 4064
Tel: 49/892 8913137
Tel: 491941 943 4059 Fax: 491941 9434064
Tel: 491251 980 1965 Fax: 491251 980 1999
Tel: 4919419434015 Fax: 491941 943 4064
xv
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Ireland
Italy
Netherlands
Portugal
Spain
Turkey
United Kingdom
Professor Dennot Diamond School of Chemical Sciences Dublin City University Dublin 9 IRELAND [email protected]
Tel: 353/1 7045404 Fax: 353/17045601
"Recognition, Transduction and Immobilisation-Fundamental Challenges for New Sensor Materials"
Angelo TagHetti Dipartimento de Chimica Generale Universita' degli Studi di Pavia Viale Taramelli 12 27100 Pavia, ITALY [email protected] "Anion Recognition Based on the Metal-Ligand Interaction"
Niels "an der Veen Department of Chemical Technology Technische Twente Hogeschool P.O. Box 217 7500 AE Enschede NETHERLANDS [email protected]
M. Alexandra Bernardo Universidade Nova de Lisboa Faculdade de Ciencias e Tecnologia Departamento de Quimica 2825 Monte de Caparica PORTUGAL [email protected]
Jose Manuel Costa-Fernandez Universidad de Oviedo Departamento de Quimica Fisica y Analitica C/Julian Claveria 8 33006 Oviedo, SPAIN
Tel: 39/382 507329 Fax: 39/382 528 544
Tel: 31153 489 2984
Tel: 35111 295 4464 Fax: 35111 2948550
Tel: 34/85103125 Fax: 34/ 8 5103125
"Sol-Gel Technologies for the Development of Room Temperature Phosphorescence Sensing Phases: Application for Oxygen and Water RTP Sensors" [email protected]
Dr. Necla CagJarirmak Mithatpasa Caddesi Cangonul Ap 218/3 Karatas-Izmir, TURKEY
Dr. Nurcan Cetinkaya [email protected]
Tel: 90/232 489 8642 Fax: 90/232 441 8720
Prof Dr. Cakil Erk Tel: 90/02122853227 Maslak, 80626, Istanbul, TURKEY Fax: 90/02 122856386 "Fluorescence Studies of the Aromatic Macrocycles and Cationic Interactions in Acetonitrile"
Thorri Gunnlaugsson School of Chemistry Queen's University of Belfast Daivd Keir Building Belfast BT 9 5AG, N. IRELAND [email protected] "A Phosphorescent Sensor for Calcium Based on PET"
Tel: 44/1 23 2245133 Fax: 44/1 23 238 2117
United States
Dr. Michael 1. Hannon Department of Chemistry University of Warwick Gibbet Hill Road, Coventry CV4 7AL, U.K [email protected].
Tel: 44/1 203 52 4107 Fax: 44/1 203 524112
"Metallosupramolecular Cage Assemblies; Boxes for Sensing Small Molecules"
Dr. Zoe Pikramenou Department of Chemistry University of Edinburgh King's Buildings, West Mains Rd. Edinburgh EH9 3JJ, u.K. [email protected] "Luminescent Lanthanide Sensors"
Xavier Poteau Chemistry Department University of Central Lancashire Preston PRI 2HE Lancashire, UNITED KINGDOM [email protected] "TICT Sensors for Metal Ions"
Andrei Bonlunov California Institute of Technology Div of Chern. and Chem. Eng. 210-41 PASADENACA 91125 [email protected] "A Polymenic Glucose Sensor"
James W. Canary Dept. of Chemistry New York University 100 Washington Square East NEW YORK NY 10003-6688 [email protected] "A Fluorescent Chemosensor with a Twist"
QingChang University of Maryland Baltimore County Dept ofChem. & Biochem. Eng, TRC Building 5200 Westland Boulevard BALTIMORE MD 21227 [email protected]
Tel: 44/1316504761 Fax: 44/1 31 6504743
Tel: 44/1 772 89 3520
Tel: 11818 395 4664 Fax: 118187999849
Tel: 112129988422 Fax: 112122607905
Tel: 11410 455 3431 Fax: 11410 455 6500
"A Lifetimed Based Intrinsic Fluorescence Film Sensor for the Methanol in Gasoline"
Virginie Dujols Ohio State University Dept. of Chemistry 100 W. 18 th Ave COLUMBUS OH 43210 [email protected]
Tel: 11614292 3143 Fax: 11614292 1685
"Long-Wavelength Fluorimetric Chemodosimeters for Copper (II) Ion in Water"
xvii
xviii
AJexey v. Elbeev Tel: In16 6452872 Dept of Medicinal Chemistry Fax: Int6 645 2393 414 Horchstetter Hall University of Buffalo BUFFALO NY 14260 [email protected] "Atrmity-Driven Chemical Evolution: Generation ofa Simple Arginine Receptor"
Dr. Huarui He A VL BioSense Corporation 50 Mansell Court ROSWELL GA 30076
Kurt HotTaeker Center for Biomedical Imaging Technology Univ. ofCoMectieutl Health Center 263 Fannington Ave -MC 1507 FARMINGTON CT 06030-1507
Tel: In70 587 4040 ext 681 Fax: In70 642 7501
Tel: 11860 679 1452 Fax: 118606791039
Shelli MeAlplne Tel: 113102061275 [email protected] Fax: 113108250767 "The Characterization and Properties of a (J-Cyclodextrin Moleeular Sensor"
Zakir Murtaza Ctr for Fluorescence Spectroscopy Dept of Biological Chemistry, Sch ofMed University of Maryland at Baltimore 108 N. Greene Street BALTIMORE MD 21201 [email protected] "Metal Ligand Complexes as Probes"
Jude Rademaeher Michigan State University Chemistry Department EAST LANSING MI 48824 [email protected]
Jeffrey Siplor University of Maryland Baltimore County Dept of Chern. and Biochern. Eng., TRC Building 5200 Westland Blvd. BALTIMORE MD 21227 [email protected]
Tel: 114107067500 Fax: 1/4107068408
Tel: 1/5173559715 ext 183 Fax: 115173551793
Tel: 114104553402 Fax: 11410 455 6500
"A Light Emitting Diode Demonstrated as an Excitation Source for Phase-Modulation Fluorescence Lifetime Measurement"
Scott Van Annan Department of Chemistry Franklin and Marshall College P.O. Box 3003 LANCASTER PA 17604 S _ [email protected] "A Ratiometric Fluorescence Probe for Zn(II)"
Tel: In17 2914355 Fax: Int7 2914343
xix
Participants front non-NATO Countries
Austria
Ireland
Japan
Romania
Russia
Dr. Marc Leiner AVL LIST OMBH Medical Instruments Kleistrasse 48 A-8020 Graz, AUSTRIA [email protected]
Tel: 43/316 9871034 Fax: 43/316987 1038
Teresa Grady Tel: 353/1 7045610 School of Chemical Sciences Fax: 353/1 704 5503 Dublin City Univenity Dublin 9 IRELAND [email protected] "Determination ofEnantiomeric Composition Based on the Quenching of a Chiral Calixarene"
Shane O'Neill School of Chemical Sciences Dublin City Univenity Dublin 9 IRELAND [email protected] "Ion-Sensing with Calixarenes"
Taiyo Aoyagl 4259 Nagatsuta-cho Midori-ku Yokohama 226, JAPAN [email protected]
Tel: 353/1 704 5792 Fax: 353/1 7045503
Tel: 81145 924 5758 Fax: 81145 923 0374
"Alizarin Yellow-Modified P-Cyclodextrin as a Color-change Indicator of Molecule Recognition"
Dr. Masayuki Takeuchi Department of Chemical Science & Technology Faculty of Engineering, Kyushu Univenity Fukuoka 812, JAPAN [email protected] "Sugar Sensing by Boronic acid-Appended Porphyrins"
Shinji Usui 4259 Nagatsuta-cho Midori-ku Yokohama 226, JAPAN [email protected]
Tel: 81192 642 3585 Fax: 81192 642 3611
Tel: 81145 924 5758 Fax: 81145 923 0374
"Molecule Recognition Sensors of Dansyl-Modified Cyclodextrins with Distorted Cavities"
Dr. Monica Caldararu Institute of Physical Chemistry "1.0. Murgulescu" of the Romanian Academy
Tel: 40/32 10472987 Fax: 40/32 10473649 40113 12 11 4711196
Spl. Independentei 202, 77208 Bucharets, ROMANIA [email protected] (after Nov. 1996, [email protected]) "Surface Dynamics of Oxides in Presence of Humid Oases, Investigated by in situ AC Electrical Conductivity. Correlation with Catalytic Properties."
Dr. Andrey Legin Fax: 7/812 218 2835 Laboratory of Chemical Sensors St. Petersburg Univenity 199034, St. Petersburg, RUSSIA [email protected] "Liquid Sensor Array for Recognition of Integral Chemical Composition of Beverages"
xx
Sweden
Switzerland
Ukrain
A1isa Rudnitskaya Fa,,: 7/812 218 2835 Department of Chemistry St. Petersburg University 199034, St. Petersburg, RUSSIA [email protected] "R&D of Sensor Materials for Solution Sensors Based on the Principles of Electronic Tongue"
Dr. RolfClUtor Siemens-Elema Life Support Division S-17195 SoIna, Sweden [email protected]
Tel: 46/87307443 Fax: 46/8 293079
Dr. Gerhard Mohr Tel: 4111445 13 50 Centre for Chemical Sensors Fax: 4111445 1235 ETH-Technopark Technoparkstr.l CH-8005 Zurich, Switzerland [email protected] "Synthesis and Characterization of Novel Chromoionophores for Optical Sensing of Ethanol"
Dr. Adrian Waldner Central Research Laboratories Ciba Geigy Ud. R-1060.2.02, P. O. Bo" CH-4002 Basel, SWITZERLAND adrian. [email protected]
Tel: 41161 9677503 Fax: 41161 967 8252
Prof. Nicolaj Staroduh Tel: 380/442939589 A V. Palladin Instiute ofBiochemsitry Fax: 380/44 229 6365 Ukrainian Academy of Sciences 9 Leontovicha Street 252030 Kiev-30, UKRAINE [email protected] "Express Control of Pesticides in Vegetables by Electrochemical Sensors"
Valentyne M. Starodub Institute of Biochemistry 9 Leotovicha Street Kiev, 252030, UKRAINE [email protected]
Galina N. Zllitseva Institute ofSorbtion & Endoecology Academy of Sciences of Ukraine Kiev UKRAINE 252125 [email protected]
Vladimir Zaitsev Kiev Shevchenko University 60 Vladimirskaya Street KIEV UKRAINE 252033 [email protected]
Tel: 380/44 293 9589 Fax: 380/44 229 6365
Tel: 380/44 2213266 Fax: 380/44483 5405
Tel: 380/44 2213266 Fax: 380/44483 5405
"Optical Sensors Based on Silica with Chemically-Modified Surface"
NOTE: The definitions of countries as NATO and NON-NATO are as listed by The North Atlantic Treaty Organization.
CONFERENCE PHOTO
Reading Left to Right
First Row: Robert Pansu, Andrei Bordunov, Caldl Erk, A.P. de Silva, Bernard Valeur, Anthony Czarnik, lean-Pierre Desvergne, Henri Bouas-Laurent, Otto Wolfbeis, Laetitia Schoutteten, Rachel Mea1et, Shelli McAlpine
Second Row: Monica Caldararu, Taiyo Aoyagi, 10hn H. T. Luong, Akihiko Ueno, Zouhair Asfari, Zakir Murtaza, Thomas Bell, Engin U. Akkaya, Galina N. Zaitseva, Nicolaj Starodub, Valentyne M. Starodub, Seiji Shinkai, M. Alexandra Bernardo
Third Row: Matthias Niggemann, Rene Lapouyade, Luigi Fabbrizzi, Teresa Grady, Dermot Diamond, Sylvie Delmond, Damien Marquis, Xavier Poteau, Vladimir Zaitsev, Gerhard Mohr, Ute Kosch, Alisa Rudnitskaya, Andrey Legin
Fourth Row: Shane O'Neill, Michael 1. Hannon, Thorri Gunnlaugsson, Zoe Pikramenou, Virginie Dujols, Frederic Fages, Qing Chang, Guenther Hennrich, Timothy Swager, Marc Leiner, Daniel Nocera, Masayuki Takeuchi, Shinji Usui
Fifth Row: Angelo Taglietti, Christian Haider, Christian Huber, Erika Pringsheim, Michel Lamotte, Tobias Werner, Kurt E. Geckeler, Alexey V. Eliseev, Scott Van Arman, lames W. Canary, Huarui He
Sixth Row: lose Manuel Costa-Fernandez, Kurt Hoffacker, Rolf Castor, Niels van der Veen, Mario Sandor, Jeffrey Sipior, Ralf Oestereich, Jude Rachemacher, Adrian Waldner, Jean-Louis Habib Jiwan, Juergen Buegler, Ewald Terpetschnig. Martial Archenault
Not pictured: Necla Caglarirmak, Nurcan Cetinkaya, David N. Reinhoudt, Uwe Trebbe, Roger Y. Tsien
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