SPECIAL FEATURES

Highlights of This Issue 503

CCR Translations

505 Human Papillomavirus Immunity inOropharyngeal Cancer: Time to Change the Game?Simon Laban and Thomas K. HoffmannSee related article, p. 634

508 Surviving Ovarian Cancer: An Affair betweenDefective DNA Repair and RB1Guang Peng and Gordon B. MillsSee related article, p. 569

Reviews

511 Breast Cancer Immunotherapy: Facts and HopesLeisha A. Emens

521 Validation of Immunohistochemical Assays forIntegral Biomarkers in the NCI-MATCHEAY131 Clinical TrialJoseph D. Khoury, Wei-Lien Wang, Victor G. Prieto,L. Jeffrey Medeiros, Neda Kalhor, Meera Hameed,Russell Broaddus, and Stanley R. Hamilton

Perspectives

532 Data Science in Radiology: A Path ForwardHugo J.W.L. Aerts

535 CAR T-Cell Therapies in Glioblastoma: A FirstLookDenis Migliorini, Pierre-Yves Dietrich, Roger Stupp,Gerald P. Linette, Avery D. Posey Jr, and Carl H. June

CANCER THERAPY: CLINICAL

541 Influence of Enzalutamide on CabazitaxelPharmacokinetics: a Drug–Drug Interaction Studyin Metastatic Castration-resistant Prostate Cancer(mCRPC) PatientsBodine P.S. Belderbos, Sander Bins,Roelof W.F. van Leeuwen, Esther Oomen-de Hoop,Nelly van der Meer, Peter de Bruijn, Paul Hamberg,Esther N.M. Overkleeft, Wendy M. van der Deure,Martijn P. Lolkema, Ronald de Wit, andRon H.J. Mathijssen

PERSONALIZED MEDICINE AND IMAGING

547 Circulating Tumor Cells from Different VascularSites Exhibit Spatial Heterogeneity in Epithelial andMesenchymal Composition and Distinct ClinicalSignificance in Hepatocellular CarcinomaYun-Fan Sun,WeiGuo, YangXu, Yin-Hong Shi, Zi-JunGong,Yuan Ji, Min Du, Xin Zhang, Bo Hu, Ao Huang,George G. Chen, Paul B.S. Lai, Ya Cao, Shuang-Jian Qiu,Jian Zhou, Xin-Rong Yang, and Jia Fan

560 Cell-Free DNA and Circulating Tumor Cells:Comprehensive Liquid Biopsy Analysis inAdvanced Breast CancerGiovanna Rossi, Zhaomei Mu, Alfred W. Rademaker,Laura K. Austin, Kimberly S. Strickland,Ricardo Lima Barros Costa, Rebecca J. Nagy,Vittorina Zagonel, Timothy J. Taxter, Amir Behdad,Firas H. Wehbe, Leonidas C. Platanias,William J. Gradishar, and Massimo Cristofanilli

569 Homologous Recombination DNA RepairPathway Disruption and RetinoblastomaProtein Loss Are Associated with ExceptionalSurvival in High-Grade Serous Ovarian CancerDale W. Garsed, Kathryn Alsop, Sian Fereday,Catherine Emmanuel, Catherine J. Kennedy,Dariush Etemadmoghadam, Bo Gao, Val Gebski,Val�erie Gar�es, Elizabeth L. Christie, Maartje C.A. Wouters,Katy Milne, Joshy George, Ann-Marie Patch, Jason Li,Gisela Mir Arnau, Timothy Semple, Sreeja R. Gadipally,Yoke-Eng Chiew, Joy Hendley, Thomas Mikeska,Giada V. Zapparoli, Kaushalya Amarasinghe,Sean M. Grimmond, John V. Pearson, Nicola Waddell,Jillian Hung, Colin J.R. Stewart, Raghwa Sharma,Prue E. Allan, Peter F. Rambau, Nadia Traficante, for theAustralian Ovarian Cancer Study Group, Orla McNally,Linda Mileshkin, Anne Hamilton, Sumitra Ananda,Marisa Grossi, Paul A. Cohen, Yee C. Leung,Robert M. Rome, Philip Beale, Penny Blomfield,Michael Friedlander, Alison Brand, Alexander Dobrovic,Martin K€obel, Paul Harnett, Brad H. Nelson,David D. L. Bowtell, and Anna deFazioSee related commentary, p. 508

581 Novel Predictors of Breast Cancer SurvivalDerived from miRNA Activity AnalysisVasily N. Aushev, Eunjee Lee, Jun Zhu,Kalpana Gopalakrishnan, Qian Li, Susan L. Teitelbaum,James Wetmur, Davide Degli Esposti,Hector Hernandez-Vargas, Zdenko Herceg,Humberto Parada, Regina M. Santella,Marilie D. Gammon, and Jia Chen

February 1, 2018 � Volume 24 � Number 3

Clinical Cancer Research

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CANCER THERAPY: PRECLINICAL

592 Systemic Antitumor Immunity by PD-1/PD-L1Inhibition Is Potentiated by Vascular-TargetedPhotodynamic Therapy of Primary TumorsMatthew J. O'Shaughnessy, Katie S. Murray,Stephen P. La Rosa, Sadna Budhu, Taha Merghoub,Alexander Somma, Sebastien Monette, Kwanghee Kim,Renato Beluco Corradi, Avigdor Scherz, andJonathan A. Coleman

600 BAP1 Is a Novel Target in HPV-Negative Headand Neck CancerXiyou Liu, Manish Kumar, Liangpeng Yang,David P. Molkentine, David Valdecanas, Shiying Yu,Raymond E. Meyn, John V. Heymach, and Heath D. Skinner

BIOLOGY OF HUMAN TUMORS

608 Protein Kinase C Epsilon Is a Key Regulator ofMitochondrial Redox Homeostasis in AcuteMyeloid LeukemiaDaniela DiMarcantonio, EstebanMartinez, Simone Sidoli,Jessica Vadaketh, Margaret Nieborowska-Skorska,AnushkGupta, JacobMichaelMeadows, Francesca Ferraro,Elena Masselli, Grant A. Challen, Michael D. Milsom,Claudia Scholl, Stefan Fr€ohling, Siddharth Balachandran,Tomasz Skorski, Benjamin A. Garcia, Prisco Mirandola,Giuliana Gobbi, Ramiro Garzon, Marco Vitale, andStephen M. Sykes

619 The NOTCH4–HEY1 Pathway InducesEpithelial–Mesenchymal Transition in Headand Neck Squamous Cell CarcinomaTakahito Fukusumi, Theresa W. Guo, Akihiro Sakai,Mizuo Ando, Shuling Ren, Sunny Haft, Chao Liu,Panomwat Amornphimoltham, J. Silvio Gutkind, andJoseph A. Califano

634 Intratumoral HPV16-Specific T Cells Constitutea Type I–Oriented Tumor Microenvironment toImprove Survival in HPV16-DrivenOropharyngeal CancerMarij J.P. Welters, Wenbo Ma, Saskia J.A.M. Santegoets,Renske Goedemans, Ilina Ehsan, Ekaterina S. Jordanova,Vanessa J. van Ham, Vincent van Unen, Frits Koning,Sylvia I. van Egmond, Pornpimol Charoentong,Zlatko Trajanoski, Lilly-Ann van der Velden, andSjoerd H. van der BurgSee related commentary, p. 505

648 A Prognostic Bio-Model Based on SQSTM1 andN-Stage Identifies Nasopharyngeal CarcinomaPatients at High Risk of Metastasis for AdditionalInduction ChemotherapyQi Yang, Meng-Xia Zhang, Xiong Zou, You-Ping Liu,Rui You, Tao Yu, Rou Jiang, Yi-Nuan Zhang, Jing-Yu Cao,Ming-Huang Hong, Qing Liu, Ling Guo, Tie-Bang Kang,Xiao-Feng Zhu, and Ming-Yuan Chen

659 The RARS–MAD1L1 Fusion Gene Induces CancerStem Cell–like Properties and TherapeuticResistance in Nasopharyngeal CarcinomaQian Zhong, Zhi-Hua Liu, Zhi-Rui Lin, Ze-Dong Hu,Li Yuan, Yan-min Liu, Ai-Jun Zhou, Li-Hua Xu,Li-Juan Hu, Zi-Feng Wang, Xin-Yuan Guan, Jia-Jie Hao,Vivian W.Y. Lui, Ling Guo, Hai-Qiang Mai,Ming-Yuan Chen, Fei Han, Yun-Fei Xia,Jennifer R. Grandis, Xing Zhang, and Mu-Sheng Zeng

674 CD271 Confers an Invasive and MetastaticPhenotype of Head and Neck Squamous CellCarcinoma through the Upregulation of SlugMan Ki Chung, Young Ho Jung, Joon Kyoo Lee,Soo Youn Cho, Oihana Murillo-Sauca,Ravindra Uppaluri, June Ho Shin, and John B. Sunwoo

684 Long Noncoding RNA NEAT1, Regulated by theEGFR Pathway, Contributes to GlioblastomaProgression Through the WNT/b-CateninPathway by Scaffolding EZH2Qun Chen, Jinquan Cai, Qixue Wang, Yunfei Wang,Mingyang Liu, Jingxuan Yang, Junhu Zhou,Chunsheng Kang, Min Li, and Chuanlu Jiang

696 Targeting the MYCN–PARP–DNA DamageResponse Pathway in NeuroendocrineProstate CancerWei Zhang, Bo Liu, Wenhui Wu, Likun Li,Bradley M. Broom, Spyridon P. Basourakos,Dimitrios Korentzelos, Yang Luan, Jianxiang Wang,GuangYang, SangheePark,AbulKalamAzad,XuhongCao,Jeri Kim, Paul G. Corn, Christopher J. Logothetis,Ana M. Aparicio, Arul M. Chinnaiyan, Nora Navone,Patricia Troncoso, and Timothy C. Thompson

708 Blocking the Feedback Loop betweenNeuroendocrine Differentiation andMacrophages Improves the Therapeutic Effects ofEnzalutamide (MDV3100) on Prostate CancerChao Wang, Guang Peng, Hai Huang, Fei Liu,De-Pei Kong, Ke-Qin Dong, Li-He Dai, Zhe Zhou,Kai-Jian Wang, Jun Yang, Yan-Qiong Cheng, Xu Gao,Min Qu, Hong-Ru Wang, Feng Zhu, Qin-Qin Tian,Dan Liu, Li Cao, Xin-Gang Cui, Chuan-Liang Xu,Dan-Feng Xu, and Ying-Hao Sun

CORRECTION

724 Correction: Blocking Tumor-Educated MSCParacrine Activity Halts OsteosarcomaProgression

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ABOUT THE COVER

The cover shows a section of an intracranial tumor model biopsy from a mouse brain.Hematoxylin and eosin (H&E) staining of the brain tissue displayed that the glioblastoma inthe control groups exhibited extensive branch-like growing patterns that spread into thesurrounding tissue. For details, see the article by Chen and colleagues on page 684 ofthis issue.

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2018;24:503-724. Clin Cancer Res     24 (3)

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