Coagulation Pathways (All Components) www.ecat.nl

Coagulation Pathways (All Components)

Symbol Name

HK High molecular weight Kininogen

FXII Factor XII

FXIIa Activated Factor XII

FXI Factor XI

FXIa Activated Factor XI

FIX Factor IX

FIXa Activated Factor IX

FVIIIa Activated Factor VIII

FX Factor X

FXa Activated Factor X

FVIIa Activated Factor VII

FVa Activated Factor V

TFPI Tissue Factor Pathway Inhibitor

Symbol Name

TAFI Thrombin-Activatable Fibrinolysis

Inhibitor

TAFIa Activated Thrombin-Activatable

Fibrinolysis Inhibitor

PC Protein C

APC Activated Protein C

TM Thrombomodulin

Inhibits

Inhibited by APC

Extrinsic Pathway

“converts”, “gives rise to”, “yields”

Intrinsic Pathway

“converts”, “gives rise to”, “yields”

Different roles of Thrombin

“converts”, “gives rise to”, “yields”

Coagulation Pathways (All Components) www.ecat.nl

Thrombin

FVIIa

TF

X

Xa

Va

IX

IXa

VIIIa

TFPI

IX

XIa

XI

Vessel Injury

X

XIIa

XII

Prothrombin

Thrombin

Platelet Activated Platelet

Thrombin

Thrombin

Thrombin

Fibrinogen FIBRIN

TAFIa

TAFI

Fibrinolysis

TM

PC APC

TM

Adapted from Broze, Semin Hematol 1992;29:159-69

Coagulation Pathways (All Components) www.ecat.nl

FVIIa

TF

Vessel Injury

XIIa

XII

Coagulation Pathways (All Components) www.ecat.nl

FVIIa

TF

X

Xa

IX

IXa

Vessel Injury

XIIa

XII

Coagulation Pathways (All Components) www.ecat.nl

FVIIa

TF

X

Xa

Va

IX

IXa

Vessel Injury

XIIa

XII

Prothrombin

Thrombin

Coagulation Pathways (All Components) www.ecat.nl

Thrombin

FVIIa

TF

X

Xa

Va

IX

IXa

XIa

XI

Vessel Injury

XIIa

XII

Prothrombin

Thrombin

Coagulation Pathways (All Components) www.ecat.nl

Thrombin

FVIIa

TF

X

Xa

Va

IX

IXa

TFPI

XIa

XI

Vessel Injury

XIIa

XII

Prothrombin

Thrombin

Coagulation Pathways (All Components) www.ecat.nl

Thrombin

FVIIa

TF

X

Xa

Va

IX

IXa

TFPI

IX

XIa

XI

Vessel Injury

XIIa

XII

Prothrombin

Thrombin

Coagulation Pathways (All Components) www.ecat.nl

Thrombin

FVIIa

TF

X

Xa

Va

IX

IXa

VIIIa

TFPI

IX

XIa

XI

Vessel Injury

X

XIIa

XII

Prothrombin

Thrombin

Coagulation Pathways (All Components) www.ecat.nl

Thrombin

FVIIa

TF

X

Xa

Va

IX

IXa

VIIIa

TFPI

IX

XIa

XI

Vessel Injury

X

XIIa

XII

Prothrombin

Thrombin

Fibrinogen FIBRIN

Coagulation Pathways (All Components) www.ecat.nl

Thrombin

FVIIa

TF

X

Xa

Va

IX

IXa

VIIIa

TFPI

IX

XIa

XI

Vessel Injury

X

XIIa

XII

Prothrombin

Thrombin

Platelet Activated Platelet

Thrombin

Fibrinogen FIBRIN

Coagulation Pathways (All Components) www.ecat.nl

Thrombin

FVIIa

TF

X

Xa

Va

IX

IXa

VIIIa

TFPI

IX

XIa

XI

Vessel Injury

X

XIIa

XII

Prothrombin

Thrombin

Platelet Activated Platelet

Thrombin

Thrombin

Fibrinogen FIBRIN

TAFIa

TAFI

Fibrinolysis

TM

Coagulation Pathways (All Components) www.ecat.nl

Thrombin

FVIIa

TF

X

Xa

Va

IX

IXa

VIIIa

TFPI

IX

XIa

XI

Vessel Injury

X

XIIa

XII

Prothrombin

Thrombin

Platelet Activated Platelet

Thrombin

Thrombin

Thrombin

Fibrinogen FIBRIN

TAFIa

TAFI

Fibrinolysis

TM

PC APC

TM

Adapted from Broze, Semin Hematol 1992;29:159-69