Expanding the Science

of Analysis

Competence in Biotechnology and Pharmaceutical Applications

Product Portfolio and Corporate Capabilities

Qualified for Pharmaceutical and Biotechnology:• Proven – installed in over 1000 facilities around the world• Compliant with EHEDG, FDA, GMP, USP class VI and 3-A guidelines• Smooth surfaces for sanitary, easy cleanability (Ra 16 µinch, 0.4 µm, 316L stainless steel)• Electrodes and sensors for CIP/SIP• Documentation and certificates

Company History

Wedgewood Analytical, Inc. (WA) is a wholly owned company of Endress+Hauser Conducta, and was established in 2003 as a result of a successful merger of Innovative Sensors, Inc. (Anaheim, CA) and Wedgewood Technology (San Carlos, CA). Innovative Sensors Inc. (ISI) was founded in 1976 as a manufacturer of electrochemical analytical sensors for industrial and laboratory applications.Wedgewood Technology started its busi-ness with in-line process photometers in 1982 focused solely on the pharmaceuti-cal and biotech industries. In 2004, the two world-wide accepted brands merged into a new state-of-the-art manufacturing facility, optimized for the highest quality production and service.

Wedgewood Analytical is aleading pioneer of in-line liquid analysis, with over 30 years of excellence in inno-vation and service

Wedgewood Analytical manufactures a wide range of precision in-line measure-ment instruments for liquid analysis, with a strong specialization in Pharmaceutical and Biotechnology applications. Based in Anaheim, California, the company is a recognized leader in the design and innovation of in-line electrochemical and optical measurement systems. Wedge-wood Analytical’s measuring systems have proven their critical use in Biotech-nology and Pharmaceutical applications due to their robust and reliable design, FDA approved materials and the extreme-ly popular EasyCal™ system.

Wedgewood Analytical is a world-class solution provider for applications including:• Concentration of proteins in chromatography • Dissolved and undissolved solids in filtration process • Color measurement • Cell growth in fermentation and bioreactors• pH/Conductivity/dissolved oxygen

Wedgewood Analytical 03Wedgewood Analytical02

SPECIALISTS: Process analytical solutions in Pharmaceutical and Biotech applications

Liquid Analytical Specialists:• Complete analytical systems – sensors, process housings, analyzers• Global network of the world’s best tech- nical sales and service representatives • World-class manufacturing facilities and processes - Over 2,000,000 electrodes installed since 1975 - Over 20,000 optical analyzers installed since 1982 - 200,000+ electrodes/year manufacturing capacity - 2000+ optical and electrochemical analyzer systems/year

• Sensor research, design and development • Factory service, calibration, certification• ATEX, FM, ISO 9001:2000 certified

Complete Analytical Solutions:• pH• Conductivity• Dissolved Oxygen• Turbidity• Cell Growth• UV Absorbance• Color

Wedgewood Analytical 03Wedgewood Analytical02

Dedicated to customer satisfactionDue to our strong history serving the world’s best pharmaceutical and biotech companies, we understand the unique requirements in this highly regulated industry.

With more than 30 years experience as an established manufacturer of high qual-ity measurement technology, Wedgewood Analytical is driven to meet or exceed customer expectations. Our dedicated customer service and technical engineer-ing staff offers assistance from initial de-sign and engineering to commissioning, maintenance, calibration and validation of installed systems. Every manufactured product is individually tested. Performance to design specifications is guaranteed.

Research and Development

Wedgewood Analytical invests more than 10% of sales back into R&D every year, driven by input from our customers to provide the most innovative, cost-effec-tive solutions. Product development and manufacturing improvements are driven by a global team of researchers located around the world, with shared resources between Wedgewood Analytical and Endress+Hauser. Chemists, physicists, mechanical and electrical engineers as well as software engineers work closely together to provide the highest quality product portfolio available in the market. The continuous implementation of new materials, manufacturing methods and innovative measuring technologies fulfills the customer demands for accuracy, reli-ability, functionality and hygiene.

FDA Compliant Quality and Services

Complete documentation through all steps to meet regulations:• Design Qualification (DQ)• Installation Qualification (IQ)• Operational Qualification (OQ)• Performance Qualification (PQ)

pH measurement

pH is a technical core competence for Wedgewood Analytical. We developed the world’s only automated factory system for pH sensor manufacturing, ensuring the highest sensor quality, reliability and measurement repeatability. The combined manufacturing of Wedgewood Analytical and Endress+Hauser is the #1 producer of industrial pH sensors in the world.

Wedgewood Analytical provides a broad range of pH sensors for applications in agent synthesis, fermentation, separa-tion, media formulation, product treatment and clarification. To meet the critical requirements for hygiene and cleanabil-ity, Wedgewood Analytical offers fully traceable FDA listed sensors that are designed to offer maximum lifetime with a high number of CIP, SIP or autoclave cycles. In addition, special pH sensors are offered with certified biocompatibility - that guarantees only biologically safe materials are in direct contact with the process medium.

Solid State electrode OPS471• Non-glass and break-proof

pH sensor• Reference gel free from

acrylamide and polyacrylamide• Sterilizable and autoclaveable• Horizontal and overhead

installation• Materials in contact with the

medium are FDA listed

Glass electrode OPS41• Combination electrode with liquid electrolyte• Refillable reference chamber• Fast response for rapidly changing media• Sterilizable up to 130°C (266°F)

Glass electrode GTDJ• Double chamber gel filled reference system• CIP/SIP resistant and autoclaveable glass• Internal compensators for fast temperature and pressure changes

Glass electrode OPS71• Double chamber gel filled reference system• Certified biocompatibility of wetted parts• Reference gel free from acrylamide and polyacrylamide• CIP/SIP resistant and autoclaveable glass• Horizontal and overhead installation for version “BU”• Ceramic diaphragm

Electrochemical measurements

Measuring principle

pH measurement is based on a potential difference between a measuring and reference electrode as in a galvanic cell. In glass electrodes the measurement is based on a special pH-sensitive glass membrane whose surface reacts to the acid content of a solution with a specific voltage. This voltage is then measured relative to a reference element which is in contact with the solution. The result-ing potential difference is measured by a transmitter and is converted directly into the pH value.

Apart from using a glass membrane, the pH value can also be measured by an ion selective field effect transistor (ISFET). Here, the sensing part is a transistor with drain and source which are isolated from the gate. The hydrogen ions at the gate cause a current flowing through the tran-sistor and the related voltage is processed as in glass electrodes.

Internal buffer pH 7

Glass membrane

H+

H+

H+

H+H+

H+H+

H+H+

H+

H+

H+ Cl-

Cl-

Cl-

Medium

Electrochemical measurement 05Electrochemical measurement04

Complete pH program

• Glass, non-glass and acrylamide-free versions• Long-life electrodes in SIP/CIP/Autoclave processes• Minimum drift• EHEDG, 3-A and 3.1B certificates• Traceability with serialization• Fully tested, proven prior to shipment

Internal buffer pH 7

Medium

Cl-Cl-Cl-Cl-

Cl-

H+ H+ H+

––

––

–

Medium

Measuringelectrode

Referenceelectrode

pH transmitter

glass electrode

ISFET sensor

The advantages of the new Memosens technology results in the lowest total cost of operation through a safe and reli-able measuring point with dramatically increased availability.

Until the innovation of Memosens, the connection between the sensor and the transmitter was the weak link in the pH measurement loop, due to problems with ground loops, corrosion, high impedance, moisture and environmental impacts. For example, even small amounts of moisture in the pH sensor connection may change the measured value and may even result in measurement failure using standard pH sensor connections. Now, the Memosens technology revolutionizes the reliability and simplicity of data transfer by digitizing and storing the measured value in the head of the pH sensor microchip.

Solid State electrode OPS441• Non-glass and break- proof pH sensor• Refillable liquid electrolyte• Horizontal and over- head installation• EHEDG certified cleanability• Biocompatibility of wetted parts

Digital transmitter 800/802• User friendly menu structure • Two-line display for measurement and temperature• Analog 0/4-20 mA outputs• Up to 4 output contacts (limit contacts, P(ID) controller, timer) • HART communication optional

Analog transmitter 602• Displays measured value and temperature• Minimum size for mounting in skids• Easy installation and commissioning• Two analog signal outputs• Manual or automatic temperature compensation

Fixed housing OPA442• Material: stainless steel 1.4435 (AISI 316L)• Variety of process connections• Electropolished surface• EHEDG certified online cleanability

Retractable housing OPA475 • Sensor removal without compromising sterility • Automation of hygienic processes• Material: stainless steel 1.4435 (AISI 316L)• 3A compliant with FDA approved materials

Electrochemical measurement 05Electrochemical measurement04

pH sensors with Memosens technology

Then transferring the information digitally to the transmitter using a non-contact, inductive connection. The leap in technol-ogy to a new generation of digital sensor provides additional advantages and elimi-nates general limitations of the technology in place to date.

The “twist and lock” coupling provides a robust and secure connection which allows a fast and easy sensor replace-ment, with complete galvanic separation and reliable measurement (shows either correct or no values). The calibration of the measuring loop is independent of cable and transmitter, allowing calibration in the laboratory. The automatic transfer of data stored in the sensor enables the user to stock calibrated replacement sensors and provides the possibility for predictive maintenance based on the sensor history.

Flow cells B605 and B606• Optimized for installation in

piping systems• Minimal housing hold-up volume• Wide range of product

connections• Available with various FDA listed

materials• Sterile and hygienic design

Conductivity measurement

Conductivity is a broad-based measuring method for determining the concentration of chemical solutions and the purity of water, since the ionic compounds of acids, alkalis and salts contribute to conductivity. For the majority of conductivity measure-ment applications, Wedgewood Analytical provides an appropriate conductivity sen-sor for each specific measuring range and installation requirement. For measuring Pure Water, USP Puri-fied Water and Water for Injection (WFI), the two-electrode sensor OLS16 with integrated temperature element is the optimum sensor due to the high sensitivity and hygienic design. For example, the stringent requirements for WFI are listed in the worldwide accepted United States Pharmacopeia (USP) standard. In section 645 the maximum allowed uncompensat-ed conductivity value is given in relation to the temperature. In combination with the digital transmitter 820/822, Wedgewood Analytical offers a complete solution to ensure WFI and cleaning water meet USP standards.

Conductivity sensor OLS16• Measuring range: 0.04 to 500 µS/cm• Different process connections• Implemented temperature element• Meets USP23 and USP24 requirements• Certified 3A and EHEDG for cleanability

Conductivity sensors BT721 and BT724• Recommended measuring range up to 200 mS/cm• 4-pole conductive measurement principle• Compact design for flow cell applications• Implemented temperature element• Sterilizable up to 130°C (266°F)

Conductivity sensor OLS54• Recommended measuring range: 100 µS/cm to 2000 mS/cm• Wide range of process connections• Implemented fast response temperature element• Fully encapsulated, inductive measurement• Hygienic design without any seals• EHEDG and 3-A certification

1

2

3

050 75 10025

Con

duct

ivity

[µS

/cm

]

Temperature [°C]

Alarm threshold as per USP

Preliminary alarm thres-hold

Ultrapure water

Electrochemical measurement 07Electrochemical measurement06

Inductive Sensors

k = 5,2 cm-1

OLS54

k = 0,1 cm-1

OLS16

k = 0,5 cm-1

BT721/724

Conductive Sensors

100001000100101100101,00,10,01

For conductivity applications in chromato-graphic separation or further purification processes the conductivity sensors BT721 and BT724 are offered as a standard qualified solution. Both sensors work with the conductive four-pole technology that results in reduced polarization effect and provides a broader measuring range com-pared to two-electrode sensors.

The integrated temperature element in one of the four titanium electrodes allows a reliable and precise compensated measurement. The sensors are specially designed to be installed in the hygienic, CIP and SIP resistant flow cells B605 and B607. Furthermore, the modular flow cell design offers a variety of process connec-tions and a broad range of materials from electropolished stainless steel (316L) to Kynar plastic for use even in corrosive salt solutions.

The optimum sensor for high conduc-tivity applications, like media and buffer preparation or monitoring of rinse cycles and CIP applications, is the OLS54 conductivity sensor. The OLS54 employs an electrodeless, inductive measuring principle with fully encapsulated design. The OLS54 is completely insensitive to contamination and meets all hygienic re-quirements. It is available with a variety of process connections, all wetted parts are FDA listed and certified according to 3A and EHEDG. Optionally, a certificate of biological reactivity tests according to USP class VI may be provided as well.

µS/cm mS/cm

Measuring principle

The conductivity of liquids is determined by measuring the electrical resistance. The measuring arrangement for determi-nation can be described as in a capacitor where two electrodes are located opposite of each other. According to Ohm’s law, the specific conductivity is given by the ratio of the cell constant which describes the ge-ometry of the electrode arrangement and the resistance. In the case of an ideal plate capacitor, the cell constant is given by the ratio of electrode distance and electrode surface.

Flow cells B605 and B607• Optimized for installation in piping systems• Combination with pH sensor in one housing• Minimal housing hold-up volume• Wide range of product connections• Available with various FDA accepted materials• Sterile and hygienic design

Analog transmitter 622• Displays measured value and temperature• Minimum size for mounting in skids• Easy installation and commissioning• Two analog signal outputs• Remote range selection capability

Digital transmitter 820/822• User friendly menu structure • Two-line display for measurement and temperature• Analog 0/4-20 mA outputs• Up to 4 output contacts (limit contacts, P(ID) controller, timer) • HART communication optional

Electrochemical measurement 07Electrochemical measurement06

For two-electrode sensors, a concentric arrangement of the cylindrical electrodes is preferred which results in an enclosed electrical field. Four-electrode sensors usually have an open electric field caused by a planar arrangement of the electrodes. Here, two current electrodes create an electrical field which is sensed by two potential electrodes. The choice of the appropriate sensor for an application de-pends on the needed measuring range.

In inductive conductivity measurement, a transmitter coil creates a magnetic alternating field which induces an electric voltage in the medium. This causes the positively or negatively charged ions in the fluid to be set in motion and an electric alternating current flows in the liquid. The resulting current generates a magnetic alternating field in the receiving coil. This causes an induction current in the coil which is evaluated and converted into conductivity units by the transmitter.

two-electrode sensor

four-electrode sensor

inductive sensor

Critical applications for oxygen measure-ment in the Biotechnology and Pharma-ceutical industries include both low-level trace oxygen and high level satu-ration measurements. Trace level oxygen measurement is essential where oxygen creates a breeding ground for unwanted microbes or where oxygen may cause an increased corrosion problem. Typical applications are in high-purity water. The higher level oxygen measurements are needed in fermentation, cell culture and pharmaceutical production steps. The measurement can be used to check and regulate processes in order to optimize yield and quality of products. With a measuring range up to 20 mg/l, the po-larographic two-electrode sensor OOS21 covers all major applications in biotechnol-ogy and pharmaceutical industry.

Hygienic requirements and sterility are critical for oxygen measurement systems. In combination with the appropriate OPA442 fixed housing or OPA475 retrac-table housing the complete measuring sys-tem is designed to meet 3A and EHEDG guidelines.

Measuring principle

The polarographic two-electrode sen-sor consists of a working and a counter electrode located in an electrolyte filled measuring chamber. Through a selec-tive membrane, oxygen permeates from the process solution into the measuring chamber and is converted into a current at the working electrode. By a chemical equivalence reaction the counter electrode keeps the system running and the result-ing current response is in direct proportion to the oxygen partial pressure. The final conversion into familiar units of oxygen concentration, saturation or partial pres-sure is done in the related transmitter.

Dissolved Oxygen measurement

Oxygen sensor OOS21 • Measuring range 0 – 20 mg/l• Steam sterilizable and autoclaveable to 135 °C (275 °F)• Standard PG 13.5 thread• Available in different lengths

Transmitter 840F/842F • Displayed values in mg/l, ppm, hPa or % SAT• Two-line display• Analog 0/4-20 mA outputs• Up to 4 output contacts (limit contacts, P(ID) controller, timer) • HART communication optional

Fixed housing OPA442 • Material: stainless steel 1.4435 (AISI 316L)• Variety of process connections• Electropolished surface• EHEDG certified online cleanability

Retractable housing OPA475 • Sensor removal without compromising sterility • Allows automation of hygienic processes• Material: stainless steel 1.4435 (AISI 316L)• 3A compliant with FDA approved materials

Optical measurement 09Electrochemical measurement08

Since the early 1980’s, when Wedgewood Analytical designed the first in-line process optical measurements for Pharmaceutical and Biotechnology industries, our systems have become the industry standard for ro-bustness, accuracy and reliability.

Wedgewood Analytical’s in-line process photometers are considered the industry standard in a variety of applications:

The Industry Standard• Chromatography control• Filter monitoring• Fermenter, cell growth control• Centrifuge control• Protein concentration• Biomass concentration

Wedgewood sensors provide direct, real-time measurement to control and monitor the processes without the need for pro-cess off-line sampling, thereby eliminat-ing the errors and high operational costs involved with off-line measurements. The combination of the low hold-up volume flow cell, optimized optical design and the unique measuring filter perfor-mance provides a very precise measure-ment, highest linearity and sensitivity and a direct correlation to lab results over the whole range of sensors. Additionally, all sensors are available with simple, trace-able calibration and verification capabilities.

Optical measurements

UV sensor AF44• Single wavelength sensor with reference• Measuring range up to 50 OD• Built-in EasyCal System to substitute Liquid Cal• Patented gas discharge light source• Simple calibration and verification capabilities• Hygienic and sterile flow cell design

High UV sensor AF45• Single wavelength sensor with reference• Provides measurement at 206, 214 or 226 nm• Includes separate high voltage power supply• Wide variety of process connections• CIP and SIP resistant wetted parts

UV sensor AF46• Dual wavelength measure- ment with reference• Measuring range up to 50 OD• Patented gas discharge light source• Discrete wavelengths between 254 and 365 nm available• Compact and modular sensor design

Optical measurement 09Electrochemical measurement08

UV-Absorption, Cell Growth, Color, Turbidity and NIR-Absorption

Unique proprietary and patented systems:• EasyCal™System for NIST traceable, accurate calibration• Optimized lamp coatings• Specialized filters for precise wavelengths

Wide variety of flow cell configurations• Lowest hold-up volume• Multiple process connections (Triclamp, flanged, welded, etc.)• Various materials (316L, Titanium, Hastelloy, PEEK, Kynar, etc.)• Ultra hygienic, CIP, SIP (Ra 16 μinch, 0.4 μm 316L stainless steel)

One of the most critical UV applications is product purification by chromatographic separation. The separation over a column with an agent-active media requires high-ly specialized instruments to ensure maxi-mum yield and purity. Sensors for UV Absorption are available as single and dual wavelength instruments at discrete wavelengths between 206 and 365 nm for concentration determination of organic compounds.

Complete chromatography monitoring solution:• pH and conductivity • Optical UV for optimum product collection• NIR for solvent mixtures• Bubble detection

The UV absorption systems are also ideal for optimizing Ultrafiltration or Reverse Osmosis operations by measuring the tar-get agent concentration in the retentate as well as the detection of the product losses through the membrane leakage.

The BT65 system is an ideal solution for monitoring bacterial fermentation and mammalian cell culture applications using optical density. The sanitary and steriliz-able insertion probe design ranging from 12 mm to 25 mm diameters, allows use in both production scale and bench top systems.

The related 950 digital transmitter is pro-grammed with proprietary signal process-ing for minimum interference caused by aeration and agitation. This enables the operator to control the whole cell growth cycle and to take rapid actions for prevent-ing product losses when abnormal shifts or deviations appear.

Turbidity and solids measurements are performed either by the scattered light sensor TF10 for low-range or the NIR absorption sensor AF12 for higher range measurements. The AF12 system is ideal for measuring suspensions and for centrifuge control. The clarity monitoring of the centrate allows an optimized and automated discharge of the centrifuge and thereby avoids product losses. In contrast, the more sensitive turbidity sensor TF10 is used for detection of filter break-through in clarification processes.

NIR sensor AF23• Dual wavelengths measure- ment with compensation• Measures accurately water in organic solvent• Allows temperature compensated measurement• Hygienic and sterile flow cell design

Measuring principle

Absorption and scattered light photom-eters utilize principals which are based on the interaction of light with process fluids. The absorption photometers measure the degradation of light intensity when pass-ing through a process solution. According to the Lambert-Beer law there is a linear dependency between the absorption of light and the concentration of the absorb-ing substance. A light source emits radia-tion through the medium and the transmit-ted radiation is measured on the detector side. After passing a filter for wavelength selection the intensity of light is deter-mined by a photodiode and converted into a photo current. The final conversion into transmission (%) or absorbance (AU, OD) units, as well as product specific concen-trations, is done by the related transmitter.

Cell growth sensor BT65S• 12mm design• Biomass measurement in laboratory fermenters • Multiple pathlengths for different cell cultures• PG 13.5 thread connection for head plate installation• Several lengths to accommo- date any bioreactor size• Ultra-hygienic: Autoclaveable, CIP/SIP

Color sensor AF21• Dual wavelengths measure- ment with compensation• Optimized for low level color applications• Easy verification capabilities• CIP and SIP resistant wetted parts

Color sensor AF22• Dual wavelengths measure- ment with compensation• Concentration and color scale measurements• Wide variety of process connections and line sizes• Hygienic and sterile flow cell design

Turbidity sensor TF10• Scattered light technology for low turbidity values• Calibration in FTU or ppm• Wide variety of process connections and line sizes• CIP and SIP resistant wetted parts

NIR sensor AF12• Measures suspended solids with optical density• Recommended measuring range: 200 ppm up to 10,000 ppm • Easy NIST traceable calibration capabilities• Hygienic and sterile flow cell design

NIR sensor AF13• Measures light transmission from 0-100%• Optimized for bubble and foam detection in liquids• Detects liquid phase variations like alcohol/water• Suitable for CIP and SIP

Cell growth sensor BT65• Measures cell mass with optical density• Optimized for pilot and production scale fermenters• 19mm and 25mm designs• CIP/SIP resistant and fully autoclaveable• Simple calibration with slide on filters• Available with various tank port fittings• Optional EasyCal to substi- tute liquid Calibration.

Optical measurement 11Optical measurement10

The scattered light instruments use the characteristics of particles, which apart from absorbing light, cause a scattering of light as well. As in the absorbance instruments, a light source emits radiation through the medium and the transmitted radiation is measured on the detector side. Here, besides the detection of the direct light, the forward scattered light is also determined by several photodiodes. Based on the ratio of the scattered and direct light, the transmitter allows the detection of particles and turbidity at very low concentration.

Single BeamAbsorption

Scattered Light

FilterMedium

Medium

Transmitter

Over 400 Biotechnology and Pharma-ceutical locations around the world are using the EasyCal™ system.The patented EasyCal™ System offers the lowest Total Cost of Ownership, because it replaces the manual, time consuming and sometimes erroneous liquid calibration procedure with an easy to use, NIST traceable optical filter based calibration method. With the improved calibration accuracy, product purification is optimized saving $ millions over the system life.

The EasyCal™ System is the most accu-rate and convenient method for in-line verification and calibration without dis-mantling the sensor from the process. The EasyCal™ unit comprises an optical detector system with two NIST traceable filters that provide an accurate and repro-ducible 3-point calibration method. The mechanically sealed and compact design of the EasyCal™ results in the longest lifetime and stability of the certified filters, even under the harshest conditions. Cali-bration is fast and easy by simply rotating the filters into the light path. All EasyCal™ units come standard with a full NIST trace-able certification.

Digital transmitter series 900• Simple and user friendly menu structure • Four-line display for measure- ment and temperature• Versatile data processing capabilities• Analog 4-20 mA outputs

Analog transmitter series 600• Displays measured value and alarm points• Minimum size for mounting in skids• Easy installation and commissioning• Two analog signal outputs• Remote range and auto zero capabilities

Biostation• Compact solution for chromato- graphy systems• Optimized for development and pilot scale applications• Large flexibility for customized configurations • Quick-connectors provide fast availability

Optical measurement 11Optical measurement10

Patented EasyCal™ and Precision Optical Pathlength (POPL)

The Precision Optical Pathlength (POPL) adjustment system allows the precise setting of the distance between the win-dows (the pathlength). The POPL system consists of adjustable window rings in the flowcell design and a certified measur-ing gauge that precisely determines the distance between the windows. This unique feature allows precise optical pathlengths down to 0.5 mm and results in an increased measuring range, a unique repeatability of measuring values, consistent readings between different instruments and fully comparable measur-ing values to lab results.

The combination of the POPL with an EasyCal™ offers the opportunity for a liquid-free, traceable calibration of the whole measuring system, and thus elimi-nates the need for time consuming calibra-tions with liquid standards.

Patented EasyCal™• Simple, in-line calibration• Robust, mechanically sealed system• NIST traceable, 3-point calibration• Repeatable results• Precise results using POPL technology at small pathlengths (< 5mm)

Wedgewood Analytical, Inc.4123 E. La Palma Ave.Suite 200Anaheim, CA 92807

Toll Free 1-800-835-5474Phone 1-714-577-5600Fax 1-714-577-5688www.WedgewoodAnalytical.com

71028989

pH measurement Conductivity Oxygen

GTDJ OPS41 OPS71 OPS441 OPS471 OLS16 OLS54BT721 BT724 OOS21

Fermentation and Cell Culture • • • • •Chromatographic separation • • • • • •

Purification Processes • • • • •

CIP Applications •

Monitoring of Rinse Cycles • • • •WFI Water Production • •

Media Formulation and Buffer Preparation • • • • • • •

UV-Absorption Cell growth Color Turbidity NIR-Absorption

AF44 AF45 AF46 BT65 BT65S AF21 AF22 TF10 AF12 AF13 AF23

Fermentation and Cell Culture • •

Product Clarification • •

Chromatographic separation • • • •

Purification Processes • • • • •Quality Control

of Products • • •

Concentration of Agents • • • • • •

Media Formulation and Buffer Preparation • •

Typical electrochemical applications in Biotechnology and Pharmaceutical

Typical optical applications in Biotechnology and Pharmaceutical