Conflict of Interest Statement

• I have ownership of the website www.GlutenFreeSociety.org

Grainflammation

How Grains Contribute to Leaky Brain and Chronic Neurological Inflammation

Does grain consumption pose a threat to the brain &

nervous system?

Isn’t Grain Supposed to Be Healthy?

• The seeds are sprayed with fungicides and insecticides.

• Xenoestrogens which effect hormone balance and contribute to many diseases (breast cancer, endometriosis, fibrocystic breasts)

Before Processing…

• The seeds are doused with hormones to aid in growth

• The grains are stored in bins sprayed with additional pesticides

• Drying of the grain causes damage to it’s proteins

Processing adds…

• Dough conditioners (bromine)

• Preservatives

• GMO Soy flour

• Synthetic vitamins

• Extrusion creates acrylamide

• Hydrogenated oils

The History of Grain in The US Diet…

• 1850: Processed flour becomes widely available.

• 1855: First description of symptoms of gluten intolerance by Dr. Gull Guy.

• 1892: William Henry Ford and Henry Drushel Perky invent a machine that shreds whole wheat, and start producing Shredded Wheat, the first packaged breakfast cereal.

• 1894: Dr. John Kellogg and his brother invent corn flakes.

• 1897: C.W. Post begins manufacturing Grape Nuts.

1922: Dr. Robert McCarrison warns medical colleagues about the increase in intestinal disorders.

1931: Dr. Willem Dicke, a Dutch pediatrician, starts experimenting with wheat-free diets for children with celiac disease.

1932: Dr. B.B. Crohn identifies a “new intestinal disorder” linked to grain consumption he calls regional ileitis, now called Crohn’s disease.

1940s: Farmers start to use chemical fertilizers to increase yields, reducing nutrients in grains and other crops. Meanwhile, government subsidies for growing corn and soy led to a processed food industry based on these ingredients, as well as high fructose corn syrup, hydrogenated oils, and corn starches.

• 1943: Due to the diseases Beri Beri and Pellagra, the United States government bans the sale of processed grains unless they are fortified with select B vitamins and minerals.

Established Medical Cause of Autoimmunity

1953: Dr. Dicke publishes an article based on his doctoral thesis linking wheat proteins to damage in the mucosal lining of the intestine

Neurological Autoimmune Disorders • Multiple Sclerosis• Alzheimer’s• Chronic Neuropathy• Bipolar• Depression• Epilepsy• Schizophrenia• Autistic Spectrum• Cerebellar Ataxia• Parkinson’s Disease• Reflex Sympathetic Dystrophy• Fibromyalgia• Narcolepsy• Neurosarcoidosis• Amyotrophic Lateral Sclerosis• Paraneoplastic & Autoimmune

Channelopathies• Guillain Barre syndrome• Acute Disseminated Encephalomyelitis

(ADEM)• Polymyelitis & Neuromyelitis Optica• Myasthenia Gravis

Is Autoimmunity “The Mother of Chronic Disease”?

“Brainflammation”Environmental

Triggers

Overburdened Immune System

Autoimmunity

Chronic Inflammation

Neurological Damage

Disease Manifestation

Leaky Gut

GMO

Gluten

Heavy

Metals

Mold

Excess Ω-6

ATI’s

Excess Carbs

Pesticides

Does grain consumption pose a threat to brain

health?

The Grainflammation Cycle…

How Does this impact the brain and nervous system?

• Increased cortisol ➔ elevated blood sugar• Excessive cortisol ➔ interference with vitamin D, calcium, and

magnesium• Lack of movement reduces CSF flow

• Lack of movement hinders lymphatic flow

Inflammation

↑ Cortisol

Muscle LossWeight Gain

Joint Compression & Pain

Prescription Pain Medications

Pain Medications…

• Don’t stop the influx of grain based poisons• Come with a plethora of detrimental side effects including:

• Death• Addiction• Intestinal erosion and leaky gut• Nutritional Deficiencies

Inflammation

↑ Cortisol

Muscle LossWeight Gain

Joint Compression & Pain

Curr Opin Clin Nutr Metab Care. 2010 Jul; 13(4): 423–428.

Indian J Med Res. 2013 Aug; 138(2): 185–193.

“Grainflammation” 9 Ways To Destroy The

Brain & Nervous System

Gluten

Clin Med Res. 2007 Oct;5(3):184-92.

Gluten Induced Neurological Diseases…

Gluten●Gluten was the first medically proven cause of autoimmunity

●All grains contain some form of gluten

●Testing antibodies to gluten is misleading

●Gluten sensitivity is not a disease

●It is a genetic predisposition that can lead to disease.

●Identification can be performed with genetic testing

Diagram modified from "Nutrition Therapy" by Stephen J. Gislason, MD

Corn Gluten

What about corn gluten?

“Maize prolamines had low but definite activity even though maize is reported to be harmless”

Gut, 1983, 24, 825-830

“The observation that corn gluten challenge induced an abnormal NO reaction in some of our patients with CD is intriguing as maize is considered safe and is recommended as the substitute cereal in a gluten free diet.”

Gut 2005;54;769-774

Accomando S., et al. Multiple food intolerance or refractory celiac sprue? Dig. Liver Dis. 2006;38:784–785.

Corn gluten contributing to persistent antibody response in celiac patients.

More on Corn Gluten…

“The allergens in rice, corn, millet and buckwheat should be better studied before they can be recommended as alternatives…”

Clin Exp Allergy. 1995 Nov;25(11):1100-7.

“High titres were also found when coeliac sera were tested against wheat glutenins, albumins, and globulins, as well as against barley, oats, and maize prolamines”

J Pediatr Gastroenterol Nutr. 1987 May Jun;6(3):346-50.

Recent Studies on Rice…

Mehr S, Kakakios A, Frith K, et al. Food Protein Induced Enterocolitis Syndrome: 16 year

experience. Pediatrics 2009;123(3): e459-3464.

Mehr S, Kakakios AM, Kemp AS. Rice: a common and severe cause of food protein induced enterocolitis syndrome. Arch Dis Child 2009;94(3):220-3.“Causative foods for the 35 children were rice (n = 14) soy (n , = 12), cow's milk (n = 7),

vegetables and fruits (n = 3), meats (n = 2), oats (n = 2), and fish (n = 1). In the 66 episodes, vomiting was the most common clinical feature (100%), followed by lethargy (85%), pallor (67%), and diarrhea (24%). A temperature of <36°C at presentation was recorded for 24% of episodes.”

More on Gluten…

Food and Brain Inflammation

Gluten Psychosis

Heavy Metals

Corn – processed corn products can contain mercury

Heavy MetalsRice – found to

contain arsenic,

cadmium, and lead

Excessive Omega 6

Omega 3 Fat Imbalance

Omega Ration in Grains

Source: NutritionData.com

Excessive Carbohydrate

Environmental Triggers

Overburdened Immune System

Autoimmunity

Chronic Inflammation

Neurological Damage

Disease Manifestation

Leaky Gut = “Pre-Autoimmunity

Intestinal Hyperpermeability70-8-% of the immune system is in the gut

What Does Leaky Gut Damage Do?

● Overstimulates the immune system● Allows bacterial and viral toxins access to the central circulation● Causes allergic hypersensitivity to foods● Sets the stage for Molecular Mimicry● Linked to abnormal microbiome● Inflammation of the GI Tract● Malabsorption of vitamins, minerals, and other nutrients● Triggers Leaky Brain

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458706/

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Leaky Gut

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The Medical Solution Is A Part of The Problem…

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Don’t forget this…

1. Hadjibabaie, et al. (2005). The Adverse Drug

Reaction in the Gastrointestinal Tract: An

Overview. International Journal of Pharmacology

1 (1), 1-8.

2. Norman, A. and Hawkey, C. (2011). Drug-

induced gastrointestinal disorders. Medicine

29(3), 162-168.

3. Osborne, P. (2016). No Grain, No

pain. Touchstone: New York, NY.

4. Richter, Joel E. (2007). Advances in

Gerd. Gastroenterology & Hepatology, 3(4).

5. Tolstoi, Linda G. (2002). Drug-induced

Gastrointestinal Disorders. Medscape

Pharmacotherapy, 4(1).

References:

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Or This…

Common medications prescribed for the

treatment of autoimmune disease cause vitamin

and mineral deficiencies that can hinder the

immune system.

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Biochemistry = Nutrition

All of the known factors involving autoimmune disease are affected by nutrition

“Each of the 100 trillion cells in the human being is a living structure that can survive indefinitely and, in most instances can even reproduce itself, provided it’s surrounding fluids contain appropriate nutrients.”

Guyton, A. Textbook of Medical Physiology 9th edition. P. 11, W.B. Saunders Co., Philadelphia, 1996.

Nutrition and the Immune System…

Am J Clin Nutr 1991;53:l087-1101.56

It’s Not Just Gluten…Sentry Plant Proteins

TLR4 Induced Inflammation

Mycotoxin

ATI’s Gluten

Omega-6

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ATI’s and other proteins that create GI Inflammation

Serpins

Purinins

α-amylase/protease inhibitors

Globulins

Farinins

Lectins

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Molds & Mycotoxins

Source: http://www.fao.org/ Food & Agriculture Org. of the United Nations59

Mycotoxins…

Mycotoxins…

US Regulation of Mycotoxins in Food is Limited

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Pesticides

● Atrazine – weed and herbicide leads to hyper estrogenic response

● Glyphosate ➢ Acts as a chelating agent causing mineral deficiency➢ Disrupts microbiome➢ Inhibits biochemical production of Serotonin

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GMO

● Alter the seeds to survive better – this includes surviving your ability to digest them.

● Manipulated genes have the potential to cross with your microbial genome.

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Environmental Triggers

Overburdened Immune System

Autoimmunity

Chronic Inflammation

Neurological Damage

Disease Manifestation

Time + Exposure = Disease

“Grainflammation”

“Brainflammation”

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