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Continuous Flow Reactors
™Flow Chemistry Specialistfrom Lab to Production Scale
®
Guidelines on when to use AMaR series of flow reactors
About AMAR Serving Industry Since 1974
ISO, CE, PED, ASME U/U2, UL, CSA, Ex-Proof, ATEX certification
Largest manufacturer & exporter of flow reactors / in Indiaautoclaves
Exports to over 50 countries worldwide
40 distributors worldwide for local support
Inline with government's MAKE IN INDIA campaign
Manufacturing on CNC/VMC & automated machines
Unmatched quality & safety standards
Pg. 1-7Metal microreactors in technical collaboration with NCL
Pg. 8-9Glass microreactor of LTF-Germany
Pg. 10-11Optional accessories
Custom built turnkey solutions with all accessories
• Inconsistent batch performance due to high sensitivity towards process variables (temperature, pressure, concentration, time and mixing)
• Process needs- High heat transfer area- Efficient mixing- Rapid mass transfer- High interfacial area
• Safety issues in- Storing large inventories of hazardous reactants- Handling of hazardous and unstable chemicals- Generation of unstable intermediate by-products during the reaction- Containing unwanted runaway
• Process waste related issues- Need for enhancing the selectivity close to theoretical value- Generation of waste that needs treatment- Need to avoid or reduce the downstream processing efforts for purification
• Distributed production- Produce only as per the local requirement/ consumption (location wise production)- Produce only as and when needed (avoid inventories)
• Optimal utilization of facility- A continuous flow manufacturing facility can also be used for production of multiple products with almost same
peripherals- Space occupancy will be less- Achieve same or even better results than conventional batch operation
Photochemical flow reactor Pg. 3
®
Transform your process development capabilities using AMaR series continuous flow reactors
AMaR series is ideal for carrying out a wide range of chemical reactions in the
field of pharmaceuticals, fine and specialty chemicals in a continuous manner.
Applications
The devices developed under AMaR series are designed to offer excellent mixing and heat transfer for carrying out fast and exothermic reactions. The design is based on extensive experiments as well as years of research on flow and transport processes carried out at CSIR-National Chemical Laboratory, Pune. The geometry is selected in a manner that while they offer high heat transfer area per unit reactor volume, they also allow flow of dilute suspension of nano-catalysts. The channels / tubes may also be packed with catalyst for catalytic reactions.
Key design attributes
• Better mixing & very high heat transfer area per unit volume.
• Faster reactions & better selectivity.
• Higher yield.
• High safety & ideal for exothermic reactions.
• Reduced waste and faster transfer of process from laboratory to pilot/commercial scale manufacturing.
• Easily scaleable
• Very small foot print
Advantages of continuous flow reactors over batch reactors:
•
• Microchannels with modular system to connect multiple reactors in series or parallel
• Pressures up to 350 bar & temperatures up to 500°C
• Flow rates up to 500 LPH per unit
• MOC: SS316, Hastelloy, Inconel, Monel, Titanium, Tantalum lined etc.
• Suitable for various liquid-liquid, gas-liquid homogeneous - multiphase reactions, gas, solid & liquid catalytic reactions
Available in integrated multilayer & tubular metal construction for reaction & heat transfermixing,
A M a R mar icro-mixer nd eactor (In technical collaboration with CSIR-NCL)
01
List of publications using AMaR reactor:
AMaR series flow reactors supplied with charging vessels, liquid metering pumps, heating cooling
circulators, back pressure regulator, condenser, gas liquid separator etc.
Suitable for
• Homogeneous reactions: Neutralization, condensation, dehydration etc.
• Multiphase Reactions:
- Gas-liquid reactions (G-L): oxidation, ozonolysis, halogenation, chlorination etc.
- Liquid-liquid reactions (L-L): nitration, diazotization, azo coupling, transfer
hydrogenation, sulfoxidation, amination, nitration of aromatic substrate, acylation,
formylation, methylation, synthesis of nanomaterials, knoevenagel condensation,
meerwein arylation, glycosylation hydrolysis, alkylation etc.
- G-L-S and L-S catalytic reactions: esterification, hydrogenation, condensation etc.
• Extraction and separation of Co from Ni using AMaR-3
• Continuous flow meerwein arylation J. Flow Chem. 2014, 4(4), 211-216.
• Continuous flow synthesis of regioregular poly (3-hexythiophene)Ultrafast polymerization with high throughput and low polydispersity indexJ. Flow Chem. 2014, 4(4), 206-210.
• 3D Flow Reactors: Flow, Hydrodynamics and PerformanceInd. Eng. Chem. Res., 2014, 53 (5), pp 1916–1923.
• CRE for MAGIC (modular, agile, intensified & continuous) processes, 2015, Chemical Engineering Journal, (doi:10.1016/j.cej.2014.12.050).
• Selectivity engineering of the diazotization reaction in a continuous flow reactor, DOI: 10.1039/C5RE00056D, Citation: React. Chem. Eng., 2016, 1, 387-396.
• Continuous flow nitration of o-Xylene: Effect of nitrating agent and feasibility of tubular reactors for scale-upDOI:10.1021/acs.oprd.5b00064, Organic Process Research Development.
• Discontinuous two step flow synthesis of m-aminoacetophenone; Green Process Synthesis; 3(4): 279-285. August 2014, DOI: 10.1515/9PS - 2014 - 0043.
• Continuous flow nitration in miniaturized devices, Beilstein J. Org. Chem., 405-424, DOI: 10.3762/bjoc.10.38, 2014.10.
• Microreactor-based continuous process for controlled synthesis of Poly-Methyl-Methacrylate-Methacrylic acid (PMMA) nanoparticles, Journal of Materials Chemistry B, 2017, DOI: 10.1039/C7TB00560A.
®
02
Technical Specifications: Standard optional
Volume (ml) 1 ----
Flow rate (L/hr) 3.6 (for 1 sec. residence time) ----
Design Pressure (bar) 50 ----
Design Temperature (°C) -40 to 200 (with Viton ‘O’ ring) -40 to 250 (with Kalrez ‘O’ ring)
MOC SS 316 Hastelloy - B/C, Inconel, Monel, Titanium,
Tantalum lined, PTFE, CFT, PEEK
Heat transfer area (m²/m³) > 2000 ----
Dimensions (mm) 115 x 58 x 14 ----
End connections 3 nos. inlet & 1 no. outlet, 1/8” O/D 1/4-28 UNF connector
tube connector
Heating/ Cooling by dipping in thermostat SS304 jacket
AMaR-1: Micromixer (Patent filed)
Application: Mixing of miscible liquids or immiscible liquids or gases creating dispersion of immiscible fluids or gases in liquids and carrying out very fast, exothermic, homogeneous & heterogeneous reactions. Some of the tested applications include nitrations, halogenations, sulfoxidation, sulfonation, esterification, diazotization, condensation reactions, halogenations, reduction, oxidation, etc.
Design: It comprises of broad converging diverging channel (with width to depth ratio between 5 to 20) with flow past triangular objects to avoid formation of dead zones. This helps to use maximum of the space and is scalable.
Flow pattern (AMaR-1 & 2)Microwavable AMaR-1 in PTFE/PEEK
It consists of AMaR-1, AMaR-3 (1 ml), 5 ml residence time
coil, 2 syringe pumps, heating cooling circulator with
optional back pressure regulator. It is ideal for educational
institutes and R&D to get introduced to flow chemistry with
proof of concept & lab trials.
Flow chemistry starter set
Flow chemistry starter set - metal microreactors
Performance Characteristics
0
0.05
0.1
0.15
0.2
0.25
0.3
0.35
0 10 20 30 40 50
Conductivity (
AU
)
Time (s)
RTD for AMaR2
0
5
10
15
20
25
30
35
0 20 40 60 80 100 120
Pre
ssure
dro
p (
kPa)
Flow rate (ml/min)
AMaR1
AMaR2
®
Technical Specifications: Standard Optional
Volume 1) 12 ml per plate
2) 50 ml per plate Upto 500 ml for 10 plates in series or parallel
3) 200 ml per plate Upto 2000 ml for 10 plates in series or parallel
Flow rate(L/hr) 0.144 to 24 (for single plate) 1.44 to 240 (for 10 plates in parallel)
Design Pressure(bar) 20 ----
Design Temperature(°C) -40 to 200 (with Viton ‘O’ ring) -40 to 250 (with Kalrez ‘O’ ring)
MOC SS316 Hastelloy B/C, Inconel, Monel, Titanium,
Tantalum Lined, PTFE,CFT , PEEK
Heat Transfer Area (m²/m³) > 2000 -----
End connections 3 nos Inlet & 1 No outlet Intermittent liquid addition or sampling
Circulating thermic fluid through Heating/Cooling -----
external SS304 jacket on both the sides
Upto 120 ml for 10 plates in series or parallel
AMaR-2: Microreactor(Patent filed)
Application: Mixing of miscible liquids or immiscible liquids or gases creating dispersion of immiscible fluids or gases in liquids and carrying out very fast, exothermic, homogeneous & heterogeneous reactions. Some of the tested applications include nitrations, halogenations, sulfoxidation, sulfonation, esterification, diazotization, condensation reactions, halogenations, reduction, oxidation etc.
Design: It comprises of broad channel (with width to depth ratio between 5 to20) with flow past triangular objects to avoid formation of dead zones. This helps to use maximum of the space and is scalable. Openable reactor plates enable easy cleaning especially for reactions involving solid formation.
12 ml AMaR-2
•the total reaction solution “sees” intense UV irradiation from the UV source. This leads to very efficient, uniform irradiation of the whole reaction solution over time.
• The UV exposure time can be precisely controlled by the flow-rate and reactor volume. This can address both the under- and over-irradiation problems encountered with batch reactors.
• A single reactor can be used to process few milligrams of substrate up to nearly a kilogram per day.
• Due to much shorter path lengths high concentration solutions can be irradiated effectively.
• Large volumes of very low concentration solutions can be irradiated. This is particularly useful for reactions with competing intermolecular side reactions, e.g., dimerisation and polymerisation.
At any one time under flow conditions only a very small amount of
Photochemical Flow ReactorOne of the key issues of scaling-up organic photochemistry in an immersion-well (batch) reactor is that light penetration to the surrounding solution is limited by the high absorption of the substrate and falls off rapidly with distance from the lamp. Essentially the reaction solution nearest the lamp screens the bulk of the reaction solution from UV. This effect is also amplified if the reaction solution is concentrated. When the scale of the reaction is increased with the same lamp it becomes increasingly more difficult to drive the reaction to completion. Attempts to do so often result in over-irradiation of the product and formation of side products and photopolymers.
This is where flow photochemistry becomes a very attractive proposition, as in principle it can overcome all the key problems of batch photochemistry.
50 ml AMaR-2
1 ml photochemical reactor
12 ml photochemical reactor
Radiated light
Lamp
Syringe
pump
Microchannels
03
®
04
Technical Specifications: Standard Optional
Volume (ml) 12, 50, 200, 1000 5 ltr. with different cone volumes
Flow rate (L/hr) 0.144 to 360 ----
Design Pressure (bar) 100 200/350
Design Temperature (°C) -40 to 250 875 (without jacket)
MOC SS 316 Hastelloy B/C, Inconel, Monel, Titanium, Tantalum lined,
Heat transfer Area (m²/m³) 1000 200 to 1000
End connections 2 nos. inlet with Y mixture, 1 no. Intermittent addition or sampling ports,
outlet, pressure gauge, rupture disc safety relief valve, thermocouple
Heating/ Cooling SS304 jacket Heating Furnace
AMaR-3: Pilot scale 3D flow reactor
AMaR-3 A: Asymmetric AMaR-3
Application: Mixing of miscible liquids or immiscible liquids or gases creating dispersion of immiscible fluids or gases in liquids and carrying out very fast, exothermic, homogeneous, heterogeneous & catalytic hydrogenation reactions.Other technical specifications: Same as AMaR-3
(Patent filed)
(Patent filed)
Design: It consists of a sequence of a 3D converging units with or without obstructions. This is scalable and gives high throughput.
symmetric
Symmetric flow pattern
Application: Mixing of miscible liquids or immiscible liquids or gases creating dispersion of immiscible fluids or gases in liquids and carrying out very fast, exothermic, homogeneous, heterogeneous & catalytic hydrogenation reactions. Some of the tested applications include diazotization, nitrations, oxidation with different oxidizing agents, sulfoxidation, hydrogenation, sulfonation, etc. The reactor has been used in many industries for a wide range of reactions under various conditions from cryogenic to High temperature & High Pressure Reactions.
Design: It consists of a sequence of 3D converging units with or without obstructions. This is scalable and gives high throughput.
symmetric
1 ltr. AMaR-3 with flame proof pumps, control panel & control valves in use
Different size AMaR-3 cones
Asymmetric flow pattern
12 ml AMaR-3
Model AMaR3-1.5 3-2 3-5 3-8AMaR AMaR AMaR
Inlet diameter (mm) 1.5 2 5 8
Reactor volume (ml) 12, 30, 50 50, 100 100, 250, 500 250, 500 1000
Preferred residence
time (s) (for above 10 - 600 10 – 600 30 - 600 60-600
reactor volumes)
Heat transfer area (m²/m³) 968 783 545 230
Residence time distribution (RTD)
®
05
Technical Specifications:
Volume (ml) 100, 200, 500, 1000, 2000 (Optional upto 16 ltr.)
Flow rate (L/hr) 0.6 to 720
Design Pressure (bar) 50 (optional upto 350 bar)
Design Temperature (°C) -40 to 250
MOC SS 316, Optional: Hastelloy - B/C, Inconel, Monel, Titanium
Heat transfer Area (m²/m³) 600 to 1850
Heating/ Cooling Circulating thermic fluid through external MS / SS304 jacket
Application: Mixing of miscible liquids or immiscible liquids or gases creating dispersion of immiscible fluids or gases in liquids and carrying out very fast, exothermic, homogeneous & heterogeneous reactions. The mass transfer will take place entirely depending upon the flow regime. This flow reactor has been fabricated and designed for various flow capacities for the industry. Standard as well as tailor made for each chemistry
Design: It consist of a sequence of coils made from pinched tube or normal tubes of various sizes. This is a scalable and high throughput flow reactor. The heat transfer area is high and the numbering up approach has been used for conducting the reactions. The reactor gives better mixing with several sampling ports measurement locations and flexibility to operate in parts.
AMaR-4P: Tubular mixer / flow reactor(Patent filed)
Application: (pilot and production scale) for mixing of miscible liquids or immiscible liquids or gases creating dispersion of immiscible fluids or gases in liquids and carrying out very fast, exothermic, homogeneous & heterogeneous reactions. Offers excellent mixing with no compromise on heat transfer rates. Can be used as a static mixer for homogeneous reaction for fluids of lower viscosity.
Excellent scalable flow reactor
AMaR-4: Production scale tubular flow reactor
Design: Helical pinch tubes of different sizes.
Flow pattern
100 ml AMaR-4P
2 ltr. AMaR-4 in operation for nitration & ammination
@ 2.4 tonnes per day throughput
Residence time distribution (RTD)
Flow pattern
AMaR-4 with charging vessels, pumps & control panel
CSIR-NCL will help you customize AMaR-4 reactors specific to your reaction needsDesign and IP of this reactor design and different variations are owned by CSIR-NCL, Pune
E (
1/5
)
PL 1.5 cm 10ml/min
20ml/min
100ml/min
200ml/min
0.1
0.08
0.06
0.04
0.02
0
Time (s)0 50 100 150 200 250 300
AMaR-4P 12 ltr. being used for neutralization4 tonnes per day throughput
Cross section AMaR-4P vertical
®
06
Amar in collaboration with NCL is in continuous process of improving the existing reactors, designing and developing new reactors for the benefit of process industry, hence all the specification are subject to change without prior notice.
AMaR-5: Solids handling flow reactor
APPLICATION: Suitable for application that generates solids during crystallization. Reaction involving slurries or the reactions where product or byproduct is solid (10% w/v and particle size <200 micron).
DESIGN: This reactor involves a passive technique using only the flow modifications without mechanical agitation or any external forces being applied apart from pumping. Internal geometry of the reactor helps to avoid retaining of solids generated in the flow.
Technical Specifications: Standard Optional
Volume (ml) 200, 500, 1000 ----
Design Pressure (bar) 20 100
Design Temperature (°C) -40 to 250 ----
MOC SS 316 Hastelloy - B/C, Inconel, Monel, Titanium
End connections Inlet & outlet, 1/4” O/D 3/8” O/D tube connectors
Heating/ Cooling SS304 jacket ----
(Patent filed)
200 ml AMaR-6
100 ml AMaR-5
Technical Specifications: Standard Optional
Volume (ml) 100, 200, 500, 1000 ----
Flow rate (L/hr) 0.6 to 360 ----
Design Pressure (bar) 20 100
Design Temperature (°C) -40 to 250 875
MOC SS 316 Hastelloy –B/C, Inconel, Titanium
Heating/ Cooling Furnace heatingSS304 Jacket
Type of particles Density Mass Particle size Flow rate Clogging
(gm/cc) (mm) (ml/min)
%
Glass particles (0.25 mm) 2.50 25 0.25 125 No clogging
Magnesium hydroxide 2.34 25 0.15 75 No clogging
Activated carbon 2-2.10 15 Fine powder 75 No clogging
Starch particles 0.82 8 1.10 75 No clogging
Crushed starch particles 0.82 10 0.55 75 Clogging in the tube
Technical specifications
AMaR-6: Mesh flow reactorApplication: Suitable for heterogeneous catalytic reactions like contact process, Haber Bosch process, Ostwald process, hydrogenation; Steam reforming, Ethylene oxide synthesis, Ziegler Natta Polymerization, hydrodesulphurization.
Flow pattern
38(ml/min)
60(ml/min)
75(ml/min)
92(ml/min)
114(ml/min)
150(ml/min)
0.03
0.025
0.02
0.015
0.01
0.005
00 20 40
Time (s)
E
Residence time distribution (RTD)
®
07
Summery of AMaR metal flow reactors from lab to production scale
Flow chemistry advanced set
It consist of jacketted AMaR-1, AMaR-3 (12 ml), AMaR-4
(100 ml), 2 HPLC pumps, heating cooling circulator with back
pressure regulator. It is ideal for R&D for advanced research.
Flow rate Production Heat transfer Design DesignVolume
Item range capacity per area pressure temperature following (ml) construction
(lit/hr) day in litres (m²/m³) in (bar) in °C application
Useful for theMaterial of
SS316, Lab scale synthesis
Hastelloy B/C, AMaR-1 involving G-L, L-L
1 3.6 86.4 >2000 50 -40 to 250 Inconel, Monel,Microreactor single & multiphase
Tantalum lined,reactions
PTFE, PEEK, CFT
3.5 to 1036.80per plate
12 0.14 to 43.035 to 10368for 10 plates Bench to pilot
SS316, Hastelloy7.2 to 432 & commercial scale
B/C, Inconel,AMaR-2 per plate for reactions
50 0.3 to 18 >2000 20 -40 to 250 Monel, Microreactor 72 to 4320 involving G-L, L-L &
Tantalum lined,for 10 plates G-L-L single &
PTFE, Peek, CFT28.8 to 1728 multiphase reactions
per plate200 1.2 to 2.4
288 to 17280for 10 plates
Bench, pilot &1 3.6 86.4AMaR-3/3A SS316, Hastelloy commercial scale12 0.14 to 43.20 3.36 to 1036.8pilot scale B/C, Inconel, for reaction
50 0.3 to 18 7.2 to 432 1000 100 -40 to 2503D flow Monel, Titanium, involving G-L, L-L, &
200 1.2 to 72 28.8 to 1728reactor Tantalum G-L-L single &1000 6 to 360 144 to 8640 multiphase reactions
AMaR-4/4P 100 0.6 to 36 14.4 to 864SS316, Hastelloy Pilot & commecial
production 200 1.2 to 72 28.8 to 1728B/C, Inconel, scale, G-L, L-L & G-L
scale 500 3 to 180 72 to 4320 600 to 1800 100 -40 to 250Monel, single & multiphase
tubular 1000 6 to 360 144 to 8640Titanium reactions
flow reactor 2000 12 to 720 288 to 17280
AMaR-5 SS316, Hastelloy Bench scale to100 0.6 to 36 14.4 to 864solid B/C, Monel, commercial scale for
200 1.2 to 72 28.8 to 1728handling 130 to 400 20 -40 to 250 Inconel, reactions involving
500 3 to 180 72 to 4320flow Titanium, solid suspension
1000 6 to 360 144 to 8640reactors Tantalum lined upto 30%
Bench scale to200 1.2 to 72 28.8 to 1728
AMaR-6 commercial scale SS316, mesh flow 500 3 to 180 36 to 4320 130 to 400 20 -40 to 250 for G-L, L-L & G-L-L,Hastelloy C
reactor G-L-S single & 1000 6 to 360 144 to 8640multiphase reactions
The reactors like AMaR-4 are in successful operation in the industry for pilot and commercial scale production. Our clients have used them for producing fine and specialty chemicals involving immiscible phases for very exothermic reactions (-40 kJ/mol<DH < -210 kJ/mol) followed by their continuous quenching, extraction and work-up to the tube of 200 kg/day to 1800 kg/day. The pinched tube reactors are also used for carrying out pilot scale reactions, L-L extraction, G-L absorption, etc. These systems can be given any form to fit in the available space. AMaR3 reactor has been successfully tested for G-L-S catalytic hydrogenation. The design of AMaR2 helps to reduce the axial dispersion significantly and also eliminates dead zones in the reactor. This has helped for successfully replicating the lab scale results at pilot scale with no deviation in selectivity. All of these are scalable designs and we encourage our clients to use more number of similar reactors rather than using less number of large volume reactors. With our existing capabilities of designing fixed bed reactors we can even connect these flow reactors with fixed bed systems to facilitate multistep synthesis at various scales.
Industry applications
®
• Easy to use f
• Plug and play
• 4 Mr. Lab reactors
• 2 Single syringe pumps
• Frame work with tube and fittings
• Instruction for 13 reactions as below
or professional education and laboratory synthesis
Flow Chemistry Starter Set
• Pressure tested @15 bar (218 psi)
• No dead volume
• Easy to use & space saving
Mr. Lab
Common reactors for common reactions
The series MR Lab was developed to integrate standard lab syntheses from batch
process to continuous process using standard lab equipments such as
temperature vessels, heaters or cooling agents.
The connecting via the front face saves the system space without creating any
dead volume. The chip is connected via 1/4” UNF 28 fittings for 1/8” pipes.
A supporting frame is designed to simplify the dipping process of chips in vessel.
LTF-
MX
LTF-
MS
LTF-V
LTF-VS
LTF-MX Micro Mixer
Internal volume 0.2 ml
regularly used for small
volumes 0.1-10 ml / min /
channel and mix intensive
chemicals.
LTF-MS
Internal volume 0.2 ml
regularly used for higher
volumes 0.5-20 ml/ min /
channel and is insensitive
against blocking.
Micro Mixer
LTF-V
internal volume 1.7 ml
used for reaction
residence time.
Micro Mixer LTF–VS
internal volume 1.1 ml
used for reaction
residence time for mix
intensive chemicals.
Micro Mixer
(The starter set has manual with details of how to carry all the reactions below)
• Iodine clock reaction (Landolts reaction)
• Hydrolysis of acetic acid chloride (acetyl chloride)
• Alkaline hydrolysis of 4-nitrophenyl acetate
• Esterification of 4-nitrophenol to 4-nitrophenyl acetate
• Hippuric acid from glycine and benzoyl
• Aldol condensation of acetone and benzaldehyde to dibenzalacetone (1, 5-
diphenyl-1, 4-pentadiene-3-one)
• Condensation of 1,3-diphenyl-2-propanone with benzil to
tetraphenylcyclopentadienone
• Addition of phenyl magnesium bromide to fluorenone
• Bromine addition to styrene to 1 ,2-dibromo-1- phenylethane
• Oxidation of 2, 2-dimethyl-1, 3-propanediol to 2, 2- dimethylmalonic acid
• Bromination of anisole to 4-bromoanisole
• Nitration of phenol to 2-nitrophenol and 4-nitrophenol
• Photooxidation of p-methoxybenzyl alcohol to p-methoxy benzaldehyde in a
microreactor with riboflavintetraacetat as a catalyst
List of some of the MRT reactions done on LTF starter set
Glass Micro Reactors from LTF-Germany•
• Micro channel with modular system to connect multiple reactors in series or parallel
• Pressures up to 100 bar & temperatures up to 400°C
• Flow rates up to 30 LPH
• Up to 500 ml internal volume
• Channel size: 5 µm - 15 mm
• Suitable for various liquid-liquid, gas-liquid homogeneous & multi phase reactions
• Microreactors from glass, quartz, silicon and glass-silicon compounds
• Useful in photochemical & UV induced reactions
Available in integrated multilayer glass construction for reaction & heat transfermixing,
Mr. Lab
www.ltf-gmbh.com
08
®
• From batch to continuous process
• Integrated layers for mixing / reaction / heat transfer
• Pressure tested @15 bar ( 218 psi)
• Connecting via 1/4“ UNF 28 fittings and ¼“ swagelok
• Easy to use & space saving
• Dimension: 150 mm *150 mm* 14mm
Heating cooling layer
Design pressure: 6 bar
Flow rate of water by 6 bar: 3-4 /lmin
Mr. XXL
• Inlet A1, A2 and A3
• Mixer of micromixer type ST
• Delay time extention channel with installed equipment type
ST, volume 8 ml
• Product: P1
Reaction stretch:
Design pressure: 15 bar
Flow rate of water by 6 bar: 50 ml/min
Mr. XXL ST 1
The following reactions are done with ST type mixer or combination of ST type and
jet mixer( emulsifier) if 2 phase reaction was carried out.
Example of Applications
• Synthesis of semiconducting polymers for OLED applications
• Synthesis of azo dye via azo coupling
• Synthesis of hydroxymethylfurfural (HMF) and furandicarbonacid (FDCA) out of renewable resources
• Synthesis and work up of nitrate ester
• Catalyzed oxidation for synthesis of functional aldehyde
• Synthesis and conversion of diazomethane
• Delay time extention channel with mixing fixture, volume 8 ml
• Product: P1
Reaction stretch:
Design pressure: 15 bar
Flow rate of water by 6 bar: 50 ml/min
Mr. XXL ST 2
• Prewarm of A1 and A2
• Additional connectors (A3/P1, A4/P2), elective
product outlet (measure outlet) or additional inlet.
• Delay time extention channel, volume: 5 ml
• Product: P3
Reaction stretch:
Design pressure: 15 bar
Flow rate of water by 6 bar: 70 ml/min
Mr. XXL ST 4
A3
A2
A1
E
P1
V=8.0 ml
A1
E
P1
V=8.0 ml
P1
P2
P3
P
P
V=1.5 ml
V=1.5 mlV=1.5 ml
V=1.0 ml
V=1.0 ml
A2
E
E
A1
A3
A2
E
P1V=1.5 ml
V=1.5 ml
V=1.5 ml
V=1.0 ml
V=1.0 mlE
A1
A4
application of the connectors A1 and
A2 as prewarm inlets and A3 and A4
as additional inlets.
application of the connectors A1 and A2
as prewarm inlets and P3 and P3 as
additional product outlets.
• Microreactor/mixer from borosilicate glass
• Mixer + Residence time for mixture-intensive substances
• Dimension: 250 x 100 x 6.4 mm
• Volume: 1 ml to 16 ml
• Inclusive connection profile 1/4"-28 UNF
Mr. Pilot
www.ltf-gmbh.com
09
XXL connected in series
®
They are used to accurately measure & control mass flow rate of gas (in gm/hr or LPH) & optionally
totalized quantity of mass / volume (in gms / ltr.) charged in system at any point at high pressures up
to 350 bar. The MFC assembly comes with inlet filter & check valve. MFC certified for use in zone 1 or
zone 2 hazardous area offered on request.
Digital Pressure Indicator
It consists of SS316 pressure sensor (transmitter) & digital pressure indicator/ controller with high
pressure alarm & safety heater cutoff. Pressure sensors with Hastelloy C / PTFE / Inconel wetted parts
can be offered on request.
Optional accessories are offered to increase the versatility of the equipment, to add value & feature
to the standard product & to provide complete range of instrument/ equipment required for a
particular application.
Pressure
Sensor
Optional Accessories
Thermal Gas Mass Flow Controller (MFC)
To manually charge gases at constant desired pressures upto 350 bar / 5000 psi into the system. It
comes with inlet - outlet pressure gauges, inline filters, check valves, On/Off valves etc.
Forward Gas Pressure Regulator
MFC
Flow Indicator
& Totaliser
Ex-proof MFC
PTFE Pressure
Sensor upto 15 bar
Safety rupture discs can be provided for pressure ratings ≥100 bar & pressure safety valves can be
provided for any pressures from 1 to 350 bar with provision to vary release pressure within a certain
range. These valves come with PTFE / Viton / Kalrez 'O' rings.
Pressure Safety Valve & Safety Rupture Disc
10
Rupture Disc
Pressure Safety Valve
This system is used to charge the liquid at desired rate from as low as 0.6ml/hr. to 100Ltr./hr, when the
system is under pressurized condition. The system comes with metering pump, flow indicator,
controller, liquid charging vessel with optional heater, level indicator & weighing balance, pressure
gauge, filter. Optionally pressure safety valve, flow totalizer is also provided. AMAR offers following
types of pumps.
a) Low cost diaphragm metering pumps for pressures upto 100 bar & min. flow range of 0.1-1 lit/hr.
to max. 10-100 lit/hr. The flow rates are varied by varying the motor speed with variable frequency
drive. MOC: SS316, Hastelloy C, Titanium.
b) High pressure accurate HPLC low flow metering pumps for pressures upto 350 bar & flow range
from 0.01 upto 100ml/min. MOC: SS316, PEEK, Hastelloy C & Titanium
c) Peristaltic pumps for low pressures
d) Low pressure low flow syringe pump
e) High pressure syringe pump for pumping slurry under pressures upto 350 bar
f) PTFE wetted parts diaphragm pump upto 10 bar
g) High pressure low flow gear pumps for pulseless flow
Optionally, in line coriolis flow meters with PID controllers & control valves can be connected to
measure & control flow of the liquids accurately
Liquid Metering Pump System
(b)(a)
(d)
(f)
(e)
(c)
To measure precise amount/quantities of feed / product consumed or produced during process.
Weighing Balance
Cabinet with nitrogen purging for explosion proof zones can be offered by mounting nonexplosion
proof instruments & assembly inside the cabinet
Purge Cabinet
(g)
Coriolis Mass Flow
Controller
®
Heating & Cooling Circulators
These are available either in bath system upto -75 °C to 200°C or single fluid closed loop system for
-60°C to 250°C for external circulation to heat or cool the load to desired temperature conditions. Only
heating or only cooling system & chillers are also available.
Optional: Flexible insulated hose & suitable thermic fluid.
It is mounted on the vent line of the system & is used for maintaining constant pressure on the
upstream. The pressure is maintained by releasing the excess pressure of gas / liquid.
Back Pressure Regulator (BPR)
Condenser
It is a SS-316 tube in tube out, helical coil in a vessel or reverse flow shell & tube heat exchanger for
condensing the vent vapours from the system. It can be offered in all different MOC, higher pressure &
different surface areas. The condensate can be collected separately in receiver .
It is a SS 316 pot connected at the outlet of the condensor to separate gas & liquid. It is offered in
different volumes & MOC on request. It can be optionally provided with level indication & control.
Gas Liquid Separator
SCADA Software for remote operation & Recording
SCADA is a supervisory control & data acquisition software with all controllers / indicators having RS485
modbus communication port or PLC & HMI / touch panel, for online display, set point changes & data
logging of pressure, temperature, liquid / gas flow rate with totaliser, heater temperature, level, weight,
etc. remotely from PC as well as locally from panel. It gives continuous online data logging at predefined
variable time interval, online graphical representation as well as historical data & graphs on PC . RS 485-232
convertor & cable upto 10m or higher is also supplied.
11
Level sensor mounted on GLS or receiver pot for continuous sampling with minimum pressure drop
Level Control
Types of BPR
a) Manual variable pressure BPR for pressures upto 350 bar. MOC: SS316, Hastelloy C, Inconel, PEEK etc. for
low to high flow rates.
b)Pneumatically actuated electronic BPR: here the pressure is set digitally & can be released at preset rate,
pressures upto 350 bar. MOC: SS316, Hastelloy C, Inconel etc., for low to high flow rates.
c) Manually operated low cost fixed pressure BPR with wetted parts of PEEK™, ETFE, Perfluoroelastomer,
where the pressure is fixed with respect to the BPR cartridge for back pressures ranging from 5 to1,000psi
(0.3 to 69 bar). Operating flow rate: 0.1 to 10mL/min. Same body can house different pressure BPR
cartridges.
d)Diaphragm type air operated BPR - MOC: ETFE and PFA, pressure range 0-300 psi, flow rates 0-20ml/min
(a)(b)
(c)
(d)
(a) PEEK
Liquid-Liquid Separator
This unit is used to separate slug flow of two immiscible liquids used in biphasic reaction or two phases of an
extraction flow. MOC: ETFE, PFA and PTFE, pressure 300 psi.
Wet Gas MeterWet gas meter is an analog instrument used to measure exhaust gas flow for gas mixer & is available in all
flow rate ranges. It can give output for digital flow indication
Sample / Status / Steam Selector Valve
These valves have unique variety of connecting slots and ports arrangements. It allows multiple planes of
ports, facilitating unique multiposition configurations useful for stream selection, column selection or
trapping. Can be configured for use at temperatures up to 350°C or pressures up to 10,000 psi.
Oven / Furnace
This can be used for various applications commonly where condensation is major issue during process. The
complete assembly can be placed inside oven to avoid condensation or to maintain particular temperature
throughout the process. Temperature rating: 200°C for oven & 500°C for furnace.
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Some of our valued customers
aetherelementally innovative
L I M I T E D
CPC Corporation, Taiwan
®
• High Pressure Autoclaves • Continuous Flow Microreactors • Fixed Bed Tubular Catalyst Reactors
• CSTR • Gas Induction Reactors • Exproof & Automated Pilot Plants • Glass / Peek Autoclaves
• High Throughput Catalyst Screening System • Super Critical Fluid System (SCFE) Technology
• HPHT Corrosion Testing System • Magnetic Drive Couplings & Mixers / Agitators
Serving Industry since 1974.
AMAR EQUIPMENTS PVT. LTD.
6, Parmar Industrial Estate, Bail Bazaar, Kale Marg, Kurla (W), Mumbai - 400 070. India.
Tel: +91-22- 6225 5000 • Fax: +91-22-2510 9565 • Website: www.amarequip.com
E-mail: [email protected] / [email protected]
®
