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Controlled Release Society
3344thth AAnnnnuuaall MMeeeettiinngg aanndd
EExxppoossiittiioonn ooff tthhee CCoonnttrroolllleedd RReelleeaassee SSoocciieettyy
22000077
July 7-11, 2007 Long Beach, California, USA
Volume 1 of 3
Printed from e-media with permission by:
Curran Associates, Inc. 57 Morehouse Lane
Red Hook, NY 12571 www.proceedings.com
ISBN: 978-1-60560-035-2
Some format issues inherent in the e-media version may also appear in this print version.
Copyright Copyright© 2007 by the Controlled Release Society All rights reserved. No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without prior permission of the publisher. The contents of this CD may not be served via a network without prior permission of the publisher. Controlled Release Society 3340 Pilot Knob Road St. Paul, MN 55121 USA
Phone: +1.651.454.7250 Fax: +1.651.454.0766 Email: [email protected]
Controlled Release Society
34th Annual Meeting and Exposition of the Controlled Release Society 2007
TABLE OF CONTENTS
Volume 1
Non-Canonical Amino Acids in Protein Design, Evolution and Analysis ..................................... 1
David Tirrell
Improved Childhood Vaccines – A Grand Challenge in Global Health ......................................... 2Stevem Buchsbaum
Cell Sheet Tissue Engineering and Their Clinical Applications .................................................... 3Teruo Okano
Engineered Drug Therapies via Lithographic Processes from the Electronics Industry ................................................................................................................................................ 5
Joseph DeSimone
The Role of Biomarkers and Biologically Interactive Delivery Systems (receptor mediated transcytosis) in the Future of Chemotherapy ................................................................. 6
Patrick Soon-Shiong
Advances in Peptide and Protein Delivery ....................................................................................... 7Edith Mathiowitz
Preparation and Characterization of Polyethylene Glycol-Modified TNF-Related Apoptosis Inducing Ligand (TRAIL).................................................................................................. 8
Cheng-Hao Jin
Clinical Trial of Recombinant Human PH20 Hyaluronidase’s Effect on Subcutaneous Absorption and Pharmacokinetics of a Large Protein Molecule Therapeutic ........................................................................................................................................ 10
Richard Yocum
Self-assembled Green Tea-nanocomplex Which Achieves Synergistic Effects ........................ 12Joo Eun Chung
MRI Contrast Enhanced Polyelectrolyte Complexes for Traceable VEGF Delivery................... 14Cory Berkland
Polymeric Micelles for Combination Drug Delivery ...................................................................... 16Glen Kwon
Poly (Ethylene Oxide)-Poly(e-caprolactone) Micelles in Different Morphologies: Advantages of Worm-like Micelles for Delivery of Paclitaxel in Lung Cancer Therapy .............................................................................................................................................. 18
Shenshen Cai
Temperature-Controlled Intracellular Localization of Thermoresponsive Polymeric Micelles ............................................................................................................................ 20
Jun Akimoto
Heparin-Immobilized Microparticles for Sustained Drug Delivery .............................................. 22Cristianne Rijcken
pH-Responsive Elastin-Like Polypeptides (ELPs) for Low pH-induced Drug Release ............. 24Daniel Callahan
Plasma Generated Polymer Films for Drug Delivery Applications .............................................. 26Richard Timmons
Control Release of Biocide Incorporated Drawn Polymers: Molecular Orientation or/and Dispersion? ........................................................................................................................... 28
George Voyiatzis
Effect of Different Plasticizers on the Storage Stability of Enteric-coated Soft Gelatine Capsules ............................................................................................................................. 30
Fuerst Thomas
Monitoring a Cross-Linked Hydrogel Reaction By FT-NIR Spectroscopy .................................. 32Paul McDonald
Application of Multivariate Analysis in Understanding Polymorphic Transformation Models .................................................................................................................... 34
Thomas Rades
In Situ Gelling Biodegradable Polymers - Intratumoral Delivery of Paclitaxel ........................... 36Abraham Domb
Synthesis of Degradable Linear Poly(ethylene glycol) a+B52s Multifunctional Drug Delivery Carriers ...................................................................................................................... 39
Youqing Shen
Self-Expandable Polymeric Stents with a Shape-Memory Property............................................ 41Hsing-Wen Sung
In Vitro Differentiation of Mouse Embryonic Stem Cells Into Pancreatic Insulin Producing Cells Using Three-Dimensional Alginate Scaffolds ................................................... 43
Nan WANG
Characterization of Charged Hydrogels for Nerve Regeneration ................................................ 45Mahrokh Dadsetan
Blood-Brain Barrier Delivery with Molecular Trojan Horses ........................................................ 47William Pardridge
Understanding Endocytic Pathways Towards Improved Intracellular Delivery and Targeting of Therapeutic Macromolecules..................................................................................... 49
Arwyn Jones
The Role of Apolipoproteins in Nanoparticle-Mediated Transport of Drugs into the Brain ................................................................................................................................................... 51
Joerg Kreuter
Controlled Cellular Delivery of Bcr-Abl Coiled-Coil Domain for Apoptosis of Chronic Myelogenous Leukemia Cells ........................................................................................... 53
Carol Lim
Biodegradable Polyesters as Excipients for Controlled Release Products ............................... 55John Gibson
Protein Formulation for Injectable Drug Delivery Systems .......................................................... 56Franklin Okumu
Multifunctionality – Novel Set of Requirements towards Pharmaceutical Nanocarriers ...................................................................................................................................... 57
Vladimir Torchilin
The Interface Between Intellectual Property Rights and the Legal Framework of the Pharmaceutical Regulatory Process ........................................................................................ 58
Anne-Marie Lademann
Human Versus Veterinary Species Comparison in GI Physiology .............................................. 59Kazuko Sagawa
Accidental Gastroretention .............................................................................................................. 60Clive Wilson
Gastro-retention – Large (Ruminant) Animals Versus Human..................................................... 62Keith Ellis
In Vivo and In Vitro Factors Influencing the Performance of Parenteral Controlled Release Systems............................................................................................................................... 64
Marilyn Martinez
Building New Vaccines against TB ................................................................................................. 66Yvonne Perrie
Liposaccharides in Vaccine Delivery.............................................................................................. 68Istvan Toth
Novel N-trimethyl Chitosan - Poly ((?-glutamic acid) Nanoparticles for Mucosal Delivery of Vaccines ......................................................................................................................... 70
H. Oya Alpar
Adsorption of Protein Antigens onto PLG Microparticles Studied by X-ray Photoelectron Spectroscopy (XPS) and Time of Flight Secondary Ion Mass Spectrometry (ToF-SIMS) ................................................................................................................. 72
Andrew Parker
Comparison of Immunogenicity of Sustained Release Implants Containing Imiquimod, A-galactosylceramide or Quil-A .................................................................................. 74
Julia Myschik
Formation And Stability Of Biopolyelectrolyte Multilayers and their Potential Use for the Encapsulation and Controlled Release of Active Ingredients From Foods ................... 76
Roger Parker
Flavour Encapsulation into Yeast Cells and Cooking Stability in Aqueous Food Products .... 78Emmanuel Heinrich
Innovative Microencapsulation and Release Technology for Accelerating Cheese Ripening ............................................................................................................................................. 80
Kasipathy Kailasapathy
Microspheres Based on Soy, Zein Protein as Oral Delivery Vehicles. In Vitro Study with a Dynamic Artificial Digestive System ........................................................................ 82
Lingyun Chen
Tailoring Efficacy by Choosing the Appropriate Encapsulation Technology ............................ 84Fanny Weinbreck
Safety Considerations Associated with Veterinary Parenteral Controlled Release Systems ............................................................................................................................................. 86
Marilyn Martinez
Quality Attributes Influencing the Performance of Parenteral Controlled Release Systems ............................................................................................................................................. 88
Mai Huynh
CRS Industrial Session: Positioning for a Liquidity Event.......................................................... 90Debra Bingham
Biodegradable Macromolecular MRI Contrast Agents.................................................................. 91Zheng-Rong Lu
Imaging Molecular Processes by Optical Methods ....................................................................... 92Samuel Achilefu
Monitoring Drug Delivery and Tissue Engineering by ESR and NMR Spectroscopy and Imaging ....................................................................................................................................... 94
Karsten Maeder
In Vivo Applications of “Sensing” Imaging Agents ...................................................................... 96Alexei Bogdanov
Bio-inspired Nanomaterials for Tissue Regeneration and Sensing ............................................ 97Molly Stevens
Surface and Nano-environmental Influences Induced by Polymer-based Nanoparticles on Skin Penetration of a Lipoidic Drug.................................................................. 98
Marc Schneider
Gold Nanorods as a Photosensitizer for Photothermal Therapy ............................................... 100Takuro Niidome
Nanofabricated Particles for Engineered Drug Therapies: A Preliminary Biodistribution Study of PRINTTM Nanoparticles ....................................................................... 102
Stephanie Gratton
Intracellular Uptake of Silica-Iron Oxide Nanotubes ................................................................... 104Anajn Nan
Supramolecular Polyrotaxanes for Drug Delivery....................................................................... 106Nobuhiko Yui
Polyarginine Segments in Block Copolypeptides Drive Vesicular Formation and Cellular Entry ................................................................................................................................... 108
Victor Sun
Well-defined Diblock Copolymers Synthesized by Atom Transfer Radical Polymerization for Gene Delivery.................................................................................................. 110
Chun Wang
PEHAM Dendrimers for Drug Delivery Applications ................................................................... 112Sonke Svenson
Cyclic Polymers as Scaffolds for Drug Delivery.......................................................................... 114Scott Grayson
Theragnostic Imaging of Tumors by Delivery Carriers............................................................... 116Ick Chan Kwon
Coenzyme Q10-Loaded Liposomes Effectively Protect the Myocardium in Rabbits with Experimental Myocardial Infarction ...................................................................................... 118
Tatyana Levchenko
A Cationic Liposomal Dosage Form of Methotrexate for Specific Delivery to Inflamed Tissue in RA..................................................................................................................... 120
Michael Rankl
In-vitro Model for the Investigation of Drug Delivery Systems Direct from Nose-to-Brain via Olfactory Epithelium....................................................................................................... 122
Alpesh Mistry
Particles Delivered via Non-degradative Pathway Spend More Time Near Cell Nucleus ............................................................................................................................................ 124
Kaoru Hida
Canine Pharmacogenetics ............................................................................................................. 126Katrina Mealey
A Single Artificial Insemination in Sows with Semen Controlled Release Capsules .............. 128Marco Klinger
Effect of Polyethylene Glycol on Release of Vitamin B12 from Ethylene-vinyl Acetate Copolymer Films ............................................................................................................... 130
Ian Tucker
In Vivo Studies with Streptococcus equi Antigens Encapsulated in Polymeric Nanospheres ................................................................................................................................... 132
Helena Florindo
Rheological and Micro-structural Characteristics of In-Situ Gelling Systems for Ocular Drug Delivery ...................................................................................................................... 134
Raid G. Alany
Diabetes Research: Obstacles and Opportunities ...................................................................... 136Aaron Kowalski, Julia Greenstein
Pharmacodynamic and Engineering Issues with Creating an Artificial Pancreas................... 138Bruce Buckingham
A Clinically Relevant Microcapsule for Islet Transplantation .................................................... 140C. Weber
Use of Encapsulated Islets to Treat Diabetes without Immunosuppression............................ 142David Scharp
Nanotechnology for Controlled Release: Putting the Market into Perspective........................ 143Marlene Bourne
Mesoporous Silica Nanoparticles with Stimulus-Controlled Drug Uptake and Release............................................................................................................................................. 144
David Oupicky
Biodegradable Planar Osmotic Pump for Long-term and Controlled Delivery of basic Fibroblast Growth Factor..................................................................................................... 146
WonHyoung Ryu
Evaluation of Mesoporous TCPSi, MCM-41, SBA-15 and TUD-1 Materials as Oral Drug Delivery Systems ................................................................................................................... 148
Teemu Heikkilä
Drug Eluting Nanostructured Coatings for Controlled Release ................................................ 150Ketul Popat
Systemic Delivery of siRNAs and Antagomirs: From Mice to Monkey, on the Way to Man............................................................................................................................................... 152
Muthiah Manoharan
Gene Delivery Systems Responding to the Cellular Signals (D-RECS ) for c-Src ................... 154Yuko Sato
Efficient Delivery of Antisense Oligo-Nucleotides In Vitro & In Vivo Using Degradable Polymersomes ............................................................................................................ 156
Younghoon Kim
Novel Non-Viral Targeted siRNA Delivery System ...................................................................... 158Chia-Ling Yang
Prevention and Reversal of Autoimmune Diabetes by PROMAXX Antisense Oligonucleotide Microspheres ...................................................................................................... 160
Larry Brown
Nanostructured Heparin Derivatives for Oral Delivery ............................................................... 162Youngro Byun
Improving Oral Delivery through the Use of Permeation Enhancers ........................................ 164Kathryn Whitehead
Oleyl Glycerate, a Structural Isomer of Monoolein, dramatically alters the Bioavailability of a Poorly Water Soluble Drug from Lipid-Based Liquid Crystalline Formulations in Rats................................................................................................... 166
Ben Boyd
Site-specific Drug Delivery to the Middle Region of the Small Intestine Reduces Food-drug Interactions That Cause Low Absorption of Drugs Taken after a Meal ................. 168
Shinji Sakuma
PAMAM Dendrimers: Surface Modification and Potential in Oral Delivery of SN-38............... 170Rohit Kolhatkar
Relationship Between the Structure of Polymeric Drugs and Their Accumulation and Intracellular Trafficking. What Do We Know About It? ........................................................ 172
Blanka Rihova
Polymer-Phloridzin Conjugates as an Anti-diabetic Drug that Inhibits Glucose Absorption through the Na+/Glucose Cotransporter (SGLT1) in the Small Intestine ........................................................................................................................................... 174
Yusuke Ikumi
A PEGylated Polymer-Photosensitizer Conjugate Containing Gd (III) for Site-Specific MRI-guided Photodynamic Therapy of Cancer ............................................................................ 176
Anagha Vaidya
Synthesis and Biological P+B2roperties of Folate-PEG-gemcitabine....................................... 178Fabiana Canal
Investigating the Cytotoxicity and Mechanism of Action of Dextrin-Phospholipase A2 Conjugates as Novel Anti-Tumour Agents ............................................................................ 180
Elaine Ferguson
Design and Selection of Extended Release Dosage Forms – An Industrial Perspective ...................................................................................................................................... 182
Ian Hardy
Development and Scale-up Considerations for Osmotic Drug Delivery Systems ................... 183Avinash Thombre
Quality by Design - Industrial Perspective ................................................................................... 184Nirdosh Jagota
Use of a Hierarchical Oxidative Stress Model to study NanoBio Interactions and Toxicity............................................................................................................................................. 185
Andre Nel
Mechanism of Oxidative Responsiveness in Polysulfide Nanoparticles.................................. 186Nicola Tirelli
Behavior of hMSC Cultured on Nanopatterned Surface ............................................................. 188Kam Leong
Biomimetic Hydrogels for Tissue Engineering and Regenerative Medicine ............................ 189Jennifer West
Nano-Scaled Layered Inorganic/Protein Hybrids and their Characterization in Biological Activity ........................................................................................................................... 191
Hsin-Cheng Chiu
BMP2 Immobilisation on Extracellular Matrices to Generate an Interactive Niche for Human Mesenchymal Stem Cells ............................................................................................ 193
Philipp Seib
Peritoneal Adhesion Prevention with an In situ Cross-linkable Hyaluronan Gel Containing Tissue-type Plasminogen Activator in a Rabbit Repeated Injury Model ............... 195
Yoon Yeo
Coating Adhesion and Cohesion Evaluation of Drug Eluting Stents........................................ 197Fuh-Wei Tang
Oral Drug Delivery with Polymeric Nanoparticles: a Mechanistic Approach ........................... 199Veronique Preat
Silicon Nanowires for Improved Intestinal Bioadhesion ............................................................ 201Kathleen Fischer
Hydrogel Filled Micro-engineered Particles for Oral Delivery of Chemotherapeutic Agents .............................................................................................................................................. 203
Sarah Tao
Efficient Oral Delivery of a Protein Pharmaceutical .................................................................... 205Randall Mrsny
Gastrointestinal Gene Delivery in Mice Using Polymeric Nanoparticles-in-Microsphere Oral System............................................................................................................... 207
Mayank Bhavsar
Novel Biomineral-binding Cyclodextrins for Controlled Drug Delivery in Oral Cavity............ 209Xin-Ming Liu
Preclinical Development of a Novel Antiinflammatory Peptide ................................................. 211David Friend
Added Product Complexities Demand Thoughtful Packaging: An Examination of What Packaging Can and Must Do for Medical Products ........................................................... 213
Laura Bix
Development of Inhaled Pulmonary Drug Products.................................................................... 215John Patton
Regulatory Issues in Obtaining Approval of Drug-Device Combination Products.................. 218George Baskinger
Probiotics: New Formulations And Controlled Release ............................................................. 219Helmut Viernstein
Applications of Novel Pregelatinized Starch As a Sustained Release Matrix Carrier .............................................................................................................................................. 221
Masaaki Endo
Application Development of EUDRAGIT®NM 30 D Diclofenac Sodium Matrix Tablet with Wet Granulation .......................................................................................................... 223
Henry Han
A New Application of Low-Substituted Hydroxypropyl Cellulose (L-HPC): Aqueous film coating for time-controlled released tablets and taste masking........................ 225
Naosuke Maruyama
Microcapsules for Multifunctional Industrial Coatings............................................................... 227James Oxley
Dendritic Cell Activation and Antigen Delivery by Cationic Lipids ........................................... 229Leaf Huang
Tumor-targeted Liposomes that Attack Tumor-associated Inflammation and Angiogenesis................................................................................................................................... 231
Raymond Schiffelers
Engineered Liposomes Containing Tunable Model-rafts: Basic Studies and Applications in Targeted Drug Delivery........................................................................................ 233
Stavroula Sofou
Design and Performance of Acid-Sensitive Liposomes Using Vinyl Ether Lipids with Tunable Reactivity .................................................................................................................. 234
David Thompson
Advances in Pulmonary Drug Delivery......................................................................................... 235Peter Byron
Optimisation of Deoxyibonuclease I (DNase I) Particles for Pulmonary Delivery ................... 237Rihab Ahmed
Effects of Cell Penetrating Peptides and Pegylation on Polyplex Size and Transfection Efficiency in Mouse Lungs ...................................................................................... 239
Juliane Nguyen
Lung Deposition and Pharmacokinetic of Tobramycin Dry Powder Formulations in Cystic Fibrosis ............................................................................................................................ 241
Gabrielle Pilcer
PROMAXX Microspheres for Pulmonary Delivery of Proteins and Peptides. Case Study : Human Growth Hormone .................................................................................................. 243
Julia E. Rashba-Step
A Surfactant-Based Glass Thermoplastic System (GTS) for Formulating Poorly Water-Soluble Weak Base Drug Candidates ................................................................................ 245
Marcus Brewster
Extended Release/High Drug Loaded Formulations Produced via Hot Melt Extrusion.......................................................................................................................................... 247
Mark Hall
Once a Day Therapy with Carvedilol Delivered in an Egalet ...................................................... 249Daniel Bar-Shalom
Evaluation of the Impact of Digestion on the in Vivo Performance of Two Lipid Based Oral Drug Delivery Systems............................................................................................... 251
Agnes Taillardat
Pharmacokinetic Studies with a Mucoadhesive Multilayer Extended-Release Tablet Formulation of Levodopa-Carbidopa in Fed and Fasted Beagles ................................. 253
Peyman Moslemy
XELLEX™ Film Devices for Sublingual Administration of Lipid Lowering Drug Actives ...... 255Ulrich Westedt
Drug Delivery for Local Tumor Management: OncoGel® Clinical Experience ........................ 257Kirk Fowers
New Biodegradable “Smart” Hydrogels Containing Poly[(R)-3-hydroxybutyrate] for Sustained Protein Delivery....................................................................................................... 259
Xian Jun Loh
Optimizing the Formulation of Thermoresponsive Hydrogels by 1H-NMR Relaxometry..................................................................................................................................... 261
Hendrik Metz
Novel Injectable Hydrogel with a pH-Responsive Property Made of Hydrophobically-Modified Chitosan Derivatives ......................................................................... 263
Ya-Ling Chiu
Controlled Release of N-Acetylcysteine from Injectable Poly (DL-lactide-co-glycolide) Implants for AIDS Associated Kaposi's Sarcoma ....................................................................... 265
Kashappa Goud Desai
Tumor pH Responsive Nanosystems ........................................................................................... 267You Han Bae
Block Ionomer Complexes for Drug Delivery .............................................................................. 268Tatiana Bronich
Stimuli-Responsive Supramolecular Nanocarriers for Site-Directed Drug Delivery ............... 270Nobuhiro Nishiyama
Smart Polymeric Carriers for Biomolecular Therapeutics.......................................................... 272Patrick Stayton
Lipid Nanocapsules: A New Tool in Cancerology ...................................................................... 273Jean-Pierre Benoit
EPR Investigations on Dynamics of Distribution Processes and In Vivo Fate of Polymeric Nanocapsules ............................................................................................................... 275
Sandra Klein
Drugs Release from Gold Nanorods Embedded N-isopropylacrylamide Hydrogels............... 277Atsushi Shiotani
Lipid Coated Nanoparticles – Physicochemical Characterization, Cellular Adhesion and Cellular Uptake ....................................................................................................... 279
Johannes Sitterberg
Development and Characterization of Bone-Targeting Nanoparticles...................................... 281Stefanie Crumlett
Controlled Release of Actives in Skin .......................................................................................... 283Bozena Michniak
Effect of Hydroxycinnamic Acid, Magnesium Ascorbyl Phosphate and Hydroquinone on Tryptophan Levels in Human Skin ................................................................. 285
Nava Dayan
Encapsulation and Photoprotection of Vitamin E in a Starch-Oil Composite Emulsion System ............................................................................................................................ 287
John Wille
Lipophilic Moisturisers Interact with Stratum Corneum Intercellular Lipids............................ 289Joke Bouwstra
Topical NO Photorelease from Drug Delivery Development System ........................................ 291Renata Fonseca, Vianna Lopez
Tumor-Specific Targeting of Drug Delivery Systems for Cancer Therapy and Imaging ............................................................................................................................................ 293
Tamara Minko
Treatment of Colorectal Cancer Liver Metastases in CBA Mice by SMA-Pirarubicin Micelles and its Augmentation by Hyperbaric Oxygen ........................................... 295
Arun Iyer
Anti-angiogenic Actions of Liposomal Prednisolone Phosphate on Tumor-Associated Inflammatory Cells In Vivo......................................................................................... 297
Manuela Banciu
Low-dose TGF-ß Inhibitor Improves Cancer Therapy Using Nanocarriers for Intractable Solid Tumors ................................................................................................................ 299
Mitsunobu Kano
Microneedle Based Intradermal Delivery of Interleukin-12 in B16F10 Tumor Bearing Mice: Comparison with Subcutaneous and Intraperitoneal Therapy......................... 301
Alfred Harvey
Drug Transport in Retinal Pigment Epithelium – Key Player in the Blood – Retina - Barrier .............................................................................................................................................. 303
Arto Urtti
Slow-Releasing Tranilast in Polytetrafluoroethylene/Polylactide-co-glycolide Laminate Delays Adjustment after Strabismus Surgery in Rabbit Model................................. 304
Ji-Young Kim
Analysis of Subconjunctival Drug Delivery in the Eye Using Magnetic Resonance Imaging ............................................................................................................................................ 306
Stephanie Kim
Steam Sterilization of Cyclosporine Solid Lipid Nanoparticles: In-vitro Evaluation of Toxicity ........................................................................................................................................ 308
Evren H. Gokçe
Pharmacokinetic Modeling to Improve the Design of Intravitreal Corticosteroid Implants for Treating Macular Edema........................................................................................... 310
Susan Lee
Transdermal Drug Delivery: State of the Art and Future Challenges ........................................ 312Joke Bouwstra
In vivo and In vitro Transport of Active Ingredients into Murine Skin Using Deformable Nanoparticles ............................................................................................................. 314
Junoh Kim
Hydration Effects on Skin Microstructure and Implications to Enhanced Transcutaneous Delivery of Biomacromolecules ....................................................................... 316
Vijay John
Impact of Skin Metabolism and Vehicle Effect on Permeation in Skin Models ........................ 318Simone Lombardi Borgia
Arc-Based Skin Ablation for Transdermal Drug Delivery ........................................................... 320Jeong Woo Lee
Formulation Development Strategies and Preliminary Clinical Results for Diindolylmethane, a Poorly Soluble Nutritional Supplement with Anti-Cancer and Anti-Viral Activity ............................................................................................................................ 322
Irwin Jacobs
Microencapsulation as a Tool for Food Fortification .................................................................. 324Yoav Blatt
Mucoadhesive Systems of Polyherbal Antimicrobial Formulation for Vaginal Drug Delivery ................................................................................................................................... 325
Shruti Chopra
Polymeric Microcapsules Entrapping Mesenchymal Stem Cells: A New Approach For Cell Based Therapy .................................................................................................................. 327
Amit Goren
Development of an Oral Osmotic Release System for Cardiovascular Disorders................... 329Juliana Marchetti
Clinical Studies of SP1049C, a Polymer-Based Anthracycline Effective Against Drug Resistant Tumors. ................................................................................................................. 331
Valery Alakhov
Development of A Novel Magnetic Resonance Imaging Contrast Agent for Imaging of Vascular Endothelial Dysfunction ............................................................................. 332
Kenjiro Ikuta
In vitro Evaluation of a Polymeric Contrast Agent for Monitoring Cancer Targeted Drug Delivery ................................................................................................................................... 334
Bahar Zarabi
Biodistribution, Clearance, and Biocompatibility of Iron-Oxide Magnetic Nanoparticles in Rats ..................................................................................................................... 336
Vinod Labhasetwar
Transit of Magnetic Tablets Using Magnetic Moment Imaging and Gamma Scintigraphy. ................................................................................................................................... 338
Kirsteen E Wilson
Oral Drug Nanocrystals: State of Industrial Development, Products and Future Trends .............................................................................................................................................. 340
Rainer Müller
An Injectable Nanosuspension for Itraconazole: Pharmacokinetic Evaluation in the Dog ............................................................................................................................................. 342
Marcus Brewster
Acid-Degradable Poly(N-vinylformamide)/Polyvinylamine Nanogel Capsules ........................ 344Cory Berkland
Co-entrapment of Cyclosporine A and Coenzyme Q10: Assessment of Polymeric Nanoparticles Ability to Entrap Two High Molecular Weight Lipophilic Compounds ..................................................................................................................................... 346
Jagdish Italai
Controlled Release of Docetaxel from Targeted Nanoparticles for Prostate Cancer Chemotherapy ................................................................................................................................. 348
Frank Gu
Potent Antibody-Drug Conjugates for Cancer Therapy.............................................................. 350Paul Carter
Overcoming MDR: Drug Delivery Systems with Monoclonal Antibodies and/or Cell-Penetrating Peptides .............................................................................................................. 351
Vladimir Torchilin
Targeted Delivery of Polymeric SMA-Aclarubicin Micelles for Reversing Anti-Cancer Drug Resistance................................................................................................................. 353
Khaled Greish
Targeted Delivery of Immunoliposomal Doxorubicin to B-lymphoid Cells via Anti-CD19 Monoclonal Antibodies and Fragments ............................................................................. 355
Wilson Cheng
A Matrix-type Microparticulate Formulation of Eudragit FS 30D for Delivery of Bioactive Compounds to Possum Hindgut .................................................................................. 357
Gopinath Devaraj
Aqueous-Soluble, Non-Reversible Lipid Conjugate of Salmon Calcitonin: Synthesis, Characterization and In Vivo Activity and Pharmacokinetics ................................. 359
Weiqiang Cheng
Cationic Polysaccharide Nanogels for Protein Delivery............................................................. 361Hirohito Ayame
Comparison of Zeta Potential and the Osmotic Second Virial Coefficient of Bovine Serum Albumin in the Determination of Protein Colloidal Stability. ............................ 362
Ravi Palaniappan
Controlled Release of Proteins and Polypeptides from Silica Microparticles.......................... 364Kim Finnie
Design and Evaluation of Controlled Release Buccoadhesive Tablets of Insulin ................... 366Jasjeet Sahni
Development of Peg-modified Liposomes Containing Hemoglobin Oxygen Carriers for Cell and Tissue Cultures ........................................................................................... 368
Valerie Centis
Effective G-CSF Site Directed PEGylation of Hindered Aminoacids ......................................... 370Stefano Salmaso
Effects of Sequential and Combinational Treatments of Chemotherapuetic Drugs and PEGylated TRAIL on Colon Tumor Models; in vitro and in vivo study.............................. 372
Su Young Chae
Evaluation of Sublingual Delivery of Glucagon Using eligen® Technology in a Dog Model ........................................................................................................................................ 374
Nai Fang Wang
Extraction of Trehalose during the Spray-Freeze / Solvent Extraction Preparation of PLGA Microparticles .................................................................................................................. 376
Michael Kennedy
GelSite® Polymer, a Versatile In-Situ Gelling Excipient for Sustained Peptide and Protein Delivery Systems ............................................................................................................... 378
Paul Stroud
Hyaluronic Acid – Chitosan Nanoparticles for the Controlled Release of Proangiogenic Factors ................................................................................................................... 380
Yolanda Parajo
In Situ Gelling Hydrogels Based on Oligolactate-grafted Dextran Microspheres.................... 382Sophie Van Tomme
In-situ Gelling Microemulsions Containing Lecithin and Capryl-caprylyl Glucoside As Nanoparticle Templates: Protein Delivery Systems with Depot Effect? ................................... 384
Anja Graf
In Vivo Pharmacological Activity of Oral Insulin Nanoparticles in Healthy and Diabetic Animal Model.................................................................................................................... 386
Bruno Sarmento
Induction of Instability in W/O/W Double Emulsions by Freeze-Thaw Cycling ........................ 388Edith Rojas
Injectable Hyaluronic Acid and TNF-Related Apoptosis-Inducing Ligand (TRAIL) Formulations ................................................................................................................................... 390
Seong Joo Na
Injectable pH/Temperature-Sensitive Hydrogel for Peptide and Protein Delivery .................. 392Doo Sung Lee
Interaction Between Insulin and N-trimethyl Chitosan During Microsphere Formulation ..................................................................................................................................... 394
Jan Steenekamp
Intermediate Permeability Behavior in a Drug Delivery Oscillator – Collapsed “Skin” Morphological Changes ..................................................................................................... 396
Amardeep Bhalla
Intracellular Processing and Apoptotic Activity of Cytochrome c-Oligoarginine Conjugates....................................................................................................................................... 398
Wei-Chiang Shen
Lecithin-cholesterol Implants for a Controlled Release of Proteins ......................................... 400Natalie Medlicott
Microparticulate Systems for the Delivery of DNase .................................................................. 402Chung-Yih Wang
Nanogel engineering for protein delivery system: Nanogel cross-linking hydrogel ............... 404Kazunari Akiyoshi
Nanoparticles from Different Structure-types of Microemulsions for Protein Delivery .......... 405Anja Graf
Neuropeptide Y Self-associates with Long-circulating, Biocompatible and Biodegradable Sterically Stabilized Phospholipid Nanomicelles Resulting in Amplified Bioactivity ............. 407
Esha Desai
Peptide Drug Delivery with Pheroid™ Technology ..................................................................... 409Abraham Kotze
Polymeric Matrix Development for Incorporation and Controlled Release of Papain............................................................................................................................................... 411
Patrícia Santos Lopes
Polymersome Encapsulation of Therapeutic Proteins ............................................................... 413David Christian
Preparation and Application of PEGylated TNF-related Apoptosis-Inducing Ligand (TRAIL) for Rheumatoid Arthritis Therapy ...................................................................... 415
Cheng-Hao Jin
Preparation and Characterization of Bioconjugated Glucagons-like Peptide-1 for Enhanced Peroral Delivery ............................................................................................................ 417
Kang Choon Lee
Preparation and Characterization of Lithocholic Acid Modified Exendin-4 (1-39) for Long-acting Therapeutic Agent for Type 2 Diabetes............................................................. 419
Kang Choon Lee
Rescue of Murine Ischemic Hindlimbs with Controlled-Release RhbFGF................................ 421Li Zhang
Self-microencapsulation in Biodegradable Polymers: A New Paradigm to Prepare Protein Controlled Release Polymers........................................................................................... 423
Samuel Reinhold
Shell-crosslinked Hyaluronic Acid/Poly-L-lysine Layer-by-Layer Polyelectrolyte Microcapsules Prepared by Removal of Reducible Hyaluronic Acid Microgel Core.............. 425
Hyukjin Lee
Silk Scaffolds As a New Application System for IGF I Loaded PLGA Microspheres .............. 426Esther Wenk
Stabilization Of Interferon In A Mucoadhesive Formulation ...................................................... 428Giuseppina Sandri
Successful Proof of Concept with ImSus Platform Technology: Preclinical Development of a 1-Month Controlled Release Formulation for a Non-Disclosed Peptide Drug .................................................................................................................................... 430
Celal Albayrak
Thermosensitive Copolymers for Controlled Release of Insulin: In Vitro Release and Stability..................................................................................................................................... 432
Jagdish Singh
Transport of a Very Rapid Acting Insulin Formulation, VIAject™, Through Oral Epithelium ........................................................................................................................................ 434
Solomon Steiner
Anionic Polymersomes for Controlled Release........................................................................... 436David Christian
Antitumor Activity of DACHPt-loaded Polymeric Micelles Against a Bioluminescent Lung Metastasis Tumor Model .......................................................................... 438
Horacio Cabral
Controlled Dual Release of bFGF and Indomethacin from Heparinized Polymeric Micelle .............................................................................................................................................. 440
Dong Hyun Go
Development of Stealth Nanoparticles with High Anti-inflammatory Activity.......................... 442Tsutomu Ishihara
Development of the Mixed Micelles That Deliver Multiple Drugs Doxorubicin (dox) and Wortmannin (wor) Simultaneously for Combination Cancer Chemotherapy ................... 444
Younsoo Bae
Hydrogel Nanoparticles Based on Hyaluronic Acid as Potential Drug Carriers ...................... 446Ki Young Choi
Hydrophobic Prodrug Strategy as a Route to Creation of pH Sensitive Micelles.................... 448Damon Sutton
Incorporation Behavior of Camptothecin into Polymeric Micelles in various Isomerization Ratios and Hydrophobic Group Contents of Inner Block .................................. 450
Tatsuhiro Yamamoto
Micellar Form of Novel Poorly Soluble Pro-apoptotic Agent, Dimethyl-PIT ............................. 452Igor Skidan
Micelles from Cholesteryl-Conjugated siRNA and Polyethylene Glycol-Phosphatidylethanolamine (PEG-PE) for Enhanced Intracellular Delivery of siRNA .............. 454
Tatyana Levchenko
Mixed Micelles Made of Pluronic and PEG-PE for Solubilization of Poorly Soluble Anticancer Drug Paclitaxel ............................................................................................................ 456
Vladimir Torchilin
Nanocarrier Formulation of a Geldanamycin Prodrug in ABC Micelles: Pharmacokinetics and Tolerability in Rats .................................................................................. 458
M. Laird Forrest
Paclitaxel Release from Hydrotropic Micelles with pH-sensitive Moiety .................................. 460Ji Young Kim
Pharmacokinetics of Nanoencapsulated Paclitaxel Hexonate Prodrug in Poly(ethylene glycol)-block-poly(e-caprolactone) Micelles........................................................ 462
M. Laird Forrest
Polymeric Micelles Made of Poly(Isoprene-Block-Ethylene Oxide) Block Copolymer for Solubilization of Poorly Soluble Drugs............................................................... 464
Tatyana Levchenko
Preparation and Characterization of Folate-mediated Nanoparticles Based on Poly(e-caprolactone) and Chondroitin Sulfate ............................................................................ 466
Li-Fang Wang
Regulation of Nano-Micelle Thermoresponse via Heterogeneous End-Functional Block Copolymer Blends and Incorporation of Hydrophobic Drugs ........................................ 468
Masamichi Nakayama
Targeted Charge-Reversal Nanoparticles for Nuclear Drug Delivery........................................ 470Youqing Shen
Worm Micelles carrying Tissue Plasminogen Activator as Prophylactic Fibrinolytic Agents.......................................................................................................................... 472
Younghoon Kim
Advances in Terahertz Pulsed Imaging as Process Analytical Technology for Tablet Film Coating......................................................................................................................... 474
Louise Ho
Dehydration of Piroxicam Monohydrate from Compacts Using Terahertz Pulsed Spectroscopy, Raman Spectroscopy and Near Infrared Spectroscopy ................................... 476
Thomas Rades
Development of Microcapsule of Diclofenac Sodium by Phase Separation Technique ........................................................................................................................................ 478
Manpreet Kaur
Effect of Drug Properties and Dissolution Medium on the In Vitro Release From Carbomer Matrix Tablets ................................................................................................................ 480
Elena Draganoiu
Formation and Stability of Amorphous Ranitidine Hydrochloride Prepared by Cryo-milling ..................................................................................................................................... 482
Norman Chieng
Investigation of Physico-chemical Properties and Stability of Two Amorphous Forms of Simvastatin...................................................................................................................... 484
Thomas Rades
Quantifying Ternary Mixtures of Different Solid-state Forms of Indomethacin by Near-infrared Spectroscopy and Partial Least Squares Analysis ............................................. 486
Thomas Rades
The Influence of Material Properties on the Quantitative X-ray Powder Diffraction and Raman Spectroscopy .............................................................................................................. 488
Thomas Rades
Using Multivariate Visualization to Screen for Differences in the Stability of Amorphous Indomethacin ............................................................................................................. 490
Thomas Rades
Chitosan Coated PLGA: Poloxamer Nanocarriers for the Mucosal Delivery of the Recombinant Hepatitis B Surface Antigen................................................................................... 492
Patrizia Paolicelli
Chitosan Derivatives for Pulmonary DNA Vaccination: Functionalization with Toll-like Receptor (TLR) Agonists......................................................................................................... 494
Simon Borchard
Development of Patch Vaccine System: Mechanism of Transcutaneous Immunization ................................................................................................................................... 496
Fumio Kamiyama
Effect of Emulsion Stabiliser on Microsphere Based Tuberculosis Vaccine Efficacy ............................................................................................................................................ 498
Daniel Kirby
Effect of the Degree of Quaternization of Trimethyl Chitosan As Mucosal Adjuvants Following Intranasal Immunization ............................................................................ 500
Worawan Boonyo
Evaluation of Albumin Microspheres As a Potential Delivery Vehicle for Oral Tuberculosis Vaccines ................................................................................................................... 502
Kwame Yeboah
Evaluation of in Vitro Gene Delivery Through Single and Double Chain Hydro and Perfluorinated Bolaamphiphiles ............................................................................................ 504
Bernard Pucci
Flocculated PLG Nanoparticles for Inhaled Vaccine Delivery ................................................... 506Cory Berkland
Functionalisation of PLGA Microspheres for Targeting Macrophages.................................... 508Nolwenn Brandhonneur
In vivo Activity of Cationic Immune Stimulating Complexes (PLUSCOMs).............................. 510Warren McBurney
In Vitro and in Vivo Investigation of Quil-A Containing Biodegradable Immunostimulatory Implants ......................................................................................................... 512
Julia Myschik
Liposaccharide Based Vaccine against Group A Streptococcal Infection ............................... 514Pavla Simerska
Modulation of Immune Response from Vaccine loaded Polymer Particles: Effect of Size............................................................................................................................................... 516
Vibhu Kanchan
Nanoparticles Composed of Amphiphilic Poly(amino Acid) for Enhanced Protein Delivery to Dendritic Cells As Vaccine Adjuvants....................................................................... 518
Takami Akagi
Novel Cationic Lipidic Dendron - PLA-PEG Nanocomposites for Vaccine Delivery ............... 520Oya Alpar
PLGA-DNA Vaccines: From Targeting to Efficient Transfection .............................................. 522Jacob Gvili
Stability Evaluation of Antigens from Neisseria Meningitides Serogroup B Adsorbed on Anionic PLG Microparticles.................................................................................... 524
Jina Kazzaz
Surface Functionalized Microparticles for Combinatorial Delivery of DNA Antigens and Adjuvants ................................................................................................................. 526
Ankur Singh
Surface Modified Biodegradable Microparticles As Delivery System for a Synthetic Carbohydrate Vaccine Candidate ................................................................................ 528
Noemi Csaba
Targeting Vaccines to Dendritic Cells: Enhanced Uptake of Polymer Particles Facilitated by a Monomeric CD40 Ligand..................................................................................... 530
Noelle Palumbo
Volume 2
The Posintro/TransVac™ Adjuvant Delivery System is Efficient and Well Tolerable for Transcutaneous Immunization ...................................................................................................... 532
Annette Heydenreich
TMC-MCC Complex Nanoparticles for Mucosal Immunisation .................................................. 534Sevda Senel
Towards the Development of Controlled Release Cancer Vaccines ......................................... 536Sarah Hook
Transcutaneous Immunization with Antigen-loaded PLA Nanospheres .................................. 538George Mattheolabakis
A Comparative Study of the Aerodynamic and Drug Release Properties of a Range of Polymeric Microspheres for Controlled Protein Delivery to the Lungs.................... 540
Neeraj Sivadas
A PAMAM Gd-DO3A Conjugate with a Degradable Disulfide Spacer for Magnetic Resonance Imaging ........................................................................................................................ 542
Rongzuo Xu
An In Vitro and In Vivo Study of ProNeuraTM EVA-Lisuride Implants for Sustained Drug Release ................................................................................................................................... 544
Joe McDonough
Assessment of a Herbal Formulation for Wound Healing Activity in Rats Using a Bioadhesive Polymer...................................................................................................................... 546
Sushma Mengi
Autologous Fat Transplantation in Severe Burn Scar Outcomes: A New Perspective for Cell Therapy and Tissue Engineering................................................................ 548
Marco Klinger
Biocompatibility Study of the Mucosal Formulations ................................................................. 550Jin-Wook Yoo
Biodegradable and In Situ Forming Hydrogel Drug Delivery System Based on Unsaturated Poly(ethylene glycol) Block Copolymers for Tamoxifen Citrate Delivery ............................................................................................................................................ 552
Azadeh S. Hashemi Doulabi
Chitosan Citrate as Vaginal Penetration Enhancer With Enzymatic Inhibition Properties ........................................................................................................................................ 554
Giuseppina Sandri
Chondrogenic Differentiation of PLA cells in 3D-HA Matrix....................................................... 556In Soo Yoon
Delivery Systems of Active Ingredients........................................................................................ 558Ted Slaghek
Development of a Citric Acid Polyester Gel with Biodegradability and pH Responsive Drug Release .............................................................................................................. 560
Kumao Uchida
Development of Polyvinyl Alcohol and Sodium alginate Gel Based Clindamycin Wound Dressing by Freeze-thawing Method ............................................................................... 562
Choi Yong
Development of Liposome Formulation Incorporated with Nitrosyl Ruthenium Complexes for PDT Application .................................................................................................... 564
Renata de Lima
Diffusion from Silicone Elastomer Matrices ................................................................................ 566Eileen McBride
Diffusion in Poly(lactide-co-glycolide) and Dichloromethane Mixtures.................................... 568Willard Foss
Effect of Terbinafine Hydrochloride Incorporated into Chitosan Gels on Candida Albicans: Ex-Vivo Evaluations ...................................................................................................... 570
Ipek Ozcan
Engineering of Biocompatible Biodegradable Alginate Foams ................................................. 572Therese Andersen
Evaluation of In-Vitro Release Properties of Vancomycin Microspheres Prepared with Polyaspartic Acid.................................................................................................................... 574
Ipek Ozcan
Fabrication and Characterization of Novel Porous CaCO3 Polyelectrolyte Microcapsules ................................................................................................................................. 576
Raid G Alany
Fabrication of Drug-loaded Microfibers via Solvent Removal ................................................... 578Danya Decoteau
Hepatoprotective and Antioxidant Effects of Cuscuta chinensis and its Nanospheres on Acetaminophen-Induced Acute Liver Injury in Rats ...................................... 580
Feng-Lin Yen
Highly Soluble Drug in Microgranules Prepared with Crosslinked Pectin and Embedded in a Mucoadhesive Polymer Matrix............................................................................ 582
Marcin Placzek
Hydrogel-like Scaffolds for Neocartilage Formation Using Rabbit Chondrocytes .................. 584Park Ji Sun
Impact of Digestion on Pharmaceutical Surfactants................................................................... 586Sandra Klein
Improvement of Chitosan Penetration Enhancement Properties by Ionic Interaction with Ascorbic Acid ...................................................................................................... 588
Giuseppina Sandri
Injectable Microdispersions for Drug Delivery ............................................................................ 590Aruna Nathan
Liposomal Alendronate Inhibits Systemic Innate Immunity and Reduces Size and Number of Endometriosis Implants in Rats ................................................................................. 592
Elran Haber
Long -Circulating Biodegradable Nanoparticles Prepared with PLA-PEG-COOH or PLGA-PEG-COOH Copolymers for Targeted Delivery ................................................................ 594
Tania Betancourt
Modified Release Patterns of PLGA Hot-melt Extruded Implants ............................................. 596Duangratana Shuwisitkul
Modified-Release of IgG from Poly(lactide-co-glycolide) Microparticles for Pulmonary Delivery: Comparison of Uncapped and Capped Polymers ................................... 598
Richard Kaye
Non-Invasive Characterization of Hydroxyapatite Loaded Collagen-Chitosan-Scaffolds for Bone ........................................................................................................................................... 600
Hagen Nitzsche
Novel Glycol Chitosan Hydrogels: pH-Sensitive Swelling, Biodegradation, and Drug Release Behavior................................................................................................................... 602
Yeon Hee Yun
Phosphorylation Of Starch Via Reactive Extrusion For Controlled Release of Drugs ........... 604Stephen O'Brien
Poly(ether-anhydride) Nanoparticles for Prolonged Anti-Cancer Drug Delivery ..................... 606Benjamin Tang
Polystyrene Microballons: A Gastro-Retentive Control Release System ................................. 608Aviral Jain
Preparation of N-acylchitosan Microspheres for Controlled Release of 6-Mercaptourine ..... 610Shu-Huei Yu
Preparation of w/o/w Templates for Preparation of Polysester Microparticles by a Single Step In-Line Emulsification. ............................................................................................... 612
Hsin-I Chang
Prolonged Release of 2-methoxyestradiol from Hydrogels ....................................................... 614Colleen Brophy
Protein Release from Self-Assembled Hydrogels ....................................................................... 616Menno de Jong
Role of Lipid Rafts in Innate Immunity and Phagocytosis of Polymer-Based Particles ......... 618Kazuo Ishii
Sequentially Crosslinked Biodegradable Poly (b-amino esters) for Drug Delivery ................. 620Santosh Hire
Statistical Approach in Alginate Membrane Formulation for Cell Encapsulation in a GMP-based cell factory ............................................................................................................... 622
Marco Klinger
Surface Characterization of Poly(lactic acid)/Everolimus and Poly(ethylene vinyl alcohol)/ Everolimus Stents ........................................................................................................... 624
Ming Wu
The Use of Design of Experiment to Optimise the Drug Loading Process in a Vaginal Hydrogel Formulation ....................................................................................................... 626
Alistair Ross
Transesterification and End Group Chemistry in Acid Terminated Biodegradable Polymers .......................................................................................................................................... 628
Keith Branham
Use of mucoadhesive Chitosan to Enhance the Cellular Association of Paclitaxel into 4T1 Cells Delivered in PLGA Nano- or Microparticles......................................................... 630
Sudhir Chakravarthi
Brain Cancer Therapy in Rats by Combination Use of PLGA Microspheres Containing Anti-cancer Drug and Thermoreversible Gelation Polymer ................................... 632
Tetsuya Ozeki
Cationic Beta-cyclodextrins for Doxorubicin Delivery Across the Blood Brain Barrier .............................................................................................................................................. 634
Eun Seok Gil
Design and Evaluation of Dopamine (DA) Nanoparticles Dispersed Within a Scaffold for Intracranial Implantation ........................................................................................... 636
Samantha Pillay
Encapsulation of Moxifloxacin in Poly(butyl cyanoacrylate) Nanoparticles Enhances Efficacy against Mycobacterium tuberculosis........................................................... 638
Svetlana Gelperina
Endocytosis and Interaction of Poly (Amidoamine) Dendrimers with CaCO-2 Cells .............. 640Kelly Kitchens
Hybrid of Cell Penetrating Peptide and Drug Binding Motif Traffic the Delivery of MDR Drug......................................................................................................................................... 642
Zhaohua Zheng
Nondegradative Trafficking of Nanoparticles to the Nuclear Region Based Solely on Size.............................................................................................................................................. 644
Samuel Lai
Novel Nanocarriers for Patient-specific Brain Tumor Therapy .................................................. 646Efstathios Karathanasis
Paclitaxel and Ceramide Combination Therapy in Biodegradable Polymeric Nanoparticles to Overcome Multidrug Resistance in Cancer .................................................... 648
Harikrishna Devalapally
Sustained intracellular Concentrations of Mometasone furoate Upon Administration in WGA-conjugated PLGA nanoparticles........................................................... 650
Sachin Naik
Transferrin Coupled PEGylated Nanoparticles for Brain Tumor Targeting.............................. 652Aviral Jain
Uptake and Intracellular Fate of Lipid-Based Particles Inside Individual Cells by Raman Micro-Spectroscopy: Studies with Plain and TAT-Modified Liposomes..................... 654
Vladimir Torchilin
Comparison of Alginate Matrix Capsules and Gelatin Matrix Capsules: Effect of Matrix Forming Materials on Flavor Release Kinetics ................................................................ 656
Jing Zhang
Flavor Release through Polymer Films using a Dynamic Vapor Gravimetric Apparatus ........................................................................................................................................ 658
Daniel Burnett
Importance of Nutraceuticals - An Overview ............................................................................... 660Rashmi Kumari
Microspheres Based on Soy, Zein Protein As Oral Delivery Vehicles - Microsphere Fabrication, Characterization and Dissolution Properties................................... 662
Lingyun Chen
Milk Casein Micellesas Potential Natural Carriers for Nutraceuticals: Electron Microscopy and Image Analysis ................................................................................................... 664
Marco Klinger
Soft Capsule as Gastrointestinal Reflux Resistant Delivery System: Concept & Delayed Release Profiles of GRAS Dietary Supplements........................................................... 666
Nachiappan Chidambram
A Cremophor-Free Formulation for 17-AAG using PEO-b-PDLA Micelles: Characterization and Pharmacokinetics in Rats ......................................................................... 668
May Xiong
A Heparin/Poly (l-lysine) Nanoparticle-Coated Polymeric Microspheres ................................. 670Sun Bo-Kyung
A New Possibility to Determine Size Distributions of Biodegradable Nanoparticles: Characterizing PLGA Nanospheres by Separation via Flow-FFF and Detection via MALS ................................................................................................................. 672
Karsten Mäder
A Novel Approach to Surface Functionalization of Nanoparticles: I. PEGylation ................... 674Yogesh Patil
Antigen-Conjugated Liposomes Enhanced Hyposensitization Immune Therapy with Extra-Low Doses..................................................................................................................... 676
Haruna Miyauchi
Cell Engineering of Corneal Epithelium by a Bowman's Membrane-mimic Nanofibrous Membrane .................................................................................................................. 678
How Tseng
Charge-Reversal PAMAM Dendrimer............................................................................................ 680Youqing Shen
Comparison of Different Homogenization Technologies to Produce Ultrafine Testosterone Nanocrystals ........................................................................................................... 682
Rachmat Mauludin
Conformally Coated Nanoparticle-Doxorubicin Therapy for Brain Tumors ............................. 684Chen-Yu Kao
Design and Characterization of Poly(lactide-co-glycolide) Nanoparticles Prepared with Polaxamer for Better Delivery of Paclitaxel ......................................................................... 686
Ranendra Saha
Designing and Characterization of Solid Lipid Nanoparticles Loaded With Terbinafine Hydrochloride ............................................................................................................. 688
Amol Borade
Development of Ascorbyl Palmitate Nanosuspension for Topical Drug Delivery System ............................................................................................................................................. 690
Veerawat Teeranachaideekul
Dual Growth Factor Loaded Scaffolds for Cell Effect ................................................................. 692Joo Mi Kim
Effect of Cross-linking Methods on Particle Size Distribution of Chitosan Nanoparticles .................................................................................................................................. 695
Anitha Dudhani
Effect of Particle Size on Solubility Properties of Ibuprofen Powder: Nanocrystallization by Ball-Milling................................................................................................ 697
Leena Peltonen
Effect of Type of Organic Phase Solvents on Preparation of Poly(D,L-lactide-co-glycolide) Nanoparticles and Release Characteristics in Vivo .................................................. 699
Girish Mittal
Effervescent Powders for Pulmonary Nanoparticle Delivery ..................................................... 701Raimar Löbenberg
Electrospinning of Collagen Type Nanofibers Onto an Anodic Oxidized Titanium Surface Enhances Osteoblast-like Cell Attachment ................................................................... 703
Sangwon Suh
Enhancing Plasma Clot Lysis by PLGA Nanoparticles Encapsulated t-PA – Effects of Coating with Chitosan and RGD .................................................................................. 705
Tze-Wen Chung
Evaluation of Novel Cationic Core-shell Chitosan Nanoparticles for Non-viral DNA Delivery ................................................................................................................................... 707
Suvimol Surassmo
Bio-adhesive Vaginal Foam – In-vitro and In-vivo Adhesion Profile ......................................... 709Doron Friedman
Formulation of Chemically Crosslinked Albumin-Chitosan Mixed Matrix Microparticulate Systems .............................................................................................................. 711
Karyn Cotta
In vitro and In vivo Occlusion Properties of Nanostructured Lipid Carriers (NLC) ................. 713Jana Pardeike
In Vitro and In Vivo Pharmacokinetic Characterization of Short Chain C6-Ceramide Liposomes...................................................................................................................... 715
Banu Zolnik
Increased Uptake of “Smart” pH-Sensitive TAT Peptide-Bearing Liposomes by Cardiac Cells in Perfused Langendorff Heart Model ................................................................... 717
Amit Kale
Investigation Of Solid Lipid Nanoparticles With Clarithromycin For The Improvement Of Therapeutic Utility .............................................................................................. 719
Mukesh Shahare
Lactose Conjugated PLGA Nanoparticles for Lung Targeting................................................... 721Aviral Jain
Alginate Sodium/Eudragit® E PO Interpolyelectrolyte Complexes for Colon Drug Delivery ............................................................................................................................................ 723
Rouslan Moustafine
Bile Acid Conjugated Chitosan Oilgosaccharide Nanoparticles for Anticancer Agent Carrier ................................................................................................................................... 725
Changyong Choi
Bio-inspired Peptide-Poly(Ethylene Oxide) Coated Iron Oxide Nanoparticles Applicable for MRI........................................................................................................................... 727
Julia Maier
Biodegradable Diclofenac Microcapsules for Sustained Drug Delivery System. .................... 729Manoj Charde
Biosynthesized Thermosensitive Drug Carriers for the Delivery of HSP90 (Heat Shock Protein 90) Inhibitor Geldanamycin (GA) Via Hyperthermal Tumor Targeting .......................................................................................................................................... 731
Younsoo Bae
Can Chitosans Get Sterilized by Electron Irradiation? Monitoring Chitosan Degradation by Flow Field-Flow Fractionation and Multi-Angle Light Scattering ................... 733
Karsten Mäder
Characterization of Acetaminophen Sustained Release Matrix Tablets Made with Eudragit® NM 30 D.......................................................................................................................... 735
Susan Shabana
Chitosan Nanoparticles Based on Polyelctrolyte Complexes of All-trans Retinoic Acid and Methoxy Poly (ethylene Glycol)-grafted-chitosan ....................................................... 737
Dong-Gon Kim
Comparative Evaluation of Chitosan/Eudragit® L100-55 Polycomplex Matrix Systems ........................................................................................................................................... 739
Evgenya Margulis
Degradation of PCL-MPEG Diblock Copolymer in Rat Plasma .................................................. 741Wen Jen Lin
Development of Extended Release Gastrorentive Dosages of Ibuprofen ................................ 743Shaukat Ali
Development of Reversible Hydrophilic/Hydrophobic Surfaces ............................................... 745Richard Suzuki
Dissolution of Ibuprofen from PVP-40 and PEG-8000 Solid Dispersions ................................. 746Zine Elabidine Nacer
Drug Delivery Carrier Using Polymeric Micelle with Iron Oxide Nanoparicles ........................ 748Hye Jung Choi
Floating Pulsatile Drug Delivery Using Cavilink™ for Chronotherapy. .................................... 750Praveen Sher
Formulation Optimization of Photocrosslinked Polyacrylic Acid Hydrogel As an Adhesive for Dematological Patches............................................................................................ 752
Yoshinori Onuki
Heparin-Immobilized Microparticles for Sustained Drug Delivery ............................................ 754Keun Sang Oh
Improved Efficacy of Poly(I:C) Mediated Immunostimulation of Dendritic Cells via a PLL-g-PEG Surface-Coated Microparticle ................................................................................ 756
Annina Hafner
In vivo-In vitro Biodegradation and Tissue Compatibility of Novel Biomaterial used as Ciprofloxacin Implant for Drug Delivery System........................................................... 758
Rita Chakole
Methacrylated Hyperbranched Polyglycerol Hydrogels: Preparation and Physical Characterization .............................................................................................................................. 760
Marion Oudshoorn
Molecular Design of Novel Biodegradable pH and Temperature- Sensitive Block Copolymer Hydrogels..................................................................................................................... 762
Minh Khanh Nguyen
Nanoparticles Preparation by Graft Copolymerisation of 2-Hydroxyethyl Methacrylate onto Thiolated Chitosan.......................................................................................... 764
Firooze Aghaei Moghaddam
New Polymeric Micelle as Drug Carriers for the Photodynamic Therapy................................. 766Chau-Hui Wang
Novel Degradable Polymer for the Controlled Release of Hydrophobic Drugs as a Drug Eluting Stent Coating ............................................................................................................ 768
Laura Patrick
Novel Film Forming Polyacid-Polybase Blends For Tailoring Drug Release ........................... 770Anupa Menjoge
Novel Poly(hexyl-substituted-lactide) based Drug Delivery Systems: Injectable Semi-solid hexPLAs and PEG-hexPLA-Micelles ......................................................................... 772
Michael Möller
Performance of Degradable Polyester Block Copolymers as Drug-Eluting Stent Coatings ........................................................................................................................................... 774
Nathan Lockwood
Polyvinyl Alcohol Grafted Polyethylene Glycol Copolymer for Application in Floating Drug Delivery Systems .................................................................................................... 776
Shaukat Ali
Release Characteristics of Lidocaine from Swellable Local Implant of Polyethyleneimine-Polyvinyl pyrrolidone (PEI-PVP) Hydrogel .................................................. 778
Ming-Thau Sheu
Semitelechelic Beta-Cyclodextrin-Poly(4-acryloylmorpholine) Conjugates For Drug Delivery ................................................................................................................................... 780
Marco Bencini
Sustained Release Chitosan Microspheres Prepared By a W/O/W Emulsion-Spray Drying Method ................................................................................................................................. 782
Inés Paños
Synthesis of Linear Multifunctional Poly(ethylene glycol) as Novel Drug Delivery Systems ........................................................................................................................................... 784
Xin-Ming Liu
Synthesis of Novel Liquid Crystalline Block Copolymer for Effective Encapsulation of Drugs.................................................................................................................. 786
Masamichi Nishihara
Synthesis, Characterization and Antibacterial Effects of Trimethylated 6-NH2-6-Deoxy Chitosan ............................................................................................................................... 788
Assal M.M.Sadeghi
Vehicle using Low Molecular Water Soluble Chitosan for Target the Specific Tissue ............................................................................................................................................... 790
Mi-Kyeong Jang
Amphotericin B – Loaded Lipid Nanospheres and Their in vitro and in vivo Characteristics ................................................................................................................................ 792
Suk Hyun Jung
Comparative Activity of Two Novel Methotrexate-Loaded W/O Microemulsions on Human Breast Cancer Cell Lines .................................................................................................. 794
Yesim Karasulu
Doxorubicin-conjugated Liposomes for Intracellular Delivery of Anti-cancer Drug ............... 796Byung Chul Shin
ESEM: An Alternative Assay for Investigating Liposome Stability. .......................................... 798Habib Ali
Formulation and Characterisation of Nanoparticulate Systems for Oral Delivery of L-Glutathione ................................................................................................................................... 800
J-Y Wen
Intracellular DNA Delivery by Chitosan-coated PLGA Nanoparticles ....................................... 802Richard Gemeinhart
Loading to Solid Lipid Nanoparticles (SLN) Improves Cutaneous Uptake of Glucocorticoides Widely Varying in Lipophilicity ...................................................................... 804
Peggy Schlupp
MAXITARG-DOX: Hepatic Targeted Drug Delivery System With Reduced Cardiac and Renal Toxicity .......................................................................................................................... 806
Rajesh Patil
Nanoparticles for Protein Delivery from Microemulsions Containing Lecithin and Decyl Glucoside .............................................................................................................................. 808
Anja Graf
Phytosterosomes: Polyoxyethylene Phytosterol Vesicles: Their Preparation, Characterization and Transdermal Application ........................................................................... 810
Gopinath Devaraj
Preparation and characterization of Long Circulating Nanoemulsion for Passive Tumor Targeting.............................................................................................................................. 812
Srinivas Ganta
Purified, Ubiquinone-loaded and Surfactant-free PLGA Nanoparticles.................................... 814Barrett Nehilla
Self-associating poly(ethylene oxide)-block-poly(eeee-caprolactone) copolymers with carboxyl, benzyl carboxylate and doxorubicin side group: Novel micellar nano-containers and drug conjugates.......................................................................................... 816
Abdullah Mahmud
Solid Lipid Nanoparticles of Methotrexate ................................................................................... 818Madhur Kulkarni
Solvent-free Biodegradable Nanoparticles as Carriers for Hydrophobic and Hydrophilic Drugs ........................................................................................................................... 820
Andrew Loxley
Chitosan/PVA Film for Ocular Drug Delivery of Water Soluble Antimicrobial Agents .............................................................................................................................................. 822
Bhupendra Prajapati
Development and Characterization of a Biodegradable Intraocular System Containing Cyclosporine A for the Treatment of Posterior Uveitis. .......................................... 823
Armando S Cunha
Effect of Enzymatic Degradation on Cyclosporine Release from Solid Lipid Nanoparticles and Determination of Cellular Uptake by Confocal Microscope ....................... 825
Evren H. Gokce
In Vitro Evaluation of Sulphacetamide Sodium Microspheres for Ocular Drug Delivery ............................................................................................................................................ 827
Nazan Bergisadi
In Vitro Ocular Delivery of Fluconazole from Two Mucoadhesive Hydrogels. ......................... 829Taís Gratieri
Novel Solid Lipid Nanoparticle Formulation for Delivery of Diclofenac Sodium to the Eye ............................................................................................................................................. 831
Anthony Attama
Preparation and In Vitro Characterization of Microspheres Containing A Macrolide Drug: Rokitamycin ........................................................................................................ 833
Giuseppina Sandri
Water-soluble Chitosan-PAA Nanosuspension for Ophthalmic Delivery of Pilocarpine ....................................................................................................................................... 835
Hong-Ru Lin
A Novel Approach for the Transdermal Delivery of Macromolecules with Biochemical Enhancers.................................................................................................................. 837
Ying-shu Quan
An Optimized Pin Prick Test for the Pharmacodynamic Quantification of the Cutaneous Penetration of Local Anaesthetics: A Pilot Study................................................... 839
Claudia Leopold
Assessment of Barrier Perturbation Caused by Maltose Microneedles ................................... 841Chandra Sekhar Kolli
Controlled Delivery of Ambroxol using the Ethylene-Vinyl Acetate.......................................... 843Yun-Sam Kim
Correlation of In Vitro Transport to the Integrated PK-PD Profiles Following Transdermal Iontophoresis of Dopamine Agonist 5-OH-DPAT in Rats ................................... 845
Joke A. Bouwstra
Delivery of pHIS-HIV-hugag into Skin using Solid Lipid Nanoparticles and Chitosan Nanoparticles .................................................................................................................. 847
Rathapon Asasutjarit
Demonstration of Dose-controlled Delivery by Dissolvable Micro-needle Arrays .................. 849Seajin Oh
Development of a Liposomal Topical Drug for Acne Treatment................................................ 851Ae-June Wang
Development of Adhesive PVA/PVP/SA Hydrogel Containing Sodium Fusidate for Wound Dressing.............................................................................................................................. 853
Sung Giu Jin
Distribution of FGF-2 Within Excisional Wounds Following Topical Application.................... 855Natalie Medlicott
Effective Topical Delivery of Peptides and Proteins Following Formulation in a Water-in-Oil Microemulsion ........................................................................................................... 857
Gregory Russell-Jones
Electrotransport Kinetics of Metoclopramide Across Porcine Skin in Vitro ............................ 859Jennyfer Cazares-Delgadillo
Enhanced Transdermal Delivery of Melatonin via Elastic Liposomes Coupled Iontophoresis .................................................................................................................................. 861
Vaibhav Dubey
Enhancement of Skin Penetration of P20 Phosphopeptide Using a Protein Transduction Domain ..................................................................................................................... 863
Luciana Lopes
Enhancement of the Transdermal Delivery of Capsaicin Derivative- Sodium Nonivamide Acetate by Microemulsion ........................................................................................ 865
Yong-Hao Lin
Enhancement of Transdermal Permeation of Granisetron......................................................... 867David Houze
Evaluate Microneedle Array Pretreatment for Transdermal Drug Delivery .............................. 869Guang Yan
Formulation and In Vitro Evaluation of Membranes for Transdermal Administration................................................................................................................................. 871
Amalia Rodriguez Bayon
Human Reconstructed Skin Models for Absorption Testing: Comparison of hydrocortisone and testosterone formulations ........................................................................... 873
Sylvia Schreiber
Improving Safety of Trasdermally Administered Potent Opioids by Incorporating a Rate-controlling Membrane ........................................................................................................ 875
Christopher Adams
In Vitro and in Vivo Evaluations of Microemulsion Formulations of CZ48, Lactone-Stabilized Camptothecin-C20-Propionate, for Transdermal Delivery........................................ 876
Yousif Rojeab
In Vitro Evaluation of Clobetasol 17-Propionate Topical Cream Formulations........................ 878Roderick Walker
In Vitro Modeling of Transdermal PTH Delivery by Dissolving Micro-needle Patch................ 880Sung-Yun Kwon
In Vitro Transdermal Delivery of Human IgG across Hairless Rat Skin .................................... 882Guohua Li
In-Vitro Transdermal Permeation Comparison of Cetirizine Base vs. Cetirizine Dihydrochloride............................................................................................................................... 884
Samara Hantman
Iontophoretic Delivery of Cream and Gel Formulations of Acyclovir ....................................... 886Srujana Siddoju
Measurement of Equilibrium Drug Concentrations in Polymers: Time-Resolved Fourier-Transform Infrared (FT-IR) Attenuated Total Reflection (ATR) Spectroscopy .................................................................................................................................. 888
Karen Schultz
Non-ionic Surfactant Based Nanovesicular Carrier for Permeation Enhancement of BCS Class IV Drug...................................................................................................................... 890
Adnan Azeem
Preparation Ketoprofen Formulations with Multi-Enhancers..................................................... 892Pao-Chu Wu
Reduction in Obesity in Swiss Mice Following Topical Administration of Insulin .................. 894Gregory Russell-Jones
Stratum Corneum Microstructure and Implications to Size Dependent Penetration .............. 895Vijay John
Synthesis and Evaluation of Skin Permeation and Accumulation Profiles of Ketorolac Fatty Acid Esters ........................................................................................................... 897
Krishna Bhandari
Synthesis and Transdermal Penetration of Selected Lamivudine Derivatives ........................ 899Jeanetta Du Plessis
Synthesis and Transdermal Penetration of Selected Stavudine Derivatives ........................... 901Jeanetta Du Plessis
The Effect of Temperature on the Co-polymerization Of NIPAAM-VP....................................... 903Swati Aerry
The Novel Permeation Enhancers Dodecyl-2-N, N-dimethylaminopropionate (DDAIP) and HCl Salt: Physiochemical Properties, Preclinical Safety and In Vitro Permeation Enhancement .............................................................................................................. 905
William Pfister
The Percutaneous Study of the Emulsion and Vesicle Containing Pseudo-Ceramide .......................................................................................................................................... 907
Masaru Hosokawa
Topical Indomethacin in a Novel Eutectic Colloidal Delivery System: Comparative Study with Oral and Topical NSAIDs ........................................................................................... 909
Joseph Schwarz
Transdermal Delivery of Meloxicam Salts Enhanced by Iontophoresis/Electroporation and Evaluated In Vitro................................................................ 911
Yi-Hung Tsai
Transdermal Drug Delivery Enhanced by Magainin Pore-forming Peptide: Modification of Electrostatic Interactions by Changing pH........................................................ 913
Yeu-chun Kim
Transdermal Iontophoretic Delivery of Granisetron Across Porcine Skin in Vitro.................. 915Jennyfer Cazares-Delgadillo
Transdermal Iontophoretic Delivery of Ketoprofen..................................................................... 917J. Anand Subramony
Transdermal Permeation of Trimetazidine from Nerodilol-based HPMC Gel Drug Reservoir System Across Rat Epidermis ..................................................................................... 919
Yellela Krishnaiah
Development of a Novel Dissolution Test Method for the Evaluation of In Vitro Release from Drug-Eluting Stents................................................................................................. 921
Anne Neubert
Mathematical Model for Design of Biodurable Drug-Eluting Stent Coatings ........................... 923Santosh Prabhu
Micropatterning of RGDC Peptide For 2D Cell Guidance ........................................................... 925Sing Tze Kho
Monitoring of Self Assembly Behavior of Chitosan Derivatives in Aqueous Solution by Photon Correlation Spectroscopy (PCS) ................................................................. 927
Shahriar Abashzadeh
Photoinitiator-free Photopolymerization Technique for Hydrogels Synthesis Involving Ampholytic Charge-Transfer Complex ........................................................................ 929
Loo-Teck Ng
Physicochemical Features of Vernix Caseosa Change Within Physiological Temperature Range ........................................................................................................................ 931
Joke Bouwstra
PLGA Microsphere/PVA Hydrogel Composites for Long-term Localized Inflammation Control ...................................................................................................................... 933
Upkar Bhardwaj
Poly(e-caprolactone) Nanowire/fiber Arrays for Drug Delivery and Control of Cellular Interactions........................................................................................................................ 935
Sarah Tao
Preparation of Growth Factors-containing Chitosan-alginate Polyelectrolyte Complex Scaffold for Wound Regeneration ................................................................................ 937
Fwu-Long Mi
Sustained Release of Fibroblast Growth Factor from Chitosan-heparin Composite Artificial Extracellular Matrix ......................................................................................................... 939
Shin-Shing Shyu
Application of an Aqueous Ethylcellulose Dispersion in Multiple-Unit Pellet Systems ........................................................................................................................................... 941
Viena Dias
Development and Evaluation of Gastroretentive Floating Drug Delivery System of Acyclovir .......................................................................................................................................... 943
Ghanshyam Das Gupta
Development and Evaluation of Gastroretentive Floating Microspheres of Silymarin .......................................................................................................................................... 945
Ghanshyam Das Gupta
Development and Evaluation of Mucoadhesive Patches of Salbutamol Sulphate in the Effective Treatment of Asthma................................................................................................ 947
Rajeev Garg
Drug-polymer Interactions in Controlled Delivery Systems: Interactions of Metoprolol Tartrate with Eudragit RL in Films ............................................................................. 949
Bianca Glaessl
Investigation of the Relationship between Formulation Variables and Drug Release in Aqueous Ethylcellulose Coating ................................................................................ 951
Kurt Fegely
Iontophoretic Delivery of Minoxidil Sulfate for Topical Androgenic Alopecia Treatment ......................................................................................................................................... 953
Renata Lopez
Pharmacokinetics of Domperidone in Rabbits from Bioadhesive Buccal Dosage Form ................................................................................................................................................. 955
Harmik Sohi
Stent for Delivery of 1,3-Dipropyl-8-cyclopentyl xanthine (DPCPX) - A Signaling Pathway Specific Drug ................................................................................................................... 957
Eunah Kang
Topical Antimicrobial Cyanoacrylate Formulations.................................................................... 959Binoy (Ben) Bordoloi
Chemical Stability of Polymer-based In Situ Gelling Intramammary Formulations ................ 961Alany Raid G
Evaluation of Polysaccharide Beads as Potential Oral Vaccine Delivery Platforms ............... 963Alan Smith
LIPOMERS: Optimization of Lipid Concentration for Splenic Targeting .................................. 965Rajesh Patil
Preparation of Josamycin Loaded Floating Microspheres for Fish Farming ........................... 967Pushp Nepal
Design and Gamma-Scintigraphic Evaluation of a Floating and Pulsatile Drug Delivery System Based on an Impermeable Cylinder ................................................................. 969
Hao Zou
Gastro-intestinal Transit of Enteric Coated Mesalazine Products: Imaging by Use of Magnetic Marker Monitoring Technique................................................................................... 971
Maria Anschütz
In vivo tracking of Mesenchymal Stem Cells by MR Imaging .................................................... 973Hye Jung Choi
Intravascular Delivery and Sustained Release of Ultrasound Contrast Microbubbles Via Intraperitoneal Administration........................................................................ 975
Alexander Klibanov
New Technology for Non-Invasive Real-Time Imaging of Liposome by Positron-Emission Tomography ................................................................................................................... 977
Takeo Urakami
Peg-Based Block Copolymers As MRI Contrast Agent, Their Longitudinal Relaxivity and Micelle Formation .................................................................................................. 979
Kouichi Shiraishi
Pharmacokinetic Analysis of Hyaluronic Acid Derivative As A Drug Carrier Using Quantum Dots ................................................................................................................................. 981
Jiseok Kim
PLGA Microparticles Containing Gd-DTPA for Imaging ............................................................. 983Amber Doiron
Preparation of Iron Oxide Nanoparticles with Different Particle Sizes and Surface Potentials for Cell Labeling............................................................................................................ 985
Yasuhiko Tabata
Quantum Dots As Tool for the Long-term Imaging of Particulate Drug Delivery Systems ........................................................................................................................................... 987
Cornelia Rose
Sulfated Polysaccharides Enhance the Biological Activities of Transforming Growth Factor-ß3 (TGF-ß3) in Hydrogel for Neocartilage Formation ....................................... 989
Dae Gyun Woo
Terahertz Pulsed Imaging for Non-destructive Analysis of Hydration dynamics of Functional Coatings and Controlled Release Products.............................................................. 991
Yao-Chun Shen
The In-Vivo Behaviour Of Erodible Tablets: A Gamma Scintigraphic Study............................ 992Manish Ghimire
Characterization of Thermosensitive Chitosan-based Hydrogels by Electron Paramagnetic Resonance Spectroscopy ..................................................................................... 994
Hendrik Metz
D-optimal Formulation Designing of Controlled Release Microiparticle Based Depot Injections of Aripiprazole .................................................................................................... 996
Tushar Nahata
Encapsulation and Release of Plasmid DNA from Uniform PLGA Microspheres.................... 997Daniel Pack
Enzyme-Mediated Injectable Hydrogels Composed of Hyaluronic Acid-Green Tea Catechin Conjugates ...................................................................................................................... 999
Motoichi Kurisawa
Essential Oil from Zantoxyllum tingoassuiba Loaded into Multilamellar Liposomes Useful as Antibiotic and Antimicrobial Agent........................................................ 1001
Elaine Cabral-Albuquerque
Influence of Poly(lactide-co-glycolide) Type and Gamma Irradiation on the Betamethasone Acetate Release from in Situ Forming Systems ............................................ 1003
Hamid Mobedi
Injection Depot Delivery of Methyl Prednisolone Acetate Using Aqueous Suspension.................................................................................................................................... 1005
Javed Ali
Leuprolide Acetate Loaded In Situ Gel Forming System: In vitro / in vivo evaluation ...................................................................................................................................... 1007
Hamid Mobedi
Mechanism of Oxytocin Release from Pluronic® F127 Gel using USP Apparatus 3............. 1009Roderick Walker
Polysaccharide/Protein Self-Association for Protein Stability in Poly(lactide-co-glycolide) Microspheres; Lysozyme Release, Stability, in vivo Behavior and Biocompatibility ............................................................................................................................ 1011
Kun Na
RhGF-loaded Microspheres for the Treatment of Neurodegenerative Disorders .................. 1013Cunxian Song
Silk-Elastinlike Hydrogels for Controlled Adenoviral Gene Delivery ...................................... 1015Ramesh Dandu
Coatings for Enzyme Delivery in Animal Feed Applications.................................................... 1017Beth Fryksdale
Controlled Delivery Mosquito Larvicide Formulations: Testing and Evaluation ................... 1019Richard Levy
Mechanically Strong Nanoclay Crosslinked Hydrogels exhibiting pH and Temperature Sensitivity ............................................................................................................... 1021
Siddharthya Mujumdar
6-Mercaptopurine Microbubbles Drug Delivery: Preparation and In-vivo Studies ................ 1023Manish Umrethia
Biodegradable and Biocompatible Nanocapsules and Particles Prepared by the Miniemulsion Polymerisation ...................................................................................................... 1025
Ruth Schmid
Controlled Release of Proteasome Inhibitor from Biodegradable Nanoparticles for Myeloma Therapies....................................................................................................................... 1027
Gianny Rossini
Cytotoxicity of Perfluorocarbon-based Emulsion Oxygen Carriers ........................................ 1029Valerie Centis
Development of Co-encapsulated Nanoparticles of Ellagic Acid and Coenzyme Q10 (NanoCAPs) and Their Evaluation in Streptozotocin Induced Diabetic Rats ................. 1031
Venkat Ratnam Devdasu
Docetaxel Loaded Chitosan Nanocapsules for Cancer Therapy ............................................. 1033Victoria Lozano
Effect of pH on the Encapsulation of Buprenorphine HCl in Polylacide-co-glycolide......................................................................................................................................... 1035
Richard Graves
Encapsulation of the Nitric Oxide Donor Trans-[RuCl([15]aneN4)NO]Cl2 in Biodegradable Polymer by Double Emulsion Method .............................................................. 1037
Fabiana Oliveira
Formulation and Characterization of Microencapsulated Catalase ........................................ 1039Rodney Siwale
Formulation and Evaluation of Submicroscopic Carrier Systems of Moxifloxacin for Ocular Delivery ........................................................................................................................ 1041
Sanjay Motwani
Formulation and Ex-vivo Evaluation of Antisense Oligonucleotides to Nf-kB Encapsulated Albumin Microspheres in a Kidney Transplant Model ..................................... 1043
Sanjay Gayakwad
Formulation of Drug Loaded Nanoparticles from Low Molecular Weight Poly(L-Lactic Acid) by a Novel Electrospraying Technique ................................................................. 1045
Leena Peltonen
Loading Capacity of Beclomethasone Dipropionate in EPC Liposome Membranes ............ 1047Fernando Vasconcellos
Lower Critical Solution Temperature Phase Behavior (LCST) Study of Poly(organophosphazenes) ......................................................................................................... 1049
Sungsook Ahn
Multifunctional Nanoparticles for Combining Ultrasonic Tumor Imaging and Targeted Chemotherapy............................................................................................................... 1051
Zhonggao Gao
Nanoparticle Encapsulated Droplets: A Novel Delivery System for Lipophilic Drugs .............................................................................................................................................. 1053
Clive Prestidge
New Concept Applying to Microencapsulation ......................................................................... 1055Younglim Chung
pH-Sensitive Liposome Based on trans-2-Aminocyclohexanols ............................................ 1057Ningrong Zhang
Photochemically Crosslinked Collagen Microspheres for Controlled Protein Release........................................................................................................................................... 1059
Cheuk Ming Chan
Polymer MW Determines Nanocarrier Characteristics to Reveal an Ideal Vehicle for Targeted Enzyme Delivery ..................................................................................................... 1061
Eric Simone
Positively Charged Polymeric Carriers for Amphotericin B Delivery...................................... 1063Satyanarayana Somavarapu
Preparation and Characterization of Bioadhesive Poly(methylmetacrylate) Nanoparticles Coated with Thiolated Chitosan ......................................................................... 1065
Mitra Seyed Moosavi
Volume 3
Preparation of Chitosan Nanoparticles Encapsulating Bovine Serum Albumin.................... 1067
Yilmaz Capan
Preparation of Polylacide-co-glycolide and Chitosan Hybrid Nanoparticles of Amifostine Using Coaxial Ultrasonic Atomizer with Solvent Evaporation ............................. 1069
Richard Graves
Release Characteristics of Novel Bioresorbable In-Situ Crosslinkable Self-Assembled nanoparticlces .......................................................................................................... 1071
Esmaiel Jabbari
Salt Addition Effects on the Poly(organophosphazenes) Thermothickening ........................ 1073Sungsook Ahn
Self-Assembled Collagen-Human Mesenchymal Stem Cell (hMSCs) Microspheres – Novel Bio-devices for Cell Delivery.......................................................................................... 1075
BP Chan
Temperature/pH-Induced Structural Variation of Shell Cross-linked Nanogels Using Poly(AAc-co-MEA)/PNIPAAm/mPEG Graft Copolymers ................................................ 1077
Wen-Hsuan Chiang
Treatment of Female Sexual Dysfunction Using Locally Applied Liposomal Sildenafil Citrate............................................................................................................................ 1079
Andreas Wagner
Utilizing Engineered Shape and Size-specific Nanoparticles for the Delivery of Biological Cargo............................................................................................................................ 1081
Ginger Rothrock
Liposomes with Hyaluronic Acid for Antitumor Drug Delivery................................................ 1083Luigi Cattel
Masking and Unmasking Targeting Ligands on Nanocarriers with Detachable PEG Coatings ................................................................................................................................ 1085
Efstathios Karathanasis
Microfabricated Components for Fully Implantable Microfluidic Drug Delivery to the Inner Ear .................................................................................................................................. 1087
Erin Leary Swan
N-Carboxymethyl Chitosan Coated Solid lipid Nanoparticles for Oral Delivery of Insulin............................................................................................................................................. 1089
Ramakrishna Sistla
Nano-Thermal Analysis of the Structural Properties of an HPMC/EC Polymer Blend .............................................................................................................................................. 1091
Andrew Parker
Optimization of TAT-peptide (TATp) Quantity on the Liposome Surface for Effective Intracellular Delivery of TATp-Conjugated PEG-Liposomes ................................... 1093
Shing-Ming Cheng
Physical stability of Nanostructured Lipid Carriers (NLC) in an o/w Urea Cream ................. 1095Jana Pardeike
Physical Stability of Rutin Nanosuspension Produced by High Pressure Homogenization ............................................................................................................................ 1097
Rachmat Mauludin
Physicochemical Characterization and Antioxidant Effects of Quercetinnano Particles ......................................................................................................................................... 1099
Tzu-Hui Wu
Physicochemical Characterizations of Lyophilized Ascorbyl Palmitate Nanosuspension ........................................................................................................................... 1101
Veerawat Teeranachaideekul
Physicochemical Evaluation of Alpha-lipoic Acid Encapsulated in Solid Lipid Nanoparticles (SLN)...................................................................................................................... 1103
Usawadee Sakulkhu
PLGA Docetaxel Nanoparticles: Preparation and In Vitro Evaluation..................................... 1105Farnaz Esmaeili
Preparation and Characterization of N-diethylmethyl Chitosan (DEMC) Nanoparticles Loaded with Insulin Using Both the Ionotropic Gelation and Polyelectrolyte Complexation Methods...................................................................................... 1107
Assal M.M. Sadeghi
Preparation and Characterization of PLGA Nanoparticles for Oral Delivery of Epigallocatechin Gallate .............................................................................................................. 1109
Pallab Datta
Preparation and Characterization of Self-Assembled Polyelectrolyte Nanocomplexes Based on Chitosan and Enoxaparin............................................................... 1111
Shirui Mao
Preparation of an Emulsion Formulation of Clopidogrel for Intravenous Administration............................................................................................................................... 1113
Rajeev Jain
Preparation of Calcium Phosphate Nanostructures Using Soft Chemical Route .................. 1115Ajeet Kumar
Preparation of Hydrophilic Antioxidant-Loaded Poly(vinyl alcohol) Nanoweb by Electrospinning and Its Wound Healing Effect .......................................................................... 1117
Won Seok Lyoo
Simultaneous Sizing of Nanoparticles by Individually Visualizing and Separately Tracking their Brownian Motion within a Suspension. ............................................................. 1119
Bob Carr
Stabilization of Chemically labile Actives Using Nanostructured Lipid Carriers (NLC)............................................................................................................................................... 1121
Aiman Hommoss
Stable Colloids of Poorly Soluble Drugs Prepared Using Layer-by-Layer Polymeric Coating of Drug Nanoparticles.................................................................................. 1123
Vladimir Torchilin
The Preparation and In Vitro Evaluation of Chitosan Nanoparticles Containing bFGF for Treatment of Neurodegenerative Diseases................................................................ 1125
Yilmaz Capan
Three-dimensional Nano/Micro Composite Scaffold by Mixing Electrospinning for Bone Tissue Engineering ............................................................................................................. 1127
Mira Jung
Transdermal Delivery of Cantilever Maltose Microneedle for Drug Customization............... 1130Yoshikazu Tobinaga
A Novel Multifunctional and Polymerizable Gene Carrier Mediated Efficient Transfection................................................................................................................................... 1132
Xuli Wang
Akt1 siRNA Delivery for Lung Carcinoma Using Poly (ester amine) ....................................... 1134Chong-Su Cho
Antisense GFP ODN-Hyaluronic Acid Conjugate/Protamine Nanocomplexes for Intracellular Gene Silencing......................................................................................................... 1136
Tae Gwan Park
Artificial Virion Nanocapsules for Gene Delivery ...................................................................... 1138Youqing Shen
Biochemical Investigation of Intracellular Transport of Polyethylenimine/DNA Polyplexes ..................................................................................................................................... 1140
Daniel Pack
Characterizations and lntracellular Distribution of Tumor Suppressor Gene (p53) Microparticles................................................................................................................................ 1142
Kadriye Ciftci
Charge Reversal Amphiphiles for DNA and siRNA Delivery .................................................... 1144Carla Hernandez Prata
Chitosan coated PLGA nanoparticles as carriers for antisense 2’-O-Methyl-RNA: evaluation of nanoplex stability and uptake into A549 lung cancer cells............................... 1146
Claus-Michael Lehr
Chitosan-coated PLGA Nanoparticles As a Flexible and Efficient Carrier for Antisense Oligonucleotides......................................................................................................... 1148
Noha Nafee
Chitosan-Mediated siRAN Delivery in Vitro: Effect of Polymer Molecular Weight and Salt Forms .............................................................................................................................. 1150
Praneet Opanasopit
Co-delivery of the Endosome-Disruptive Peptide INF 7 Improves Gene Delivery of Poly(N,N-dimethylaminoethyl methacrylate)-graft-polyethylenglycol (pdMAEMA-g-PEG) Copolymers ...................................................................................................................... 1152
Senta Uezguen
Effect of Counter Ion on the pH Sensitivity and Gene Transfection of Ortho Ester-Based Lipoplexes.......................................................................................................................... 1154
Xin Guo
Effect of Molecular Balance of Head-Tail type Polycation Vector to In Vitro Trasnfection Efficiency................................................................................................................. 1156
Atsushi Harada
Encapsultion and Cellular Delivery of Small-interfering Rna by Poly (ethylene Oxide)-poly (lactic Acid) Bilayer Polymersomes ...................................................................... 1158
Shenshen Cai
Encapsulation and Controlled Release of DNA from Silica Particles ..................................... 1160Linggen Kong
Enhanced Gene Delivery Using Disulfide-Crosslinked Polycations with Listeriolysin O Conjugates .......................................................................................................... 1162
Suna Choi
Folate Conjugated Poly(ester amine) for Lung Cancer Therapy ............................................. 1164Myung Haing Cho
Galactosylated Chitosan-graft-polyethylenimine as a Gene Carrier for Hepatocyte Targeting ........................................................................................................................................ 1166
You-Kyoung Kim
Gene Carrier for Enhanced Transfection Efficiency using Low Molecular Water Soluble Chitosan........................................................................................................................... 1168
Jae-Woon Nah
Gene Transfer Using Protamine Derivatives.............................................................................. 1170Li-Chien Chang
In Vitro Gene Transfer Efficiency of Urocanic Acid-modified Non-viral Polymeric Gene Transfer Agents................................................................................................................... 1172
Markus Elfinger
Introduction of Secondary and Tertiary Amines to Chitosan for Enhanced Delivery of Nucleic Acids ............................................................................................................. 1174
Bilal Ghosn
Investigation of in vitro/in vivo Correlates for Liposomal DNA Vaccines............................... 1176Sarah McNeil
Methylated N-(4-N,N-dimethylaminobenzyl) Chitosan for a Novel Effective Gene Carrier ............................................................................................................................................ 1178
Theerasak Rojanarata
Modified Polyallylamine Nanoparticles for Efficient Gene Delivery ........................................ 1180Atul Pathak
PEG-Detachable Polyplex Micelles Responding to Reduced Environment Based on PEG-b-Polyasparatamide Catiomers ..................................................................................... 1182
Seiji Takae
PEI / DNA / Alginate Polyplex As An Efficient In Vivo Gene Delivery System........................ 1184Ge Jiang
Physico-Chemical Characterization of the of Plasmid DNA and Nuclear Localization Signal Peptide Packed in Liposomes ................................................................... 1186
Maria Helena Santana
PLGA Nanoparticles for Gene Therapy – Waiving Complexity, Increasing Transfectivity................................................................................................................................. 1188
Jacob Gvili
Poly (lactide-co-glycolide)-polymethacrylate Nanoparticles for Gene Delivery..................... 1190Jagdish Singh
Polyethylenimine-based antisense oligodeoxynucleotide of interleukin-4 complex alleviate the interleukin-4 level in the murine model with allergic asthma ............................. 1192
Ji-Hye Seong
Preparation and Investigation of Octa(3-aminopropyl) Silsesquioxane L-Lysine Dendrimers as Nucleic Acid Carriers.......................................................................................... 1194
Todd Kaneshiro
SiRNA-Mediated Knockdown of EGFR Is Improved by Strategies Which Facilitate SiRNA-Endosomal Escape........................................................................................................... 1196
Sabrina Oliveira
Site-specific Delivery of Oligonucleotides to Hepatocytes ...................................................... 1198Lin Zhu
Supramolecular Control of Polyplex Decondensation and Cell Transfection: Efficacy of Amine and Threading Cyclodextrin on Biocleavable Polyrotaxanes................... 1200
Atsushi Yamashita
Synthesis, Characterization and Transfection of a Novel Folate-targeted Multipolymeric Delivery System for Gene Therapy................................................................... 1202
Nie Yu
Target-specific Intracellular Delivery of siRNA Using Degradable Hyaluronic Acid Nanogels ........................................................................................................................................ 1204
Hyukjin Lee
TATp-bearing Immunoliposome for Gene Delivery to Hypoxic Cardiomyocytes In Vitro ................................................................................................................................................ 1206
Young Tag Ko
The Development of p27kip1 Nanoliposome Gene Delivery System and Its Growth Inhibition Effects on Human Lung Caner Cells ......................................................................... 1208
Hongwei Zhang
The Effect of Remnant Cationic Dendrimers on RNA Purification .......................................... 1210Junghua Kuo
Thermo-sensitive Nano Gene Carriers Surface-modified with Pluronic Polymers................ 1212Jung Im Lee
Thiolated Chitosan Nanoparticles: Transfection Study in the CaCO-2 Transwell Cell Culture .................................................................................................................................... 1214
Ronny Martien
6-Month Administration of Oral Insulin at Lunchtime in Juvenile Type-1 DM Subjects on Basal Glargine Insulin and Pre-Breakfast and Pre-Dinner Regular Insulin............................................................................................................................................. 1216
Jaime Guevara-Aguirre
A Bioequivalent 120mg Pseudoephedrine HCl Extended-Release Monolithic Tablet.............................................................................................................................................. 1218
Stephen Turner
A Multiparticulate Drug Delivery System To Target Celecoxib To The Colon........................ 1220Manuel Guzman
A Novel Preparation Method for Rapidly Dissolving Biorelevant Media for Dissolution Testing – FaSSIF and FeSSIF Instant Powders..................................................... 1222
Kathrin Nollenberger
A Solid Dispersion Comprising Sibutramine Base Intended for Enhanced Solubilization ................................................................................................................................. 1224
HeeChul Chang
Acidified Solid Dispersions to Modify the Release Rates of Weak Bases.............................. 1226Madhav Vasanthavada
Adjustment of Desired Drug Release Patterns From Pellets Coated With Aqueous Ethylcellulose Dispersions: Importance of the Type of Core and Drug Solubility ................ 1228
Juergen Siepmann
Alcohol Influence on Drug Release - Concept for Rugged Formulations............................... 1230Brigitte Skalsky
Anionic Methacrylic Acid Copolymers as Release Enhancers ................................................ 1232Hema Ravishankar
Application Related Properties of a New Fast Dispersible Excipient...................................... 1234Karl Kolter
Assessment of Luminal Concentration of Drugs in GI Tract After Oral Administration............................................................................................................................... 1236
Takanori Goto
Assessment of Novel Liquid Crystalline Materials in the Oral Controlled Delivery of Lipophilic Compounds............................................................................................................. 1238
Tri-Hung Nguyen
Basic butylated methacrylate copolymers (Ph.Eur.) for stabilized Solid Solutions of Ibuprofen ................................................................................................................................... 1240
Andreas Gryczke
Bioavailability Study of Modified Amoxicillin/Clavulanate Therapeutic System ................... 1242Janez Kerc
Carboxymethyl High Amylose Starch – Chitosan Tablets Affording Colon Probiotic Delivery.......................................................................................................................... 1244
Carmen Calinescu
Characterization of Floating Kollidon® SR Matrix tablets ........................................................ 1246Sandra Struebing
Characterization of Permeation Processes of Coated Dosage Forms with Novel Polymers ........................................................................................................................................ 1248
Sandra Struebing
Coating of Pellets with Aqueous Dispersions Or Organic Solutions of Water-insoluble Polymers ....................................................................................................................... 1250
Mesut Ciper
Comparison of In Vitro Release Characteristics of Venlafaxine From Tablets Containing Different HPMC Polymers......................................................................................... 1252
Fusun Acarturk
Continuous Wavelet and DerivativeTransforms for the DissolutionTest of Levodopa - Benserazide Tablets ................................................................................................ 1254
Tanver Doganay
Controlled Release Study of 5-fluorouracil Loaded Chitosan/PEG Microparticles ............... 1256Chuen-Chang Lin
Correlating Dissolution Rates to Surface Properties Measured by Inverse Gas Chromatography ........................................................................................................................... 1258
Dan Burnett
Correlation between In Vitro Dissolution Profiles of Drugs from Enteric-coated Dosage Forms and In Vivo Drug Absorption ............................................................................. 1260
Ryoko Ogura
Curing Procedures for Matrix Tablets with EUDRAGIT® RS 30 D ........................................... 1262Brigitte Skalsky
Design of Biodegradable Nanoparticles of Atorvastatin Calcium (nanostatin) for Oral Delivery and Their Evaluation in High Fat Diet Fed Rats for Improved Efficacy with Reduced Toxicity ................................................................................................... 1264
Chandraiah Godugu
Design and Optimization of Mefloquine Hydrochloride Reverse Enteric Chitosan Microparticles (RE-Chi) for Bitter Taste Masking ...................................................................... 1266
Punit Shah
Design of a Monolithic Controlled Release Formulation of Ondansetron HCl for Oral Administration....................................................................................................................... 1268
Catherine Federici
Development and Characterization of a Solid Microemulsion Preconcentrate System for Oral Delivery of Poorly Water Soluble Drugs ......................................................... 1270
Abu Serajuddin
Development and Characterization of Carvedilol Fast Dissolving Tablet : Using Superdisintigrates and Solid Dispersion Technique. ............................................................... 1272
Shailesh Sharma
Development and Characterization Of Controlled Release Floating Pellets Of Clarithromycin ............................................................................................................................... 1274
Jessy Shaji
Development and Evaluation of New Floating Levodopa Sustained Release Minitablets ..................................................................................................................................... 1276
Goole Jonathan
Development of a Biorelevant Physiological Dissolution Stress Test Device ....................... 1278Grzegorz Garbacz
Development of a Novel Floating Pulsatile System for Chronotherapeutic Release of Aceclofenac............................................................................................................................... 1280
Vishal Patole
Development of an In-Vitro Dissolution Model for Prediction of In-Vivo Absorption of Poorly Water Soluble Drugs................................................................................ 1282
Saroj Vangani
Development of Clinical Dosage Forms for a Poorly Water-Soluble Drug II: Comparative Evaluation of Solid Dispersion, Solid Microemulsion Preconcentrate and Lipid-based Formulations..................................................................................................... 1284
Abu Serajuddin
Development of Mathematical Model for Predicting Formulation of Sustained Release Products .......................................................................................................................... 1286
Pirthi Pal Singh
Development of Self-Microemulsifying Drug Delivery Systems (SMEDDS) for Oral Bioavailability Enhancement of Saquinavir ............................................................................... 1288
Deepa Patel
Development of a Sustained Release Tablet for Water Soluble Compounds ........................ 1290Ray Lo
Drug Abuse Resistant Controlled Release Using Egalet® Dosage Units .............................. 1292Pernille Hemmingsen
Drug Permeability Across a Phospholipid Vesicle Based Barrier: Barrier Structure Characterization and Effect of Agitation on Barrier Integrity and Drug Permeability................................................................................................................................... 1294
Gøril Eide Flaten
Drug Release Properties of Kollidon® VA 64/polyacrylic Acid Interpolymer Complexes for Oral Delivery ....................................................................................................... 1296
Ilshat Arislanov
Effect of Betacyclodextrin Complexation on Diffusion, Permeability and Bioavailability of Carbamazepine................................................................................................ 1298
Sarasija Suresh
Effect of Bio-relevant Media on the Properties of Hydroxypropyl Methyl Cellulose (HPMC) ........................................................................................................................................... 1300
Ian Hardy
Effect of Drug Solubility on the Properties of Hydroxypropyl Methyl Cellulose (HPMC) Tablets.............................................................................................................................. 1302
Ian Hardy
Effect of Formulation on Adinazolam Pharmacokinetics and Pharmacodynamics .............. 1304Viera Lukacova
Effect of Temperature on the In Vitro Transbuccal Permeation............................................... 1306Upendra Kulkarni
Effect of Thermodynamic Activities of the Unionized and Ionized Drug on Flux across Buccal Mucosa ................................................................................................................. 1308
Amit Kokate
Effervescent Floating Matrix System of DA 6034, a New Drug Candidate, for Gastroretentive Sustained Release............................................................................................. 1310
Sun Jang
Evaluation of Chemically Modified Starches as Sustained-Release Agents in Monolithic Tablets......................................................................................................................... 1312
Fernanda Onofre
Evaluation of the Ninhydrin Assay for Gabapentin Determination ......................................... 1314Karla LaPorte
Evaluation of the Effect of Hydroalcoholic Media of Textural and Rheological Characteristics of Hyrpomellose Matrices ................................................................................. 1316
Shahrzad Missaghi
Fast Dissolving Oral Strips Containing Garcinia Mangostana Husk Extract ......................... 1318Suchada Chutimaworapan
Fixed Dose Combination of Simvastatin and Ramipril ............................................................. 1320Jung Chul Joo
Formulation Development of a Novel Nanoparticle-based Therapeutic System for the Chemoprevention of Colon Cancer ..................................................................................... 1322
Naveen Kanthamneni
Formulation of Peppermint Oil in a Self-Emulsifying Drug Delivery System (SEDDS) for Oral Administration................................................................................................. 1324
Rainer Müller
Formulation optimization for improving in vitro dissolution and oral absorption of hydrophobic drugs ....................................................................................................................... 1326
CS Hsu
Glimepiride/L-arginine systems for higher hypoglycemic effects........................................... 1328Jeong-Soo Kim
Hydrodynamic Robustness of Hypromellose and Hydroxypropyl Cellulose Based Modified Release Matrix Systems .............................................................................................. 1330
Thomas Durig
Improved Solubility and Dissolution of Itraconazole by preparing Gelatin Based Microcapsules ............................................................................................................................... 1332
Dongxun Li
Improvement of Oral Absorption Behavior of Poorly Water-Soluble Drug Using SMEDDS: Pharmacokinetic Analysis and Prediction Based on GlTA Model ......................... 1334
Toshikiro Kimura
Improving Solubility, Dissolution and Bioavailability of Drugs Having Low Melting Points Using a Simple Technique ............................................................................................... 1336
Madhuri Newa
Influence of Ionic Interactions in Controlled Release Formulations of Water-Soluble Drug .................................................................................................................................. 1338
Kathrin Nollenberger
Improving the Dissolution Rate of Carbamazepine Using Melt Extrusion.............................. 1340Amit Kokate
In Silico Prediction of Drug Permeation Across Buccal Mucosa ............................................ 1342Herbert Hoyer
In Vitro and In Vivo Evaluation of a Patch System Based on Thiolated Polymers ................ 1344Wen Jen Lin
In Vitro In Vivo Study of Micropore-Controlled Release Tablet ............................................... 1346Manish Ghimire
In Vitro Characterisation of Radiolabelled Erodible Tablets .................................................... 1348Hema Ravishankar
Influence of Buffer Salts on Ammonioalkyl Methacrylate Copolymers .................................. 1350Volga Devabhaktuni
Insulin-coenzyme Q10 Coencapsulated PLGA Nanoparticles for Oral Delivery: A Better Regimen for Treatment of Diabetes Mellitus and Its Complications............................ 1352
Gaurav Sharma
The Influence of Different Types of Carbopol® on the Composition of Interpolyelectrolyte Complexes with Eudragit ® E Po Using Viscosity Measurements ............................................................................................................................... 1354
Tatiana Kabanova
Investigation of Changes in a Controlled Release Formulation upon Accelerated Aging .............................................................................................................................................. 1356
Andrew Parker
Investigation of Granule Microstructure using Micro-Computed Tomography and Raman Microscopy ....................................................................................................................... 1358
Andrew Parker
Large Polymeric Nanoparticles That Overcome The Mucus Barrier ....................................... 1360Samuel Lai
Limitations in the Ph-independent Extended Release of Weakly Basic Drugs from Eudragit RS 30D Coated Pellets .................................................................................................. 1362
Martin Koerber
Lymphatic Transport Contribution Towards the Systemic Exposure of Orally Administered pH-sensitive Nanoparticles (NP) Loaded with a Model Hydrophilic Peptidomimetic Drug .................................................................................................................... 1364
Rosa Pereira
Mathematical Model for Simulation and Control of Drug Release from Hydrophilic Matrices.......................................................................................................................................... 1366
Sandip Tiwari
Micro-environment Adjustment Improves the Release of Verapamil Hydrochloride from HPMC Based Mini-tablets.................................................................................................... 1368
Roderick Walker
Nanoparticles for Oral Insulin Delivery....................................................................................... 1370Kiran Sonaje
Nanosuspension of DA 6034, a New Drug Candidate, by pH-Dependent Solvent Diffusion Method for Enhancing Local Gastro-protective Effect............................................. 1372
Sun Jang
Nmr Studies of the Variation Due to Formulation in Evolving Pore Structures in Millimetre Sized Pellets ................................................................................................................ 1374
James Collins
Novel Carboxymethyl Starch Excipients for Oral Dosage Forms............................................ 1376Mircea Alexandru Mateescu
Novel Design of Three Oral Controlled Release Formulations of Phenylephrine HCl .................................................................................................................................................. 1378
Haiyan Zhang
Novel User-Friendly Dosage Forms of Choline ......................................................................... 1380Satishkumar Jain
Oral Bioavailability of Solutions vs Suspensions in Labrafil® 2125CS and In Vivo In Vitro Relations........................................................................................................................... 1382
Anette Mullertz
Oral Cyclosporine A Formulation for Chronic Immunosuppression: Implication of Nanotechnology in Reducing Nephrotoxicity ............................................................................ 1384
Jagdish Italia
Performance of A-PAMPA: A Three Lipid PAMPA System and Comparing PAMPA and CaCO-2 Permeability ............................................................................................................. 1386
Zeynep Teksin
Permeabilities of Polyethylene Glycol across Different Regions of Porcine Oral Mucosa ........................................................................................................................................... 1388
Tarun Goswami
Permeation Barriers to Two Lipophilic Cations in CaCO-2 Cell Monolayers ......................... 1390Ian G. Tucker
Pharmacokinetic and Pharmacodynamic Aspects of Gastro-retentive Metformin Pellets............................................................................................................................................. 1392
Jingshu Piao
Pharmacokinetic Evaluation of Extended Release and Immediate Release Formulations of Pramipexole ...................................................................................................... 1394
Dinesh Haswani
Pharmacokinetic Studies with a Mucoadhesive Multilayer Extended-Release Tablet Formulation of Levodopa-Carbidopa in Healthy Volunteers ........................................ 1396
Peyman Moslemy
Pharmacokinetics of Gabapentin After Single and Repeated Dosing of Gabapentin Extended Release Tablets (G-ER) and Instant Release (IR) Tablets in Healthy Male and Female Volunteers.......................................................................................... 1398
Toufigh Gordi
Physical Characterization of Oleanolic Acid Nonsolvate and Solvates Prepared by Solvent Recrystallization ............................................................................................................. 1400
H. H. Y. Tong
Prandial Oral Insulin (Generex Oral-lynTM) in Adult Type-1 DM Subjects Receiving Basal s.c. Twice Daily Isophane Insulin (NPH) ........................................................ 1402
Jaime Guevara-Aguirre
Predictive Models for Drugs Exhibiting Negative Food Effects Based on their Biopharmaceutical Characteristics............................................................................................. 1404
Venugopal Marasanapalle
Preparation and Characterization of Piroxicam/Poloxamer Solid Dispersion Prepared by Melting Method ........................................................................................................ 1406
Hang Yu
Preparation and Evaluation of Self Microemulsifying Drug Delivery System(SMEDDS) of Valdecoxib. ................................................................................................ 1408
Vishwesh Joshi
Preparation and in Vitro Modulation of Chitosan Microsphere for Controlled Drug Delivery System ............................................................................................................................ 1410
Shital Lodha
Preparation and Optimization of Probucol Self-Emulsified Drug Delivery System (PBSEDDS) Applying Response Surface Methodology............................................................ 1412
Abdelazim Zaghloul
Prodrugs of 3-hydroxyphenazepam for Oral Delivery .............................................................. 1414Iryna Kravchenko
Proliposomal Formulations of Exemestane for Improved Oral Delivery ................................ 1416Praveen Hiremath
Prospects of using Honey as a Sustained Release Adjuvant in the Pharmaceutical Manufacture of Oral Dosage Formulations. ................................................... 1418
Musa Autamashih
Rheological Investigation of Mucoadhesive Interaction between Pectin and Mucin ............ 1420Nartaya Thirawong
Scalability Evaluation of Monolithic Controlled Release Gabapentin Formulations for Oral Administration................................................................................................................. 1422
Karla LaPorte
Solid Dispersions of Cilostazol Prepared Using Solution Enhanced Dispersion by Supercritical Fluids....................................................................................................................... 1424
Min-Soo Kim
Stability and Release Behavior of an Oral System Intended for Time-Based Colon Delivery of Insulin ......................................................................................................................... 1426
Mauro Serratoni
Sustained-release Formulations with Lipidic Excipients ......................................................... 1428Delphine Marchaud
Tabletting of Non-sticking Ibuprofen DC 85® with Different Disintegrants............................ 1430Karl Kolter
The Effect of Hypromellose as a Pore-Former on Drug Release from Aqueous Ethylcellulose Film-Coated Dipyridamole-Loaded Nonpareil Beads ...................................... 1432
Marina Levina
The Effect of Different Oils on the Absorption of a-Tocopherol in the Rat: Comparison of Palm Oil, Soybean Oil and Coconut Oil ........................................................... 1434
Tommy Julianto
The Effects of Pigments on Eudragit® NM 30 D Polymeric Dispersions and Formulations ................................................................................................................................. 1436
Dave Klimkowsky
The Influence of Fumed Silicon Dioxides on the Physical Aging and Drug Release Rate of EUDRAGIT® RS/RL 30 D Film-Coated Theophylline Pellets ....................................... 1438
Shawn Kucera
The Influence of Plasticizer Type and Level on Acid Resistance from Tablets Coated with an Aqueous Delayed Response Film Coaring System ........................................ 1440
Cara Young
The Influence of Solvent System on the Performance of Polyvinyl Acetate Phthalate (PVAP) Delayed Release Coating Systems............................................................... 1442
Kurt Fegely
The Stability of Ethylcellulose Film Coatings Containing PG alginate or Carrageenan .................................................................................................................................. 1444
Juergen Siepmann
Viscometry, a Method for Assessing Rate-Controlling Excipients ......................................... 1446Karla LaPorte
Sun Protection Factor (SPF) Increase Using Nanostructured Lipid Carriers (NLC) .............. 1448Aiman Hommoss
A New High Loading PEG for Drug Release .............................................................................. 1450Anna Mero
Biodistribution Study of Rifampin Bound to PLGA Nanoparticles Following Different Routes of Administration ............................................................................................. 1452
Svetlana Gelperina
Epirubicin-PEG Conjugate Releasing Nitric Oxide: In Vivo Evaluation ................................. 1454Gianfranco Pasut
Glipizide- Beta Cyclodextrin Inclusion Complexes for Dissolution and Bioavailability Enhancement ....................................................................................................... 1456
Vinay Batra
Glycopolymer Conjugates for Targeting Tumor Vascular Endothelium................................. 1458Ayelet David
In Vitro Investigations of a Permeation Enhancing Effect of Thiolated Chitosan on Oral Tobramycin Sulfate Uptake ................................................................................................. 1460
Juliane Hombach
In vivo Efficacy of Stabilized Doxorubicin Hydrazone-Conjugated Polymeric Micelles with Intracellular pH-Controlled Activation................................................................. 1462
Iulian Bobe
Novel Methods of Intracellular Delivery of ?F508-CFTR Correctors ....................................... 1463Luigi Cattel
Novel Multifunctional Polymeric Micelles for Targeted Drug Delivery.................................... 1465Xiao-Bing Xiong
Pharmacokinetic Behavior of Stabilized Doxorubicin Hydrazone-Conjugated Polymeric Micelles with Intracellular pH-Controlled Activation .............................................. 1467
Mitsunori Harada
Polymer Anticancer Drugs with Peptide Targeting ................................................................... 1468Martin Studenovsky
Synthesis and Characterization of Hyaluronic Acid-Peptide Conjugate for FPRL-1 Receptor......................................................................................................................................... 1470
Eun Ju Oh
Targetable Polymer - Antiangiogenic Drug Conjugates For Systemic Cancer Therapy .......................................................................................................................................... 1472
Anjan Nan
The Chemopreventive and Anticancer Activity of HPMA Copolymer-Fenretinide Conjugate In Vitro ......................................................................................................................... 1474
Alexander Malugin
The Impact of Free or N-(2-hydroxypropyl)methacrylamide (HPMA) Bound Doxorubicin on Surface Membrane Glycosylation: the Possible Role of CD43. ................... 1476
Lubomir Kovar
A Novel In Vitro Pulmonary Dissolution Testing Method for Controlled Release Inhalation Formulations ............................................................................................................... 1478
Yoen Ju Son
Characterization of Nebulized Liposomes: Preliminary Studies for Inhalative Application of a Liposomal Drug Delivery System for Vasoactive Intestinal Peptide ........................................................................................................................................... 1480
Brigitte Stark
Development of Pulmonary Administration System of Ciprofloxacin Incorporated Into Liposomesfor Treatment of Respiratory Intracellular Parasite Infections ...................... 1482
Kazuhiro Morimoto
Effects of Air Flow Rate and Relative Humidity on the Electrostatic Properties of Lactose Carriers for Dry Powder Inhalers .................................................................................. 1484
Keat Theng Chow
Effects of Rifampicin and DPPC Concentrations on the Aerodynamic Properties of PLGA Microspheres Prepared by Spray Drying Method ...................................................... 1486
Takehisa Nakajima
Evaluation of in vitro Methodologies used for Testing Controlled Release DPI Formulations ................................................................................................................................. 1488
Rania Salama
In Vitro and In Vivo Evaluation of Poly(ether-anhydride) Particles for Potential Treatment of Lung Cancer ........................................................................................................... 1490
Benjamin Tang
Nanosized Non-ionic Surfactant Vesicles (niosomes) for Enhanced Absorption of Low Molecular Weight Heparin Via the Pulmonary Route........................................................ 1492
Fakhrul Ahsan
Optimization of Jet Milling Conditions for Particle Size Reduction of Soft Materials......................................................................................................................................... 1494
Imran Saleem
Particles For Enhanced Aerosol Drug Delivery In Cystic Fibrosis .......................................... 1496Martin Donovan
Preparation and Characterization of Interleukin-2 Liposome for Pulmonary Administration............................................................................................................................... 1498
Nevin Celebi
Preparation and Properties of Inhalable Nanocomposite Particles ........................................ 1500Keishiro Tomoda
The Effect of Various Polymers on in Vivo Evaluation of Insulin/mannitol Spray Dried Powder for Inhalation ......................................................................................................... 1502
Morteza Rafiee-Tehrani
Design and Development of a Polymer-Blend Nanoparticle Drug Delivery System to Overcome Multidrug Resistance in Cancer .......................................................................... 1504
Lilian van Vlerken
Drug Delivery Systems In Pain Management ............................................................................. 1506Hamid Mobedi
Identification And Characterization Of Peptides Binding To A Novel Histone H1 Monoclonal Antibody By Phage Display .................................................................................... 1507
Kuei-Chen Chiang
Preparation and Characterization of Radiolabeled Antibodies for Targeted Therapy and Imaging .................................................................................................................... 1509
So-Young Lee
The Mechanism and Extent of Liposome Internalization by Macrophages ............................ 1511Elran Haber
Thiomers: Polymeric Efflux Pump Inhibitors in Oral Drug Delivery ........................................ 1513Andreas Bernkop-Schnürch
A Novel Approach to Surface Functionalization of Nanoparticles: II. Folic Acid Conjugated Nanoparticles ........................................................................................................... 1515
Yogesh Patil
A Novel Phage Identified Peptide Targets Nanocarriers to Gliomas of the Brain.................. 1517Abhiruchi Agarwal
Analysis of BiP Protein As a Targeting Molecule to Tumor Endothelium for Drug Delivery System ............................................................................................................................ 1519
Yasufumi Katanasaka
Anti-EGFR Peptide-Conjugated STEALTH Liposomes for Cancer Therapy........................... 1521Ken Huang
Bioadhesion of N-2(-Hydroxypropyl) Methacrylamide (HPMA) Copolymer-RGDfK Conjugates: Influence of Peptide Content ................................................................................ 1523
Mark Borgman
Bubble Dynamic Conditions for Drug Release from Pluronic Micelles .................................. 1525Mario Diaz de la Rosa
Characterization of Transferrin Conjugated Liposomes for Tumor Targeting Applications Using Bioimaging................................................................................................... 1526
Murali Divi
Chemoprevention of Tumor Metastasis by Liposomal ß-Sitosterol Intake ............................ 1528Hiromichi Imanaka
Chemosensitization of Multi-Drug Resistant Human Small Cell Lung Cancer Cells to Doxorubicin ............................................................................................................................... 1530
Imran Saleem
Coenzyme Q10 Loaded PLGA Nanoparticles for Oral Cancer Therapy: Assessment of Antioxidant’s Potential Against a Standard Chemotherapeutic Agent Paclitaxel. ........................................................................................................................... 1532
Dhawal Ankola
Differences in HSP Expression After the Treatment of Cancer Cell Lines with Different Polymeric Conjugates .................................................................................................. 1534
Ondrej Hovorka
Dual Function of Pluronic P85 in Treatment of Experimental Carcinoma in Rat ................... 1536Tianyi Krupka
Dual Specific Targeting of Tumor Angiogenesis....................................................................... 1538Deepali Vartak
Effects and Mechanisms of Glycocholic Acid on Modulation of Multidrug Resistance and Induction of Apoptosis in Caco-2 Cells .......................................................... 1540
Yu-li Lo
Effects of Carrier on Disposition and Antitumor Activity of Intraperitoneal Paclitaxel........................................................................................................................................ 1542
Jessie Au
Engineering Transferrin for Improved Drug Carrier Efficacy ................................................... 1544Bert Lao
Enhanced Efficiency of Transfection of Tumor Cells In Vivo by Using “Smart” pH-Sensitive TAT-Peptide-Modified PEGylated Liposomes........................................................... 1546
Amit Kale
Extracorporeal Elimination of Liposomes Used in Cancer Chemotherapy ............................ 1548Gerhard Putz
Folate Appended Liposomes for Enhanced Delivery of Doxorubicin to B16F10 Melanoma Cells ............................................................................................................................. 1550
Yashwant Gupta
Folate-Poly(ethylene glycol)-g-Polyethylenimine/ Retinoic Acid Nanoparticles for Receptor-mediated Tumor Targeting.......................................................................................... 1552
Mi-Kyong Yoo
Glutaraldehyde Improves Binding And Uptake Of RGD- Modified Erythrocytes By Angiogenic Endothelial Cells ...................................................................................................... 1554
Marcel Fens
In Vitro Efficacy of Core Shell Microparticle to Circumvent Efflux Transporter .................... 1556Kiran Dharmala
In Vitro Evaluation of Topical Iontophoretic Delivery of Doxorubicin..................................... 1558Renata Fonseca Vianna Lopez
Long-CirculatingPoly (EthyleneGlycol) - Coated Emulsionsto Target Solid Tumors ........................................................................................................................................... 1560
Joanna Rossi
Microemulsions for Topical Delivery of 5-Aminolevulinic Acid and its Hexil Ester in Photodynamic Therapy ............................................................................................................ 1562
Renata Fonseca Vianna Lopez
Multifunctional Micelles for Cancer Cell Targeting, Distribution Imaging, and Anticancer Drug Delivery ............................................................................................................. 1564
Ging-Ho Hsiue
Novel Amphiphilic Carriers for Folate Receptor Targeted Drug Delivery............................... 1566Shiladitya Bhattacharya
Novel Doxorubicin-Detergent Complexes for Improved Stealth Polymeric Nanoparticle Delivery ................................................................................................................... 1568
Xinyi Gu
Novel EPR-Independent Camptothecin Conjugate with Dual-phase Drug Release: A Blood Pool Effect? .................................................................................................................... 1570
Mikhail ("Misha") Papisov
Organ- and Cell-type Specific Delivery of Kinase Inhibitors .................................................... 1572Robbert Kok
Oxystress Induced Antitumor Therapeutics Via Tumor-targeted Delivery of PEG-Conjugated D-amino Acid Oxidase ............................................................................................. 1574
Jun Fang
Polymeric Magneto-Immunomicelles: Potential for Targeted MRI Imaging Probe ................ 1576Rishikesh Sawant
Polymeric-based pH-sensitive Immunoliposomes Specific to Human Myeloid Leukemic Cells .............................................................................................................................. 1578
Pierre Simard
Preclinical Application of Paclitaxel-Eluting Polyurethane Membrane for Bile Duct Stent ............................................................................................................................................... 1580
Seok Jeong
Prostate Cancer-Specific mAb 5D4 Significantly Enhances the Cytotoxicity of Doxorubicin-Loaded Liposomes Against Target Cells In Vitro................................................ 1582
Rishikesh Sawant
Pullulan/Deoxycholic Acid/Histidine Nanogels Responding to Extracellular Tumor pH; pH-Dependent Drug Release and In Vitro Cytotoxicity...................................................... 1584
Kun Na
Receptor-Mediated Gene Delivery by Folate-PEG-Baculovirus In Vitro and In Vivo ............. 1586You-Kyoung Kim
Synthesis and Targeted Radiotherapeutic Assessment of 188Re(V)DMSA Microspheres In Glioma ............................................................................................................... 1588
Jaya Shukla
Synthesis of Methotrexate-a-peptide Conjugates with Anti-parallel ß-Hairpin Structure ........................................................................................................................................ 1590
Phanidhara Kotamraj
Targeting and Bio-imaging of Solid Tumors Using RGD-fluorescent Liposomes ................. 1592Vinayagam Kannan
Transferrin Coupled Solid Lipid Nanoparticles Bearing Doxorubicin for Enhanced Delivery to MDA-MB-468 Breast Cancer Cells ........................................................................... 1594
Anekant Jain
Transferrin-Modified Procationic Liposomes as a New Carrier for the Delivery of Plasmid DNA.................................................................................................................................. 1596
Qin He
Ultrasonically-Assisted Drug Delivery in Rats Reduces Tumor Growth................................. 1598Bryant Staples
Useful Combination Therapy of Anti-angiogenic Agent with Chemotherapeutic Agents or Radionuclide Therapy for Cancer Treatment ........................................................... 1599
SunJu Choi
Author Index